Publikationen
Possible New Strategies for the Treatment of Congenital Hyperinsulinism
Jelena Sikimic, Theresa Hoffmeister, Anne Gresch, Julia Kaiser, Winfried Barthlen, Carmen Wolke, Ilse Wieland, Uwe Lendeckel, Peter Krippeit-Drews, Martina Düfer and Gisela Drews
Front. Endocrinol., 27 October 2020 | doi.org/10.3389/fendo.2020.545638
Acyl-Ghrelin Influences Pancreatic β-Cell Function by Interference with KATP Channels.
Diabetes. 2020 Nov 5:db200231. doi: 10.2337/db20-0231.
Approved LXR agonists exert unspecific effects on pancreatic β-cell function.
Endocrine. 2020 Jun;68(3):526-535. doi: 10.1007/s12020-020-02241-4. Epub 2020 Mar 7.
Sikimic J, McMillen TS, Bleile C, Dastvan F, Quast U, Krippeit-Drews P, Drews G, Bryan J.
J Biol Chem. 2018 Dec 26. pii: jbc.RA118.005236. doi: 10.1074/jbc.RA118.005236. [Epub ahead of print]
Maczewsky J, Kaiser J, Gresch A, Gerst F, Düfer M, Krippeit-Drews P, Drews G.
Diabetes. 2018 Nov 8. pii: db180315. doi: 10.2337/db18-0315. [Epub ahead of print]
ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic β-cells.
Bauer C, Kaiser J, Sikimic J, Krippeit-Drews P, Düfer M, Drews G.
Endocrine. 2018 Sep 18. doi: 10.1007/s12020-018-1731-0. [Epub ahead of print]
Energy depletion and not ROS formation is a crucial step of glucolipotoxicity (GLTx) in pancreatic beta cells.
Barroso Oquendo M, Layer N, Wagner R, Krippeit-Drews P, Drews G.
Pflugers Arch. 2018, 470:537-547.
Atrial Natriuretic Peptide Affects Stimulus-Secretion Coupling of Pancreatic β-Cells.
Undank S, Kaiser J, Sikimic J, Düfer M, Krippeit-Drews P, Drews G.
Diabetes. 2017, 66:2840-2848.
The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism.
Maczewsky J, Sikimic J, Bauer C, Krippeit-Drews P, Wolke C, Lendeckel U, Barthlen W, Drews G.
Endocrinology. 2017, 158:2145-2154.
The Angiotensin-(1-7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo.
Sahr A, Wolke C, Maczewsky J, Krippeit-DrewsP, Tetzner A, Drews G, Venz S, Gürtler S, van den Brandt J, Berg S, Döring P, Dombrowski F, Walther T, Lendeckel U.
Endocrinology. 2016 157:4677-4690.
Evidence against a Ca2+-induced potentiation of dehydrogenase activity in pancreatic beta-cells.
Drews G, Bauer C, Edalat A, Düfer M, Krippeit-Drews P.
Pflügers Arch. 2015 467:2389-2397.
Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells.
Edalat A, Schulte-Mecklenbeck P, Bauer C, Undank S, Krippeit-Drews P, Drews G, Düfer M.
Diabetologia. 2015 58:1532-1541.
Human Islets Exhibit Electrical Activity on Microelectrode Arrays (MEA).
Schönecker S, Kraushaar U, Guenther E, Gerst F, Ullrich S, Häring HU, Königsrainer A, Barthlen W, Drews G, Krippeit-Drews P.
Exp Clin Endocrinol Diabetes. 2015 123:296-298.
Role of FXR in β-cells of lean and obese mice.
Schittenhelm B, Wagner R, Kähny V, Peter A, Krippeit-Drews P, Düfer M, Drews G.
Endocrinology. 2015 156:1263-1271.
Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays.
Schönecker S, Kraushaar U, Düfer M, Sahr A, Härdtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G.
"Integrative biology: quantitative biosciences from nano to macro" Integr Biol (Camb). 2014 6:540-544.
Glitazones exert multiple effects on β-cell stimulus-secretion coupling.
Düfer M, Noack K, Edalat A, Krippeit-Drews P, Drews G.
"Molecular pharmacology"Mol Pharmacol. 2013 83:51-60.
The significance of the nuclear farnesoid X receptor (FXR) in β cell function.
Düfer M, Hörth K, Krippeit-Drews P, Drews G.
"Islets" Islets. 2012 4:333-338. Review.
H₂O₂ lowers the cytosolic Ca²⁺ concentration via activation of cGMP-dependent protein kinase Iα.
Müller PM, Gnügge R, Dhayade S, Thunemann M, Krippeit-Drews P, Drews G, Feil R.
"Free radical biology & medicine"Free Radic Biol Med. 2012 53:1574-1583.
Role of K(ATP) channels in β-cell resistance to oxidative stress.
Drews G, Düfer M.
"Diabetes, obesity & metabolism" Diabetes Obes Metab, 2012 Suppl 3:120-128
Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition.
Düfer M, Hörth K, Wagner R, Schittenhelm B, Prowald S, Wagner TF, Oberwinkler J, Lukowski R, Gonzalez FJ, Krippeit-Drews P, Drews G.
"Diabetes" Diabetes. 2012 61:1479-1489
Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays.
Pfeiffer T, Kraushaar U, Düfer M, Schönecker S, Haspel D, Günther E, Drews G, Krippeit-Drews
"Pflugers Archiv: European journal of physiology" Pflügers Arch - EJP. 2011 462:835-840.
Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells.
Düfer M, Noack K, Krippeit-Drews P, Drews G.
"Islets" Islets. 2010 2:156-63.
BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells.
Düfer M, Neye Y, Hörth K, Krippeit-Drews P, Hennige A, Widmer H, McClafferty H, Shipston MJ, Häring HU, Ruth P, Drews G.
Diabetologia. 2011 54:423-432
Oxidative stress and beta-cell dysfunction.
Drews G, Krippeit-Drews P, Düfer M.
Pflügers Arch -EJP. 2010 Jul 23. [Epub ahead of print]
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.
Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N.
J Clin Invest. 2010 May 3. pii: 41541. doi: 10.1172/JCI41541. [Epub ahead of print]
Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse beta-cell
Martina Düfer, Katja Noack, Peter Krippeit-Drews and Gisela Drews
Islets 2010;2:1-9
Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction.
Hennige AM, Ranta F, Heinzelmann I, Düfer M, Michael D, Braumüller H, Lutz SZ, Lammers R, Drews G, Bosch F, Häring HU, Ullrich S.
Diabetes. 2010;59:119-127
Electrophysiology of islet cells.
Drews G, Krippeit-Drews P, Düfer M.
"Advances in experimental medicine and biology"Adv Exp Med Biol. 2010;654:115-63
Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.
Gier B, Krippeit-Drews P, Sheiko T, Aguilar-Bryan L, Bryan J, Düfer M, Drews G.
"The Journal of clinical investigation" J Clin Invest. 2009;119:3246-3256
Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.
Düfer M, Gier B, Wolpers D, Krippeit-Drews P, Ruth P, Drews G.
"Diabetes" Diabetes. 2009;58:1835-1843.
Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells.
Düfer M, Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G.
"Pflugers Archiv: European journal of physiology" Pflugers Arch. 2009;457:1351-1360.
Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis.
Ranta F, Düfer M, Stork B, Wesselborg S, Drews G, Häring HU, Lang F, Ullrich S.
Cell Signal. 2008;20:1780-1786
An adenylate kinase is involved in KATP channel regulation of mouse pancreatic beta cells.
Schulze DU, Düfer M, Wieringa B, Krippeit-Drews P, Drews G.
"Diabetologia"Diabetologia. 2007;50:2126-2134.
The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells.
Dufer M, Haspel D, Krippeit-Drews P, Kelm M, Ranta F, Nitschke R, Ullrich S, Aguilar-Bryan L, Bryan J, Drews G.
"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology" Cell Physiol Biochem. 2007;20:65-74.
Resveratrol binds to the sulfonylurea receptor (SUR) and induces apoptosis in a SUR subtype-specific manner.
Hambrock A, de Oliveira Franz CB, Hiller S, Grenz A, Ackermann S, Schulze DU, Drews G, Osswald H.
J Biol Chem. 2007;282:3347-3356
ABCC8 and ABCC9: ABC transporters that regulate K+ channels.
Bryan J, Muñoz A, Zhang X, Düfer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L.
"Pflugers Archiv: European journal of physiology" Pflügers Arch. 2007 Feb;453:703-718.
HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents.
Neye Y, Düfer M, Drews G, Krippeit-Drews P.
"The Journal of pharmacology and experimental therapeutics" J Pharmacol Exp Ther. 2006;316:106-112.
Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4.
Ranta F, Avram D, Berchtold S, Düfer M, Drews G, Lang F, Ullrich S.
Diabetes. 2006;55:1380-1390
Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice.
Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G, Düfer M.
"Diabetologia" Diabetologia. 2005;48:913-921.
Direct interference of HIV protease inhibitors with pancreatic beta-cell function.
Düfer M, Neye Y, Krippeit-Drews P, Drews G.
"Naunyn-Schmiedeberg's archives of pharmacology" Naunyn Schmiedebergs Arch Pharmacol. 2004;369:583-590.
Oscillations of membrane potential and cytosolic Ca2+ concentration in SUR1-/- beta cells.
Düfer M, Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G.
"Diabetologia" Diabetologia. 2004;47:488-498.
Palmitate-induced Ca2+-signaling in pancreatic beta-cells.
Remizov O, Jakubov R, Düfer M, Krippeit Drews P, Drews G, Waring M, Brabant G, Wienbergen A, Rustenbeck I, Schöfl C.
"Molecular and cellular endocrinology" Mol Cell Endocrinol. 2003;212:1-9
Phosphocreatine as a determinant of KATP channel activity in pancreatic beta-cells.
Krippeit-Drews P, Bäcker M, Düfer M, Drews G.
"Pflugers Archiv: European journal of physiology" Pflügers Arch. 200 ;445:556-562.
Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate.
Düfer M, Krippeit-Drews P, Buntinas L, Siemen D, Drews G.
"The Biochemical journal" Biochem J. 2002;368:817-825.
Inhibition of mitochondrial function affects cellular Ca2+ handling in pancreatic B-cells.
Düfer M, Krippeit-Drews P, Drews G.
"Pflugers Archiv: European journal of physiology" Pflügers Arch. 2002;444:236-243.
Diabetogenic effect of cyclosporin A is mediated by interference with mitochondrial function of pancreatic B-cells.
Düfer M, Krippeit-Drews P, Lembert N, Idahl LA, Drews G.
"Molecular pharmacology" Mol Pharmacol. 2001;60:873-879
Stimulation of leukotriene synthesis in intact polymorphonuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid.
Boden SE, Schweizer S, Bertsche T, Düfer M, Drews G, Safayhi H.
Mol Pharmacol. 2001;60:267-273
Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells.
Drews G, Krämer C, Düfer M, Krippeit-Drews P.
Biochem J. 2000;352:389-397
Dual effect of NO on KATP current of mouse pancreatic B-cells: stimulation by deenergizing mitochondria and inhibition by direct interaction with the channel.
Drews G, Krämer C, Krippeit-Drews P.
"Biochimica et biophysica acta" Biochim Biophys Acta. 2000;1464:62-68
Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells.
Krippeit-Drews P, Düfer M, Drews G.
Biochem Biophys Res Commun. 2000;267:179-183
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