Institute of Organic Chemistry

Research

Our research focuses on flow chemistry and the development of new applications in the broad field of organic chemistry.

Flow chemistry offers the unique advantages of improved mixing and heating efficiency and ease of scale-up while reducing reaction time and solvent consumption. Due to its advantageous properties, numerous applications have been developed for research and industrial organic synthesis. One major drawback is the requirement for expensive proprietary equipment, which is not always affordable and usually very bulky. To introduce accessible flow chemistry into research facilities, systems need to be affordable and more compact. 3D printing technology offers the solution. We are combining our experience in 3D printing and synthetic chemistry to develop flow devices that could overcome the hurdle of expensive, bulky devices.

An overview of the devices released so far can be found here.

The flow systems are used for various chemical syntheses, e.g. for the synthesis of radiopharmaceuticals in cooperation with the Werner Siemens Imaging Center (WSIC) of the UKT.

Publications

  • Open-source flow setup for rapid and efficient [18F]fluoride drying for automation of PET tracer syntheses, F. Menzel, J. Cotton, T. Ziegler, A. Maurer, J. M. Neumaier, J. Label. Compd. Radiopharm. 2023, 1-19, https://doi.org/10.1002/jlcr.4080

  • FOMSy: 3D-printed flexible open-source microfluidic system and flow synthesis of PET-tracer. F. Menzel, J. Cotton, T. Klein, A. Maurer, T. Ziegler, J. M. Neumaier, J. Flow Chem. 2023, https://doi.org/10.1007/s41981-023-00267-z

  • 3D-printed PEEK reactors and development of a complete continuous flow system for chemical synthesis. F. Menzel, T. Klein, T. Ziegler, J. M. Neumaier, React. Chem. Eng. 2020, 5, 1300-1310. http://dx.doi.org/10.1039/d0re00206b

  • Low-budget 3D-printed equipment for continuous flow reactions. J. M. Neumaier, A. Madani, T. Klein, T. Ziegler, Beilstein J. Org. Chem. 2019, 15, 558-566. https://doi.org/10.3762/bjoc.15.50