SBSCL is a comprehensive implementation of systems biology simulation methods in Java™. SBSCL can solve complex differential equation systems (including delays, algebraic systems, spontaneous events, and rules) as well as flow balance analysis using the Simplex method. Currently, an interpreter for SBML models is built in. Extensions for other formats are possible. Due to the integrated support of SED-ML, simulation experiments can be clearly repeated.
https://github.com/draeger-lab/SBSCL/