Computational Systems Biology of Infections

and Antimicrobial-Resistant Pathogens

Welcome to the Draeger Research Group!

The Dräger working group was founded in July 2018 and since then has been dedicated to computer-aided systems biology with a focus on infections and antimicrobial-resistant pathogens. The research foci of the group cover all steps from the biological phenomenon to its simulation in the computer. The work includes the reconstruction of biological systems, their mathematical modeling, the standardization of these models, as well as the development of specialized software solutions and the application of methods of machine learning. A primary goal is to derive model-driven new hypotheses to combat increasing antibiotic resistance systematically.

Systems Biology: A short overview


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Latest Publications

  1. FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2
    A. Renz, L. Widerspick, and A. Dräger
    Accepted in Bioinformatics, preprint from February 15th 2020.
    [ DetailsDOIPDF | BibTeX ]
  2. Computational Model Informs Effective Control Interventions against Y. enterocolitica Co-Infection
    R. Mostolizadeh and A. Dräger
    Biology, 9(12), Special Issue Computational Biology, November 30th 2020.
    [ Details | DOI | Preprints | PubMed | PDF | BibTeX ]
  3. Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories
    J. P. Bernardes, N. Mishra, F. Tran, T. Bahmer, L. Best, J. I. Blase, D. Bordoni, J. Franzenburg, U. Geisen, J. Josephs-Spaulding, P. Köhler, A. Künstner, E. Rosati, A. C. Aschenbrenner, P. Bacher, N. Baran, T. Boysen, B. Brandt, N. Bruse, J. Dörr, A. Dräger, G. Elke, D. Ellinghaus, J. Fischer, M. Forster, A. Franke, S. Franzenburg, N. Frey, A. Friedrichs, J. Fuß, A. Glück, J. Hamm, F. Hinrichsen, M. P. Höppner, S. Imm, R. Jünker, S. Kaiser, Y. H. Kan, R. Knoll, C. Lange, G. Laue, C. Lier, M. Lindner, G. Marinos, R. Markewitz, J. Nattermann, R. Noth, P. Pickkers, K. F. Rabe, A. Renz, C. Röcken, J. Rupp, A. Schaffarzyk, A. Scheffold, J. Schulte-Schrepping, D. Schunck, D. Skowasch, T. Ulas, K.-P. Wandinger, M. Wittig, J. Zimmermann, H. Busch, B. F. Hoyer, C. Kaleta, J. Heyckendorf, M. Kox, J. Rybniker, S. Schreiber, J. Schultze, and P. Rosenstiel
    Immunity, November 26th 2020.
    [ Details | DOI | MedRxiv | PubMed | PDF | BibTeX ]
  4. Genome-Scale Metabolic Modeling of Escherichia coli and Its Chassis Design for Synthetic Biology Applications
    B. S. Mienda and A. Dräger
    Computational Methods in Synthetic Biology. M. A. Marchisio (editor), part of the series Methods in Molecular Biology (MIMB, volume 2189), pages 217-229, November 13th 2020
    [ Details | DOI | PubMedPDF | BibTeX ]
  5. SysMod: the ISCB community for data-driven computational modelling and multi-scale analysis of biological systems
    A. Dräger, T. Helikar, M. Barberis, M. Birtwistle, L. Calzone, C. Chaouiya, J. Hasenauer, J. R. Karr, A. Niarakis, M. Rodríguez Martínez, J. Saez-Rodriguez, and J. Thakar
    Zenodo, preprint, October 31st 2020.
    [ Details | DOI | PDF | BibTeX ]
  6. COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms
    M. Ostaszewski, A. Niarakis, A. Mazein, I. Kuperstein, R. Phair, A. Orta-Resendiz, V. Singh, S. S. Aghamiri, M. L. Acencio, E. Glaab, A. Ruepp, G. Fobo, C. Montrone, Barbara Brauner, Goar Frishman, L. C. Monraz Gómez, J. Somers, M. Hoch, S. Kumar Gupta, J. Scheel, H. Borlinghaus, T. Czauderna, F. Schreiber, A. Montagud, M. Ponce de Leon, A. Funahashi, Y. Hiki, N. Hiroi, T. G. Yamada,  A. Dräger, A. Renz, M. Naveez, Z. Bocskei, F. Messina, D. Börnigen, L. Fergusson, M. Conti, M. Rameil, V. Nakonecnij, J. Vanhoefer, L. Schmiester, M. Wang, E. E. Ackerman, J. E. Shoemaker, J. Zucker, K. L. Oxford, J. Teuton, E. Kocakaya, G. Y. Summak, K. Hanspers, M. Kutmon, S. Coort, L. Eijssen, F. Ehrhart, R. D. A. B., D. Slenter, M. Martens, R. Haw, B. Jassal, L. Matthews, M. Orlic-Milacic, A. Senff-Ribeiro, K. Rothfels, V. Shamovsky, R. Stephan, C. Sevilla, T. M. Varusai, J.-M. Ravel, R. Fraser, V. Ortseifen, S. Marchesi, P. Gawron, E. Smula, L. Heirendt, V. Satagopam, G. Wu, A. Riutta, M. Golebiewski, S. Owen, C. Goble, X. Hu, R. Overall, D. Maier, A. Bauch, J. A. Bachman, B. M. Gyori, C. Vega, V. Grouès, M. Vazquez, P. Porras, L. Licata, M. Iannuccelli, F. Sacco, D. Turei, A. Luna, O. Babur, S. Soliman, A. Valdeolivas, M. Esteban-Medina, M. Peña-Chilet, T. Helikar, B. Lal Puniya, A. Nesterova, A. Yuryev, A. de Waard, D. Modos, A. Treveil, M. L. Olbei, B. De Meulder, A. Naldi, A. Dugourd, V. Noël, L. Calzone, C. Sander, E. Demir, T. Korcsmaros, T. C. Freeman, F. Auge, J. S. Beckmann, J. Hasenauer, O. Wolkenhauer, E. Willighagen, A. R. Pico, C. Evelo, M. Gillespie, L. D. Stein, H. Hermjakob, P. DʼEustachio, J. Saez-Rodriguez, J. Dopazo, A. Valencia, H. Kitano, E. Barillot, C. A., R. Balling, R. Schneider, and the COVID-19 Disease Map Community
    BioRxiv, October 28th 2020.
    [ Details | DOI | PDF | BibTeX ]
  7. Overview: Standards for Modeling in Systems Medicine
    A. Dräger and D. Waltemath
    Systems Medicine. Integrative, Qualitative and Computational Approaches. Olaf Wolkenhauer (Editor), Volume 3, 2021, Pages 245–353
    [ Details | DOI | PubMed | PDF | BibTeX ]
  8. Community standards to facilitate development and address challenges in metabolic modeling
    M. A. Carey, A. Dräger, M. E. Beber, J. A. Papin, and J. T. Yurkovich
    Molecular Systems Biology, August 26th 2020.
    [ Details | DOI | PubMedBioRxiv | PDF | BibTeX ]
  9. SBML Level 3: an extensible format for the exchange and reuse of biological models
    S. M. Keating, D. Waltemath, M. König, F. Zhang, A. Dräger, C. Chaouiya, F. T. Bergmann, A. Finney, C. Gillespie, T. Helikar, S. Hoops, R. Malik-Sheriff, S. Moodie, I. Moraru, C. J. Myers, A. Naldi, B. Olivier, S. Sahle, J. Schaff, L. P. Smith, M. Swat, D. Thieffry, L. Watanabe, D. Wilkinson, M. L. Blinov, K. Begley, J. Faeder, H. Gómez, T. M. Hamm, Y. Inagaki, W. Liebermeister, A. Lister, D. Lucio, E. Mjolsness, C. Proctor, K. Raman, N. Rodriguez, C. Shaffer, B. Shapiro, J. Stelling, N. Swainston, N. Tanimura, J. Wagner, M. Meier-Schellersheim, H. Sauro, B. Ø. Palsson, H. Bolouri, H. Kitano, A. Funahashi, H. Hermjakob, J. C. Doyle, M. Hucka, and the SBML Level 3 Community members: R. R. Adams, N. A. Allen, B. R. Angermann, M. Antoniotti, G. D. Bader, J. Červený, M. Courtot, C. D. Cox, P. Dalle Pezze, E. Demir, W. S. Denney, H. Dharuri, J. Dorier, D. Drasdo, A. Ebrahim, J. Eichner, J. Elf, L. Endler, C. T. Evelo, C. Flamm, R. M. T. Fleming, M. Fröhlich, M. Glont, E. Gonçalves, M. Golebiewski, H. Grabski, A. Gutteridge, D. Hachmeister, L. A. Harris, B. D. Heavner, R. Henkel, W. S. Hlavacek, B. Hu, D. R. Hyduke, H. Jong, N. Juty, P. D. Karp, J. R. Karr, D. B. Kell, R. Keller, I. Kiselev, S. Klamt, E. Klipp, C. Knüpfer, F. Kolpakov, F. Krause, M. Kutmon, C. Laibe, C. Lawless, L. Li, L. M. Loew, R. Machne, Y. Matsuoka, P. Mendes, H. Mi, F. Mittag, P. T. Monteiro, K. N. Natarajan, P. M. F. Nielsen, T. Nguyen, A. Palmisano, J.‐B. Pettit, T. Pfau, R. D. Phair, T. Radivoyevitch, J. M. Rohwer, O. A. Ruebenacker, J. Saez‐Rodriguez, M. Scharm, H. Schmidt, F. Schreiber, M. Schubert, R. Schulte, S. C. Sealfon, K. Smallbone, S. Soliman, M. I. Stefan, D. P. Sullivan, K. Takahashi, B. Teusink, D. Tolnay, I. Vazirabad, A. Kamp, U. Wittig, C. Wrzodek, F. Wrzodek, I. Xenarios, A. Zhukova, and J. Zucker.
    Molecular Systems Biology, August 26th 2020
    [ Details | DOI | PubMed | PDF | BibTeX ]
  10. Model-based prediction of bacterial population dynamics in gastrointestinal infection
    J. Geißert, E. Bohn, R. Mostolizadeh, A. Dräger, I. Autenrieth, S. Beier, O. Deusch, M. Eichner, and M. Schütz
    BioRxiv, August 11th 2020.
    [ Details | DOI | PDF | BibTeX ]
  11. Systems biology markup language (SBML) level 3 package: multistate, multicomponent and multicompartment species, version 1, release 2
    F. Zhang, L. P. Smith, M. L. Blinov, J. Faeder, W. S. Hlavacek, J.-J. Tapia, S. M. Keating, N. Rodriguez, A. Dräger, L. A. Harris, A. Finney, B. Hu, M. Hucka, and M. Meier-Schellersheim
    Journal of Integrative Bioinformatics, July 6th 2020.
    [ Details | DOI | PubMed | PDF | BibTeX ]
  12. Systems biology graphical notation markup language (SBGNML) version 0.3
    F. T. Bergmann, T. Czauderna, U. Dogrusoz, A. Rougny, A. Dräger, V. Touré, A. Mazein, M. L. Blinov, and A. Luna
    Journal of Integrative Bioinformatics, June 22nd 2020.
    [ Details | DOI | PubMed | PDF | BibTeX ]
  13. COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms
    M. Ostaszewski, A. Mazein, M. E. Gillespie, I. Kuperstein, A. Niarakis, H. Hermjakob, A. R. Pico, E. L. Willighagen, C. T. Evelo, J. Hasenauer, F. Schreiber, A. Dräger, E. Demir, O. Wolkenhauer, L. I. Furlong, E. Barillot, J. Dopazo, A. Orta-Resendiz, F. Messina, A. Valencia, A. Funahashi, H. Kitano, C. Auffray, R. Balling, and R. Schneider
    Scientific Data 7, 136. May 5th 2020.
    [ Details | DOI | PubMed | PDF | BibTeX ]
  14. Visualizing metabolic network dynamics through time-series metabolomic data
    L. F. Buchweitz, J. T. Yurkovich, C. BlessingV. Kohler, F. Schwarzkopf, Z. A. King, L. Yang, F. Jóhannsson, Ó. Sigurjónsson, Ó. Rolfsson, J. Heinrich, and A. Dräger.
    BMC Bioinformatics 21, 130. April 3rd 2020.
    Details | DOI | PubMed | BioRxiv | PDF | BibTeX ]
  15. MEMOTE for standardized genome-scale metabolic model testing
    C. Lieven, M. E. Beber, B. G. Olivier, F. T. Bergmann, M. Ataman, P. Babaei, J. A. Bartell, L. M. Blank, S. Chauhan, K. Correia, C. Diener, A. Dräger, B. E. Ebert, J. N. Edirisinghe, J. P. Faria, A. M. Feist, G. Fengos, R. M. T. Fleming, B. García-Jiménez, V. Hatzimanikatis, W. van Helvoirt, C. S. Henry, H. Hermjakob, M. J. Herrgård, A. Kaafarani, H. U. Kim, Z. A. King, S. Klamt, E. Klipp, J. J. Koehorst, M. König, M. Lakshmanan, D.-Y. Lee, S. Y. Lee, S. Lee, N. E. Lewis, F. Liu, H. Ma, D. Machado, R. Mahadevan, P. Maia, A. Mardinoglu, G. L. Medlock, J. M. Monk, J. Nielsen, L. K. Nielsen, J. Nogales, I. Nookaew, B. O. Palsson, J. A. Papin, K. R. Patil, N. D. Price, O. Resendis-Antonio, A. Richelle, I. Rocha, B. J. Sánchez, P. J. Schaap, R. S. M. Sheriff, S. Shoaie, N. Sonnenschein, B. Teusink, P. Vilaça, J. O. Vik, J. A. H. Wodke, J. C. Xavier, Q. Yuan, M. Zakhartsev, and C. Zhang.
    Nature Biotechnology, March 2nd 2020.
    [ Details | DOIBioRxiv | PDF | PubMedBibTeX ]
  16. Clinical Applications of Metabolic Models in SBML Format
    A. RenzR. Mostolizadeh, and A. Dräger
    Reference Module in Biomedical Sciences, Elsevier, January 30th 2020
    [ DetailsDOI | PDF | PubMed | BibTeX ]
  17. The Systems Biology Graphical Notation: Current Status and Applications in Systems Medicine
    V. Touré, A. Dräger, A. Luna, U. Dogrusoz, and A. Rougny
    Reference Module in Biomedical Sciences, Elsevier, January 25th 2020
    [ DetailsDOI | PDF | PubMed | BibTeX ]