Publications
Google Scholar ORCID ResearchGate
K. D. Kiran Kumar, S. Singh, S. M. Schmelzle, P. Vogel, C. Fruhner, A. Hanswillemenke, A. Brun, J. Wettengel, Y, Füll, L. Funk, V. Mast, J. J. Botsch, P. Reautschnig, J. B. Li, T. Stafforst*, Nature Communications 2024, in press
Precise in-vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA
P. Reautschnig*, C. Fruhner, N. Wahn, C. P. Weigand, S. Kragness, J. F. Yung, D. T. Hofacker, J. Fisk, M. Edelman, N. Waffenschmidt, M. Feige, L. S. Pfeiffer, A. E. Schulz, Y, Füll, E. Y. Levanon, G. Mandel, T. Stafforst*, Nature Biotechnology 2024, online (open access)
Profiling the Interactome of Oligonucleotide Drugs by Proximity Biotinylation
A. Hanswillemenke, D. T. Hofacker, M. Sorgenfrei, C. Fruhner, M. Franz-Wachtel, D. Schwarzer, B. Macek and T. Stafforst*, Nature Chemical Biology 2024, online (open access)
Review: Precision RNA base editing with engineered and endogenous effectors
L. S. Pfeiffer and T. Stafforst*, Nature Biotechnology 2023, 41, 1526-42.
Precise and efficient C-to-U RNA Base Editing with SNAP-CDAR-S
N. Latifi, A. M. Mack, I. Tellioglu, S. Di Giorgio, T. Stafforst*, Nucl. Acids Res. 2023, gkad598.
ADAR1-mediated RNA editing promotes B cell lymophomagenesis
R. Pecori et al., iScience 2023, 26, 106864.
M. Helm et al., ACS Chem. Biol. 2023, 18, 2441-9.
CLUSTER guide RNAs enable precise and efficient RNA editing in cell culture and in vivo
P. Reautschnig, N. Wahn, J. Wettengel, A. E. Schulz, N. Latifi, P. Vogel, T.-W. Kang, L. S. Pfeiffer, C. Zarges, U. Naumann, L. Zender, J. B. Li and T. Stafforst*, Nature Biotechnology 2022, 40, 759–768.
Harnessing self-labeling enzymes for selective and concurrent A-to-I and C-to-U RNA base editing
A. Stroppel, N. Latifi, A. Hanswillemenke, R.N. Tasakis, F.N. Papavasiliou and T. Stafforst*, Nucl. Acids Res. 2021, 49, gkab541.
Controlling Site-directed RNA Editing by Chemically Induced Dimerization
A. Stroppel, R. Lappalainen and T. Stafforst*, ChemEurJ 2021, 27, 12300-12304.
New Frontiers for Site-Directed RNA Editing: Harnessing Endogenous ADARs
T. Merkle and T. Stafforst*, Methods in Molecular Biology 2021, 2181. Humana press, New York (eds, E. Picardi, G. Pesole)
Protocols for the generation of caged guideRNAs for light-triggered RNA-targeting with SNAP-ADARs
A. Hanswillemenke and T. Stafforst*, Methods Enzym. 2019, 624, 47-68.
Chemistry helps to bump off-target edits away
T. Stafforst*, Cell Chem. Biol. 2019, 26, 151-152.
Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
T. Merkle, S. Merz, P. Reautschnig, A. Blaha, Q. Li, P. Vogel, J. Wettengel, J. B. Li, T. Stafforst*, Nature Biotechnology 2019, 37, 133-138.
Critical review on engineering deaminases for site-directed RNA editing
P. Vogel, T. Stafforst*, Current Opin. Biotech. 2019, 55, 74-80.
Efficient and Precise Editing of Endogenous Transcripts with SNAP-tagged ADARs
P. Vogel, M. Moschref, Q. Li, T. Merkle, K. D. Selvasaravanan, J. B. Li, T. Stafforst*. Nature Methods 2018, 15, 535-38.
A. S. Stroppel, M. Paolillo, T. Ziegler, R. Feil, T. Stafforst*. ChemBioChem 2018, 19, 1312-18.
*highlighted in ChemistryViews*
highlighted as "very important paper"
Switching protein localization by site-directed RNA editing under control of light
P. Vogel, A. Hanswillemenke, T. Stafforst*, ACS Synth. Biol. 2017, 6, 1642-9.
*open access*
M. Heep, P. Mach, P. Reautschnig, J. Wettengel, T. Stafforst*, Genes 2017, 8, 34 (special issue on RNA editing).
*open access*
Harnessing human ADAR2 for RNA repair – Recoding a PINK1 mutation rescues mitophagy
J. Wettengel, P. Reautschnig, S. Geisler, P. J. Kahle, T. Stafforst*, Nucl. Acids Res. 2017, 45, 2797-2808.
*open access*
The notorious R.N.A. in the Spotlight - Drug or Target for the Treatment of Disease
P. Reautschnig, P. Vogel, T. Stafforst*, RNA Biology 2017, 14, 651-668 (invited review).
*open access*
A. Hanswillemenke, T. Kuzdere, P. Vogel, G. Jekely, T. Stafforst*, J. Am. Chem. Soc. 2015, 137, 15 875-81.
*open access*
Trendbericht Biochemie 2014: Biochemie natürlicher RNA-Modifikationen
T. Stafforst*, Nachrichten aus der Chemie 2015, 63, 306-9.
Upon the photostability of 8-nitro-cGMP and its caging as a 7-dimethylaminocoumarinyl ester
A. Samanta, M. Thunemann, R. Feil, T. Stafforst*, Chem. Commun. 2014, 50, 7120-23.
Site-directed RNA editing with Antagomir-deaminases - a tool to study protein and RNA function
P. Vogel, T. Stafforst*, ChemMedChem 2014, 9, 2021-25.
Improving Directed RNA Editing In Vitro and in Cell Culture by Chemical Modification of the guideRNA
P. Vogel, M. F. Schneider, J. Wettengel, T. Stafforst*, Angew. Chem. Int. Ed. 2014, 53, 6267-71.
German version:
Angew. Chem. 2014, 126, 6382-86.
Optimal guideRNAs for Re-directing Deaminase Activity of hADAR1 and hADAR2 in trans
M. F. Schneider, J. Wettengel, P. C. Hoffmann, T. Stafforst*, Nucl. Acids Res. 2014, 42, e87.
*open access*
Pyrene Chromophores for the Photoreversal of Psoralen Interstrand Crosslinks
J. M. Stadler, T. Stafforst*, Org. Biomol. Chem. 2014, 12, 5260-66.
Gerichtete Editierung – ein Werkzeug zur Reprogrammierung von RNA
T. Stafforst*, Biospektrum 2014, 20, 231-233.
T. Stafforst*, ChemBioChem 2014, 15, 356-58.
Diskussionspapier: Biotechnologie - der Schlüssel zur Bioökonomie
Zukunftsforum der Dechema, Dechema 2014.
S. J. Bachmann, Z. Lin, T. Stafforst, W. F. van Gunsteren, J. Dolenc*, J. Chem. Theor. Comp. 2014, 10, 391-400.
Photoactivation of a Psoralen-blocked Luciferase Gene by Blue Light
T. Stafforst*, J. M. Stadler, Angew. Chem. Int. Ed. 2013, 52, 12448-51.
German version:
Photoaktivierung eines Psoralen-vernetzten Luciferasegens mit blauem Licht
Angew. Chem. 2013, 125, 12676-80.
An RNA-Deaminase Conjugate Selectively Repairs Point Mutations
T. Stafforst*, M. F. Schneider, Angew. Chem. Int. Ed. 2012, 51, 11166-9.
German version:
Ein RNA-Deaminase-Konjugat ermöglicht die selektive Reparatur von Punktmutationen
Angew. Chem. 2012, 124, 11329-32.
A FlAsH Reporter for Protein-Dimerization Triggers
T. Stafforst*, ChemBioChem 2012, DOI: 10.1002/cbic.201100787
Photolyase-like Repair of Psoralen-crosslinked Nucleic Acids
T. Stafforst*, D. Hilvert*, Angew. Chem. Int. Ed. 2011, 50, 9483-9486; Angew. Chem. 2011, 123, 9655-9658.
German version:
Photolyase-artige Reparatur Psoralen-quervernetzter Nucleinsäuren
Angew. Chem. 2011, 123, 9655-58.
K. E. Otto, S. Hesse, T. N. Wassermann, C. A. Rice, M. A. Suhm*, T. Stafforst, U. Diederichsen, Phys. Chem. Chem. Phys. 2011, 13, 14119 - 14130.
Modulating PNA-DNA Hybridization by Light
T. Stafforst*, D. Hilvert*,
Angew. Chemie Int. Ed. 2010, 49, 9998-10001; Angew. Chem. 2010, 122, 10195-10198
German version:
Photokontrolle der PNA-DNA-Hybridisierung
Angew. Chem. 2010, 122, 10195-98.
Kinetic Characterization of Spiropyrans in Aqueous Media
T. Stafforst*, D. Hilvert, Chem. Commun. 2009, 287 - 288.
T. Stafforst, U. Diederichsen*, Eur. J. Org. Chem. 2007, 899 - 911.
Synthesis of acid-sensitive N-(2-aminoethyl)glycine-PNA oligomers via Fmoc/Bhoc strategy
T. Stafforst, U. Diederichsen*, Eur. J. Org. Chem. 2007, 681 - 688.
T. Stafforst, U. Diederichsen*, Angew. Chem. Int. Ed. 2006, 45, 5376 - 5380.
German version:
Angew. Chem. 2006, 118, 5502 – 06.
(6-4)-Photolyase activity requires a charge shift reaction
T. Stafforst, U. Diederichsen*, Chem. Commun. 2005, 3430 - 3432.
Aggregation behaviour of p-n-alkylbenzamidinium chloride surfactants
R. Talhout, T. Stafforst, J. B. F. N. Engberts*, J. Colloid Interface Sci. 2004, 276, 212 - 220