I) Original data, peer-reviewed:

1991-1994:

1) Menz, B., Winter, G., Ilg, T., Lottspeich, F. and Overath, P. (1991) Purification and cha­racteri­za­tion of membrane-bound acid phosphatase of Leishmania mexicana. Molecular and Biochemical Parasitology 47, 101-108.

2) Ilg, T., Menz, B., Winter, G., Russell, D., Etges, R., Schell, D. and Overath, P. (1991a) Monoclonal antibodies to Leishmania mexicana promastigote antigens. I. Secreted acid phosphatase and other proteins share epitopes with lipophospho­glycan. Journal of Cell Science 99, 175-180.

3) Ilg, T., Stierhof, Y.-D., Etges, R. Adrian, M., Harbecke, D. and Overath, P. (1991b) Secreted acid phosphatase of Leishmania mexicana: A filamenteous phosphoglyco­protein polymer. Proceedings of the National Academy of Sciences, U. S. A. 88, 8774-8778.

4) Ilg, T., Etges, R., Overath, P., McConville, M. J., Thomas-Oates, J., Thomas, J., Homans, S. W. and Ferguson, M. A. J. (1992) Structure of Leishmania mexicana lipophosphoglycan. Journal of Biological Chemistry 267, 6834-6840.

5) Komuniecki, R., Bruchhaus, I., Ilg, T., Wilson, K., Zhang, Y. and Fairlamb, A. H. (1992) Purification of glutathione reductase from muscle of the adult parasitic nematode Ascaris suum. Molecular and Biochemical Parasitology 51, 331-333.

6) Bahr, V., Stierhof, Y.-D., Ilg, T., Demar, M., Quinten, M. and Overath, P. (1993) Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glyco­protein 63 in promastigotes and amastigotes of Leishmania mexicana. Molecular and Biochemical Parasitology 58, 107-122.

7) Ilg, T., Harbecke, D. and Overath, P. (1993a) The lysosomal gp63-related protein in Leishmania mexicana amastigotes is a soluble metalloproteinase with an acidic pH optimum. FEBS Letters 327/1, 103-107.

8) Ilg, T., Harbecke, D., Wiese, M. and Overath, P. (1993b) Monoclonal antibodies to Leishmania secreted acid phosphatase and lipophosphoglycan: Partial characteri­zation of private and public epitopes. European Journal of Biochemistry 217, 603-615.

9) Stierhof, Y.-D., Ilg T., Russell, D. G., Hohenberg, H. and Overath, P. (1994) The flagellar pocket as secretory organelle: Characterization of polymer release from Leishmania mexicana promastigotes. Journal of Cell Biology 125, 321-331.

10) Ilg T., Stierhof, Y.-D., Wiese, M., McConville, M. J. and Overath, P. (1994a) Characterization of phosphoglycan-containing secretory products of Leishmania. Parasitology 108, 63-71.

11) Ilg, T., Fuchs, M., Gnau, V., Wolfram, M., Harbecke, D. and Overath, P. (1994b) Distribution of parasite cysteine proteinases in lesions of mice infected with Leishmania mexicana amastigotes. Molecular and Biochemical Parasitology 67, 193-203.

12) Ilg, T., Overath, P., Ferguson, M. A. J., Rutherford, T., Campbell, D. G. and McConville, M. J. (1994c) N- and O-glycosylation of the Leishmania mexicana secreted acid phosphatase. Characterization of a new class of phosphoserine-linked glycans. Journal of Biological Chemistry 269, 24073-24081.

1995-1998:

13) Ilg, T., Stierhof, Y.-D., McConville, M. J. and Overath, P. (1995) Purification, partial characterization and immunolocalization of a proteophosphoglycan secreted by Leishmania mexicana amastigotes. European Journal of Cell Biology 66, 205-215.

14) Wolfram, M., Ilg, T., Mottram, J. and Overath, P. (1995) Antigen presentation by Leishmania mexicana-infected macrophages: activation of helper T cells specific for amastigote cysteine proteinases requires intracellular killing of the parasites. European Journal of Immunology 25, 1094-1100.

15) Wiese, M., Ilg, T., Lottspeich, F. and Overath, P. (1995) Ser/Thr-rich repetitive motifs as targets for phosphoglycan modifications in Leishmania mexicana secreted acid phosphatase. EMBO Journal 14, 1067-1074.

16) Ilg, T., Stierhof, Y.-D., Craik, D., Simpson, R., Handman, E. and Bacic, A. (1996) Purification and structural characterization of a filamentous mucin-like proteophosphoglycan secreted by Leishmania parasites. Journal of Biological Chemistry 271, 21583-21596.

17) Peters, C., Stierhof, Y.-D. and Ilg, T. (1997) Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages. Infection and Immunity 65, 783-786.

18) Peters, C., Kawakami, M., Kaul, M., Ilg,T., Overath P. and Aebischer, T. (1997) Secreted proteophosphoglycan of Leishmania mexicana amastigotes activates complement by triggering the mannan binding lectin pathway. European Journal of Immunology 27, 2666-2672.

19) Stierhof Y.-D., Wiese M., Ilg T., Overath P., Haener M. and Aebi U. (1998) Structure of a filamentous phosphoglycoprotein polymer: The secreted acid phosphatase of Leishmania mexicana. Journal of Molecular Biology 282, 137-148.

20) Ilg T., Craik D., Currie, G., Multhaup G. and Bacic A. (1998) Stage-specific proteophosphoglycan from Leishmania mexicana amastigotes. Journal of Biological Chemistry 273, 13509-13523.

1999-2002:

21) Piani, A., Ilg, T., Elefanty, E. G., Curtis, J. and Handman, E. (1999) Leishmania major proteophosphoglycan is expressed in amastigotes and has an immunomodulatory effect. Microbes and Infection 1, 589-599.

22) Stierhof, Y.-D., Bates, P. A., Jacobson, R., Schlein, Y., Rogers, M., Handman, E. and Ilg, T. (1999) Filamentous proteophosphoglycan secreted by Leishmania promastigotes forms gel-like threedimensional meshworks that obstruct the digestive tract of infected sandfly vectors. European Journal of Cell Biology 78, 675-689.

23) Aebischer, T., Harbecke, D. and Ilg, T. (1999) Proteophosphoglycan, a major secreted product of intracellular Leishmania mexicana amastigotes, is a poor B-cell antigen and does not elicit a specific conventional CD4 T cell response. Infection and Immunity 67, 5379-5385.

24) Ilg, T., Montgomery, J., Stierhof, Y.-D. and Handman, E. (1999c) Molecular cloning and characterization of a novel repeat-containing Leishmania major gene, ppg1, that encodes a membrane-bound proteophosphoglycan with a putative glycosyl-phosphatidyl-inositol anchor. Journal of Biological Chemistry 274, 31410-31420.

25) Klein, C., Göpfert, U., Goehring, N., Stierhof, Y.-D. and Ilg, T. (1999) Proteophosphoglycans of Leishmania mexicana. I) Identification, purification, structural and ultrastructural characterization of Leishmania mexicana promastigote pPPG2, a stage-specific glycoisoform of amastigote aPPG. Biochemical Journal 344, 775-786.

26) Göpfert, U., Goehring, N., Klein, C. and Ilg, T. (1999) Proteophosphoglycans of Leishmania mexicana. II) Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans aPPG and pPPG2 that are secreted by amastigotes and promastigotes. Biochemical Journal 344, 787-795.

27) Aebischer, T., Wolfram, M., Patzer, S. I., Ilg, T., Wiese, M., and Overath, P. (2000) Subunit vaccination of mice against New World cutaneous Leishmaniasis: comparison of three proteins expressed in amastigotes and six adjuvants. Infection and Immunity 68, 1328-1336.

28) Ilg, T. (2000) Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana. EMBO Journal 19, 1-11.

29) Montgomery, J., Ilg, T., Kobe , B. and Handman, E. (2000) Identification and predicted structure of a leucine rich repeat motif shared by membrane-bound Leishmania major proteophosphoglycan and promastigote surface antigen 2. Molecular and Biochemical Parasitology 107, 289-295.

30) Ilg, T., Demar M. and Harbecke D. (2001) Phosphoglycan repeat-deficient Leishmania mexicana remain infectious to macrophages and mice. Journal of Biological Chemistry 276, 4988-4997.

31) Garami, A. and Ilg T. (2001) The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence. Journal of Biological Chemistry, 276, 6566-6575.

32) Garami, A. and Ilg T. (2001) Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence but not for viability. EMBO J., 20, 1-10.

33) Garami, A., Mehlert, A. and Ilg T. (2001) Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants. Molecular and Cellular Biology 21, 8168-8183.

34) Saeed M., Ilg T. and Voelter W. (2001) The total synthesis and antileishmanial activity of R-(-)-argentilactone. Tetrahedron Letters 42, 7401-7403.

35) Ilg T. (2002) Generation of myo-inositol-auxotrophic Leishmania mexicana mutants by targeted replacement of the myo-inositol-1-phosphate synthase gene. Molecular and Biochemical Parasitology 120, 151-156.

36) Foth B., Piani A., Curtis J.M., Ilg T., McConville M. and Handman E. (2002) Leishmania major proteophosphoglycans exist as membrane-bound and soluble forms and localise to the cell membrane, the flagellar pocket and the lysosome. International Journal for Parasitology 19, 1701-1708.

2003-2007:

37) Nylen S., Maasho K., Soderstrom K., Ilg T., Akuffo H. (2003) Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma. Clinical and Experimental Immunology 131, 457-467.

38) Davis A.J., Perugini M.A., Smith B.J., Stewart J.D., Ilg T., Hodder A.N., Handman E. (2004) Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana. Journal of Biological Chemistry 279, 12462-12468.

39) Rogers M.E., Ilg T., Nikolaev A.V., Ferguson M.A.J. and Bates P.A. (2004) Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of filamentous proteophosphoglycan. Nature 430, 463-467.

40) Aebischer T., Bennett C.L., Pelizzola M., Vizzardelli C., Pavelka N., Urbano M., Capozzoli M., Luchini A., Ilg T., Granucci F., Blackburn C. and Ricciardi-Castagnoli P. (2005) A critical role for lipophosphoglycan in proinflammatory responses of dendritic cells to Leishmania mexicana. European Journal of Immunology 35, 476-486.

41) Stewart J. Curtis J. Spurck T.P., Ilg T., Garami A., Baldwin T., Courret N., McFadden G.I., Davis A., Handman E. (2005) Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase. International Journal for Parasitology 35, 861-873.

42) Mbuchi M., Bates P.A., Ilg T., Coe J.E., Raynes J.G. (2006) C-reactive protein initiates transformation of Leishmania donovani and Leishmania mexicana through binding to lipophosphoglycan. Molecular and Biochemical Parasitology 146, 259-264.

43) Kedzierski L., Malby R.L., Smith B.J., Perugini M.A., Hodder A.N., Ilg T., Colman P.M., Handman E. (2006) Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms. Journal of Molecular Biology 363, 215-227.

2008-2012:

44) Rothacker B., Ilg T. (2008) Functional characterization of a Drosophila melanogaster succinic semialdehyde dehydrogenase and a non-specific aldehyde dehydrogenase. Insect Biochemistry and Molecular Biology 38, 354-366.

45) Chassaing C., Berger M., Heckeroth A., Ilg T., Jaeger M., Kern C., Schmid K., Uphoff M. (2008) Highly water-soluble prodrugs of anthelmintic benzimidazole carbamates: synthesis, pharmacodynamics, and pharmacokinetics. Jornal of Medicinal Chemistry 51, 1111-1114.

46) Rothacker B., Werr M., Ilg T. (2008) Molecular cloning, partial genomic structure and functional characterization of succinic semialdehyde dehydrogenase genes from the parasitic insects Lucilia cuprina and Ctenocephalides felis. Insect Molecular Biology 17, 279-291.

47) Jäger M., Rothacker B., Ilg T. (2008) Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Biochemical and Biophysical Research Communications 372, 400-406.

48) Rothacker B., Werr M., Ilg T. (2008) Succinic semialdehyde dehydrogenase from the parasitic cattle tick Rhipicephalus microplus: gene identification, biochemical characterization and comparison with the mouse ortholog. Molecular and Biochemical Parasitology 161, 32-43.

49) Werr M., Cramer J., Ilg T. (2009) Identification and characterization of two arginine kinases from the parasitic insect Ctenocephalides felis. Insect Biochem. Mol. Biol. 39, 634-645.

50) Ilg T., Schmalz S., Werr M., Cramer J. (2010) Acetylcholinesterases of the cat flea Ctenocephalides felis: identification of two distinct genes and biochemical characterization of recombinant and in vivo enzyme activities. Insect Biochem. Mol. Biol. 40, 153-164.

51) Dederer H, Werr M, Ilg T. (2011) Differential sensitivity of Ctenocephalides felis and Drosophila melanogaster nicotinic acetylcholine receptor α1 and α2 subunits in recombinant hybrid receptors to nicotinoids and neonicotinoid insecticides. Insect Biochem. Mol. Biol. 41, 51-61.

52) Ilg T., Cramer J., Lutz J., Noack S., Schmitt H., Williams H., Newton T. (2011) The characterization of Lucilia cuprina acetylcholinesterase as a drug target, and the identification of novel inhibitors by high throughput screening. Insect Biochem. Mol. Biol. 41, 470-483.

53) Spehr V., Warrass R., Höcherl K., Ilg T. (2011) Large-scale production of the immunomodulator c-di-GMP from GMP and ATP by an enzymatic cascade. Appl. Biochem. Biotechnol. 165, 761-775.

54) Ilg T., Werr M. (2012) Arginine kinase of the sheep blowfly Lucilia cuprina: gene identification and characterization of the native and recombinant enzyme. Pest. Biochem. Physiol. 102, 115-123.

II) Reviews

1) Ilg, T., Handman, E., Ng, K., Stierhof, Y.-D. and Bacic, A. (1999a) Mucin-like proteophosphoglycans from the protozoan parasite Leishmania. Trends Glycosci. Glycotechnol. 11, 1-19.

2) Ilg, T., Handman, E. and Stierhof, Y.-D. (1999b) Proteophosphoglycans from Leishmania promastigotes and amastigotes. Biochem. Soc. Trans. 27, 48-55.

3) Ilg, T. (2000b) Proteophosphoglycans of Leishmania. Parasitol. Today 16, 489-497.

4) Handman, E., Sjölander, A., Ilg, T., Montgomery, J., Piani, A., Curtis, J.M., Elso, C., Roberts, L.J. and Foote, S.J. (2001) Host-parasite interactions in leishmaniasis. Immunologist 8, 42-44.

5) Ilg, T. (2001) Lipophosphoglycan of the protozoan parasite Leishmania: Differential and species-specific importance for colonization of the sandfly vector, transmission and virulence to mammals. Med. Microbiol. Immunol. 190, 13-17.

III) Book chapters

Meyer, T., Schröder, J., Uphoff, M., Noack, S., Heckeroth, A.R., Gassel, M., Rohrwild, P., Ilg, T. (2009) Chemical optimization of anthelmintic compounds – a case study. In: Drug Discovery in Infectious Diseases: From Molecular Targets to Drug Candidates. pp 357- 371. Edited by Paul M. Selzer. Wiley-VCH Verlag GmbH & Co KgaA, Weinheim

IV) Patents

1) Chassaing C., Schröder J., Ilg, T, Uphoff M., Meyer T. Anthelmintic agents and their use. (2007) USA, Application No 61/014242; (2008) EP08101961.4

2) Ilg T., Spehr V., Warrass R. Enzymatic production of cyclic di-guanosine monophosphate. (2008) EP08171026.1