Publications
2021
Bauer A. · Forchhammer K. 2021. Bacterial predation on cyanobacteria. Microb Physiol. 31: 99–108. |
Engelbrecht, A., H. Saad , H. Gross, L. Kaysser. 2021. Natural Products from Nocardia and Their Role in Pathogenicity. Microb. Physiol. doi: 10.1159/000516864 |
Garg R, Maldener I. The Formation of Spore-Like Akinetes: A Survival Strategy of Filamentous Cyanobacteria. Microb Physiol. 1-10. doi:10.1159/000517443. |
Garg R, Maldener I. The Dual Role of the Glycolipid Envelope in Different Cell Types of the Multicellular Cyanobacterium Anabaena variabilis ATCC29413. 2021. Front Microbiol.12:645028. doi: 10.3389/fmicb.2021.645028. |
Gómez-Pérez D, Chaudhry V, Kemen A, Kemen E. 2021. Amyloid Proteins in Plant-Associated Microbial Communities. Microb Physiol. 2021;1–11. |
Gómez-Pérez D, and Kemen E. 2021. Predicting Lifestyle from Positive Selection Data and Genome Properties in Oomycetes. Pathogens 10 (7). doi.org/10.3390/pathogens10070807 |
Gómez-Pérez, D. & Kemen, E. 2021. Predicting Lifestyle and Host From Positive Selection Data and Genome Properties in Oomycetes. Research Square doi:10.21203/rs.3.rs-157744/v1 |
Hottmann I. · Borisova M. · Schäffer C. · Mayer C. 2021. Peptidoglycan Salvage Enables the Periodontal Pathogen Tannerella forsythia to Survive within the Oral Microbial Community. Microb Physiol 2021;31:123–134 (DOI:10.1159/000516751) |
Illigmann, A., Thoma, Y., Pan, S., Reinhardt, L., Brötz-Oesterhelt H. Contribution of the Clp Protease to Bacterial Survival and Mitochondrial Homoeostasis. Microb Physiol. 26:1-20. doi: 10.1159/000517718 |
Koch, M., and K.Forchhammer (2021). „Polyhydroxybutyrate: A Useful Product of Chlorotic Cyanobacteria“ Microb Physiol. 31: 67–77 (DOI:10.1159/000515617) |
Krysenko S, Matthews A, Busche T, Bera A, Wohlleben W. 2021. Poly- and Monoamine Metabolism in Streptomyces coelicolor: The New Role of Glutamine Synthetase-Like Enzymes in the Survival under Environmental Stress. Microb Physiol. 27:1-15 |
Neumann N. · Doello S. · Forchhammer K. (2021) Recovery of unicellular cyanobacteria from nitrogen chlorosis: A model for Resusciation of Dormant Bacteria. Microb Physiol 31:78–87 |
Rohmer, C. & Wolz, C. 2021. The Role of hlb-Converting Bacteriophages in Staphylococcus aureus Host Adaption, Microb Physiol. 31, 109-122 |
Rosigkeit H, Kneißle L, Obruca S, Jendrossek D. 2021. The multiple roles of polyphosphate in Ralstonia eutropha and other bacteria. Microb Physiol 31:1–15 |
Torres Salazar B.O. · Heilbronner S. · Peschel A. · Krismer B. 2021. Secondary Metabolites Governing Microbiome Interaction of Staphylococcal Pathogens and Commensals. Microb Physiol doi: 10.1159/000517082 |
| Yu-Ming Huang, Daniel Straub, Nia Blackwell, Andreas Kappler, and Sara Kleindienst (2021): Meta-omics reveal Gallionellaceae and Rhodanobacter as interdependent key players for Fe(II) oxidation and nitrate reduction in the autotrophic enrichment culture KS. Applied and Environmental Microbiology. DOI: 10.1128/AEM.00496-21 |
| Yu-Ming Huang, Daniel Straub, Andreas Kappler, Nicole Smith, Nia Blackwell and Sara Kleindienst (2021): A novel enrichment culture highlights core features of microbial networks contributing to autotrophic Fe(II) oxidation coupled to nitrate reduction. Microbial Physiology. |
| Rapp, J., Rath, P., Killian, J., Brilisauer, K., Grond, S., Forchhammer, K.: A bioactive molecule made by unusual salvage of radical SAM enzyme by-product 5-deoxyadenosine blurs the boundary of primary and secondary metabolism. – Journal of Biological Chemistry, In press, doi: 10.1016/j.jbc.2021.100621. |
| Michaelis, L., Treß, M., Löw, H.C., Klees, J., Klameth, C., Lange, A., Grießhammer, A., Schäfer, A., Menz, S., Steimle, A., Schulze-Osthoff, K., Frick, J.S.: Gut commensal-induced IκBζ expression in dendritic cells influences the Th17 response. Frontiers in Immunology 11, 612336 (2021) |
Doello S., Burkhardt M., Forchhammer K., 2021, The essential role of sodium bioenergetics and ATP homeostasis in the developmental transitions of a cyanobacterium. Current Biology 31, 1–10 |
Koch, M., Bruckmoser, J., Scholl, J., Hauf, W., Rieger, B., Forchhammer, K., 2020: Maximizing PHB content in Synechocystis sp.PCC 6803: a new metabolic engineering strategy based on the regulator PirC. Microb Cell Fact 19, 231 (2020). doi.org/10.1186/s12934-020-01491-1 |
| Müller M, Calvert M, Hottmann I, Kluj RM, Teufel T, Balbuchta K, Engelbrecht A, Selim KA, Xu Q, Borisova M, Titz A, Mayer C. The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases. J Biol Chem. 2021 Mar 5:100519. doi: 10.1016/j.jbc.2021.100519. Epub ahead of print. PMID: 33684445. |
2020
| Maerz, J.K., Trostel, C., Lange, A., Parusel, R., Michaelis, L., Schäfer, A., Yao, H., Löw, H.C., Frick, J.S.: Bacterial immunogenicity is critical for the induction of regulatory B cells in suppressing inflammatory immune responses. Frontiers in Immunology 10, 3093 (2020) |
| Raue S, Fan SH, Rosenstein R, Zabel S, Luqman A, Nieselt K & Götz F., 2020. The Genome of Staphylococcus epidermidis O47. Front. Microbiol. 11:2061. doi: 10.3389/fmicb.2020.02061 |
Shvarev D, Maldener I. The HlyD-like membrane fusion protein All5304 is essential for acid stress survival of the filamentous cyanobacterium Anabaena sp. PCC 7120. FEMS Microbiol Lett. 2020 Aug 1;367(15):fnaa108. doi: 10.1093/femsle/fnaa108. PMID: 32592389. |
Chilczuk T, Monson R, Schmieder P, Christov V, Enke H, Salmond G, and Niedermeyer THJ (2020): Ambigols from the Cyanobacterium Fischerella ambigua Increase Prodigiosin Production in Serratia spp. ACS Chem. Biol. 2020, XXXX, XXX, XXX-XXX, Publication Date:November 4, 2020, doi.org/10.1021/acschembio.0c00554 |
Koch Moritz, Orthwein Tim, Alford Janette T., Forchhammer Karl (2020) The Slr0058 Protein From Synechocystis sp. PCC 6803 Is a Novel Regulatory Protein Involved in PHB Granule Formation. Frontiers in Microbiology 11. 809. www.frontiersin.org/article/10.3389/fmicb.2020.00809 |
Selim KA, Tremino L, Marco-Marin C, Alva V, Espinosa J, Contreras A, Hartmann M, Forchhammer K, Rubio V (2020) Functional and structural characterization of PII_like protein CutA does not support involvement in heavy metal tolerance and hints at a small_molecule carrying/signaling role. FEBS doi.org/10.1111/febs.15464 |
Koch, M.; Berendzen, K.W.; Forchhammer, K. On the Role and Production of Polyhydroxybutyrate (PHB) in the Cyanobacterium Synechocystis sp. PCC 6803. Life 2020, 10, 47 |
Jochim A., Adolf L., Belikova D., Schilling N.A., Setyawati I., Chin D., Meyers S., Verhamme P., Heinrichs D.E., Slotboom D.J., Heilbronner S. (2020): An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis. eLife 2020;9:e57322 DOI: 10.7554/eLife.57322 |
| Forchhammer K, Selim KA. (2020): Carbon/Nitrogen Homeostasis Control in Cyanobacteria. FEMS Microbiol Rev. 2020 Jan 1;44(1):33-53. doi: 10.1093/femsre/fuz025. |
| Frank, C., Jendrossek, D. (2020). Acidocalcisomes and Polyphosphate Granules Are Different Subcellular Structures in Agrobacterium tumefaciens. Applied and Environmental Microbiology, 86 (8). doi: 10.1128/AEM.02759-19 |
2019
Shvarev D, Nishi CN, Maldener I. Glycolipid composition of the heterocyst envelope of Anabaena sp. PCC 7120 is crucial for diazotrophic growth and relies on the UDP-galactose 4-epimerase HgdA. Microbiologyopen. 2019 Aug;8(8):e00811. doi: 10.1002/mbo3.811. Epub 2019 Feb 25. PubMed PMID: 30803160; PubMed Central PMCID: PMC6692557. |
Shvarev D, Maldener I. Roles of DevBCA-like ABC transporters in the physiology of Anabaena sp. PCC 7120. Int J Med Microbiol. 2019 Jul;309(5):325-330. doi: 10.1016/j.ijmm.2019.04.005. Epub 2019 Apr 28. Review. PubMed PMID: 31133373 |
Shvarev D, Nishi CN, Maldener I. Two DevBCA-like ABC transporters are involved in the multidrug resistance of the cyanobacterium Anabaena sp. PCC 7120. FEBS Lett. 2019 Jul;593(14):1818-1826. doi: 10.1002/1873-3468.13450. Epub 2019 Jun 4. PubMed PMID: 31116406. |
| Walter A, Mayer C. (2019) Chapter 6: Peptidoglycan structure, biosynthesis, and dynamics during bacterial growth In: Extracellular sugar-based biopolymers matrices, Ephraim Cohen & Hans Merzendorfer (eds), pp:237-299. Springer Nature, Switzerland. doi.org/10.1007/978-3-030-12919-4_6. |
| Mayer C, Kluj RM, Mühleck M, Walter A, Unsleber S, Hottmann I, Borisova M. (2019) Bacteria's different ways to recycle their own cell wall. Int. J. Med. Microbiol. 309(7):151326. doi: 10.1016/j.ijmm.2019.06.006. |
| Mayer C. (2019) Peptidoglycan Recycling, a Promising Target for Antibiotic Adjuvants in Antipseudomonal Therapy. Journal of Infectious Diseases 220(11): 1713-1715. doi: 10.1093/infdis/jiz378 |
| Dörr T, Moynihan PJ, Mayer C. (2019) Editorial: Bacterial Cell Wall Structure and Dynamics. Front. Microbiol. 10: 2051.doi: 10.3389/fmicb.2019.02051 |
| Mayer VMT, Hottmann I, Figl R, Altmann F, Mayer C*, Schäffer C.* (2019) Peptidoglycan-type analysis of the N-acetylmuramic acid auxotrophic oral pathogen Tannerella forsythia and reclassification of the peptidoglycan-type of Porphyromonas gingivalis. BMC Microbiology 19(1). doi: 10.1186/s12866-019-1575-7. |
| Carlos Moreno-Cinos, Elisa Sassetti, Irene G. Salado, Gesa Witt, Siham Benramdane, Laura Reinhardt, Cristina D. Cruz, Jurgen Joossens, Pieter Van der Veken, Heike Brötz-Oesterhelt, Päivi Tammela, Mathias Winterhalter, Philip Gribbon, Björn Windshügel, and Koen Augustyns. (2019): α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease. Journal of Medicinal Chemistry 2019 62 (2), 774-797. DOI: 10.1021/acs.jmedchem.8b01466 |
| Nadine A. Schilling, Anne Berscheid, Johannes Schumacher, Julian S. Saur, Martin C. Konnerth, Sebastian N. Wirtz, José M. Beltrán-Belena, Alexander Zipperer, Bernhard Krismer, Andreas Peschel, Hubert Kalbacher, Heike Brötz-Oesterhelt, Claudia Steinem, and Stephanie Grond (2019): Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability. Angew. Chem. Int. Ed. 2019, 58, 1 – 6 |
| Walter J, Selim KA, Leganés F, Fernández-Piñas F, Vothknecht UC, Forchhammer K, Aro EM, Gollan PJ. (2019): A novel Ca2+-binding protein influences photosynthetic electron transport in Anabaena sp. PCC 7120. Biochim Biophys Acta Bioenerg. 2019 Jun 1;1860(6):519-532. doi: 10.1016/j.bbabio.2019.04.007. |
| Selim KA, Lapina T, Forchhammer K, Ermilova E. (2019): Interaction of N-acetyl-l-glutamate kinase with the PII signal transducer in the non-photosynthetic alga Polytomella parva: Co-evolution towards a hetero-oligomeric enzyme. FEBS J. 2019 Jul 9. doi: 10.1111/febs.14989. |
| Fan SH, Ebner P, Reichert S, Hertlein T, Zabel S, Lankapalli AK, Nieselt K, Ohlsen K, Götz F. (2019): MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels. Nat Commun. 2019 Aug 9;10(1):3627. doi: 0.1038/s41467-019-11547-5 |
| Steimle A, Michaelis L, Di Lorenzo F, Kliem T, Münzner T, Maerz JK, Schäfer A, Lange A, Parusel R, Gronbach K, Fuchs K, Silipo A, Öz HH, Pichler BJ, Autenrieth IB, Molinaro A, Frick JS: Weak Agonistic LPS Restores Intestinal Immune Homeostasis. Mol Ther. 2019 Nov 6;27(11):1974-1991. doi: 10.1016/j.ymthe.2019.07.007. |
| Steimle A, Menz S, Bender A, Ball B, Weber ANR, Hagemann T, Lange A, Maerz JK, Parusel R, Michaelis L, Schäfer A, Yao H, Löw HC, Beier S, Tesfazgi Mebrhatu M, Gronbach K, Wagner S, Voehringer D, Schaller M, Fehrenbacher B, Autenrieth IB, Oelschlaeger TA, Frick JS: Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains. PLoS Biol. 2019 Jun 17;17(6):e3000334. doi: 10.1371/journal.pbio.3000334. |
| Lange A, Schäfer A, Frick JS: A Galleria mellonella Oral Administration Model to Study Commensal-Induced Innate Immune Responses. J Vis Exp. 2019 Mar 21;(145). doi: 10.3791/59270. |
| George SE, Hrubesch J, Breuing I, Vetter N, Korn N, Hennemann K, Bleul L, Willmann M, Ebner P, Götz F, Wolz C (2019): Oxidative stress drives the selection of quorum sensing mutants in the Staphylococcus aureus population. PNAS 2019 Sep 17;116(38):19145-19154. doi: 10.1073/pnas.1902752116 |
| Keinhörster D, George SE, Weidenmaier C, Wolz C (2019): Function and regulation of Staphylococcus aureus wall teichoic acids and capsular polysaccharides. Int J Med Microbiol. 2019 Jul 18:151333. doi: 10.1016/j.ijmm.2019.151333. |
| Keinhörster D, Salzer A, Duque-Jaramillo A, George SE, Marincola G, Lee JC, Weidenmaier C, Wolz C (20019): Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus. Molecular Microbiology 2019 Jul 8. doi: 10.1111/mmi.14347. |
| Koch M, Doello S, Gutekunst K, Forchhammer K. (2019): PHB is Produced from Glycogen Turn-over during Nitrogen Starvation in Synechocystis sp. PCC 6803. Int J Mol Sci. 2019 Apr 20;20(8). pii: E1942. doi: 10.3390/ijms20081942. |
| Krysenko S, Matthews A, Okoniewski N, Kulik A, Girbas MG, Tsypik O, Meyners CS, Hausch F, Wohlleben W, Bera A. (2019): Initial Metabolic Step of a Novel Ethanolamine Utilization Pathway and Its Regulation in Streptomyces coelicolor M145. MBio. 2019 May 21;10(3). pii: e00326-19. doi: 10.1128/mBio.00326-19 |
Klaus Brilisauer, Johanna Rapp, Pascal Rath, Anna Schöllhorn, Lisa Bleul, Elisabeth Weiß, Mark Stahl, Stephanie Grond and Karl Forchhammer (2019): Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms. Nature Communications, volume 10, Article number: 545 (2019) |
| Schweizer M, Brilisauer K, Triebskorn R, Forchhammer K, Köhler H. 2019. How glyphosate and its associated acidity affect early development in zebrafish (Danio rerio) PeerJ 7:e7094 doi.org/10.7717/peerj.7094 |
Tribelli PM, Luqman A, Nguyen MT, Madlung J, Fan SH,Macek B, Sass P, Bitschar K, Schittek B, Kretschmer D & Götz F., 2019. Staphylococcus aureusLpl protein triggers human host cell invasion via activation of Hsp90 receptor, Cellular Microbiology, e13111. https://doi.org/10.1111/cmi.13111 |
2018
Perez R, Wörmer L, Sass P, Maldener I. A highly asynchronous developmental program triggered during germination of dormant akinetes of filamentous diazotrophic cyanobacteria. FEMS Microbiol Ecol. 2018 Jan 1;94(1). doi: 10.1093/femsec/fix131. PMID: 29228342. |
| Hottmann I, Mayer VMT, Tomek MB, Friedrich V, Calvert MB, Titz A, Schäffer C, Mayer C. (2018) N-Acetylmuramic Acid (MurNAc) Auxotrophy of the Oral Pathogen Tannerella forsythia: Characterization of a MurNAc kinase and analysis of its role in cell wall metabolism. Front Microbiol. 9:19. doi: 10.3389/fmicb.2018.00019. |
| Gratani FL, Horvatek P, Geiger T, Borisova M, Mayer C, Grin I, Wagner S, Steinchen W, Bange G, Velic A, Maček B, Wolz C. (2018) Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus. PLoS Genet. 14(7):e1007514. doi: 10.1371/journal.pgen.1007514. |
| Jorge AM, Schneider J, Unsleber S, Xia G, Mayer C, Peschel A. (2018) Staphylococcus aureus counters phosphate limitation by scavenging wall teichoic acids from other staphylococci via the teichoicase GlpQ. J Biol Chem. 293(38):14916-14924. doi: 10.1074/jbc.RA118.004584. |
| Kluj RM, Ebner P, Adamek M, Ziemert N, Mayer C, Borisova M. (2018) Recovery of the peptidoglycan turnover product released by the autolysin Atl in Staphylococcus aureus involves the phosphotransferase system transporter MurP and the novel 6-phospho-N-acetylmuramidase MupG. Front Microbiol. 9:2725. doi: 10.3389/fmicb.2018.02725. |
| Hottmann I, Mayer VMT, Tomek MB, Friedrich V, Calvert MB, Titz A, *Schäffer C, *Mayer C. 2018. N-acetylmuramic acid (MurNAc) auxotrophy of the oral pathogen Tannerella forsythia: characterization of a MurNAc kinase and analysis of its role in cell wall metabolism. Front Microbiol. 9:19. doi: 10.3389/fmicb.2018.00019. |
| Kluj RM, Ebner P, Adamek M, Ziemert N, *Mayer C, Borisova M. 2018. Recovery of the Peptidoglycan turnover product released by the autolysin Atl in Staphylococcus aureus involves the phosphotransferase system transporter MurP and the novel 6-phospho-N-acetylmuramidase MupG. Front Microbiol.9:2725. doi: 10.3389/fmicb.2018.02725. |
| Lange A, Schäfer A, Bender A, Steimle A, Beier S, Parusel R, Frick JS: Galleria mellonella: A Novel Invertebrate Model to Distinguish Intestinal Symbionts From Pathobionts. Front Immunol. 2018 Sep 19;9:2114. doi: 10.3389/fimmu.2018.02114. |
| Lange A, Beier S, Huson DH, Parusel R, Iglauer F, Frick JS: Genome Sequence of Galleria mellonella (Greater Wax Moth). Genome Announc. 2018 Jan 11;6(2). pii: e01220-17. doi: 10.1128/genomeA.01220-17. |
| Maerz JK, Steimle A, Lange A, Bender A, Fehrenbacher B, Frick JS: Outer membrane vesicles blebbing contributes to B. vulgatus mpk-mediated immune response silencing. Gut Microbes. 2018 Jan 2;9(1):1-12. doi: 10.1080/19490976.2017.1344810. |
Casey Bryce, Nia Blackwell, Caroline Schmidt, Julia Otte, Yu‐Ming Huang, Sara Kleindienst, Elizabeth Tomaszewski, Manuel Schad, Viola Warter, Chao Peng, James M. Byrne, Andreas Kappler. Microbial anaerobic Fe(II) oxidation – Ecology, mechanisms and environmental implications. Environmental Microbiology (2018) 20(10), 3462–3483 |
Shvarev, D.; Nishi, C.N.; Wörmer, L.; Maldener, I. The ABC Transporter Components HgdB and HgdC are Important for Glycolipid Layer Composition and Function of Heterocysts in Anabaena sp. PCC 7120. Life 2018, 8, 26. |
Dmitry Shvarev, Iris Maldener; ATP-binding cassette transporters of the multicellular cyanobacterium Anabaena sp. PCC 7120: a wide variety for a complex lifestyle, FEMS Microbiology Letters, Volume 365, Issue 4, 1 February 2018, fny012, doi.org/10.1093/femsle/fny012 |
Björn Watzer and Karl Forchhammer. Cyanophycin Synthesis Optimizes Nitrogen Utilization in the Unicellular Cyanobacterium Synechocystis sp. Strain PCC 6803. Journal of Applied and Environmental Microbiology 84, 20, e-01298-18. doi.org/10.1128/AEM.01298-18. |
Sebastian Reichert, Patrick Ebner, Eve-Julie Bonetti, Arif Luqman, Mulugeta Nega, Jacques Schrenzel, Cathrin Spröer, Boyke Bunk, Jörg Overmann, Peter Sass, Patrice François and Friedrich Götz (2018) Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus. Fontiers in Microbiology 9, Article 1539. doi.org/10.3389/fmicb.2018.01539 |
Jüngert, J. R., Patterson, C., & Jendrossek, D. (2018). Ralstonia eutropha's Poly(3-hydroxybutyrate)(PHB) polymerase PhaC1 and PHB depolymerase PhaZa1 are phosphorylated in vivo. Applied and Environmental Microbiology, AEM.00604–18. doi.org/10.1128/AEM.00604-18 |
Khaled A. Selim, Florian Haase, Marcus D. Hartmann, Martin Hagemann, and Karl Forchhammer. P II -like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response. PNAS 115 21 (2018)E4861-E4869. |
Sofia Doello, Alexander Klotz, Alexander Makowka, Kirstin Gutekunst, Karl Forchhammer. A specific glycogen mobilization strategy enables awakening of dormant cyanobacteria from chlorosis. Plant Physiology Preview. Published on April 27, 2018, as DOI:10.1104/pp.18.00297 |
Philipp Spät, Alexander Klotz, Sascha Rexroth, Boris Maček and Karl Forchhammer. Chlorosis as a developmental program in cyanobacteria: the proteomic fundament for survival and awakening. MCP 17 (9) 1650-1669; doi.org/10.1074/mcp.RA118.000699. |
Tominski C, Lösekann-Behrens T, Ruecker A, Hagemann N, Kleindienst S, Mueller CW, Höschen C, Kögel-Knabner I, Kappler A, Behrens S. 2018. Insights into carbon metabolism provided by fluorescence in situ hybridization-secondary-ion mass spectrometry imaging of an autotrophic, nitrate-reducing, FeII-oxidizing enrichment culture. Appl Environ Microbiol 84:e02166-17. doi.org/10.1128/AEM.02166-17. |
Tominski C, Heyer H, LösekannBehrens T, Behrens S, Kappler A. 2018. Growth and population dynamics of the anaerobic FeII-oxidizing and nitrate-reducing enrichment culture KS. Appl Environ Microbiol 84:e02173-17. doi.org/10.1128/AEM.02173-17. |
2017
| Jorge AM, Schneider J, Unsleber S, Göhring N, Mayer C, Peschel A. (2017) Utilization of glycerophosphodiesters by Staphylococcus aureus. Mol Microbiol. 103(2):229-241. doi: 10.1111/mmi.13552. |
| Schüller A, Matzner D, Lünse CE, Wittmann V, Schumacher C, Unsleber S, Brötz-Oesterhelt H, Mayer C, Bierbaum G, Mayer G. (2017) Activation of the glmS ribozyme confers bacterial growth inhibition. Chembiochem. 18(5):435-440. doi: 10.1002/cbic.201600491. |
| Parusel R, Steimle A, Lange A, Schäfer A, Maerz JK, Bender A, Frick JS: An important question: Which LPS do you use? Virulence. 2017 Nov 17;8(8):1890-1893. doi: 10.1080/21505594.2017.1361100. |
Bornikoel J, Carrión A, Fan Q, Flores E, Forchhammer K, Mariscal V, Mullineaux CW, Perez R, Silber N, Wolk CP, Maldener I. Role of Two Cell Wall Amidases in Septal Junction and Nanopore Formation in the Multicellular Cyanobacterium Anabaena sp. PCC 7120. Front Cell Infect Microbiol. 2017 Sep 5;7:386. doi: 10.3389/fcimb.2017.00386. eCollection 2017. PubMed PMID: 28929086; PubMed Central PMCID: PMC5591844. |
Nordhoff, M., Tominski, C., Halama, M., Byrne, J.M., Obst, M., Kleindienst, S., Behrens, S., Kappler, A. (2017) Insights into nitrate-reducing Fe(II) oxidation mechanisms by analyzing cell-mineral associations, cell encrustation and mineralogy in the chemolithoautotrophic nitrate-reducing Fe(II)-oxidizing enrichment culture KS. Applied and Environmental Microbiology, in press. |
Borisova, M and Mayer, C (2017). Analysis of N-acetylmuramic acid-6-phosphate (MurNAc-6P) Accumulation by HPLC-MS. Bio-protocol 7(15): e2420. doi: 10.21769/BioProtoc.2420. |
| Borisova, M., Gisin, J. and Mayer, C. The N-Acetylmuramic Acid 6-Phosphate Phosphatase MupP Completes the Pseudomonas Peptidoglycan Recycling Pathway Leading to Intrinsic Fosfomycin Resistance. Mbio 8:e00092-17. doi: 10.1128/mBio.00092-17 |
| Jüngert, J.R., Borisova, M., Mayer, C., Wolz, C., Brigham, C.J., Sinskey, A.J. and Jendrossek, D. Absence of ppGpp Leads to Increased Mobilization of Intermediately Accumulated Poly(3-hydroxybutyrate) (PHB) in Ralstonia eutropha H16. Appl Environ Microbiol. 2017 Jul 1; 83(13) pii: AEM.00755-17. doi: 10.1128/AEM.00755-17. |
| Klotz, A. and Forchhammer, K. Glycogen, a major player for bacterial survival and awakening from dormancy. Future Microbiol 12:101-104. doi: 10.2217/fmb-2016-0218 |
| Krysenko, S., Okoniewski, N., Kulik, A., Matthews, A., Grimpo, J., Wohlleben, W., and Bera, A. Gamma-Glutamylpolyamine Synthetase GlnA3 Is Involved in the First Step of Polyamine Degradation Pathway in Streptomyces coelicolor M145. Front Microbiol 2017 Apr 25;8:726. doi: 10.3389/fmicb.2017.00726. eCollection 2017. |
Morales Angeles, D., Liu, Y., Hartman, A.M., Borisova, M., de Sousa Borges, A., de Kok, N., Beilharz, K., Veening, J.W., Mayer, C., Hirsch, A.K. and Scheffers, D.J. Pentapeptide-rich peptidoglycan at the Bacillus subtilis cell-division site. Mol Microbiol. 2017 Jan 24. doi: 10.1111/mmi.13629. [Epub ahead of print] |
| Luddecke, J., Francois, L., Spät, P., Watzer, B., Chilczuk, T. et al. PII Protein-Derived FRET Sensors for Quantification and Live-Cell Imaging of 2-Oxoglutarate. Sci Rep 7: 1437 |
| Röther, W., Birke, J., Grond, S., Beltran, J.M. and Jendrossek, D. Production of functionalized oligo-isoprenoids by enzymatic cleavage of rubber. Microb Biotechnol 43:1238 |
| Unsleber, S., Borisova, M. and Mayer, C. Enzymatic synthesis and semi-preparative isolation of N-acetylmuramic acid 6-phosphate. Carbohydrate Research doi:10.1016/j.carres.2017.04.005 |
| Wanner, S., Schade, J., Keinhorster, D., Weller, N., George, S. E., Kull, L., Bauer, J., Grau, T., Winstel, V., Stoy, H., Kretschmer, D., Kolata, J., Wolz, C., Broker, B. M. and Weidenmaier, C. Wall teichoic acids mediate increased virulence in Staphylococcus aureus. Nat Microbiol 2, 16257 doi:10.1038/nmicrobiol.2016.257 |
| Zipperer, A. and Kretschmer, D. Cytotoxicity assays as predictors of the safety and efficacy of antimicrobial agents. Methods Mol Biol. 1520:107-118 doi:10.1007/978-1-4939-6634-9_6 [Epub ahead of print] |
2016
| Amin, R., Franz-Wachtel, M., Tiffert, Y., Heberer, M., Meky, M., Ahmed, Y., Matthews, A., Krysenko, S., Jakobi, M., Hinder, M., Moore, J., Okoniewski, N., Maček, B., Wohlleben, W. and Bera, A. Post-translational Serine/Threonine Phosphorylation and Lysine Acetylation: A Novel Regulatory Aspect of the Global Nitrogen Response Regulator GlnR in S. coelicolor M145. Front Mol Biosci, 9;3:38. doi: 10.3389/fmolb.2016.00038. eCollection 2016. |
| Borisova, M., Gaupp, R., Duckworth, A., Schneider, A., Dalügge, D., Mühleck, M., Deubel D., Unsleber, S., Yu, W., Muth, G., Bischoff, M., Götz, F. and Mayer, C. Peptidoglycan Recycling in Gram-Positive Bacteria Is Crucial for Survival in Stationary Phase. MBio, 11;7(5). pii: e00923-16. doi: 10.1128/mBio.00923-16 |
| Bresan, S., Sznajder, A., Hauf, W., Forchhammer, K., Pfeiffer, D. and Jendrossek, D. Polyhydroxyalkanoate (PHA) Granules have no Phospholipids. Accepted by Scientific Reports on May, 5 (SREP-16-09104A) |
| Carevic, M., Oz, H., Fuchs, K., Laval, J., Schroth, C., Frey, N., Hector, A., Bilich, T., Haug, M., Schmidt, A., Autenrieth, S.E., Bucher, K., Beer-Hammer, S., Gaggar, A,. Kneilling, M., Benarafa, C., Gao, J.L., Murphy, P.M., Schwarz, S., Moepp,s B. and Hartl, D. CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense. J Innate Immun doi: 10.1159/000444125. [Epub ahead of print] |
| Forchhammer, K., Watzer, B. Closing a gap in cyanophisin metabolism. Microbiology, doi: 10.1099/mic.0.000260. [Epub ahead of print] |
| Gauger, T., Byrne, J.M., Konhauser, K.O., Obst, M., Crowe, S., Kappler, A. Influence of organics and silica on Fe(II) oxidation rates and cell-mineral aggregate formation by the green-sulfur Fe(II)-oxidizing bacterium Chlorobium ferrooxidans KoFox - implications for Fe(II) oxidation in ancient oceans. Earth and Planetary Science Letters, 443, 81-89 doi: 10.1016/j.epsl.2016.03.022 |
| Gauger, T., Konhauser, K.O. and Kappler, A. Protection of nitrate-reducing Fe(II)-oxidizing bacteria from UV radiation by biogenic Fe(III) minerals. Astrobiology 16(4):301-10 |
| Hauf, W., Schmidt, K., Gerhardt, E.C.M., Huergo, L.F. and Forchhammer, K. Interaction of the Nitrogen Regulatory Protein GlnB (PII) with Biotin Carboxyl Carrier Protein (BCCP) Controls Acetyl-CoA Levels in the Cyanobacterium Synechocystis sp. PCC 6803. Front Microbiol, doi:http://dx.doi.org/10.3389/fmicb.2016.01700 [Epub ahead of print] |
| He, S., Tominski, C., Kappler, A., Behrens, S. and Roden, E.E. Metagenomic analyses of the autotrophic Fe(II)-oxidizing, nitrate-reducing enrichment Culture KS. Appl Environ Microbiol 8;82(9):2656-68, doi:10.1128/AEM.03493-15 |
| Iftime, D., Kulik, A., Härtner, T., Rohrer, S., Niedermeyer, T.H.J., Stegmann, E., ... and Wohlleben, W. Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365. J Ind Microbiol Biotechnol. 43(2-3):277-91 |
| Janek, D., Zipperer, A., Kulik, A., Krismer, B. and Peschel, A. High frequency and diversity of antimicrobial activities produced by nasal Staphylococcus strains against bacterial competitors. PLoS Pathog 12(8):e1005812 doi: 10.1371/journal.ppat.1005812 |
| Klotz, A. Georg, J., Bučinská, L., Watanabe, S., Reimann, V., Januszewski, W., Sobotka, R., Jendrossek, D., Hess, W.R. and Forchhammer, K. Awakening of a Dormant Cyanobacterium from Nitrogen Chlorosis Reveals a Genetically Determined Program. Curr Biol, doi:10.1016/j.cub.2016.08.054 [Epub ahead of print] |
| Lange, A., Beier, S., Autenrieth, I.B., Huson, D. and Frick, J.S. Extensive mobilome-driven genome diversification in gut-associated Bacteroides vulgatus mpk. Genome Biology and Evolution doi:10.1093/gbe/evw070 |
| Ost, M., Singh, A., Peschel, A., Mehling, R., Rieber, N. and Hartl, D. Myeloid-Derived Suppressor Cells in Bacterial Infections. Front Cell Infect Microbiol. 31;6:37, doi:10.3389/fcimb.2016.00037 |
| Perez, R., Forchhammer, K. Salerno, G. and Maldener, I. Clear differences in metabolic and morphological adaptations of akinetes of two Nostocales living in different habitats. Microbiology 162(2):214-23, doi: 10.1099/mic.0.000230 |
| Ruscitto, A., Hottmann, I., Stafford, G. P., Schaffer, C., Mayer, C. and Sharma, A. Identification of a Novel N-Acetylmuramic Acid Transporter in Tannerella forsythia. J Bacteriol 198(22): 3119-3125. |
| Schmidt, A., Hammerbacher, A.S., Bastian, M., Nieken, K.J., Klockgether, J., Merighi, M., Lapouge, K., Poschgan, C., Kölle, J., Acharya, K.R., Ulrich, M., Tümmler, B., Unden, G., Kaever, V., Lory, S., Haas, D., Schwarz, S.*and Döring, G.* Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa. Environ Microbiol, doi: 10.1111/1462-2920.13208. [Epub ahead of print] |
| Selim, K.A., El-Beih, A.A., AbdEl-Rahman, T.M., El-Diwany, A.I. High Expression Level of Antioxidants and Pharmaceutical Bioactivities of Endophytic Fungus Chaetomium Globosum JN711454. Prep. Biochem. Biotechnol. 46(2):131-40 |
| Steimle, A., Autenrieth, I.B. and Frick, J.S. Structure and function: Lipid A modifications in commensals and pathogens . Int J Med Microbiol, doi: 10.1016/j.ijmm.2016.03.001 |
| Steimle, A., Gronbach, K., Beifuss, B., Schäfer, A., Harmening, R., Bender, A., Maerz, J.K., Lange, A., Michaelis, L., Maurer, A., Menz, S., McCoy, K., Autenrieth, I.B., Kalbacher, H., Frick, J.S. Symbiotic gut commensal bacteria act as host cathepsin S activity regulators. Journal of Autoimmunity 75:82-95 |
| Studer, P., Borisova, M., Schneider, A., Ayala, J.A., Mayer, C., Schuppler, M., Loessner, M.J. and Briers, Y. The absence of a mature cell wall sacculus in stable Listeria monocytogenes L-form cells is independent of peptidoglycan synthesis. PLoSOne, 5;11(5):e0154925, doi: 10.1371/journal.pone.0154925 |
| Trautmann, A., Watzer, B., Wilde, A., Forchhammer, K. and Posten, C. Effect of phosphate availability on cyanophycin accumulation in Synechocystis sp PCC 6803 and the production strain BW86. Algal Res 20: 189-96 |
| Zipperer, A., Konnerth, M.C., Laux, C., Berscheid, A., Janek, D., Weidenmaier, C., Burian, M., Schilling, N.A., Slavetinsky, C., Marschal, M., Willman, M., Kalbacher, H., Schitteck, B., Brötz-Oesterhelt, H., Grond, S., Peschel, A. andKrismer, B. Human commensals producing a novel antibiotic impair pathogen colonization. Nature, doi:10.1038/nature18634 |
2015
| Gauger, T., Konhauser, K., and Kappler, A. Protection of phototrophic iron (II)-oxidizing bacteria from UV irradiation by biogenic iron (III) minerals: Implications for early Archean banded iron formation. Geology, 43(12):1067-1070 | |
| George, S.E., Nguyen T., Geiger, T., Weidenmaier C., Lee JC., Liese J. and Wolz C. Phenotypic Heterogeneity and Temporal Expression of the Capsular Polysaccharide in Staphylococcus aureus. Mol Microbiol. 98(6):1073–1088 | |
| Hauf, W., Watzer, B., Roos, N., Klotz, A. and Forchhammer, K. Photoautotrophic PHB granule formation: Identification and characterization of the cyanobacterial Phasin in Synechocystis sp. PCC 6803. Appl Environ Microbiol 81(13):4411-4422 | |
| Kästle, B., Geiger, T., Gratani, F. L., Reisinger, R., Goerke, C., Borisova, M., Mayer, C. and Wolz, C. rRNA regulation during growth and under stringent conditions in Staphylococcus aureus. Environ Microbiol 17(11):4394-405 | |
| Klotz, A., Reinhold, E., Doello, S. and Forchhammer, K. Nitrogen Starvation Acclimation in Synechococcus elongatus: Redox-Control and the Role of Nitrate Reduction as an Electron Sink. Life. 5(1):888-904 | |
| Mayer, S., Steffen, W., Steuber, J. and Götz, F. The Staphylococcus aureus NuoL-like protein MpsA contributes to the generation of membrane potential. J Bacteriol. 197(5):794-806 | |
| Renner-Schneck, M., Hinderberger, I., Gisin, J., Exner, T., Mayer, C. and Stehle, T. Crystal Structure of the N-Acetylmuramic Acid α-1-Phosphate (MurNAc-α1-P) Uridylyltransferase MurU, a Minimal Sugar Nucleotidyltransferase and Potential Drug Target Enzyme in Gram-negative Pathogens. J Biol Chem. 290(17):10804-10813 | |
| Spohn, M. Wohlleben, W. and Stegmann, E. Elucidation of the zinc dependent regulation in Amycolatopsis japonicum enabled the identification of the ethylenediamine-disuccinate ([S,S]-EDDS) genes. Environ Microbiol 18(4):1249-63, doi: 10.1111/1462-2920.13159 | |
Sukenik, A., Maldener, I., Delhaye, T., Viner-Mozzini, Y., Sela, D. and Bormans, M. Carbon assimilation and accumulation of cyanophycin during the development of dormant cells (akinetes) in the cyanobacterium Aphanizomenon ovalisporum. Front Microbiol. 6:1067. doi: 10.3389/fmicb.2015.01067. eCollection 2015 | |
| Watzer, B., Engelbrecht, A., Hauf, W., Stahl, M., Maldener, I. and Forchhammer, K. Metabolic pathway engineering using the central signal processor PII. Microbial Cell Factories 14(1):192 doi: 10.1186/s12934-015-0384-4 | |
| Wittmann, A., Bron, P.A., van Swam, I.I., Kleerebezem, M., Adam, P., Gronbach, K., Menz, S., Flade, I., Bender, A., Schäfer, A., Korkmaz, A.G., Parusel, R., Autenrieth, I.B., and Frick, J.S. TLR Signaling-Induced CD103-Expressing Cells Protect Against Intestinal Inflammation. Inflamm. Bowel Dis. 21(3):507-519 |
2014
| Borisova, M., Gisin, J. and Mayer, C. Blocking peptidoglycan recycling in Pseudomonas aeruginosa attenuates intrinsic resistance to fosfomycin. Microb Drug Resist 20(3): 231–237 | |
| Döring, G., Bragonzi, A., Paroni, M., Akturk, F.F., Cigana, C., Schmidt, A., et al. BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs. J Cyst Fibros.13(2):156-163 | |
| Gronbach, K., Flade, I., Holst, O., ... Autenrieth, I.B. and Frick, J.S. Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice. Gastroenterology 146(3):765-775 | |
| Iatsenko, I., Conton, C., Pickard, D., Dougan, G. and Sommer, R. J. Draft genome sequence of highly nematicidal Bacillus thuringiensis DB27. Genome Announcements. 2(1):e00101-14 | |
| Iatsenko, I., Boichenko, I. and Sommer, R. J. Bacillus thuringiensis DB27 produces two novel protoxins, Cry21Fa1 and Cry21Ha1, which act synergistically against nematodes. Appl. Environ. Microbiol. 80(10):3266-3275 | |
| Iatsenko, I., Nikolov, A. and Sommer, R.J. Identification of distinct Bacillus thuringiensis 4A4 nematicidal factors using the model nematodes Pristionchus pacificus and Caenorhabditis elegans. Toxins 6(7):2050-2063 | |
| Iatsenko, I., Yim, J.J., Schroeder, F.C. and Sommer, R.J. Bacillus subtilis GS67 protects C. elegans from Gram-positive pathogens via fengycin-mediated microbial antagonism. Current Biol. 24(22):2720-2727 | |
| Schmidt, A., Belaaouaj, A., Bissinger, R., ...and Döring, G. Neutrophil elastase-mediated increase in airway temperature during inflammation. J Cyst Fibros. 13(6):623-631 | |
| Schröder, W., Bernhardt, J., Marincola, G., Klein-Hitpass, L., Herbig, A., Krupp, G., Nieselt, K. and Wolz, C. Altering gene expression by aminocoumarins: the role of DNA supercoiling in Staphylococcus aureus. BMC Genomics. 15:291 | |
| Selim, K.A., El-Beih, A.A., AbdEl-Rahman, T.M., El-Diwany, A.I. Biological evaluation of endophytic fungus Chaetomium globosum JN711454 as potential candidates for improving drug discovery. Cell Biochemistry and Biophysics 68(1):67-82 | |
| Spohn, M., Kirchner, N., Kulik, A......Wohlleben, W. and Stegmann, E. Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17. Antimicrob Agents Chemother. 58(10):6185-6196 | |
Stegmann E, Albersmeier A, Spohn M, Gert H, Weber T, Wohlleben W, Kalinowski J, and Rückert C. Complete genome sequence of the actinobacterium Amycolatopsis japonica MG417-CF17(T) (=DSM 44213T) producing (S,S)-N,N'-ethylenediaminedisuccinic acid. J Biotechnol. 189:46-47 |
2013
| Gisin, J., Schneider, A., Nägele, B., Borisova, M. and Mayer, C. A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis. Nat Chem Biol. 9(8):491–493 | |
| Hauf, W., Schlebusch, M., Hüge, J., Kopka, J., Hagemann, M., Forchhammer, K. Metabolic Changes in Synechocystis PCC6803 upon Nitrogen-Starvation: Excess NADPH Sustains Polyhydroxybutyrate Accumulation. Metabolites 3(1):101-118 | |
| Iatsenko, I., Sinha, A., Rödelsperger, C., Sommer, R. J. New Role for DCR-1/Dicer in Caenorhabditis elegans Innate Immunity against the Highly Virulent Bacterium Bacillus thuringiensis DB27. Infect. Immunity. 81(10):3942–3957 | |
| Kienle, S. and Sommer, R.J. Cryptic variation in vulva development by cis-regulatory evolution of a HAIRY- binding site. Nat. Commun. 4:1714. doi:10.1038/ncomms2711 | |
| Lehner J, Berendt S, Dörsam B, Pérez R, Forchhammer K, and Maldener I. Prokaryotic multicellularity: a nanopore array for bacterial cell communication. FASEB J. 227(6):2293-2300. doi: 10.1096/fj.12-225854. | |
| Mayer, S. and Götz, F. Both terminal oxidases contribute to fitness and virulence during organ-specific Staphylococcus aureus colonization. Mbio 4(6):e00976-13. doi: 10.1128/mBio.00976-13 | |
| Nurjadi, D., Herrmann, E., Hinderberger, I., Zanger, P. Impaired β-defensin expression in human skin links DEFB1 promoter polymorphisms with persistent Staphylococcus aureus nasal carriage. J Infect Dis. 207(4):666-674 | |
| Schröder, W., Goerke, C. and Wolz, C. Opposing effects of aminocoumarins and fluoroquinolones on the SOS response and adaptability in Staphylococcus aureus. J. Antimic. Chemother. 63(3): 529-538 |
2012
| Gauger, T., Weihs, F., Mayer, S., Krismer, B., Liese, J., Kull, M., and. Bertram, R. Intracellular monitoring of target protein production in Staphylococcus aureus by peptide tag-induced reporter fluorescence. Microb. Biotechnol. 5(1):129-134 | |
| Sinha, A., Rae, R., Iatsenko, I., and Sommer, R. J. System wide analysis of the evolution of innate immunity in the nematode model species Caenorhabditis elegans and Pristionchus pacificus. Plos ONE. 7(9):e44255 |
Patent Applications
| Zipperer, A. and Konnert, M., Grond, S., Peschel, A., Janek D. and Krismer, B. Chemical structure of lugdunin European patent office (EPO), 2015 5402P541EP (submitted) | |
| Stegmann, E., Wohlleben, W., Spohn, M., Weber,T. [S,S]-EDDS Biosynthesegene und -proteine und Verfahren zur Biosynthese von [S,S]-EDDS.10 2013 217 543.4 |
* Joint first authors