Mit dem Format „Science and Career Talks“ verstärkt die Universität im Rahmen der Exzellenzstrategie ihre Aktivitäten im Bereich Gleichstellung und lädt erfahrene und erfolgreiche Wissenschaftlerinnen nach Tübingen ein. Diese berichten in einem öffentlichen Vortrag von ihrer Forschung und teilen in einem Workshop ihre persönlichen Erfahrungen, die sie auf ihrem fachspezifischen Karriereweg gemacht haben. Nachwuchswissenschaftlerinnen vor Ort haben so die Möglichkeit, die Wissenschaftlerinnen als Vorbilder (role models) kennenzulernen und sich von deren Arbeit und Karriereweg inspirieren zu lassen.
Laboratory of Neuroepigenetics, University and ETH Zürich
Isabelle Mansuy is professor in Neuroepigenetics at the Medical Faculty of the University of Zurich and the Department of Health Science and Technology of the ETH Zurich. She trained as neurobiologist and conducted research on the molecular mechanisms of memory for 20 years. In the recent years, she switched to the novel discipline of epigenetic inheritance and has become one of the pioneers in the field. Her findings contribute to the paradigm shift in biology that integrates epigenetics into the notion of heredity. Her lab identified some of the epigenetic factors and mechanisms responsible for the transmission of the consequences of traumatic experiences in early life on physical and mental health across generations. I. Mansuy authored >150 research articles, reviews and book chapters in neurosciences and neuroepigenetics. She published a book on epigenetics for the lay public “Reprenons le contrôle de nos gènes”, Larousse (April 2019) and “Wir können unsere Gene steuern” Berlin Verlag (Aug 2020). She is active in multiple scientific and research funding boards, and is member of the Swiss Academy of Medical Sciences, the European Academy of Sciences (EURASC), and the European Molecular Biology Organization. She is Knight in the National Order of Merit and holds the Legion of Honor in France. She is also nominator for the Nobel Prize in Physiology or Medicine.
Online via Zoom, date to be announced.
Behavior and physiology in mammals are strongly influenced by the environment and by experiences, particularly in early life. While positive factors can favor proper development and a balanced mental and physical health later in life, childhood adversity and traumatic experiences can increase the risk for psychiatric, metabolic and autoimmune diseases, and cancer. Such disorders can affect exposed individuals directly but in some cases, they also impact their offspring sometimes across generations. Childhood trauma is one of the strongest risk factors for mental disorders and chronic comorbidities across families in humans, and affects about 25% of children worldwide. The biological mechanisms underlying the transmission of symptoms induced by experience from parent to offspring are thought to involve epigenetic factors but are not fully identified. This talk will present a transgenerational model of postnatal traumatic stress in mice that recapitulates trauma symptoms including increased risktaking, depressive behaviors, cognitive and social deficits. metabolic dysregulation and cardiovascular deficiencies in adulthood. The symptoms are pronounced, persist throughout life, and are transmitted to the offspring, in some cases, up to the 4th or 5th generation. Symptoms are associated with molecular changes involving RNA in germ cells, that in mice, are shown to be causally linked to symptoms expression and transmission. MiRNAs are also affected in extracellular vesicles from the reproductive tract. Comparable behavioral and metabolic alterations are observed in traumatized children and miRNAs changes in sperm of adult men, indicating conserved effects in mouse and humans. Recent work identified circulating factors as potential mediators of alterations in germ cells. Chronic injection of serum from trauma-exposed mouse males into control males recapitulates metabolic phenotypes in the offspring, suggesting information transfer from serum to germ cells. Circulating factors involving peroxisome proliferator-activated receptor (PPAR) pathways are causally linked to these effects, and pharmacological PPAR activation in vivo reproduces the metabolic dysfunctions in the offspring and grand-offspring of injected males, and affects the sperm transcriptome. Together, these results suggest an ensemble of mechanisms from the periphery to germ cells responsible for the inheritance of acquired traits.
How to attend
Information on how to attend will be available shortly.
Online via Zoom, date to be announced.
How to attend
The workshop is primarily aimed at early-career female scientists at the University. The number of participants is limited. Please register by email to exu and state @uni-tuebingen.de
- your career level (master student (which semester), PhD student, postdoc (how many years after PhD), junior professor?),
- your department,
- topics you would like to discuss / aspects you would need advice on / personal or professional questions you have (will be passed on to Prof. Mansuy anonymously).
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