News and Events

2024

Congratulations to Aylin Balmes for her doctoral defense!

On December 13, 2024 Aylin Balmes (project 3) successfully defended her doctoral thesis entitled “The role of cyclic guanosine monophosphate signaling in biomechanics". Her project was supervised by Prof. Tilman Schäffer at the Institute for Applied Physics, Tübingen and by her co-mentor Assist. Prof. Francesca Seta, PhD from Boston University, USA.

Congratulations, Dr. Balmes!

Aylin with her examination committee. From left to right: Prof. Robert Lukowski, Prof. Tilman Schäffer, Dr. Aylin Balmes, PD Dr. Johannes Rheinlaender and Prof. Robert Feil

Congratulations to Timo Kopp for his doctoral defense!

On December 5, 2024 Timo Kopp (project 4) successfully defended his doctoral thesis entitled “Modulation of NO/cGMP sinalling by infrared light and mechanical forces”. His project was supervised by Dr. Susanne Feil at the Interfaculty Institute of Biochemistry, Tübingen and by his co-mentors Prof. Paul Huang, MD PhD and Dmitriy Atochin, M.D., Ph.D. from Massachusetts General Hospital, Boston, USA.

Congratulations, Dr. Kopp!

Timo with family members and his examination committee: Dr. Susanne Feil, Prof. Tilman Schäffer, PD Dr. Hannes Schmidt and Prof. Gabriele Dodt (not in the photo)

December 3

Reinhard Frank Minisymposium “Tübingen Meets Boston Junior Researchers”

Where: Interfaculty Institute of Biochemistry, Lecture Hall

When: 2:30-6:30 p.m.

Program

October 28

On October 18, 2024, Daniel Stehle received the "Hans Machleidt Biochemistry Innovation Prize“, which is endowed with €15,000. Daniel completed his doctoral studies with the lab of Prof. Robert Feil (Project 1) and was also a member of our GRK 2381. He is currently a postdoc at the University of California in San Diego. Daniel received the prize for his innovative approaches to elucidating the spatial location of the cAMP/PKA signaling pathway in the interaction of tumor and immune cells. The prize was awarded at the first Hans Machleidt Symposium, at which renowned biochemists gave presentations. The new prize is to be awarded every two years from 2024 onwards. The primary target group of the award are successful and innovative young scientists in postdoctoral studies or in an advanced phase of their doctorate who are doing or have done their doctorate in biochemistry at the University of Tübingen.

See more here and here

Daniel Stehle (middle) receives the award certificate from Johannes Klumpp (left) and Dr. Sieglinde Göhring-Machleidt (right)

October 24

Ophthalmic Research Symposium

Dr. Philip Williams, Assistant Professor, Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine (Co-mentor GRK 2381 Project 8)

“Mitochondrial Calcium Modulation as a Protective Strategy for Retinal Ganglion Cells in Neurodegenerative Disease”

Where: HNO Lecture Hall

When: 3-4.30 p.m.

October 22

Dr. Daniel Stehle, UC San Diego, USA

Workshop for Junior Scientists

“Grant Application 101: Navigating Funding Opportunities and Writing Scientific (Application) Documents”

Where: IFIB, Level 6, Room 6X38

When: 9-12:00

October 21

IFIB Institute's Colloquium

Prof. Dr. Timo Müller (Institute for Diabetes and Obesity, Oberschleißheim)

“Novel insights into regulation of energy and glucose metabolism by GIPR agonism and GLP-1:GIPR co-agonism”

Speaker invited by Prof. Robert Feil

Where: IFIB, Lecture Hall

When: 5 pm

October 14-18

The cGMP World I

Where: IFIB, Level 6, Room 6X38

When: 9-12am and 2-5 pm

Short test on October 31, 2024: 9-11 am, IFIB, Room 6X38

Schedule

GRK 2381 Science Forum

Seminar Schedule September 2024- July 2025

September 23

We had a great Retreat in Herrsching am Ammersee (17.-19.9.2024). The event was combined with the first International Symposium “The Different Facets of Guanine Nucleotide Signaling”, which was jointly organized by GRK 2816 and GRK 2381. In addition to excellent presentations and poster sessions, there was also plenty of time for activities and discussions between junior and senior researchers. We are delighted that two of our doctoral students won a Poster Prize. Congratulations to Timo Kopp and Timo Hinnenthal (both Project 4), also known as “Timo and Timo” or Team “T'n'T”. Here are some impressions from the meeting in Herrsching:

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September 17-19

International Symposium "The Different Facets of Guanine Nucleotide Signaling"

Organized by GRK 2381 and RTG 2816

Where: Haus der bayerischen Landwirtschaft, Herrsching am Ammersee

Final schedule

August 1

Student Awards for Aylin Balmes and Hendrik von Eysmondt from the 21st IUPAB Congress 2024 (IUPAB2024), Kyoto, Japan

We are happy to announce that our doctoral fellow Aylin Balmes and our associated doctoral fellow Hendrik von Eysmondt (both from Project 3) received a BPS-IUAPAB Student Award during the 21st IUPAB Congress 2024 (IUPAB2024) in Kyoto, Japan.

The conference was held under a “Rocking out Biophysics” theme. The scientific session chairs choose candidates, whose posters were then evaluated by the poster selection committee.

We congratulate Aylin and Hendrik for being two out of only four awardees!

Awardees Hendrik von Eysmondt, Aylin Balmes and Nathan Nunes Evangelista with the Executive Officer of the Biophysical Society Jennifer Pesanelli

July 30

From July 22-26 we held a Welcome Week for our new doctoral fellows of the 3rd cohort.

On Monday, July 22, after several presentations with important information on our GRK as well as the University Graduate Academy, we enjoyed a punting trip along the Neckar as our evening highlight. For the rest of the Welcome Week, the new fellows visited all the GRK labs and were introduced to their research topics and techniques. On Friday, we closed the Welcome Week with a productive feedback session.

We warmly welcome our new doctoral fellows and wish them a good start in the GRK.

We are looking forward to fruitful collaborations in the next years!

Old and new GRK members on the first day of the Welcome Week in the IFIB courtyard

Impressions from the Welcome Week 2024

July 16

End of June 2024, members of the GRK 2381 presented their work at the 11th International Conference on cGMP in Lübeck, Germany. It was a great meeting and success for our junior researchers. We are particularly happy and honoured that Timo Kopp (Project 4) won the Best Poster Prize for his PhD project "Mechanosensitive cGMP signaling in vascular smooth muscle cells". Congratulations, Timo!

For impressions from Lübeck, see here.

Left: Timo Kopp at his poster Middle: Award ceremony at the historical Schiffergesellschaft (with the selection committee) Right: Timo Kopp presenting his data in a rapid fire talk

Timo Kopp receives the Best Poster Prize at the International cGMP Confenerence 2024 in Lübeck, Germany. The picture shows Timo (center) and the members of the selection committee.

Congratulations to Dila Calis for her doctoral defense!

On June 26, 2024 Dila Çaliş (project 9) successfully defended her doctoral thesis entitled "cGMP Signaling as a Molecular Target for Central Adaptation in Age-Related Cochlear Synaptopathy". Her project was supervised by Prof. Marlies Knipper at the Tübingen Hearing Research Center and by her co-mentor Prof. Michele Jacob, PhD from Tufts University.

Congratulations, Dr. Çaliş!

Dila with her examination committee. From left to right: Prof. Dr. Peter Ruth, Prof. Dr. Robert Lukowski, Dr. Dila Çaliş and Prof. Dr. Robert Feil

June 10

In April 2024, following a highly competitive application round, the GRK 2381 invited a group of shortlisted potential doctoral candidates to Tübingen for an on-site visit.

The candidates had the opportunity to present their previous research work and talk to the current GRK doctoral students and project leaders.

An informal get-together at a local brewery and visits of the GRK labs helped to get to know each other and find matching interests between candidates and existing project teams.

We hope that the site visit was a positive experience for all participants. We would like to thank all applicants for their interest in joining GRK 2381 and all current GRK members for their help in organizing this event.

Above all, we are pleased to welcome the selected doctoral students as new members of the GRK 2381. We wish them a good start in Tübingen and all the best for their doctoral projects in the GRK 2381.

Members of GRK 2381 with the applicants for the doctoral positions of the third cohort in April 2024

June 5

GRK 2381 Science Forum

Dr. Moritz Lehners

“CNP-dependent cGMP signalling in pathological vascular remodelling ”

Where: Institute of Pharmacy, Auf der Morgenstelle 8, Level 7, Room Nr. B7N19

When: 5:15 pm

May 8

GRK 2381 Science Forum

David-Maximilian Spähn (associated doctoral fellow)

“BK channels contribute to brown adipocyte cell activity, energy balance and body weight regulation”

Where: Institute of Pharmacy, Auf der Morgenstelle 8, Level 7, Room Nr. B7N19

When: 5:15 pm

Congratulations to Malte Roeßing for his doctoral defense!

On April 11, 2024 Malte Roeßing (project 4) successfully defended his doctoral thesis entitled "Pathophysiological and Pharmacological Relevance of NO/cGMP Signaling in Atherosclerosis". His project was supervised by Dr. Susanne Feil at the Interfaculty Institute of Biochemistry in Tübingen and by his co-mentor Dmitriy Atochin, MD, PhD from Massachusetts General Hospital, Cardiovascular Research Center.

Congratulations, Dr. Roeßing!

Malte with his examination committee. From left to right: PD Dr. Hannes Schmidt, Dr. Susanne Feil, Dr. Malte Roeßing, Prof. Dr. Robert Lukowski and Prof. Dr. Peter Ruth

April 11

Doctoral defense Malte Roeßing (1st Cohort)

"Pathophysiological and Pharmacological Relevance of NO/cGMP Signaling in Atherosclerosis"

Where: IFIB Lecture Hall

When: 4:00 pm

April 3

GRK 2381 Science Forum

Dr. Anne-Katrin Rohlfing (University Clinics Tübingen, Cardiology)

“How to prevent hemin-induced platelet activation, degranulation & ferroptosis?”

Where: Interfaculty Institute of Biochemistry (IFIB), Lecture Hall Level 2 (2T26)

When: 5:15 pm

March 21

Aylin Balmes (P3) selected as a Young Scientist for the 73rd Lindau Nobel Laureate Meeting

The GRK 2381 congratulates Aylin Balmes (P3) for being selected as a Young Scientist for the 73rd Lindau Nobel Laureate Meeting taking place from June 30 to July 5, 2024.

Since their foundation in 1951, the annual Lindau Nobel Laureate Meetings have provided an opportunity for an exchange between different generations, cultures and disciplines. Once every year, around 30-40 Nobel Laureates convene in Lindau to meet the next generation of leading scientists from all over the world.

Congratulations to Alexandra Böttcher for her doctoral defense!

On March 19, 2024 Alexandra Böttcher (project 7) successfully defended her doctoral thesis entitled "Identification of Novel Components in a cGMP-dependent Signaling Pathway Mediating Sensory Axon Bifurcation". Her project was supervised by PD Dr. Hannes Schmidt at the Interfaculty Institute of Biochemistry in Tübingen and by her co-mentor Assoc. Prof. Robert Blanton M.D., M.A. from the Tufts University.

Congratulations, Dr. Böttcher!

Alexandra with her examination committee. From left to right: Prof. Dr. Peter Ruth, Prof. Dr. Robert Feil, Dr. Alexandra Böttcher and PD Dr. Hannes Schmidt

March 19

Doctoral defense Alexandra Böttcher (1st Cohort)

"Identification of Novel Components in a cGMP-dependent Signaling Pathway Mediating Sensory Axon Bifurcation"

Where: IFIB Lecture Hall

When: 4:00 pm

Congratulations to Krithika Rajeeth for her doctoral defense!

On March 19, 2024 Krithika Rajeeth (project 1) successfully defended her doctoral thesis entitled "Activation of NO/cGMP signalling as a potential therapy for metabolic dysfunction associated steatotic liver disease". Her project was supervised by Prof. Robert Feil at the Interfaculty Institute of Biochemistry in Tübingen.

Congratulations, Dr. Rajeeth!

Krithika with her examination committee. From left to right: Prof. Alexander Weber, Dr. Krithika Rajeeth, Prof. Dr. Robert Feil, and PD Dr. Hannes Schmidt

March 12

New GRK 2381 manuscript accepted for publication

We are happy to announce that a new publication with contributions from researchers of our GRK was accepted by Stroke and will be soon online:

Yokomizo S., Kopp T., Roessing M., Morita A., Lee S., Cho S., Ogawa E., Komai E.,Inoue K., Fukushi M., Feil S., Kim H., Bragin DE., Gerashchenko D., Huang PL:, Kashiwagi S., Atochin DN. Near-infrared II photobiomodulation preconditioning ameliorates stroke injury via phosphorylation of eNOS., Stroke
Congratulations to everyone involved!

March 8

New GRK 2381 publication

We are happy to announce a new publication from our GRK in Platelets.

Congratulations to Melanie Cruz Santos for her doctoral defense!

On January 12, 2024 Melanie Cruz Santos (project 2) successfully defended her doctoral thesis entitled "Myofibroblast specific cGMP/cGKI signaling counteracts And II-induced cardiac remodeling". Her project was supervised by Prof. Robert Lukowski at the Institute of Pharmacy in Tübingen and by her co-mentor Fumito Ichinose, MD, PhD from the Massachusetts General Hospital.

Congratulations, Dr. Cruz Santos!

Melanie with her examination committee. From left to right: Prof. Dr. Bertolt Gust, Prof. Adrian Hobbs, PhD, Dr. Melanie Cruz Santos, Prof. Dr. Robert Lukowski and Prof. Dr. Peter Ruth

Congratulations to Thomas Pham for his doctoral defense!

On January 11, 2024 Thomas Pham (project 6) successfully defended his doctoral thesis entitled "Influence of large conductance Ca²⁺- and voltage- activated K⁺ channels (BK) on synaptic plasticity in young and aged mice". His project was supervised by Prof. Peter Ruth at the Institute of Pharmacy in Tübingen and by his co-mentor Assoc. Prof. Jesse D. Roberts, MD from the Massachusetts General Hospital, Cardiovascular Research Center.

Congratulations, Dr. Pham!

Thomas with a part of his examination committee. From left to right: Prof. Dr. Ulrich Rothbauer, Dr. Thomas Pham, Prof. Dr. Robert Lukowski. Not in the picture: Prof. Dr. Norbert Klugbauer, Prof. Dr. Peter Ruth

Dr. Thomas Pham with his GRK 2381- certificate

2023

Congratulations to Dominic Gonschorek for his doctoral defense!

On December 18, 2023 Dominic Gonschorek (project 8) successfully defended his doctoral thesis entitled "Neuromodulatory effects on early visual signal processing". His project was supervised by Prof. Thomas Euler at the Werner Reichardt Center for Integrative Neuroscience in Tübingen and by his co-mentor Assoc. Prof. Clint L. Makino, PhD from the Boston University.

Congratulations, Dr. Gonschorek!

Dominic with his examination committee. From left to right: Prof. Dr. Aristides Arrenberg, Prof. Dr. Thomas Euler, Dr. Dominic Gonschorek, Prof. Dr. Philipp Berens, Prof. Dr. Jan Benda

Minisymposium GRK 2381 Meets Tübingen Neuroscience, December 11, 2023

December 11

Minisymposium GRK 2381 Meets Tübingen Neuroscience

Program

Where: Freistil, Wöhrdstraße 25

When: 3:15 pm

November 29

New GRK 2381 publication in Cell Mol Life Sci.

We are happy to announce a new publication from Thomas Pham (P6) and many GRK-members and collaborators titled "BK channels sustain neuronal Ca²⁺ oscillations to support hippocampal long-term potentiation and memory formation".

Congratulations to everyone involved!

Congratulations to Marcel Kremser for his doctoral defense!

On November 27, 2023 Marcel Kremser (project 5) successfully defended his doctoral thesis entitled "cGMP regulates hemin-induced ferroptosis of platelets". His project was supervised by Prof. Meinrad Gawaz at the Department of Cardiology and Angiology, University Hospital in Tübingen and by his co-mentor Assist. Prof. Dmitriy Atochin, MD PhD from Massachusetts General Hospital in Boston.

Congratulations, Dr. Kremser!

Marcel with his examination committee. From left to right: Prof. Robert Feil, Prof. Alexander Weber, Dr. Marcel Kremser, Prof. Peter Ruth, and Prof. Meinrad Gawaz

After the successful defense - Dr. Marcel Kremser

Dr. Marcel Kremser receives his GRK 2381 certificate from the GRK coordinator Dr. Petya Georgieva

November 27

Doctoral defense Marcel Kremser (1st Cohort)

"cGMP regulates hemin-induced ferroptosis of platelets"

Where: Medical Clinic, Building 500, Level 4, Room 212

When: 1:00 pm

Congratulations to Mariagiovanna Barresi for her doctoral defense!

On November 16, 2023 Mariagiovanna Barresi (project 1) successfully defended her doctoral thesis entitled "Visualizing and understanding the role of cGMP in breast cancer". Her project was supervised by Prof. Robert Feil at the Interfaculty Institute of Biochemistry in Tübingen and by her co-mentor Assoc. Prof. Dai Fukumura MD, PhD from Harvard Medical School in Boston.

Congratulations, Dr. Barresi!

After the successful defense - Prof. Robert Feil and Dr. Mariagiovanna Barresi

Mariagiovanna with her examination committee. From left to right: Prof. Robert Feil, Dr. Mariagiovanna Barresi, Prof. Peter Ruth, and PD Dr. Hannes Schmidt (Assoc. Prof. Dai Fukumura MD, PhD took part online)

The after party

November 16

Doctoral defense Mariagiovanna Barresi (1st Cohort)

"Visualizing and understanding the role of cGMP in breast cancer"

Where: IFIB Lecture Hall

When: 5:00 pm

November 8

We are happy to announce that the German Research Foundation (DFG) has extended our Research Training Group for a second funding period from January 2024 till June 2028!

https://www.dfg.de/service/presse/pressemitteilungen/2023/pressemitteilung_nr_45/index.html

We are looking forward to the next 4.5 years of fruitful scientific cooperations in the RTG 2381!

GRK 2381 Science Forum

Seminar Schedule November 2023- June 2024

October 23

IFIB Monday Seminar

Prof. Jens Fischer (Institut für Pharmakologie, Universitätsklinikum Düsseldorf)

"Protective Role of Endogenous Hyaluronic Acid Synthesis in Myocardial Infarction"

Where: IFIB Lecture Hall

When: 5 pm

GRK 2381 fellow Dr. Daniel Stehle wins PhD award

We are happy and proud that one of our GRK 2381 junior scientists, Dr. Daniel Stehle, has received this year's PhD award from the University of Tübingen. His PhD thesis is entitled “cGMP Imaging Uncovers New Roles and Therapeutic Implications of NO/cGMP Signaling in the Kidney and in Melanoma”. The prize was awarded by Rector Professor Dr. Karla Pollmann and Dean Professor Dr. Thilo Stehle on July 15, 2023 during the central doctoral graduation ceremony.

We congratulate Daniel for his excellent work!

Daniel will now continue his academic career as postdoc at the University of San Diego (UCSD) in La Jolla, USA.
We wish him all the best and much success.

from left to right: Dean Professor Dr. Thilo Stehle, Dr. Daniel Stehle and Rector Professor Dr. Karla Pollmann

Congratulations to Johanna Rodriguez for her doctoral defense!

On July 10, 2023 Johanna Gabriela Rodriguez Cabezas (project 3) successfully defended her doctoral thesis entitled "Understanding the role of NO-GC/cGMP in human, murine, and HIV-positive patient's platelets and the effect of biochemical confinement in platelet morphology and mechanics". Her project was supervised by Prof. Tilman Schäffer at the Institute of Applied Physics in Tübingen and by her co-mentor Assoc. Prof. Francesca Seta from the Boston University.

Congratulations, Dr. Rodriguez Cabezas!

Johanna with her examination committee. From left to right: Prof. Robert Feil, Dr. Johanna Gabriela Rodriguez Cabezas, Prof. Tilman Schäffer, and Prof. Robert Lukowski (Assoc.-Prof. Francesca Seta took part online)

July 5

GRK 2381 Science Forum

Dr. Daniel Stehle (Interfaculty Institute of Biochemistry (IFIB), Signal Transduction, Transgenic Models)

"Shedding light on cGMP signaling with in situ imaging"

Where: Institute of Pharmacy, Auf der Morgenstelle 8, B9N22 and online

When: 5:15 pm

June 7

GRK 2381 Science Forum

Work in Progress Seminar of the Doctoral Fellows

Where: Institute of Pharmacy, Auf der Morgenstelle 8, Seminar Room B9N22 and online

When: 5:15 pm

May 15

IFIB Monday Seminar

Prof. Dr. Sven Nahnsen (Quantitative Biology Center (QBiC), University of Tübingen)

"The power of FAIR data and tools for biomedical research"

Where: IFIB Lecture Hall

When: 5 pm

May 2

Short Talk by Tom Schwerd-Kleine at ARVO 2023

Tom Schwerd-Kleine's abstract "Neuromodulation of retinal bipolar cell glutamate signalling by nitric oxide and endocannabinoids" was selected for a short talk at the ARVO 2023 meeting in New Orleans. The Association for Research in Vision and Ophthalmology (ARVO) is the largest and most respected eye and vision research organization in the world.

March 30

PhD Position (f/m/x) in Biomedicine cGMP in Cancer

The Feil Lab (Interfaculty Institute of Biochemistry, University of Tübingen, Germany) has an opening for a PhD student position (65% TV-L 13) starting as soon as possible.

Application now closed

February 24

New GRK 2381 publication in Frontiers in Molecular Neuroscience

We are happy to announce a new publication from Dila Calis (P9) and colleagues on "Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling".

Congratulations to everyone involved!

January 11 and 17

Minisymposium "Cell Signaling"

Agenda

2022

November 18

Add-on Fellowship for Aylin Balmes from the Joachim Herz Foundation

The GRK 2381 congratulates Aylin Balmes on her successful application for an Add-on Fellowship for Interdisciplinary Life Science from the Joachim Herz Foundation.

The foundation supports young scientists who want to use interdisciplinary approaches to answer biological research questions while promoting “thinking outside the box” and networking.

The Add-on Fellows receive financial support over a period of two years for international networking and further training in a different subject – for example, biologists can immerse themselves in mathematics and modelers in life sciences. The individually and flexibly adapted funding enables research stays, conference visits, the purchase of aids such as laptops or software solutions and participation in fellowship meetings.

November 16

New junior scientists in the GRK 2381

The GRK 2381 welcomes our first postdoc Daniel Stehle as well as a number of new junior scientists that are associated with individual projects:

Katharina Paulus (Project 2), David Spähn (Project 2), Konstantin Krutzke (Project 3), Jan Seifert (Project 3), Krithika Rajeeth (Project 1) and Janina Brückner (Project 6)

We would like to thank our new colleagues for their interest in the GRK 2381!

November 2

GRK 2381 Autumn School 2022

Conference Report and Photo Gallery

October 26-27

GRK 2381 Science Forum

Yearly Progress Reports of the Doctoral Fellows

Where: Institute of Pharmacy, Auf der Morgenstelle 8, Seminar Room B7N19

When: 1-6 pm

Schedule

October 24

IFIB Monday Seminar

Prof. Dr. Kristina Lorenz (Institute of Pharmacology and Toxicology, Julius-Maximilians-University Würzburg)

"Targeting of pathological ERK1/2 signaling"

Where: IFIB Lecture Hall and online

When: 5 pm

GRK 2381 Science Forum

Seminar Schedule October 2022- July 2023- update

October 10-13

Autumn School 2022 organised by the doctoral fellows of the second GRK cohort

preliminary schedule

September 6

We are happy to announce the first two joint publications with our Boston partners. You can read more about them here and here.

Congratulations to doctoral fellows Malte Roeßing and Timo Kopp, as well as to their Tübingen supervisor Susanne Feil and the co-mentors from Boston Paul Huang and Dmitriy Atochin.

September 1

Research Stay Report, Boston, 2nd Cohort

Congratulations to the first Dr. of the GRK 2381!

On July 22, 2022, only three years after the start of the GRK 2381, Philine Marchetta (project 9) successfully defended her doctoral thesis entitled "cGMP pathways as novel molecular targets in the brain for fast auditory processing and cognitive function". Her project was supervised by Prof. Marlies Knipper at the Hearing Research Center in Tübingen and by her co-mentor Prof. Michele Jacob from Tufts University, Boston. Philine is the first “Dr. rer. nat.” graduating in the GRK 2381 and we are happy and proud that she completed her doctoral thesis in such a short time and with such a high quality.

Congratulations, Dr. Marchetta!

Dr. Philine Marchetta (left) receives her GRK 2381 certificate from Dr. Petya Georgieva (right)

A nice flower touch from Florian Tübingen.

Philine with her examination committee. From left to right: Prof. Peter Pilz, Dr. Philine Marchetta, Prof. Marlies Knipper, Prof. Peter Ruth and Prof. Robert Lukowski

With the doctoral cap

July 15

Research Stay Report, Boston, 1st Cohort

July 6

GRK 2381 Science Forum

Dr. Clément Cochain (Comprehensive Heart Failure Center Würzburg (CHFC))

"Macrophage heterogeneity in ischemic heart repair"

Where: online

When: 5:15 pm

June 1

GRK 2381 Science Forum

Dr. Maike Frye (Center for Diagnostics, Clinical Chemistry and Laboratory Medicine, UKE Hamburg)

"Selective regulators of endothelial junctions"

Where: online

When: 5:15 pm

May 20

New GRK 2381 publications

We are happy to announce two new publications from the GRK 2381 published in Science Advances and iScience

Congratulations to everyone involved!

May 6

Themed Issue on "cGMP Signalling in Cell Growth and Survival"

We are happy to announce the publication of a Themed Issue on "cGMP Signalling in Cell Growth and Survival" in the British Journal of Pharmacology (Volume 179, Issue 11; Published 05 May 2022). Many thanks to all the contributors, many of whom are members of the GRK 2381!

May 4

GRK 2381 Science Forum

Dr. Mike Emerson (Imperial College London, Faculty of Medicine, National Heart & Lung Institute)

“Investigations with platelets and endothelial cells to reduce cardiovascular risk in people living with HIV”

Where: IFIB Lecture Hall

When: 5:15 pm

April 13

Reinhard-Frank-Mini-Symposium GRK Trainees in Boston

Where: Tufts University School of Medicine Medical Education Building 145 Harrison Ave., Room 316 Boston, MA

When: 12 noon

Schedule

April 6

GRK 2381 Science Forum

Prof. Mikael Simons (Institute of Neuronal Cell Biology (TUM-NZB), Technical University of Munich, German Center for Neurodegenerative Diseases (DZNE))

“Molecular mechanisms of remyelination in the CNS”

Where: IFIB Lecture Hall

When: 5:15 pm

Meet-the-prof at 4pm, IFIB, Level 6. Some impressions:

Meet-the-Prof. with Prof. Mikael Simons, April 6, 2022

March 9

GRK 2381 Science Forum

Dr. Wibke Singer (Tübingen Hearing Research Centre, Department of Otolaryngology, Head and Neck Surgery)

“Auditory processing, cGMP signalling and stress”

Where: IFIB Lecture Hall

When: 5:15 pm

GRK 2381 Science Forum

Seminar Schedule December 2021- July 2022

February 2

GRK 2381 Science Forum

Dr. Bettina Weigelin (Multiscale Immunoimaging, Werner Siemens Imaging Center, Department for Preclinical Imaging and Radiopharmacy, University of Tübingen)

“Intravital microscopy for understanding immune cell function in tissues”

Where: IFIB Lecture Hall

When: 12:15 pm

January 31

GRK 2381 PhD Conference CanCaN2021

Conference Report and Photo Gallery

January 12

GRK 2381 Science Forum

Dr. Lucas Matt, (Department of Pharmacology, Toxicology and Clinical Pharmacy, University of Tübingen)

“Synaptic plasticity – from molecular biology to physiology and behavior”

Where: IFIB Lecture Hall

When: 12:15 pm

January 10

German Pharmaceutical Society Lessmüller Poster Prize

Thomas Pham from our first-year doctoral cohort (Project 6, Prof. Peter Ruth) received the Lesmüller Poster Prize in the beginning of January.

https://www.dphg.de/news-folder/detailansicht/lesmueller-posterpreis-2021/b50f7aecf20f6cfa8acc512f87570b19/

With the prize, endowed with 200 euros, the German Pharmaceutical Society (DPhG) and the Dr. August and Dr. Anni Lesmüller Foundation honor a total of five scientists for outstanding contributions.

January 10

10th International Conference on cGMP

The "10th International Conference on cGMP" will take place in Augsburg, Germany (June 17-19, 2022). Please visit the conference homepage at http://www.cyclicgmp.net/ for more details.

2021

December 1

GRK 2381 Science Forum

Dr. Judith Feucht, Cluster of Excellence “iFIT” (EXC2180) and University Children’s Hospital Tübingen

"Novel CAR T cell designs and therapeutic applications"

Where: IFIB Lecture Hall

When: 12:15 pm

November 17-19

1st PhD students-conference of the GRK 2381 on Cancer, Cardiovascular diseases & Neurological disorders: CanCaN2021

General Invitation

Conference Flyer

Conference Report

Conference Impressions

Where/When: see Program

The participants of CanCaN 2021 on the steps of St. George's Collegiate Church in the old town of Tübingen. (Photo by J. Smykowski)

The GRK 2381 doctoral researchers. (Photo by J. Smykowski)

The poster prize winners R. Zalfen (left) and L. Kreutz (right). (Photo by S. Munir)

November 8

IFIB Monday Seminar

Prof. Dr. Dieter Saur (TU Munich)

"Modelling and targeting pancreatic cancer and its microenvironment".

Where: IFIB lecture hall. The seminar might also be streamed. For info see: https://uni-tuebingen.de/de/13323

When: 5 pm

October 12-13

GRK 2381 Doctoral Fellows Symposium

Where: IFIB Lecture Hall

When: see schedule

August 23 & 30

Time & Project Management for Scientists

Dr. Andrew Wold

Where: online

When: t.b.a.

July 28

GRK 2381 Highlight Seminar

Prof. Dr. Franz Hofmann, TU München- What have we learned about the biological function of cGMP?

Prof. Dr. Johannes-Peter Stasch, Bayer AG and University Halle-Wittenberg- sGC stimulators and sGC activators: Past, present and future

Where: IFIB Lecture Hall

When: 10:30 am

Schedule

Some impressions from the seminar:

Cancelled- July 7

GRK 2381 Science Forum

Prof. Claudia Lengerke Internal Medicine II, University Clinics Tübingen

t.b.a.

Where: online meeting

When: 5:15 pm

June 23

GRK 2381 Seminar on Gender Equality and Science

Prof. Brigitte Malgrange, University of Liège, GIGA-Stem cells, Developmental Neurobiology Unit

State of the art and challenges in treating deafness

Where: online meeting

When: 5 pm

June 22

Best Poster Award in the Category Audience Favourite at the 2nd Cardiovascular Disease Symposium of the IRTG 1902 and SFB 1116 in Düsseldorf

Congratulations to Marcel Kremser for the Poster Award for his research on Platelet-derived PCSK9.

June 9

GRK 2381 Science Forum

Dr. Anouar Belkacemi, Center for Molecular Signaling (PZMS), Saarland University

Cav-independent functions of the Cavβ3 subunit

Where: online meeting

When: 5:15 pm

May 10

IFIB Institutskolloquium

Prof. Mathias Heikenwälder, German Cancer Research Center (DKFZ), Heidelberg

Inflammatory signatures and its consequences for liver cancer-therapy

Where: online meeting

When: 5:00 pm

May 5-6

Tumor Heterogeneity, Plasticity and Therapy Conference (virtual edition)

Where: online meeting

Agenda

May 5

GRK 2381 Science Forum

Prof. Axel Gödecke Institute of Cardiovascular Physiology, Heinrich Heine University Düsseldorf

Insulin like growth factor I acts as a cytokine with cardio-protective potential

Where: online meeting

When: 5:15 pm

April 19-23

The cGMP World II (for 1st and 2nd cohort of doctoral researchers)

Where: currently planned as an online meeting

Schedule

April 14

GRK 2381 Science Forum

Prof. Jos Prickaerts School for Mental Health and Neuroscience, Maastricht University

Targeting cGMP in CNS drug discovery: A translational approach into cognition enhancement

Where: online meeting

When: 5:15 pm

April 8

Good Scientific Practice Course

Mandatory for the GRK 2381- second cohort doctoral fellows

Schiller & Mertens GbR

Where: online meeting

When: 9am - 3 pm

April 7

Best Poster Award “87th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT)”!

Congratulations to Thomas Pham for his work on the importance of the large-conductance Ca2+- and voltage-activated potassium channel (BK), a cGKI substrate, for synaptic plasticity and memory formation.

March 22-26

The cGMP World I (for 2nd cohort of doctoral researchers)

Where: online meeting

Short test on April 12, 2021: 9-10 am, IFIB, Lecture Hall

Schedule

March 3

GRK 2381 Science Forum

Prof. Emmanuel Buys Cyclerion Therapeutics, Cambridge, MA

Developing CY6463 for the treatment of CNS disease

Where: online meeting

When: 5:15 pm

March 1-3

6th German Pharm-Tox Summit

Where: online meeting

Agenda; Conference Flyer

February 3

GRK 2381 Science Forum

Francesca Seta, PhD, Vascular Biology Section, Boston University School of Medicine

Novel insights on molecular and cellular determinants of arterial stiffness

Where: online meeting

When: 5:15 pm

January 12-15

GRK 2381 Welcome Week

Where: online meeting

Schedule

News Archive

2020

2019

December 13

Christmas Breakfast GRK 2381

Where: IFIB, Hoppe-Seyler-Str. 4, social room, second floor

When: 10 am - noon

December 2-6

The cGMP World I (Seminar on scientific background and methods in cGMP research)

Where: IFIB, Hoppe-Seyler-Str. 4, Seminar Room 2 (north entry level, right-side)

When: 8:15 am -11 am

Exam: Friday, December 13, 9-10 am, IFIB seminar room 2

November 29

Good Scientific Practice Course, Schiller & Mertens

Where: IFIB, conference room 225, ground floor

When: 9 am - 4 pm

Mandatory for all GRK 2381 doctoral students

November 18

8th Methods and Techniques Lectures

Where: Conference Center Schnarrenberg UKT, 1st floor (Building 520, Otfried-Müller-Str. 6)

When: 9 am - 4:30 pm

Final Program

November 6

GRK 2381 Science Forum

Prof. Bernd Pichler, Department of Preclinical Imaging and Radiopharmacy

Preclinical multiparametric imaging and beyond: new tracers, novel methods, converging data

Where: IFIB, social room, 2nd floor

When: 12:15 pm - 1:45 pm

October 21

Drivers of tumorigenesis in pre-leukemia bone marrow failure syndromes

Prof. Dr. Yulia Skokowa, University's medical clinic, Tübingen

Where: IFIB, small lecture hall

When: 5 pm

October 9

GRK 2381 Science Forum, organisational meeting

Where: IFIB, social room, 2nd floor

When: 12:15 pm- 1:45 pm

More: Schedule October 2019- July 2020

August 1

Welcome! Our first doctoral students have started.

July 25

Mini symposium on "Live (and high-resolution) cell imaging"

Where: Institute of Pharmacy, 9th floor, 9A29

When: 1 pm- 4 pm

July 8

"You are a killer!"- Speaking about laboratory animals in public and in private. Dr. Florian Alexander Dehmelt, Pro-Test Deutschland e.V.

Where: IFIB, small lecture hall

When: 5 pm

July 2- 5

Welcome Week for the GRK 2381 new doctoral students

Where: participating institutions

When: July 2- 5, all day

Agenda GRK 2381 Meeting

May 24

GRK 2381 at TÜFFF

Where: Hörsaalzentrum Morgenstelle

When: May 24, 3 pm- 10 pm

Incoming doctoral students have presented the GRK 2381 at the TÜFFF (Tübinger Fenster für Forschung, German only) to an audience of all ages.

We thank our numerous visitors, tall and small, for their interest, and our team, Melanie, Philine, Moritz and Thomas for doing a great job.

Here are some impressions

2018

December 18

9th International Conference on cGMP

cGMP: Generators, Effectors and Therapeutic Implications

Where: Mainz (Germany)

When: 14-16 June 2019

November 16

New Research Training Group "cGMP: From Bedside to Bench"

The newly approved GRK 2381 investigates new therapeutic options for established cGMP-modulating drugs.

When: Starting July 2019