News and Events
2023
GRK 2381 fellow Dr. Daniel Stehle wins PhD award
We are happy and proud that one of our GRK 2381 junior scientists, Dr. Daniel Stehle, has received this year's PhD award from the University of Tübingen. His PhD thesis is entitled “cGMP Imaging Uncovers New Roles and Therapeutic Implications of NO/cGMP Signaling in the Kidney and in Melanoma”. The prize was awarded by Rector Professor Dr. Karla Pollmann and Dean Professor Dr. Thilo Stehle on July 15, 2023 during the central doctoral graduation ceremony.
We congratulate Daniel for his excellent work!
Daniel will now continue his academic career as postdoc at the University of San Diego (UCSD) in La Jolla, USA.
We wish him all the best and much success.
Congratulations to Johanna Rodriguez for her doctoral defense!
On July 10, 2023 Johanna Gabriela Rodriguez Cabezas (project 3) successfully defended her doctoral thesis entitled "Understanding the role of NO-GC/cGMP in human, murine, and HIV-positive patient's platelets and the effect of biochemical confinement in platelet morphology and mechanics". Her project was supervised by Prof. Tilman Schäffer at the Institute of Applied Physics in Tübingen and by her co-mentor Assoc. Prof. Francesca Seta from the Boston University.
Congratulations, Dr. Rodriguez Cabezas!
July 5
GRK 2381 Science Forum
Dr. Daniel Stehle (Interfaculty Institute of Biochemistry (IFIB), Signal Transduction, Transgenic Models)
"Shedding light on cGMP signaling with in situ imaging"
Where: Institute of Pharmacy, Auf der Morgenstelle 8, B9N22 and online
When: 5:15 pm
June 7
GRK 2381 Science Forum
Work in Progress Seminar of the Doctoral Fellows
Where: Institute of Pharmacy, Auf der Morgenstelle 8, Seminar Room B9N22 and online
When: 5:15 pm
May 15
IFIB Monday Seminar
Prof. Dr. Sven Nahnsen (Quantitative Biology Center (QBiC), University of Tübingen)
"The power of FAIR data and tools for biomedical research"
Where: IFIB Lecture Hall
When: 5 pm
May 2
Short Talk by Tom Schwerd-Kleine at ARVO 2023
Tom Schwerd-Kleine's abstract "Neuromodulation of retinal bipolar cell glutamate signalling by nitric oxide and endocannabinoids" was selected for a short talk at the ARVO 2023 meeting in New Orleans. The Association for Research in Vision and Ophthalmology (ARVO) is the largest and most respected eye and vision research organization in the world.
March 30
PhD Position (f/m/x) in Biomedicine cGMP in Cancer
The Feil Lab (Interfaculty Institute of Biochemistry, University of Tübingen, Germany) has an opening for a PhD student position (65% TV-L 13) starting as soon as possible.
Application now closed
February 24
New GRK 2381 publication in Frontiers in Molecular Neuroscience
We are happy to announce a new publication from Dila Calis (P9) and colleagues on "Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling".
Congratulations to everyone involved!
2022
November 18
Add-on Fellowship for Aylin Balmes from the Joachim Herz Foundation
The GRK 2381 congratulates Aylin Balmes on her successful application for an Add-on Fellowship for Interdisciplinary Life Science from the Joachim Herz Foundation.
The foundation supports young scientists who want to use interdisciplinary approaches to answer biological research questions while promoting “thinking outside the box” and networking.
The Add-on Fellows receive financial support over a period of two years for international networking and further training in a different subject – for example, biologists can immerse themselves in mathematics and modelers in life sciences. The individually and flexibly adapted funding enables research stays, conference visits, the purchase of aids such as laptops or software solutions and participation in fellowship meetings.
November 16
New junior scientists in the GRK 2381
The GRK 2381 welcomes our first postdoc Daniel Stehle as well as a number of new junior scientists that are associated with individual projects:
Katharina Paulus (Project 2), David Spähn (Project 2), Konstantin Krutzke (Project 3), Jan Seifert (Project 3), Krithika Rajeeth (Project 4) and Janina Brückner (Project 6)
We would like to thank our new colleagues for their interest in the GRK 2381!
October 26-27
GRK 2381 Science Forum
Yearly Progress Reports of the Doctoral Fellows
Where: Institute of Pharmacy, Auf der Morgenstelle 8, Seminar Room B7N19
When: 1-6 pm
October 24
IFIB Monday Seminar
Prof. Dr. Kristina Lorenz (Institute of Pharmacology and Toxicology, Julius-Maximilians-University Würzburg)
"Targeting of pathological ERK1/2 signaling"
Where: IFIB Lecture Hall and online
When: 5 pm
GRK 2381 Science Forum
October 10-13
Autumn School 2022 organised by the doctoral fellows of the second GRK cohort
September 6
We are happy to announce the first two joint Tübingen-Boston publications in the The FASEB Journal (Volume 36, Issue 9-10; Sept./Oct. 2022). Congratulations to doctoral fellows Malte Roeßing and Timo Kopp, as well as to their Tübingen supervisor Susanne Feil and the co-mentors from Boston Paul Huang and Dmitriy Atochin.
September 1
Congratulations to the first Dr. of the GRK 2381!
On July 22, 2022, only three years after the start of the GRK 2381, Philine Marchetta (project 9) successfully defended her doctoral thesis entitled "cGMP pathways as novel molecular targets in the brain for fast auditory processing and cognitive function". Her project was supervised by Prof. Marlies Knipper at the Hearing Research Center in Tübingen and by her co-mentor Prof. Michele Jacob from Tufts University, Boston. Philine is the first “Dr. rer. nat.” graduating in the GRK 2381 and we are happy and proud that she completed her doctoral thesis in such a short time and with such a high quality.
Congratulations, Dr. Marchetta!
July 6
GRK 2381 Science Forum
Dr. Clément Cochain (Comprehensive Heart Failure Center Würzburg (CHFC))
"Macrophage heterogeneity in ischemic heart repair"
Where: online
When: 5:15 pm
June 1
GRK 2381 Science Forum
Dr. Maike Frye (Center for Diagnostics, Clinical Chemistry and Laboratory Medicine, UKE Hamburg)
"Selective regulators of endothelial junctions"
Where: online
When: 5:15 pm
May 20
New GRK 2381 publications in Science Advances and iScience
We are happy to announce two new publications from the GRK 2381 in 2022.
Congratulations to everyone involved!
May 6
Themed Issue on "cGMP Signalling in Cell Growth and Survival"
We are happy to announce the publication of a Themed Issue on "cGMP Signalling in Cell Growth and Survival" in the British Journal of Pharmacology (Volume 179, Issue 11; Published 05 May 2022). Many thanks to all the contributors, many of whom are members of the GRK 2381!
May 4
GRK 2381 Science Forum
Dr. Mike Emerson (Imperial College London, Faculty of Medicine, National Heart & Lung Institute)
“Investigations with platelets and endothelial cells to reduce cardiovascular risk in people living with HIV”
Where: IFIB Lecture Hall
When: 5:15 pm
April 13
Reinhard-Frank-Mini-Symposium GRK Trainees in Boston
Where: Tufts University School of Medicine Medical Education Building 145 Harrison Ave., Room 316 Boston, MA
When: 12 noon
April 6
GRK 2381 Science Forum
Prof. Mikael Simons (Institute of Neuronal Cell Biology (TUM-NZB), Technical University of Munich, German Center for Neurodegenerative Diseases (DZNE))
“Molecular mechanisms of remyelination in the CNS”
Where: IFIB Lecture Hall
When: 5:15 pm
Meet-the-prof at 4pm, IFIB, Level 6. Some impressions:
March 9
GRK 2381 Science Forum
Dr. Wibke Singer (Tübingen Hearing Research Centre, Department of Otolaryngology, Head and Neck Surgery)
“Auditory processing, cGMP signalling and stress”
Where: IFIB Lecture Hall
When: 5:15 pm
GRK 2381 Science Forum
February 2
GRK 2381 Science Forum
Dr. Bettina Weigelin (Multiscale Immunoimaging, Werner Siemens Imaging Center, Department for Preclinical Imaging and Radiopharmacy, University of Tübingen)
“Intravital microscopy for understanding immune cell function in tissues”
Where: IFIB Lecture Hall
When: 12:15 pm
January 12
GRK 2381 Science Forum
Dr. Lucas Matt, (Department of Pharmacology, Toxicology and Clinical Pharmacy, University of Tübingen)
“Synaptic plasticity – from molecular biology to physiology and behavior”
Where: IFIB Lecture Hall
When: 12:15 pm
January 10
German Pharmaceutical Society Lessmüller Poster Prize
Thomas Pham from our first-year doctoral cohort (Project 6, Prof. Peter Ruth) received the Lesmüller Poster Prize in the beginning of January.
With the prize, endowed with 200 euros, the German Pharmaceutical Society (DPhG) and the Dr. August and Dr. Anni Lesmüller Foundation honor a total of five scientists for outstanding contributions.
January 10
10th International Conference on cGMP
The "10th International Conference on cGMP" will take place in Augsburg, Germany (June 17-19, 2022). Please visit the conference homepage at http://www.cyclicgmp.net/ for more details.
2021
December 1
GRK 2381 Science Forum
Dr. Judith Feucht, Cluster of Excellence “iFIT” (EXC2180) and University Children’s Hospital Tübingen
"Novel CAR T cell designs and therapeutic applications"
Where: IFIB Lecture Hall
When: 12:15 pm
November 17-19
1st PhD students-conference of the GRK 2381 on Cancer, Cardiovascular diseases & Neurological disorders: CanCaN2021
Where/When: see Program
November 8
IFIB Monday Seminar
Prof. Dr. Dieter Saur (TU Munich)
"Modelling and targeting pancreatic cancer and its microenvironment".
Where: IFIB lecture hall. The seminar might also be streamed. For info see: https://uni-tuebingen.de/de/13323
When: 5 pm
July 28
GRK 2381 Highlight Seminar
Prof. Dr. Franz Hofmann, TU München- What have we learned about the biological function of cGMP?
Prof. Dr. Johannes-Peter Stasch, Bayer AG and University Halle-Wittenberg- sGC stimulators and sGC activators: Past, present and future
Where: IFIB Lecture Hall
When: 10:30 am
Some impressions from the seminar:
Cancelled- July 7
GRK 2381 Science Forum
Prof. Claudia Lengerke Internal Medicine II, University Clinics Tübingen
t.b.a.
Where: online meeting
When: 5:15 pm
June 23
GRK 2381 Seminar on Gender Equality and Science
Prof. Brigitte Malgrange, University of Liège, GIGA-Stem cells, Developmental Neurobiology Unit
State of the art and challenges in treating deafness
Where: online meeting
When: 5 pm
June 22
Best Poster Award in the Category Audience Favourite at the 2nd Cardiovascular Disease Symposium of the IRTG 1902 and SFB 1116 in Düsseldorf
Congratulations to Marcel Kremser for the Poster Award for his research on Platelet-derived PCSK9.
June 9
GRK 2381 Science Forum
Dr. Anouar Belkacemi, Center for Molecular Signaling (PZMS), Saarland University
Cav-independent functions of the Cavβ3 subunit
Where: online meeting
When: 5:15 pm
May 10
IFIB Institutskolloquium
Prof. Mathias Heikenwälder, German Cancer Research Center (DKFZ), Heidelberg
Inflammatory signatures and its consequences for liver cancer-therapy
Where: online meeting
When: 5:00 pm
May 5-6
Tumor Heterogeneity, Plasticity and Therapy Conference (virtual edition)
Where: online meeting
May 5
GRK 2381 Science Forum
Prof. Axel Gödecke Institute of Cardiovascular Physiology, Heinrich Heine University Düsseldorf
Insulin like growth factor I acts as a cytokine with cardio-protective potential
Where: online meeting
When: 5:15 pm
April 19-23
The cGMP World II (for 1st and 2nd cohort of doctoral researchers)
Where: currently planned as an online meeting
April 14
GRK 2381 Science Forum
Prof. Jos Prickaerts School for Mental Health and Neuroscience, Maastricht University
Targeting cGMP in CNS drug discovery: A translational approach into cognition enhancement
Where: online meeting
When: 5:15 pm
April 8
Good Scientific Practice Course
Mandatory for the GRK 2381- second cohort doctoral fellows
Schiller & Mertens GbR
Where: online meeting
When: 9am - 3 pm
April 7
Best Poster Award “87th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT)”!
Congratulations to Thomas Pham for his work on the importance of the large-conductance Ca2+- and voltage-activated potassium channel (BK), a cGKI substrate, for synaptic plasticity and memory formation.
March 22-26
The cGMP World I (for 2nd cohort of doctoral researchers)
Where: online meeting
Short test on April 12, 2021: 9-10 am, IFIB, Lecture Hall
March 3
GRK 2381 Science Forum
Prof. Emmanuel Buys Cyclerion Therapeutics, Cambridge, MA
Developing CY6463 for the treatment of CNS disease
Where: online meeting
When: 5:15 pm
February 3
GRK 2381 Science Forum
Francesca Seta, PhD, Vascular Biology Section, Boston University School of Medicine
Novel insights on molecular and cellular determinants of arterial stiffness
Where: online meeting
When: 5:15 pm
News Archive
2020
December 7
GRK 2381 Science Forum
Dr. Remco Megens, Imaging and Biophysics Shared Resource Lab, LMU Munich
Laser scanning microscopy in cardiovascular research
Where: online meeting
When: 12:15 pm
June 25
GRK 2381 Science Forum
Dr. Polina Geva, Boston University
The effect of bicarbonate and cell structure on signaling in retinal rods and cones
Where: online meeting
When: 4 pm
June 17
GRK 2381 Science Forum
Prof. Michael Marletta, University of California, Berkeley, California Institute for Quantitative Biosciences
Nitric Oxide Activation of Soluble Guanylate Cyclase
Where: online meeting
When: 5 pm
May 6
GRK 2381 Science Forum
Prof. Michele Jacob, Graduate School of Biomedical Sciences, Tufts University, Boston
ß-Catenin in Human Autism
Where: online meeting
When: 4 pm
April 17
First GRK paper published!
Congratulations to Philine Marchetta on her work on cGMP and hearing loss.
January 29
GRK 2381 Science Forum
Prof. Gerald Meininger, Dalton Cardiovascular Research Center, University of Missouri
Novel insights into vascular stiffness in hypertension and aging involving the vascular smooth muscle cell
Where: IFIB, social room, 2nd floor
When: 12:15- 1:45 pm
January 16
First visit of GRK 2381 doctoral researchers in Boston in November 2019
With support from the Reinhard Frank-Stiftung, four of our doctoral researchers (M. Barresi, A. Böttcher, T. Pham, M. Roeßing) and our training coordinator (Prof. R. Lukowski) were able to make a short-term trip to our partners in Boston in November 2019. This visit was extremely useful to get in touch with host PIs and their laboratories and to establish solid grounds for the future exchange of junior scientists. Our doctoral researchers also presented a poster of the GRK 2381 at the cGMP Forum in Boston and had the opportunity to network with pharma industry. For a full version of their report on their first academic Boston experience, see here.
2019
December 13
Christmas Breakfast GRK 2381
Where: IFIB, Hoppe-Seyler-Str. 4, social room, second floor
When: 10 am - noon
December 2-6
The cGMP World I (Seminar on scientific background and methods in cGMP research)
Where: IFIB, Hoppe-Seyler-Str. 4, Seminar Room 2 (north entry level, right-side)
When: 8:15 am -11 am
Exam: Friday, December 13, 9-10 am, IFIB seminar room 2
November 29
Good Scientific Practice Course, Schiller & Mertens
Where: IFIB, conference room 225, ground floor
When: 9 am - 4 pm
Mandatory for all GRK 2381 doctoral students
November 18
8th Methods and Techniques Lectures
Where: Conference Center Schnarrenberg UKT, 1st floor (Building 520, Otfried-Müller-Str. 6)
When: 9 am - 4:30 pm
November 6
GRK 2381 Science Forum
Prof. Bernd Pichler, Department of Preclinical Imaging and Radiopharmacy
Preclinical multiparametric imaging and beyond: new tracers, novel methods, converging data
Where: IFIB, social room, 2nd floor
When: 12:15 pm - 1:45 pm
October 21
Drivers of tumorigenesis in pre-leukemia bone marrow failure syndromes
Prof. Dr. Yulia Skokowa, University's medical clinic, Tübingen
Where: IFIB, small lecture hall
When: 5 pm
October 9
GRK 2381 Science Forum, organisational meeting
Where: IFIB, social room, 2nd floor
When: 12:15 pm- 1:45 pm
August 1
July 25
Mini symposium on "Live (and high-resolution) cell imaging"
Where: Institute of Pharmacy, 9th floor, 9A29
When: 1 pm- 4 pm
July 8
"You are a killer!"- Speaking about laboratory animals in public and in private. Dr. Florian Alexander Dehmelt, Pro-Test Deutschland e.V.
Where: IFIB, small lecture hall
When: 5 pm
July 2- 5
Welcome Week for the GRK 2381 new doctoral students
Where: participating institutions
When: July 2- 5, all day
May 24
GRK 2381 at TÜFFF
Where: Hörsaalzentrum Morgenstelle
When: May 24, 3 pm- 10 pm
Incoming doctoral students have presented the GRK 2381 at the TÜFFF (Tübinger Fenster für Forschung, German only) to an audience of all ages.
We thank our numerous visitors, tall and small, for their interest, and our team, Melanie, Philine, Moritz and Thomas for doing a great job.
Here are some impressions
2018
December 18
9th International Conference on cGMP
cGMP: Generators, Effectors and Therapeutic Implications
Where: Mainz (Germany)
When: 14-16 June 2019
November 16
New Research Training Group "cGMP: From Bedside to Bench"
The newly approved GRK 2381 investigates new therapeutic options for established cGMP-modulating drugs.
When: Starting July 2019