News and Events


GRK 2381 fellow Dr. Daniel Stehle wins PhD award

We are happy and proud that one of our GRK 2381 junior scientists, Dr. Daniel Stehle, has received this year's PhD award from the University of Tübingen. His PhD thesis is entitled “cGMP Imaging Uncovers New Roles and Therapeutic Implications of NO/cGMP Signaling in the Kidney and in Melanoma”. The prize was awarded by Rector Professor Dr. Karla Pollmann and Dean Professor Dr. Thilo Stehle on July 15, 2023 during the central doctoral graduation ceremony.

We congratulate Daniel for his excellent work!

Daniel will now continue his academic career as postdoc at the University of San Diego (UCSD) in La Jolla, USA.
We wish him all the best and much success.

from left to right: Dean Professor Dr. Thilo Stehle, Dr. Daniel Stehle and Rector Professor Dr. Karla Pollmann

Congratulations to Johanna Rodriguez for her doctoral defense!

On July 10, 2023 Johanna Gabriela Rodriguez Cabezas (project 3) successfully defended her doctoral thesis entitled "Understanding the role of NO-GC/cGMP in human, murine, and HIV-positive patient's platelets and the effect of biochemical confinement in platelet morphology and mechanics". Her project was supervised by Prof. Tilman Schäffer at the Institute of Applied Physics in Tübingen and by her co-mentor Assoc. Prof. Francesca Seta from the Boston University.

Congratulations, Dr. Rodriguez Cabezas!

Johanna with her examination committee. From left to right: Prof. Robert Feil, Dr. Johanna Gabriela Rodriguez Cabezas, Prof. Tilman Schäffer, and Prof. Robert Lukowski (Assoc.-Prof. Francesca Seta took part online)

July 5

GRK 2381 Science Forum

Dr. Daniel Stehle (Interfaculty Institute of Biochemistry (IFIB), Signal Transduction, Transgenic Models)

"Shedding light on cGMP signaling with in situ imaging"

Where: Institute of Pharmacy, Auf der Morgenstelle 8, B9N22 and online

When: 5:15 pm

June 7

GRK 2381 Science Forum

Work in Progress Seminar of the Doctoral Fellows

Where: Institute of Pharmacy, Auf der Morgenstelle 8, Seminar Room B9N22 and online

When: 5:15 pm

May 15

IFIB Monday Seminar

Prof. Dr. Sven Nahnsen (Quantitative Biology Center (QBiC), University of Tübingen)

"The power of FAIR data and tools for biomedical research"

Where: IFIB Lecture Hall

When: 5 pm

May 2

Short Talk by Tom Schwerd-Kleine at ARVO 2023

Tom Schwerd-Kleine's abstract "Neuromodulation of retinal bipolar cell glutamate signalling by nitric oxide and endocannabinoids" was selected for a short talk at the ARVO 2023 meeting in New Orleans. The Association for Research in Vision and Ophthalmology (ARVO) is the largest and most respected eye and vision research organization in the world.

March 30

PhD Position (f/m/x) in Biomedicine cGMP in Cancer

The Feil Lab (Interfaculty Institute of Biochemistry, University of Tübingen, Germany) has an opening for a PhD student position (65% TV-L 13) starting as soon as possible.

Application now closed

February 24

New GRK 2381 publication in Frontiers in Molecular Neuroscience

We are happy to announce a new publication from Dila Calis (P9) and colleagues on "Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling".

Congratulations to everyone involved!

January 11 and 17

Minisymposium "Cell Signaling"



November 18

Add-on Fellowship for Aylin Balmes from the Joachim Herz Foundation 

The GRK 2381 congratulates Aylin Balmes on her successful application for an Add-on Fellowship for Interdisciplinary Life Science from the Joachim Herz Foundation.

The foundation supports young scientists who want to use interdisciplinary approaches to answer biological research questions while promoting “thinking outside the box” and networking.

The Add-on Fellows receive financial support over a period of two years for international networking and further training in a different subject – for example, biologists can immerse themselves in mathematics and modelers in life sciences. The individually and flexibly adapted funding enables research stays, conference visits, the purchase of aids such as laptops or software solutions and participation in fellowship meetings.

November 16

New junior scientists in the GRK 2381

The GRK 2381 welcomes our first postdoc Daniel Stehle as well as a number of new junior scientists that are associated with individual projects:

Katharina Paulus (Project 2), David Spähn (Project 2), Konstantin Krutzke (Project 3), Jan Seifert (Project 3), Krithika Rajeeth (Project 4) and Janina Brückner (Project 6)

We would like to thank our new colleagues for their interest in the GRK 2381!

November 2

GRK 2381 Autumn School 2022

Conference Report and Photo Gallery

October 26-27

GRK 2381 Science Forum

Yearly Progress Reports of the Doctoral Fellows

Where: Institute of Pharmacy, Auf der Morgenstelle 8, Seminar Room B7N19

When: 1-6 pm


October 24

IFIB Monday Seminar

Prof. Dr. Kristina Lorenz (Institute of Pharmacology and Toxicology, Julius-Maximilians-University Würzburg)

"Targeting of pathological ERK1/2 signaling"

Where: IFIB Lecture Hall and online

When: 5 pm

October 10-13

Autumn School 2022 organised by the doctoral fellows of the second GRK cohort

preliminary schedule

September 6

We are happy to announce the first two joint Tübingen-Boston publications in the The FASEB Journal (Volume 36, Issue 9-10; Sept./Oct. 2022). Congratulations to doctoral fellows Malte Roeßing and Timo Kopp, as well as to their Tübingen supervisor Susanne Feil and the co-mentors from Boston Paul Huang and Dmitriy Atochin.

more information

Congratulations to the first Dr. of the GRK 2381!

On July 22, 2022, only three years after the start of the GRK 2381, Philine Marchetta (project 9) successfully defended her doctoral thesis entitled "cGMP pathways as novel molecular targets in the brain for fast auditory processing and cognitive function". Her project was supervised by Prof. Marlies Knipper at the Hearing Research Center in Tübingen and by her co-mentor Prof. Michele Jacob from Tufts University, Boston. Philine is the first “Dr. rer. nat.” graduating in the GRK 2381 and we are happy and proud that she completed her doctoral thesis in such a short time and with such a high quality.

Congratulations, Dr. Marchetta!

Dr. Philine Marchetta (left) receives her GRK 2381 certificate from Dr. Petya Georgieva (right)
A nice flower touch from Florian Tübingen.
Philine with her examination committee. From left to right: Prof. Peter Pilz, Dr. Philine Marchetta, Prof. Marlies Knipper, Prof. Peter Ruth and Prof. Robert Lukowski
With the doctoral cap

July 6

GRK 2381 Science Forum

Dr. Clément Cochain (Comprehensive Heart Failure Center Würzburg (CHFC))

"Macrophage heterogeneity in ischemic heart repair"

Where: online

When: 5:15 pm

June 1

GRK 2381 Science Forum

Dr. Maike Frye (Center for Diagnostics, Clinical Chemistry and Laboratory Medicine, UKE Hamburg)

"Selective regulators of endothelial junctions"

Where: online

When: 5:15 pm

May 20

New GRK 2381 publications in Science Advances and iScience

We are happy to announce two new publications from the GRK 2381 in 2022.

Congratulations to everyone involved!

May 6

Themed Issue on "cGMP Signalling in Cell Growth and Survival"

We are happy to announce the publication of a Themed Issue on "cGMP Signalling in Cell Growth and Survival" in the British Journal of Pharmacology (Volume 179, Issue 11; Published 05 May 2022). Many thanks to all the contributors, many of whom are members of the GRK 2381!

May 4

GRK 2381 Science Forum

Dr. Mike Emerson (Imperial College London, Faculty of Medicine, National Heart & Lung Institute)

“Investigations with platelets and endothelial cells to reduce cardiovascular risk in people living with HIV”

Where: IFIB Lecture Hall

When: 5:15 pm

April 13

Reinhard-Frank-Mini-Symposium GRK Trainees in Boston

Where: Tufts University School of Medicine Medical Education Building 145 Harrison Ave., Room 316 Boston, MA

When: 12 noon


April 6

GRK 2381 Science Forum

Prof. Mikael Simons (Institute of Neuronal Cell Biology (TUM-NZB), Technical University of Munich, German Center for Neurodegenerative Diseases (DZNE))

“Molecular mechanisms of remyelination in the CNS”

Where: IFIB Lecture Hall

When: 5:15 pm

Meet-the-prof at 4pm, IFIB, Level 6. Some impressions:

Meet-the-Prof. with Prof. Mikael Simons, April 6, 2022
Meet-the-Prof. with Prof. Mikael Simons, April 6, 2022

March 9

GRK 2381 Science Forum

Dr. Wibke Singer (Tübingen Hearing Research Centre, Department of Otolaryngology, Head and Neck Surgery)

“Auditory processing, cGMP signalling and stress”

Where: IFIB Lecture Hall

When: 5:15 pm

February 2

GRK 2381 Science Forum

Dr. Bettina Weigelin (Multiscale Immunoimaging, Werner Siemens Imaging Center, Department for Preclinical Imaging and Radiopharmacy, University of Tübingen)

“Intravital microscopy for understanding immune cell function in tissues”

Where: IFIB Lecture Hall

When: 12:15 pm

January 31

GRK 2381 PhD Conference CanCaN2021

Conference Report and Photo Gallery

January 12

GRK 2381 Science Forum

Dr. Lucas Matt, (Department of Pharmacology, Toxicology and Clinical Pharmacy, University of Tübingen)

“Synaptic plasticity – from molecular biology to physiology and behavior”

Where: IFIB Lecture Hall

When: 12:15 pm

January 10

German Pharmaceutical Society Lessmüller Poster Prize

Thomas Pham from our first-year doctoral cohort (Project 6, Prof. Peter Ruth) received the Lesmüller Poster Prize in the beginning of January.


With the prize, endowed with 200 euros, the German Pharmaceutical Society (DPhG) and the Dr. August and Dr. Anni Lesmüller Foundation honor a total of five scientists for outstanding contributions.

January 10

10th International Conference on cGMP

The "10th International Conference on cGMP" will take place in Augsburg, Germany (June 17-19, 2022). Please visit the conference homepage at http://www.cyclicgmp.net/ for more details.


December 1

GRK 2381 Science Forum

Dr. Judith Feucht, Cluster of Excellence “iFIT” (EXC2180) and University Children’s Hospital Tübingen

"Novel CAR T cell designs and therapeutic applications"

Where: IFIB Lecture Hall

When: 12:15 pm

November 17-19

1st PhD students-conference of the GRK 2381 on Cancer, Cardiovascular diseases & Neurological disorders: CanCaN2021

General Invitation

Conference Flyer

Conference Report

Conference Impressions

Where/When: see Program

The participants of CanCaN 2021 on the steps of St. George's Collegiate Church in the old town of Tübingen. (Photo by J. Smykowski)
The GRK 2381 doctoral researchers. (Photo by J. Smykowski)
The poster prize winners R. Zalfen (left) and L. Kreutz (right). (Photo by S. Munir)

November 8

IFIB Monday Seminar

Prof. Dr. Dieter Saur (TU Munich) 

"Modelling and targeting pancreatic cancer and its microenvironment".

Where: IFIB lecture hall. The seminar might also be streamed. For info see: https://uni-tuebingen.de/de/13323

When: 5 pm

October 12-13

GRK 2381 Doctoral Fellows Symposium

Where: IFIB Lecture Hall

When: see schedule

August 23 & 30

Time & Project Management for Scientists

Dr. Andrew Wold

Where: online

When: t.b.a.

July 28

GRK 2381 Highlight Seminar

Prof. Dr. Franz Hofmann, TU München- What have we learned about the biological function of cGMP?

Prof. Dr. Johannes-Peter Stasch, Bayer AG and University Halle-Wittenberg- sGC stimulators and sGC activators: Past, present and future

Where: IFIB Lecture Hall

When: 10:30 am


Some impressions from the seminar:

Cancelled- July 7

GRK 2381 Science Forum

Prof. Claudia Lengerke Internal Medicine II, University Clinics Tübingen


Where: online meeting

When: 5:15 pm

June 23

GRK 2381 Seminar on Gender Equality and Science

Prof. Brigitte Malgrange, University of Liège, GIGA-Stem cells, Developmental Neurobiology Unit

State of the art and challenges in treating deafness 

Where: online meeting

When: 5 pm

June 22

Best Poster Award in the Category Audience Favourite at the 2nd Cardiovascular Disease Symposium of the IRTG 1902 and SFB 1116 in Düsseldorf

Congratulations to Marcel Kremser for the Poster Award for his research on Platelet-derived PCSK9.

read more

June 9

GRK 2381 Science Forum

Dr. Anouar Belkacemi, Center for Molecular Signaling (PZMS), Saarland University

Cav-independent functions of the Cavβ3 subunit

Where: online meeting

When: 5:15 pm

May 10

IFIB Institutskolloquium

Prof. Mathias Heikenwälder, German Cancer Research Center (DKFZ), Heidelberg

Inflammatory signatures and its consequences for liver cancer-therapy

Where: online meeting

When: 5:00 pm

May 5-6

Tumor Heterogeneity, Plasticity and Therapy Conference (virtual edition)

Where: online meeting


May 5

GRK 2381 Science Forum

Prof. Axel Gödecke Institute of Cardiovascular Physiology, Heinrich Heine University Düsseldorf

Insulin like growth factor I acts as a cytokine with cardio-protective potential

Where: online meeting

When: 5:15 pm

April 19-23

The cGMP World II (for 1st and 2nd cohort of doctoral researchers)

Where: currently planned as an online meeting


April 14

GRK 2381 Science Forum

Prof. Jos Prickaerts School for Mental Health and Neuroscience, Maastricht University

Targeting cGMP in CNS drug discovery: A translational approach into cognition enhancement

Where: online meeting

When: 5:15 pm

April 8

Good Scientific Practice Course

Mandatory for the GRK 2381- second cohort doctoral fellows 

Schiller & Mertens GbR

Where: online meeting

When: 9am - 3 pm

April 7

Best Poster Award “87th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT)”!

Congratulations to Thomas Pham for his work on the importance of the large-conductance Ca2+- and voltage-activated potassium channel (BK), a cGKI substrate, for synaptic plasticity and memory formation.

read more

March 22-26

The cGMP World I (for 2nd cohort of doctoral researchers)

Where: online meeting

Short test on April 12, 2021: 9-10 am, IFIB, Lecture Hall


March 3

GRK 2381 Science Forum

Prof. Emmanuel Buys Cyclerion Therapeutics, Cambridge, MA

Developing CY6463 for the treatment of CNS disease

Where: online meeting

When: 5:15 pm

March 1-3

6th German Pharm-Tox Summit

Where: online meeting

AgendaConference Flyer

February 3

GRK 2381 Science Forum

Francesca Seta, PhD, Vascular Biology Section, Boston University School of Medicine

Novel insights on molecular and cellular determinants of arterial stiffness

Where: online meeting

When: 5:15 pm

January 12-15

GRK 2381 Welcome Week

Where: online meeting


News Archive


December 7

GRK 2381 Science Forum

Dr. Remco Megens, Imaging and Biophysics Shared Resource Lab, LMU Munich

Laser scanning microscopy in cardiovascular research

Where: online meeting

When: 12:15 pm

June 25

GRK 2381 Science Forum

Dr. Polina Geva, Boston University

The effect of bicarbonate and cell structure on signaling in retinal rods and cones

Where: online meeting

When: 4 pm


June 17

GRK 2381 Science Forum

Prof. Michael Marletta, University of California, Berkeley, California Institute for Quantitative Biosciences

Nitric Oxide Activation of Soluble Guanylate Cyclase

Where: online meeting

When: 5 pm

May 6

GRK 2381 Science Forum

Prof. Michele Jacob, Graduate School of Biomedical Sciences, Tufts University, Boston

ß-Catenin in Human Autism

Where: online meeting

When: 4 pm

April 1- Postponed for April 29

GRK 2381 Science Forum, Doctoral researcher presentations

Alexandra Böttcher (Project 7), Mariagiovanna Barresi (Project 1) and Melanie Cruz Santos (Project 2)

Where: IFIB, small lecture hall 

When: 12:15- 1:45 pm

April 17

First GRK paper published!

Congratulations to Philine Marchetta on her work on cGMP and hearing loss.

read more

March 4

GRK 2381 Science Forum, Doctoral researcher presentations

Malte Roeßing (Project 4), Marcel Kremser (Project 5) and Thomas Pham (Project 6)

Where: IFIB, social room, 2nd floor

When: 12:15- 1:45 pm

February 5

GRK 2381 Science Forum, Doctoral researcher presentations

Dominic Gonschorek (Project 8), Philine Marchetta (Project 9) and Johanna Rodriguez (Project 3)

Where: IFIB, social room, 2nd floor

When: 12:15- 1:45 pm

January 29

GRK 2381 Science Forum

Prof. Gerald Meininger, Dalton Cardiovascular Research Center, University of Missouri

Novel insights into vascular stiffness in hypertension and aging involving the vascular smooth muscle cell

Where: IFIB, social room, 2nd floor

When: 12:15- 1:45 pm

January 16

First visit of GRK 2381 doctoral researchers in Boston in November 2019

With support from the Reinhard Frank-Stiftung, four of our doctoral researchers (M. Barresi, A. Böttcher, T. Pham, M. Roeßing) and our training coordinator (Prof. R. Lukowski) were able to make a short-term trip to our partners in Boston in November 2019. This visit was extremely useful to get in touch with host PIs and their laboratories and to establish solid grounds for the future exchange of junior scientists. Our doctoral researchers also presented a poster of the GRK 2381 at the cGMP Forum in Boston and had the opportunity to network with pharma industry. For a full version of their report on their first academic Boston experience, see here.


December 13

Christmas Breakfast GRK 2381

Where: IFIB, Hoppe-Seyler-Str. 4, social room, second floor

When: 10 am - noon

​​​​​​​December 2-6

The cGMP World I (Seminar on scientific background and methods in cGMP research)

Where: IFIB, Hoppe-Seyler-Str. 4, Seminar Room 2 (north entry level, right-side)

When: 8:15 am -11 am 

Exam: Friday, December 13, 9-10 am, IFIB seminar room 2


November 29

Good Scientific Practice Course, Schiller & Mertens

Where: IFIB, conference room 225, ground floor

When: 9 am - 4 pm 

Mandatory for all GRK 2381 doctoral students

​​​​​​​November 18

8th Methods and Techniques Lectures

Where: Conference Center Schnarrenberg UKT, 1st floor (Building 520, Otfried-Müller-Str. 6)

When: 9 am - 4:30 pm 

Final Program

​​​​​​​November 6

GRK 2381 Science Forum

Prof. Bernd Pichler, Department of Preclinical Imaging and Radiopharmacy

Preclinical multiparametric imaging and beyond: new tracers, novel methods, converging data

Where: IFIB, social room, 2nd floor

When: 12:15 pm - 1:45 pm

​​​​​​​October 21

Drivers of tumorigenesis in pre-leukemia bone marrow failure syndromes

Prof. Dr. Yulia Skokowa, University's medical clinic, Tübingen

Where: IFIB, small lecture hall

When: 5 pm

​​​​​​​October 9

GRK 2381 Science Forum, organisational meeting

Where: IFIB, social room, 2nd floor

When: 12:15 pm- 1:45 pm

More: Schedule October 2019- July 2020

​​​​​​​July 25

Mini symposium on "Live (and high-resolution) cell imaging"

Where: Institute of Pharmacy, 9th floor, 9A29

When: 1 pm- 4 pm


​​​​​​​July 8

"You are a killer!"- Speaking about laboratory animals in public and in private. Dr. Florian Alexander Dehmelt, Pro-Test Deutschland e.V.

Where: IFIB, small lecture hall

When: 5 pm

​​​​​​​July 2- 5

Welcome Week for the GRK 2381 new doctoral students

Where: participating institutions

When: July 2- 5, all day

Agenda GRK 2381 Meeting

May 24

GRK 2381 at TÜFFF

Where: Hörsaalzentrum Morgenstelle

When: May 24, 3 pm- 10 pm

Incoming doctoral students have presented the GRK 2381 at the TÜFFF (Tübinger Fenster für Forschung, German only) to an audience of all ages.

We thank our numerous visitors, tall and small, for their interest, and our team, Melanie, Philine, Moritz and Thomas for doing a great job.

Here are some impressions


December 18

9th International Conference on cGMP

cGMP: Generators, Effectors and Therapeutic Implications

Where: Mainz (Germany) 

When: 14-16 June 2019


​​​​​​​November 16

New Research Training Group "cGMP: From Bedside to Bench"

The newly approved GRK 2381 investigates new therapeutic options for established cGMP-modulating drugs.

When: Starting July 2019