2024
Roslan A, Paulus K, Yang J, et al., Cardiovasc Res. 2024
Roslan A, Paulus K, Yang J, Matt L, Bischof H, Längst N, Schanz S, Luczak A, Cruz Santos M, Burgstaller S, Skrabak D, Bork NI, Malli R, Schmidtko A, Gawaz M, Nikolaev VO, Ruth P, Ehinger R, Lukowski R. Slack K+ channels confer protection against myocardial ischemia/reperfusion injury. Cardiovasc Res. 2024 Aug 5:cvae155. doi: 10.1093/cvr/cvae155. Online ahead of print. PMID: 39102831 [pubmed][project 2][project 5][project 6]
Sigle M, Rohlfing AK, Cruz Santos M et al., Circ Res. 2024
Sigle M, Rohlfing AK, Cruz Santos M, Kopp T, Krutzke K, Gidlund V, Kollotzek F, Marzi J, von Ungern-Sternberg S, Poso A, Heikenwälder M, Schenke-Layland K, Seizer P, Möllmann J, Marx N, Feil R, Feil S, Lukowski R, Borst O, Schäffer TE, Müller KAL, Gawaz MP, Heinzmann D. Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts., Circ Res. 2024;135:758-773. doi: 10.1161/CIRCRESAHA.124.324812. [pubmed][Project 1][Project 2][Project 3][Project 4][Project 5]
Yokomizo S, Kopp T, Roessing M et al., Stroke. 2024
Yokomizo S, Kopp T, Roessing M, Morita A, Lee S, Cho S, Ogawa E, Komai E, Inoue K, Fukushi M, Feil S, Kim H, Bragin DE, Gerashchenko D, Huang PL, Kashiwagi S, Atochin DN. Near-infrared II photobiomodulation preconditioning ameliorates stroke injury via phosphorylation of eNOS., Stroke. 2024;55:1641-1649. doi: 10.1161/STROKEAHA.123.045358. [pubmed] [Project 4]
Balmes A, Rodriguez JG et al., Platelets. 2024
Balmes A, Rodriguez JG, Seifert J, Pinto-Quintero D, Khawaja AA, Boffito M, Frye M, Friebe A, Emerson M, Seta F, Feil R, Feil S, Schäffer TE. Role of the NO-GC/cGMP signaling pathway in platelet biomechanics. Platelets. 2024;35:2313359. doi: 10.1080/09537104.2024.2313359. [pubmed] [Project 1] [Project 3] [Project 4] [Project 5]
Marchetta P et al., Faseb J. 2024
Marchetta P, Dapper K, Hess M, Calis D, Singer W, Wertz J, Fink S, Hage S, Alam M, Schwabe K, Lukowski R, Bourin J, Puel JL, Jacob M, Munk M, Land R, Rüttiger L, Knipper M. Dysfunction of specific auditory fibers impact cortical oscillations, driving an autism phenotype despite near-normal hearing. Faseb J. 2024;38:e23411. doi: 10.1096/fj.202301995R. [pubmed] [Project 2] [Project 9]
Seizer P et al., Cardiovasc Res. 2024
Seizer P, von Ungern-Sternberg SNI, Haug V, Dicenta V, Rosa A, Butt E, Nöthel M, Rohlfing A-K, Sigle M, Nawroth PP, Nussbaum C, Sperandio M, Kusch C, Meub M, Sauer M, Münzer P, Bieber K, Stanger A, Mack AF, Huber R, Brand K, Lehners M, Feil R, Poso A, Krutzke K, Schäffer TE, Nieswandt B, Borst O, May AE, Zernecke A, Gawaz M, Heinzmann D. Cyclophilin A is a ligand for RAGE in thrombo-inflammation. Cardiovasc Res. 2024;120:385-402. doi: 10.1093/cvr/cvad189. [pubmed] [Project 1] [Project 3] [Project 4] [Project 5]
2023
Rohlfing AK et al., Thromb Res. 2023
Rohlfing AK, Kremser M, Schaale D, Dicenta-Baunach V, Laspa Z, Fu X, Zizmare L, Sigle M, Harm T, Münzer P, Pelzer A, Borst O, Trautwein C, Feil R, Müller K, Castor T, Lämmerhofer M, Gawaz MP. cGMP modulates hemin-mediated platelet death. Thromb Res. 2023;234:63-74. doi: 10.1016/j.thromres.2023.12.008. [pubmed] [Project 1] [Project 5]
Pham T et al., Cell Mol Life Sci. 2023
Pham T, Hussein T, Calis D, Bischof H, Skrabak D, Cruz Santos M, Maier S, Spähn D, Kalina D, Simonsig S, Ehinger R, Groschup B, Knipper M, Plesnila N, Ruth P, Lukowski R, Matt L. BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation. Cell Mol Life Sci. 2023;80:369. doi: 10.1007/s00018-023-05016-y. [pubmed] [Project 2] [Project 6] [Project 9]
Schütte JP et al., Circ Res. 2023
Schütte JP, Manke MC, Hemmen K, Münzer P, Schörg BF, Ramos GC, Pogoda M, Dicenta V, Hoffmann SHL, Pinnecker J, Kollotzek F, Zdanyte M, Mueller KAL, Singh Y, Mack AF, Pichler B, Lang F, Nieswandt B, Gawaz M, Heinze KG, Casadei N, Borst O. Platelet-derived microRNAs regulate cardiac remodeling after myocardial ischemia. Circ Res. 2023;132:e96-e113. doi: 10.1161/CIRCRESAHA.122.322459. [pubmed] [Project 5]
Skrabak D et al., Commun Biol. 2023
Fink A et al., Thromb Haemost. 2023
Fink A, Rohlfing AK, Dicenta V, Schaale D, Kremser M, Laspa Z, Sigle M, Fu X, Pelzer A, Fischer M, Münzer P, Castor T, Müller KAL, Borst O, Lämmerhofer M, Gawaz MP. The subtilisin-like protease furin regulates hemin-dependent ectodomain shedding of glycoprotein VI. Thromb Haemost. 2023;123:679-691. doi: 10.1055/s-0043-1768057. [pubmed] [Project 5]
Calis D et al., Front Mol Neurosci. 2023
Calis D, Hess M, Marchetta P, Singer W, Modro J, Nelissen E, Prickaerts J, Sandner P, Lukowski R, Ruth P, Knipper M, Rüttiger L. Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling. Front Mol Neurosci. 2023;16:1017761. [pubmed] [Project 2] [Project 6] [Project 9]
2022
Bayrak A et al., J Med Chem. 2022
Bayrak A, Mohr F, Kolb K, Szpakowska M, Shevchenko E, Dicenta E, Rohlfing AK, Kudolo M, Pantsar T, Günther M, Kaczor AA, Poso A, Chevigné A, Pillaiyar T, Gawaz M, Laufer SA. Discovery and development of first-in-class ACKR3/CXCR7 superagonists for platelet degranulation modulation. J Med Chem. 2022;65:13365-13384. [pubmed] [Project 5]
Katagiri W et al., Faseb J. 2022
Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S. Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy. FASEB J. 2022;36:e22521. [pubmed] [Project 1] [Project 4]
Yokomizo S et al., Faseb J. 2022
Savitska D et al., Front Neurosci. 2022
Baumann J et al., Sci Adv. 2022
Baumann J, Sachs L, Otto O, Schoen I, Nestler P, Zaninetti C, Kenny M, Kranz R, von Eysmondt H, Rodriguez J, Schäffer TE, Nagy Z, Greinacher A, Palankar R, Bender M. Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease. Sci Adv. 2022;8:eabn2627. [pubmed] [Project 3]
Nestele J A et al., Int J Mol Sci. 2022
Nestele J A, Rohlfing AK, Dicenta V, Bild A, Eißler D, Emschermann F, Kremser M, Krutzke K, Schäffer TE, Borst O, Levi M, Korin N, Gawaz MP. Characterization of GPVI- or GPVI-CD39-coated nanoparticles and their impact on in vitro thrombus formation. Int J Mol Sci. 2022;23:11. [pubmed] [Project 3] [Project 5]
Rohlfing AK et al., Nat Commun. 2022
Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke M-C, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Caglar Beker M, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer H F, Rath D, Gawaz MP. ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nat Commun. 2022;13:1823. [pubmed] [Project 3] [Project 5]
Marchetta P et al., Br J Pharmacol. 2022
Marchetta P, Rüttiger L, Hobbs AJ, Singer W, Knipper M. The role of cGMP signalling in auditory processing in health and disease. Br J Pharmacol. 2022;179:2378-2393. [Project 9]
2021
Bork NI et al., Redox Biol. 202, 2021
Gonschorek D et al., NeurIPS 2021
Gonschorek D, Höfling L, Szatko KP, Franke K, Schubert T, DunnB A, Berens P, Klindt DA, Euler T. Removing inter-experimental variability from functional data in systems neuroscience. Thirty-Fifth Conference on Neural Information Processing Systems (NeurIPS 2021). doi:10.1101/2021.10.29.466492. [Project 8]
Matt L at al., Cell Mol Life Sci. 2021
Petersen-Uribe A et al., Int J Mol Sci. 2021
Petersen-Uribe A, Kremser M, Rohlfing AK , Castor T, Kolb K, Dicenta V, Emschermann F, Li B, Borst O, Rath D, Müller K, Gawaz MP. Platelet-derived PCSK9 is associated with LDL metabolism and modulates atherothrombotic mechanisms in coronary artery disease. Int J Mol Sci. 2021;22:11179. [pubmed] [Project 5]
Längst N et al., Int J Mol Sci. 2021
Stehle D et al., Br J Pharmacol. 2021
Stehle D, Xu MZ, Schomber T, Hahn MG, Schweda F, Feil S, Kraehling JR, Eitner F, Patzak A, Sandner P, Feil R, Benardeau A. Novel sGC activators increase glomerular cGMP, induce vasodilation, and improve blood flow in the murine kidney. Br J Pharmacol. 2021;179;2476-2489. [pubmed] [Project 1] [Project 4]
Eckert P et al., Front Mol Neurosci. 2021
Eckert P, Marchetta P, Manthey MK, Walter MH, Jovanovic S, Savitska D, Singer W, Jacob MH, Rüttiger L, Schimmang T, Milenkovic I, Pilz PKD, Knipper M. Deletion of BDNF in Pax2+ lineage-derived interneuron precursors in the hindbrain hampers maturation of excitation/inhibition balance, learning and behavior. Front Mol Neurosci. 2021;14:642679. [pubmed] [Project 9]
Tikoo S et al., J Invest Dermatol. 2021
2020
Marchetta P et al., Brain Sci. 2020
Marchetta P, Savitska D, Kübler A, Asola G, Manthey M, Möhrle D, Schimmang T, Rüttiger L, Knipper M, Singer W. Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit LTP/BDNF. Brain Sci. 2020;10:710. [pubmed] [Project 9]
Marchetta P et al., Front Aging Neurosci. 2020
Marchetta P, Möhrle D, Eckert P, Reimann K, Wolter S, Tolone A, Lang I, Wolters M, Feil R, Engel J, Paquet-Durand F, Kuhn M, Knipper M, Rüttiger L. Guanylyl cyclase A/cGMP signaling slows hidden, age- and acoustic trauma-induced hearing loss. Front Aging Neurosci. 2020;12:83 [pubmed] [Project 1] [Project 9]