2023

Pham T, Hussein T, Calis D, Bischof H, Skrabak D, Cruz Santos M, Maier S, Spähn D, Kalina D, Simonsig S, Ehinger R, Groschup B, Knipper M, Plesnila N, Ruth P, Lukowski R, Matt L. BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation. Cell Mol Life Sci. 2023;80:369. doi: 10.1007/s00018-023-05016-y. [pubmed] [Project 2] [Project 6] [Project 9]

Seizer P, von Ungern-Sternberg SNI, Haug V, Dicenta V, Rosa A, Butt E, Nöthel M, Rohlfing A-K, Sigle M, Nawroth PP, Nussbaum C, Sperandio M, Kusch C, Meub M, Sauer M, Münzer P, Bieber K, Stanger A, Mack AF, Huber R, Brand K, Lehners M, Feil R, Poso A, Krutzke K, Schäffer TE, Nieswandt B, Borst O, May AE, Zernecke A, Gawaz M, Heinzmann D. Cyclophilin A is a ligand for RAGE in thrombo-inflammation. Cardiovasc Res. 2023; in press. [Project 1] [Project 3] [Project 4] [Project 5]

Rodriguez JG, Balmes A, Seifert J, Pinto-Quintero D, Khawaja AA, Boffito M, Frye M, Friebe A, Emerson M, Seta F, Feil R, Feil S, Schäffer TE. Role of the NO-GC/cGMP signaling pathway in platelet biomechanics. BioRxiv. 2023; doi: https://doi.org/10.1101/2023.04.28.538670. [Project 1] [Project 3] [Project 4] [Project 5]

Schütte JP, Manke MC, Hemmen K, Münzer P, Schörg BF, Ramos GC, Pogoda M, Dicenta V, Hoffmann SHL, Pinnecker J, Kollotzek F, Zdanyte M, Mueller KAL, Singh Y, Mack AF, Pichler B, Lang F, Nieswandt B, Gawaz M, Heinze KG, Casadei N, Borst O. Platelet-derived microRNAs regulate cardiac remodeling after myocardial ischemia. Circ Res. 2023;132:e96-e113. doi: 10.1161/CIRCRESAHA.122.322459. [pubmed] [Project 5]

Skrabak D, Bischof H, Pham T, Ruth P, Ehinger R, Matt L, Lukowski R. Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing. Commun Biol. 2023;6:1029. doi: 10.1038/s42003-023-05387-9. [pubmed] [Project 2] [Project 6]

Fink A, Rohlfing AK, Dicenta V, Schaale D, Kremser M, Laspa Z, Sigle M, Fu X, Pelzer A, Fischer M, Münzer P, Castor T, Müller KAL, Borst O, Lämmerhofer M, Gawaz MP. The subtilisin-like protease furin regulates hemin-dependent ectodomain shedding of glycoprotein VI. Thromb Haemost. 2023;123:679-691. doi: 10.1055/s-0043-1768057. [pubmed] [Project 5]

Qiu Y, Klindt DA, Szatko KP, Gonschorek D, Hoefling L, Schubert T, Busse L, Bethge M, Euler T. Efficient coding of natural scenes improves neural system identification. PLoS Comput Biol. 2023;19:e1011037. [pubmed] [Project 8]

Calis D, Hess M, Marchetta P, Singer W, Modro J, Nelissen E, Prickaerts J, Sandner P, Lukowski R, Ruth P, Knipper M, Rüttiger L.  Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling. Front Mol Neurosci. 2023;16:1017761. [pubmed] [Project 2] [Project 6] [Project 9]

Stehle D, Barresi M, Schulz J, Feil R. Heterogeneity of cGMP signalling in tumour cells and the tumour microenvironment: Challenges and chances for cancer pharmacology and therapeutics. Pharmacol Ther. 2023;242:108337. [pubmed] [Project 1]

2022

Bayrak A, Mohr F, Kolb K, Szpakowska M, Shevchenko E, Dicenta E, Rohlfing AK, Kudolo M, Pantsar T, Günther M, Kaczor AA, Poso A, Chevigné A, Pillaiyar T, Gawaz M, Laufer SA. Discovery and development of first-in-class ACKR3/CXCR7 superagonists for platelet degranulation modulation. J Med Chem. 2022;65:13365-13384. [pubmed] [Project 5]

Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S. Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy. FASEB J. 2022;36:e22521. [pubmed] [Project 1] [Project 4]

Yokomizo S, Roessing M, Morita A, Kopp T, Ogawa E, Katagiri W, Feil S, Huang PL, Atochin DN, Kashiwagi S. Near-infrared II photobiomodulation augments nitric oxide bioavailability via phosphorylation of endothelial nitric oxide synthase. FASEB J. 2022;36:e22490. [pubmed] [Project 4]

Savitska D, Hess M, Calis D, Marchetta P, Harasztosi C, Fink S, Eckert P, Ruth P, Rüttiger L, Knipper M, Singer W. Stress affects central compensation of neural responses to cochlear synaptopathy in a cGMP-dependent way. Front Neurosci. 2022;16:864706. [pubmed] [Project 6] [Project 9]

Seifert J, Rheinlaender J, von Eysmondt H, Schäffer TE. Mechanics of migrating platelets investigated with scanning ion conductance microscopy. Nanoscale. 2022;14:8192-8199. [pubmed] [Project 3]

Zhang Y, Benz P, Stehle D, Yang S, Kurz H, Feil S, Nagel G, Feil R, Gao S, Bender M. Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes. Open Biol. 2022;12:220058. [pubmed] [Project 1] [Project 4]

Baumann J, Sachs L, Otto O, Schoen I, Nestler P, Zaninetti C, Kenny M, Kranz R, von Eysmondt H, Rodriguez J, Schäffer TE, Nagy Z, Greinacher A, Palankar R, Bender M. Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease. Sci Adv. 2022;8:eabn2627. [pubmed] [Project 3]

Marchetta P, Eckert P, Lukowski R, Ruth P, Singer W, Rüttiger L, Knipper M. Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea. iScience. 2022;25:103981. [pubmed] [Project 2] [Project 6] [Project 9]

Nestele J A, Rohlfing AK, Dicenta V, Bild A, Eißler D, Emschermann F, Kremser M, Krutzke K, Schäffer TE, Borst O, Levi M, Korin N, Gawaz MP. Characterization of GPVI- or GPVI-CD39-coated nanoparticles and their impact on in vitro thrombus formation. Int J Mol Sci. 2022;23:11. [pubmed] [Project 3] [Project 5]

Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke M-C, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Caglar Beker M, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer H F, Rath D, Gawaz MP. ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nat Commun. 2022;13:1823. [pubmed] [Project 3] [Project 5]

Lukowski R, Cruz Santos M, Kuret A, Ruth P. cGMP and mitochondrial K+ channels-compartmentalized but closely connected in cardioprotection. Br J Pharmacol. 2022;179:2344-2360. [pubmed] [Project 2] [Project 6]

Schmidt H, Böttcher A, Gross A, Schmidtko A. cGMP signalling in dorsal root ganglia and the spinal cord: various functions in development and adulthood. Br J Pharmacol. 2022;179:2361-2377. [pubmed] [Project 7]

Marchetta P, Rüttiger L, Hobbs AJ, Singer W, Knipper M. The role of cGMP signalling in auditory processing in health and disease. Br J Pharmacol. 2022;179:2378-2393. [Project 9]

Feil R, Lehners M, Stehle D, Feil S. Visualising and understanding cGMP signals in the cardiovascular system. Br J Pharmacol. 2022;179:2394-2412. [pubmed] [Project 1] [Project 4]

2021

Bork NI, Kuret A, Cruz Santos M, Molina CE, Reiter B, Reichenspurner H, Friebe A, Skryabin BV, Rozhdestvensky TS, Kuhn M, Lukowski R, Nikolaev VO. Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia. Redox Biol. 202;48:102179. [pubmed] [Project 2]

Gonschorek, D, Höfling, L, Szatko KP, Franke K, Schubert T, DunnB A, Berens P, Klindt DA, Euler T. Removing inter-experimental variability from functional data in systems neuroscience. Thirty-Fifth Conference on Neural Information Processing Systems (NeurIPS 2021). doi:10.1101/2021.10.29.466492. [Project 8]

Matt L, Pham T, Skrabak D, Hoffmann F, Eckert P, Yin J, Gisevius M, Ehinger R, Bausch A, Ueffing M, Boldt K, Ruth P, Lukowski R. The Na+-activated K+ channel Slack contributes to synaptic development and plasticity. Cell Mol Life Sci. 2021;78:7569-7587. [pubmed] [Project 2] [Project 6]

Petersen-Uribe A, Kremser M, Rohlfing AK , Castor T, Kolb K, Dicenta V, Emschermann F, Li B, Borst O, Rath D, Müller K, Gawaz MP. Platelet-derived PCSK9 is associated with LDL metabolism and modulates atherothrombotic mechanisms in coronary artery disease. Int J Mol Sci. 2021;22:11179. [pubmed] [Project 5]

Längst N, Adler J, Schweigert O, Kleusberg F, Cruz Santos M, Knauer A, Sausbier M, Zeller T, Ruth P, Lukowski R. Cyclic GMP-dependent regulation of vascular tone and blood pressure involves cysteine-rich LIM-Only protein 4 (CRP4). Int J Mol Sci. 2021; 22:9925. [pubmed] [Project 2] [Project 6]

Stehle D, Xu MZ, Schomber T, Hahn MG, Schweda F, Feil S, Kraehling JR, Eitner F, Patzak A, Sandner P, Feil R, Benardeau A. Novel sGC activators increase glomerular cGMP, induce vasodilation, and improve blood flow in the murine kidney. Br J Pharmacol. 2021;179;2476-2489. [pubmed]  [Project 1] [Project 4]

Eckert P, Marchetta P, Manthey MK, Walter MH, Jovanovic S, Savitska D, Singer W, Jacob MH, Rüttiger L, Schimmang T, Milenkovic I, Pilz PKD, Knipper M. Deletion of BDNF in Pax2+ lineage-derived interneuron precursors in the hindbrain hampers maturation of excitation/inhibition balance, learning and behavior. Front Mol Neurosci. 2021;14:642679. [pubmed] [Project 9]

Tikoo S, Jain R, Tomasetig F, On K, Martinez B, Heu C, Stehle D, Obeidy P, Guo D, Vincent JN, Cook AJL, Roediger B, Feil R, Whan RM, Weninger W. Amelanotic B16-F10 melanoma compatible with advanced 3-D imaging modalities. J Invest Dermatol. 2021; 141:2090-2094.e6. [pubmed] [Project 1]

Krämer MS, Feil R, Schmidt H. Analysis of gene expression using lacZ reporter mouse lines. Methods Mol Biol. 2021;2224:29-45.  [pubmed] [Project 1] [Project 7]

2020

Marchetta P, Savitska D, Kübler A, Asola G, Manthey M, Möhrle D, Schimmang T, Rüttiger L, Knipper M, Singer W. Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit LTP/BDNF. Brain Sci. 2020;10:710. [pubmed] [Project 9]

Marchetta P, Möhrle D, Eckert P, Reimann K, Wolter S, Tolone A, Lang I, Wolters M, Feil R, Engel J, Paquet-Durand F, Kuhn M, Knipper M, Rüttiger L. Guanylyl cyclase A/cGMP signaling slows hidden, age- and acoustic trauma-induced hearing loss. Front Aging Neurosci. 2020;12:83 [pubmed] [Project 1] [Project 9]