Image-Guided and Functionally Instructed Tumor Therapies (iFIT)

The Image-Guided and Functionally Instructed Tumor Therapies (iFIT) Cluster of Excellence teams world-leading expertise in three important areas of cancer research which have so far been largely separated, but, when combined promise an unprecedented level of understanding of tumor biology and the development of novel diagnostic and therapeutic approaches for the treatment of tumor diseases These areas include A) the identification of “functionally instructed molecular therapies” via functional genomics, B) their combination with and further development of advanced immunotherapies and C) the use of multiparametric imaging techniques to guide tumor therapies and to unravel novel classes of therapeutic targets.

iFIT scientists will particularly focus biological processes which enable tumors to survive under stress. State-of-the-art imaging techniques will be used used to visualize stress states and responses of tumors, enabling to apply novel molecular cancer therapies in an image guided and personalized setting. Spokesman of the cluster is the oncologist Professor Lars Zender, Medical Director of the department of Internal Medicine VIII - Clinical Tumorbiology. Co-spokesmen are Professor Bernd Pichler, Director of the Werner Siemens Imaging Center at the University of Tübingen, and immunologist Professor Hans-Georg Rammensee. Further participating institutions in the cluster are the Max Planck Institutes for Developmental Biology and Intelligent Systems, the Natural and Medical Sciences Institute at the University of Tübingen, and the Margarete Fischer Bosch Institute for Clinical Pharmacology.