Computational Systems Biology of Infections
and Antimicrobial-Resistant Pathogens
Welcome to the Draeger Research Group!
The Dräger research group (est. July 2018) applies computer-aided systems biology, focusing on infections and antimicrobial-resistant pathogens. The research covers all steps from the biological phenomenon to its simulation in the computer, including the reconstruction of biological systems, their mathematical modeling, the standardization of these models, the development of specialized software solutions, and the application of machine learning and data visualization. Deriving model-driven new hypotheses from combating increasing antibiotic resistance systematically constitutes a primary aim.
Systems Biology: A short overview
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Latest Publications
- An integrated systems-biology approach reveals differences in formate metabolism in the genus Methanothermobacter
I. Casini, T. McCubbin, S. Esquivel-Elizondo, G. G. Luque, D. Evseeva, C. Fink, S. Beblawy, N. D. Youngblut, L. Aristilde, D. H. Huson, A. Dräger, R. E. Ley, E. Marcellin, L. T. Angenent, B. Molitor.
iScience, September 22nd, 2023
[ Details | DOI | Preprint | PDF | PubMed | BibTeX ] - Exploring the metabolic profiling of A. baumannii for antimicrobial development using genome-scale modeling
N. Leonidou, Y. Xia und A. Dräger
BioRxiv, September 15th, 2023.
[ Details | DOI | PDF | PubMed | BibTeX ] - Can Genome Sequencing Coupled to Flux Balance Analyses Offer Precision Guidance for Industrial Strain Development? The Lessons from Carbon Trafficking in Corynebacterium glutamicum ATCC 21573
E. Kurpejović, D. Wibberg, G. M. Bastem, A. Burgardt, T. Busche, F. E. A. Kaya, A. Dräger, V. F. Wendisch und B. S. Akbulut
OMICS: A Journal of Integrative Biology, September 14th, 2023.
[ Details | DOI | PDF | PubMed | BibTeX ] - Advancements in Computational Modelling of Biological Systems: seventh annual SysMod meeting
B. L. Puniya and A. Dräger
Bioinformatics, September 14st 2023.
[ Details | DOI | PDF | PubMed | BibTeX ] - SBOannotator: a Python Tool for the Automated Assignment of Systems Biology Ontology Terms
N. Leonidou, E. Fritze, A. Renz, and A. Dräger
Bioinformatics, July 14th 2023.
[ Details | DOI | Preprint | PDF | PubMed | BibTeX ] - Genome-scale metabolic models consistently predict in vitro characteristics of Corynebacterium striatum
F. Bäuerle, G. O. Gusak, L. Camus, S. Heilbronner, and A. Dräger
BioRxiv, April, 29th 2023.
[ Details | DOI | PDF | PubMed | BibTeX ] - New Workflow Predicts Drug Targets Against SARS-CoV-2 via Metabolic Changes in Infected Cells
N. Leonidou, A. Renz, R. Mostolizadeh, and A. Dräger
PLOS Computational Biology, 19(3): e1010903, March 23rd, 2023.
[ Details | DOI | Preprint | PDF | PubMed | BibTeX ] - Standard-GEM: Standardization of open-source genome-scale metabolic models
M. Anton, E. Almaas, R. Benfeitas, S. Benito-Vaquerizo, L. M. Blank, A. Dräger, J. M. Hancock, C. Kittikunapong, M. König, F. Li, U. W. Liebal, H. Lu, H. Ma, R. Mahadevan, A. Mardinoglu, J. Nielsen, J. Nogales, M. Pagni, J. A. Papin, K. R. Patil, N. D. Price, J. L. Robinson, B. J. Sánchez, M. Suarez Diez, S. Sulheim, L. T. Svensson, B. Teusnik, W. Vongsangnak, H. Wang, A. A. Zeidan, and E. J. Kerkhoven
BioRxiv, March 23rd, 2023.
[ Details | DOI | PDF | PubMed | BibTeX ] - Genome-scale model of Pseudomonas aeruginosa metabolism unveils virulence and drug potentiation
S. Dahal, A. Renz, A. Dräger und L. Yang
Communications Biology, 6, 165, 10. Februar 2023.
[ Details | DOI | PDF | PubMed | BibTeX ] - Hierarchical modelling of microbial communities
M. Glöckler, A. Dräger, and R. Mostolizadeh
Bioinformatics, January 17th, 2023
[ Details | DOI | PDF | PubMed | BibTeX ] - Metabolic Modeling Elucidates Phenformin and Atpenin A5 as Broad-Spectrum Antiviral Drugs
A. Renz, M. Hohner, M. Breitenbach, J. Josephs-Spaulding, J. Dürrwald, L. Best, R. Jami, G. Marinos, F. Cabreiro, A. Dräger, M. Schindler und C. Kaleta
Preprints 2022, 2022100223, October 17th, 2022.
[ Details | DOI | PDF | PubMed | BibTeX ] - Computational modelling in health and disease. Highlights of the 6th annual SysMod meeting
A. Niarakis, J. Thakar, M. Barberis, M. Rodríguez Martínez, T. Helikar, M. Birtwistle, C. Chaouiya, L. Calzone, and A. Dräger
Bioinformatics, September 22nd, 2022.
[ Details | DOI | PDF | PubMed | BibTeX ]