Center for Plant Molecular Biology

Research group Lozano-Durán

Research | Staff | Publications

PUBLICATIONS (since 2015)

(Lab members appear in bold)


Wei H, Lozano-Durán R (2023). The primase subunits of DNA polymerase α, PRIM1 and PRIM2, are required for the replication of the geminivirus tomato yellow leaf curl virus in the host plant. Micropublications Biology, in press.

Wang L, Lozano-Durán R (2023). Manipulation of plant RNA biology by geminiviruses. J Exp Bot, in press.


Wang L, Fan P, Jimenez-Gongora T, Zhang D, Ding X, Medina-Puche L, Lozano-Durán R (2022). The V2 protein from the geminivirus tomato yellow leaf curl virus largely associates to the endoplasmic reticulum and promotes the accumulation of the viral C4 protein in a silencing suppression-independent manner. Viruses, 14:2804.

Wang Z, Wang Y, Lozano-Duran R, Hu T, Zhou X (2022). Identification of a novel C6 protein encoded by tomato leaf curl China virus. Phytopathology Res. 4:46.

Wang L, Tan H, Medina-Puche L, Wu M, Garnelo Gomez B, Gao M, Shi C, Jimenez-Gongora T, Fan P, Ding X, Zhang D, Ding Y, Rosas-Diaz T, Liu Y, Aguilar E, Fu X, Lozano-Durán R (2022). Combinatorial interactions between viral proteins expand the potential functional landscape of the tomato yellow leaf curl proteome. PLoS Pathog. 18;18:e1010909.

Zhao L, Zhou Q, He L, Deng L, Lozano-Duran R, Li G, Zhu JK (2022). DNA methylation underpins the epigenomic landscape regulating genome transcription in Arabidopsis. Genome Biol. 20; 23:197.

Medina-Puche L, Lozano-Durán R (2022). Plasma membrane-to-organelle communication in plant stress signaling. Current Opinion in Plant Biology, 69:102269. doi: 10.1016/j.pbi.2022.102269.

Aguilar E, Lozano-Durán R (2022). On the inhibition of RNA silencing movement by the tombusvirus P19 protein: reliance on sRNA binding and correlation with local silencing suppression. New Phytol, 235:830-835.

Wang L, Lozano-Durán R (2022). Arabidopsis AGO4 loses its Cajal body localization when heterologously expressed in Nicotiana benthamiana. Communicative & Integrative Biology, in press.

Aguilar E, Lozano-Durán R (2022). Plant viruses are probes to engineer tolerance to abiotic stress in crops. Stress Biology, in press.

He L, Huang H, Bradai M, Zhao C, You Y, Ma J, Zhao L, Lozano-Durán R, Zhu J-K (2022). DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development. Nat Comms, in press.

Jiménez-Góngora T, Tan H, Lozano-Durán R (2022). Transient overexpression of E2Fb to induce cell divisions in Nicotiana benthamiana pavement cells. Methods Mol Biol. 2382:115-127.


Bradai M, Amorim-Silva V, Belgaroui N, Esteban Del Valle A, Chabouté ME, Schmit AC, Lozano-Duran R, Botella MA, Hanin M, Ebel C (2021). Wheat type one protein phosphatase participates in the brassinosteroid control of root growth via activation of BES1. Int J Mol Sci. 27;22(19):10424.

Medina-Puche L, Orílio AF, Zerbini FM, Lozano-Durán R (2021). Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein. PLoS Pathog. 7;17(10):e1009915.

Medina-Puche L, Kim C, Lozano-Durán R, Dogra V (2021). Protocol for evaluating protein relocalization from the plasma membrane to chloroplasts. STAR Protoc. 14;2(4):100816. 

Garnelo Gómez B, Holzwart E, Shi C, Lozano-Durán R, Wolf S (2021). Phosphorylation-dependent routing of RLP44 towards brassinosteroid or phytosulfokine signalling. J Cell Sci, 15;134(20):jcs259134

He L, Zhao C, Zhang Q, Zinta G, Wang D, Lozano-Durán R, Zhu JK (2021). Pathway conversion enables a double-lock mechanism to maintain DNA methylation and genome stability. PNAS, 118(35):e2107320118.

Gong P, Tan H, Zhao S, Li H, Liu H, Ma Y, Zhang X, Rong J, Fu X, Lozano-Durán R*, Li F*, Zhou X* (2021). Geminiviruses encode additional small proteins with specific subcellular localizations and virulence function. Nat Commun, 13;12:4278. *Co-corresponding authors.

Wu M, Wei H, Tan H, Pan SJ, Liu Q, Bejarano ER, Lozano-Durán R (2021). Plant DNA polymerases α and δ mediate replication of geminiviruses. Nat Commun, 13;12:2780. doi: 10.1038/s41467-021-23013-2.

Cañibano E, Bourbousse C, Garcia-León M, Gómez BG, Wolff L, Garcia-Baudino C, Lozano-Durán R, Barneche F, Rubio V, Fonseca S (2021). DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis. Mol Plant. 2021 Mar 9:S1674-2052(21)00084-8. doi: 10.1016/j.molp.2021.03.009.

Petre B, Contreras MP, Bozkurt TO, Schattat MH, Sklenar J, Schornack S, Abd-El-Haliem A, Castells-Graells R, Lozano-Duran R, Dagdas YF, Menke FLH, Jones AME, Vossen JH, Robatzek S, Kamoun S, Win J (2021). Host-interactor screens of Phytophthora infestans RXLR proteins reveal vesicle trafficking as a major effector-targeted process. The Plant Cell. 2021 Mar 2:koab069. doi: 10.1093/plcell/koab069.

Fan P, Aguilar E, Bradai M, Xue H, Wang H, Rosas-Diaz T, Tang W, Wolf S, Zhang H, Xu L, Lozano-Durán R (2021). The receptor-like kinases BAM1 and BAM2 are required for root xylem patterning. PNAS. 2021 Mar 23;118(12):e2022547118. doi: 10.1073/pnas.2022547118.

Lozano-Duran R and Dong S (2021). Plant biotic interactions: from fundamental research toward sustainable agriculture. J Integr Plant Biol. 2021 Feb;63(2):275-276. doi: 10.1111/jipb.13072.


Pan Liu, Wen-Feng Nie, Xiansong Xiong, Yuhua Wang, Yuwei Jiang, Pei Huang, Xueqiang Lin, Guochen Qin, Huan Huang, Qingfeng Niu, Jiamu Du, Zhaobo Lang, Rosa Lozano-Duran, and Jian-Kang Zhu (2020). A novel protein complex that regulates active DNA demethylation in Arabidopsis. J Integr Plant Biol. doi: 10.1111/jipb.13045.

Wang L, Ding Y, Li H, Zhang G, Zhu JK, Lozano-Duran R (2020). A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body. eLife, 16;9:e55542.

Garnelo Gomez B, Rosas-Diaz T, Shi C, Fan P, Zhang D, Rufian JS, Lozano-Duran R (2020). The viral silencing suppressor P19 interacts with the receptor-like kinases BAM1 and BAM2 and suppresses the cell-to-cell movement of RNA silencing independently of its ability to bind sRNA. New Phytol, doi: 10.1111/nhp.16981.

Yang R, He L, Huang H, Zhu JK, Lozano-Duran R, Zhang H (2020). RNA-directed DNA methylation has an important developmental function in Arabidopsis that is masked by the chromatin remodeller PICKLE. J Integr Plant Biol, 62(11):1647-1652.

Medina-Puche L, Tan H, Dogra V, Wu M, Rosas-Diaz T, Wang L, Ding X, Zhang D, Fu X, Kim C, Lozano-Duran R (2020). A defence pathway linking plasma membrane and chloroplasts co-opted by pathogens. Cell, 3;182(5):1109-1124.

Lee KP, Liu K, Kim EY, Medina-Puche L, Duan J, Li Y, Dong H, Lv R, Li Z, Lozano-Duran R, Kim CH (2020). PLANT NATRIURETIC PEPTIDE A antagonizes salicylic acid-primed cell death. The Plant Cell, 32(7):2237-2250.

Li J, Yang DL, Huang H, Zhang G, He L, Pang J, Lozano-Duran R, Lang Z, Zhu JK (2020). Epigenetic memory marks determine epiallele stability at loci targeted by de novo DNA methylation. Nature Plants, (6):661-674.

Luna AP*, Lozano-Duran R* (2020). Geminivirus-encoded proteins: not all positional homologues are made equal. Frontiers in Microbiology, 11:878. *Co-corresponding authors.

Aguilar E, Garnelo Gomez B, Lozano-Duran R (2020). Recent advances in the plant manipulation by geminiviruses. Current Opinion in Plant Biology, 56:56-64.

Xue H, Lozano-Duran R*, Macho AP* (2020). Insights into the root invasion by the plant pathogenic bacterium Ralstonia solanacearum. Plants, 16;9(4). *Co-corresponding authors.

Ding Y and Lozano-Duran R (2020). The Cajal body in plant-virus interactions. Viruses, 23;12(2).



Medina-Puche L and Lozano-Duran R (2019). Tailoring the cell: a glimpse of how plant viruses manipulate their hosts. Current Opinion in Plant Biology, Dec;52:164-173.

Garnelo Gomez B, Zhang D, Rosas-Diaz T, Wei Y, Macho AP, Lozano-Duran R (2019). The C4 protein from Tomato yellow leaf curl virus can broadly interact with plant receptor-like kinases. Viruses, Oct 31;11(11). pii: E1009.

Corrales M, Medina-Puche L, Yu Y, Wang L, Ding X, Luna AP, Bejarano ER, Castillo AG, Lozano-Duran R (2019). The C4 protein from the geminivirus Tomato yellow leaf curl virus confers drought tolerance in Arabidopsis through an ABA-independent mechanism. Plant Biotechnology Journal, Oct 21. doi: 10.1111/pbi.13280.

Jimenez-Gongora T, Tan H, Lozano-Duran R (2019). Transient overexpression of E2Fb triggers cell divisions in pavement cells of Nicotiana benthamiana leaves. Plant Cell Reports, Dec;38(12):1465-1471.

Nie WF, Lei M, Zhang M, Tang K, Huang H, Zhang CJ, Miki D, Liu P, Yang Y, Wang X, Zhang H, Lang Z, Liu N, Xu X, Yelagandula R, Zhang H, Wang Z, Chai X, Yu JQ, Berger F, Lozano-Duran R, Zhu JK (2019). Histone Acetylation Recruits the SWR1 Complex to Regulate a Subset of Genomic Loci Targeted by Active DNA Demethylation in Arabidopsis. PNAS, Aug 13;116(33):16641-16650.

Ding X, Jimenez-Gongora T, Krenz B, Lozano-Duran R (2019). Chloroplast clustering around the nucleus is a general response to pathogen perception. Molecular Plant Pathology, Sep;20(9):1298-1306.

Wu M, Ding X, Fu X, Lozano-Duran R (2019). Transcriptional reprogramming caused by the geminivirus Tomato yellow leaf curl virus in local or systemic infections in Nicotiana benthamiana. BMC Genomics, Jul 4;20(1):542.

Macho AP and Lozano-Duran R (2019). Molecular dialogues between viruses and receptor-like kinases in plants. Molecular Plant Pathology, Sep;20(9):1191-1195.


Zhao C, Zayed O, Yu Z, Jiang W, Tang K, Zhu P, Hsu CC, Nie W, Zhang L, Xie S, Tao A, Lozano-Durán R, Zhu JK (2018). Leucine-rich Repeat Extensin Proteins Regulate Plant Salt Tolerance in Arabidopsis. PNAS, Dec 18;115(51):13123-13128.

Mei Y, Yang Q, Wang Y, Lozano-Duran R, Sunter G, Zhou X (2018). Nucleocytoplasmic shuttling of the geminivirus C4 protein mediated by phosphorylation and myristoylation is critical for viral pathogenicity. Mol Plant, 2018 Dec 3;11(12):1466-1481.

Carluccio AV, Prigigallo MI, Rosas-Diaz T, Lozano-Duran R, Stavolone L (2018). S-acylation mediates Mungbean yellow mosaic virus AC4 localization to the plasma membrane and in turn gene silencing suppression. PLoS Pathog. 2018 Aug 1;14(8):e1007207.

Wang Y, Li Y, Rosas-Diaz T, Caceres-Moreno C, Lozano-Duran R, Macho AP. The IMMUNE-ASSOCIATED NUCLEOTIDE BINDING 9 protein is a regulator of basal immunity in Arabidopsis thaliana (2018). Mol Plant Microbe Interact. 2018 Jun 29. doi: 10.1094/MPMI-03-18-0062-R.

Cana-Quijada P, Bejarano ER, Lozano-Duran R, Rosas-Diaz T (2018). Transient Expression Assay in NahG Arabidopsis Plants Using Agrobacterium tumefaciens. Bio-Protocol. 2018, Vol 8, Iss 12, June 20.

Rosas-Diaz T, Zhang D, Fan P, Wang L, Ding X, Jiang Y, Jimenez-Gongora T, Medina-Puche L, Zhao Z, Feng Z, Zhang G, Liu X, Bejarano ER, Tan L, Zhang H, Zhu JK, Xing W, Faulkner C, Nagawa S, Lozano-Duran R (2018). A virus-targeted plant receptor-like kinase promotes cell-to-cell spread of RNAi. PNAS. 2018 Feb 6;115(6):1388-1393. doi: 10.1073/pnas.1715556115.

Wei Y, Caceres-Moreno C, Jimenez-Gongora T, Wang K, Sang Y, Lozano-Duran R, Macho AP (2018). The Ralstonia solanacerasum csp22 peptide, but not flagellin-derived peptides, is perceived by plants from the Solanaceae family. Plant Biotechnology Journal, Jul;16(7):1349-1362.


Wang L, Tan H, Wu M, Jimenez-Gongora T, Tan L, Lozano-Duran R (2017). Dynamic virus-dependent subnuclear localization of the capsid protein from a geminivirus. Front Plant Sci, 2017 Dec 22;8:2165.

Wang L, Ding X, Xiao J, Jimenez-Gongora T, Liu R, Lozano-Duran R (2017). Inference of a geminivirus-host protein-protein interaction network through affinity purification and mass spectrometry analysis. Viruses, Sep 25:9(10).

Luna AP, Rodriguez-Negrete EA, Morilla G, Wang L, Lozano-Duran R, Castillo AG, Bejarano ER (2017). V2 from a curtovirus is a suppressor or post-transcriptional gene silencing. Journal of General Virology, 2017 Oct;98(10):2607-2614.

Rosas-Díaz T, Zhang D, Lozano-Durán R (2017). No evidence of seed transmissibility of Tomato yellow leaf curl virus in Nicotiana benthamiana. J Zhejiang Univ Sci B. 2017 May;18(5):437-440. doi: 10.1631/jzus.B1600463.

Rosas-Díaz T, Cana-Quijada P, Amorim-Silva V, Botella MA, Lozano-Durán R* and Bejarano ER* (2017). Arabidopsis NahG plants as a suitable and efficient system for transient expression using Agrobacterium tumefaciens. Mol Plant. 2017 Feb 13;10(2):353-356. doi: 10.1016/j.molp.2016.11.005. Epub 2016 Nov 17. *Co-corresponding authors.

Lozano-Duran R* and Belkhadir Y* (2017). A technical framework for studying the signaling nexus of brassinosteroids and immunity. Methods for Brassinosteroid Analysis. Methods Mol Biol. 2017;1564:49-61. doi: 10.1007/978-1-4939-6813-8_6. *Co-corresponding authors.


Rosas-Díaz T, Macho AP, Beuzón C, Lozano-Durán R*, Bejarano ER* (2016). The C2 protein from the geminivirus Tomato yellow leaf curl Sardinia virus decreases sensitivity to jasmonates and suppresses jasmonate-mediated defences. Plants. 2016, 5, 8; doi:10.3390. *Co-corresponding authors.

Jiménez-Góngora T, Kim S-K, Lozano-Durán R* and Zipfel C* (2015). Flg22-triggered immunity negatively regulates key BR biosynthetic genes. Front Plant Sci. 2015 Nov 9;6:981. *Co-corresponding authors.


Lozano-Durán R (2015). Geminiviruses for biotechnology: the art of parasite taming. New Phytologist. 2015 Jul 27. doi: 10.1111/nph.13564.

Couto D, Stransfeld L, Arruabarrena A, Zipfel C* and Lozano-Durán R* (2015). Broad application of a simple and affordable protocol for isolating plant RNA. BMC Res Notes. 2015 Apr 16;8:154.*Co-corresponding authors.

Macho AP, Lozano-Durán R, Zipfel C (2015). Importance of tyrosine phosphorylation in receptor kinase complexes. Trends Plant Sci. 2015 May;20(5):269-72.

Lozano-Durán R* and Robatzek S (2015). 14-3-3 proteins in plant-pathogen interactions. Mol Plant Microbe Interact. 2015 May;28(5):511-8.  *Corresponding author.