P1: Heterogeneity of cGMP signaling in the tumor microenvironment

Julia Hoffmeister obtained her bachelor’s degree in biology at the University of Hamburg, where she developed an interest in microbiology and metagenomics. In her bachelor thesis Julia performed functional screenings of gene libraries in the search of novel glycosyltransferases. Julia continued her studies with a consecutive master’s program and completed her master thesis at the Leibniz Institute of Virology. Here, she researched the impact of H3N2 influenza A viruses on the expression of aromatase, which is the enzyme that metabolizes testosterone to estradiol.

After obtaining her M. Sc. degree Julia decided to expand her knowledge on biomedicine by switching to a different field, which is how she came to pursue a PhD at the group of Prof. Dr. Robert Feil.  
Today, she is a member of Project 1 of the GRK 2381 “cGMP: From Bedside to Bench” and her research focuses on the role of cGMP signalling pathways in cancer.

Alisa Groh completed a Bachelor’s degree in biochemistry at the Julius Maximilian University of Würzburg. Here, she developed a strong interest in molecular oncology and for her thesis explored the mutation profile of molecular and clinical subgroups in follicular lymphoma. Continuing her academic journey, Alisa pursued a Master’s degree in Molecular Cell Biology and Immunology at the University of Tübingen. During her studies, Alisa spent a semester abroad at National Taiwan University in Taipei. Here, she was first introduced into the topic of stem cells and regenerative medicine while experiencing a vibrant new culture and academic environment. Because of this, she decided to complete her master thesis working with hiPSC-derived retinal organoids. In October 2024, Alisa joined the Feil Lab to pursue her PhD, focusing on shear stress induced cGMP signaling in tumor vessels. In her free time, Alisa enjoys creative pursuits such as sewing, crafting or music, as well as staying active through sports like dancing and aqua fitness. 

Mariagiovanna obtained her B.Sc. in Biotechnology at the University of Padua, Italy, where she developed a strong interest in cancer research. Her Bachelor’s thesis focused on the validation of a new zebrafish reporter line for STAT3, protein which is involved in uncontrolled tumor proliferation. Then, she continued her studies earned her Master’s degree in Industrial Biotechnology in Padua. She did her Master’s thesis in the Functional Genomics Lab of G. Lanfranchi in the Department of Biology and CRIBI Biotechnology Centre, moving her interest on the study of non-coding RNAs, such as miRNAs, to analyse how their expression, if altered, can determine or influence invasiveness and therefore progression in malignant melanoma. After her M.Sc., Mariagiovanna joined in the laboratory of Robert Feil to do her PhD. Here, her research focusses on the role of cGMP signalling in cancer.

Jennifer Schulz obtained her B.Sc. in biology at the Justus-Liebig-University of Gießen with an emphasis in immunology, micro- and molecular biology. In her master´s studies at the Justus-Liebig-University in Gießen, she focused on biomedicine. Due to her strong interest in pharmacology and signaling pathways, she completed her master´s thesis at the Rudolf-Buchheim-Institute of pharmacology in Gießen. Her thesis was about the function of the nuclear cap-binding complex in epithelial cells and its association to the IL-1 signaling pathway as well as diseases. An internship at the ICM at the Uppsala University encouraged her to strive towards a scientific career. After completing her M.Sc., Jennifer took the opportunity as a doctoral student of the GRK2381 “cGMP: From Bedside to Bench” in the group of Robert Feil to follow her keen interest in the investigation of molecular mechanisms and their association to diseases. Her project focuses on the visualization and investigation of the role of cGMP in cancer.

Krithika obtained her B.Sc. in biotechnology from SRM University, India, with a focus on molecular biology. After completing her bachelor’s, she earned a master's degree in Biochemistry from Ruhr Universität Bochum. She did her master thesis at the Institute of Molecular Oncology and Experimental Therapeutics at Marien Hospital Herne. Her master thesis focused on investigating the mechanism of epithelial mesenchymal transition in ovarian cancer. After M.Sc., Krithika joined the group of Prof. Robert Feil. Here, her PhD thesis focuses on investigating the role of cGMP signalling in non-alcoholic steatohepatitis (NASH) and liver fibrosis.

Daniel studied Biochemistry in Tübingen. His interests guided him towards the fields of oncology and immune response. Consequently, he finished his Bachelor in the department of immunology. In his Master studies, Daniel deepened his experience in cell biology. This is also reflected in the topic of his Master’s thesis, where he analyzed functional aspects of apoptosis induction. After earning his M.Sc., Daniel did his PhD in the Feil laboratory. His research focusses on the role of cGMP in melanoma, with a focus on the tumor microenvironment. Daniel graduated in summer 2022 with "summa cum laude" and subsequently received start-up funding to support his further career as a potdoc at the IFIB (see also here).