Uni-Tübingen

2024

Roslan A, Paulus K, Yang J, et al., Cardiovasc Res. 2024

Roslan A, Paulus K, Yang J, Matt L, Bischof H, Längst N, Schanz S, Luczak A, Cruz Santos M, Burgstaller S, Skrabak D, Bork NI, Malli R, Schmidtko A, Gawaz M, Nikolaev VO, Ruth P, Ehinger R, Lukowski R. Slack K+ channels confer protection against myocardial ischemia/reperfusion injury. Cardiovasc Res. 2024 Aug 5:cvae155. doi: 10.1093/cvr/cvae155. Online ahead of print. PMID: 39102831 [pubmed][project 2][project 5][project 6]

Sigle M, Rohlfing AK, Cruz Santos M et al., Circ Res. 2024

Sigle M, Rohlfing AK, Cruz Santos M, Kopp T, Krutzke K, Gidlund V, Kollotzek F, Marzi J, von Ungern-Sternberg S, Poso A, Heikenwälder M, Schenke-Layland K, Seizer P, Möllmann J, Marx N, Feil R, Feil S, Lukowski R, Borst O, Schäffer TE, Müller KAL, Gawaz MP, Heinzmann D. Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts., Circ Res. 2024;135:758-773. doi: 10.1161/CIRCRESAHA.124.324812. [pubmed][Project 1][Project 2][Project 3][Project 4][Project 5]

Yokomizo S, Kopp T, Roessing M et al., Stroke. 2024

Yokomizo S, Kopp T, Roessing M, Morita A, Lee S, Cho S, Ogawa E, Komai E, Inoue K, Fukushi M, Feil S, Kim H, Bragin DE, Gerashchenko D, Huang PL, Kashiwagi S, Atochin DN. Near-infrared II photobiomodulation preconditioning ameliorates stroke injury via phosphorylation of eNOS., Stroke. 2024;55:1641-1649. doi: 10.1161/STROKEAHA.123.045358.   [pubmed] [Project 4]

Balmes A, Rodriguez JG et al., Platelets. 2024

Balmes A, Rodriguez JG, Seifert J, Pinto-Quintero D, Khawaja AA, Boffito M, Frye M, Friebe A, Emerson M, Seta F, Feil R, Feil S, Schäffer TE. Role of the NO-GC/cGMP signaling pathway in platelet biomechanics. Platelets. 2024;35:2313359. doi: 10.1080/09537104.2024.2313359. [pubmed] [Project 1] [Project 3] [Project 4] [Project 5]

Marchetta P et al., Faseb J. 2024

Marchetta P, Dapper K, Hess M, Calis D, Singer W, Wertz J, Fink S, Hage S, Alam M, Schwabe K, Lukowski R, Bourin J, Puel JL, Jacob M, Munk M, Land R, Rüttiger L, Knipper M. Dysfunction of specific auditory fibers impact cortical oscillations, driving an autism phenotype despite near-normal hearing. Faseb J. 2024;38:e23411. doi: 10.1096/fj.202301995R. [pubmed] [Project 2] [Project 9]

Seizer P et al., Cardiovasc Res. 2024

Seizer P, von Ungern-Sternberg SNI, Haug V, Dicenta V, Rosa A, Butt E, Nöthel M, Rohlfing A-K, Sigle M, Nawroth PP, Nussbaum C, Sperandio M, Kusch C, Meub M, Sauer M, Münzer P, Bieber K, Stanger A, Mack AF, Huber R, Brand K, Lehners M, Feil R, Poso A, Krutzke K, Schäffer TE, Nieswandt B, Borst O, May AE, Zernecke A, Gawaz M, Heinzmann D. Cyclophilin A is a ligand for RAGE in thrombo-inflammation. Cardiovasc Res. 2024;120:385-402. doi: 10.1093/cvr/cvad189. [pubmed] [Project 1] [Project 3] [Project 4] [Project 5]

2023

Rohlfing AK et al., Thromb Res. 2023

Rohlfing AK, Kremser M, Schaale D, Dicenta-Baunach V, Laspa Z, Fu X, Zizmare L, Sigle M, Harm T, Münzer P, Pelzer A, Borst O, Trautwein C, Feil R, Müller K, Castor T, Lämmerhofer M, Gawaz MP. cGMP modulates hemin-mediated platelet death. Thromb Res. 2023;234:63-74. doi: 10.1016/j.thromres.2023.12.008. [pubmed] [Project 1] [Project 5]

Pham T et al., Cell Mol Life Sci. 2023

Pham T, Hussein T, Calis D, Bischof H, Skrabak D, Cruz Santos M, Maier S, Spähn D, Kalina D, Simonsig S, Ehinger R, Groschup B, Knipper M, Plesnila N, Ruth P, Lukowski R, Matt L. BK channels sustain neuronal Ca2+ oscillations to support hippocampal long-term potentiation and memory formation. Cell Mol Life Sci. 2023;80:369. doi: 10.1007/s00018-023-05016-y. [pubmed] [Project 2] [Project 6] [Project 9]

Schütte JP et al., Circ Res. 2023

Schütte JP, Manke MC, Hemmen K, Münzer P, Schörg BF, Ramos GC, Pogoda M, Dicenta V, Hoffmann SHL, Pinnecker J, Kollotzek F, Zdanyte M, Mueller KAL, Singh Y, Mack AF, Pichler B, Lang F, Nieswandt B, Gawaz M, Heinze KG, Casadei N, Borst O. Platelet-derived microRNAs regulate cardiac remodeling after myocardial ischemia. Circ Res. 2023;132:e96-e113. doi: 10.1161/CIRCRESAHA.122.322459. [pubmed] [Project 5]

Skrabak D et al., Commun Biol. 2023

Skrabak D, Bischof H, Pham T, Ruth P, Ehinger R, Matt L, Lukowski R. Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing. Commun Biol. 2023;6:1029. doi: 10.1038/s42003-023-05387-9. [pubmed] [Project 2] [Project 6]

Fink A et al., Thromb Haemost. 2023

Fink A, Rohlfing AK, Dicenta V, Schaale D, Kremser M, Laspa Z, Sigle M, Fu X, Pelzer A, Fischer M, Münzer P, Castor T, Müller KAL, Borst O, Lämmerhofer M, Gawaz MP. The subtilisin-like protease furin regulates hemin-dependent ectodomain shedding of glycoprotein VI. Thromb Haemost. 2023;123:679-691. doi: 10.1055/s-0043-1768057. [pubmed] [Project 5]

Qiu Y et al., PLoS Comput Biol. 2023

Qiu Y, Klindt DA, Szatko KP, Gonschorek D, Hoefling L, Schubert T, Busse L, Bethge M, Euler T. Efficient coding of natural scenes improves neural system identification. PLoS Comput Biol. 2023;19:e1011037. [pubmed] [Project 8]

Calis D et al., Front Mol Neurosci. 2023

Calis D, Hess M, Marchetta P, Singer W, Modro J, Nelissen E, Prickaerts J, Sandner P, Lukowski R, Ruth P, Knipper M, Rüttiger L.  Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling. Front Mol Neurosci. 2023;16:1017761. [pubmed] [Project 2] [Project 6] [Project 9]

Stehle D et al., Pharmacol Ther. 2023

Stehle D, Barresi M, Schulz J, Feil R. Heterogeneity of cGMP signalling in tumour cells and the tumour microenvironment: Challenges and chances for cancer pharmacology and therapeutics. Pharmacol Ther. 2023;242:108337. [pubmed] [Project 1]

2022

Bayrak A et al., J Med Chem. 2022

Bayrak A, Mohr F, Kolb K, Szpakowska M, Shevchenko E, Dicenta E, Rohlfing AK, Kudolo M, Pantsar T, Günther M, Kaczor AA, Poso A, Chevigné A, Pillaiyar T, Gawaz M, Laufer SA. Discovery and development of first-in-class ACKR3/CXCR7 superagonists for platelet degranulation modulation. J Med Chem. 2022;65:13365-13384. [pubmed] [Project 5]

Katagiri W et al., Faseb J. 2022

Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S. Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy. FASEB J. 2022;36:e22521. [pubmed] [Project 1] [Project 4]

Yokomizo S et al., Faseb J. 2022

Yokomizo S, Roessing M, Morita A, Kopp T, Ogawa E, Katagiri W, Feil S, Huang PL, Atochin DN, Kashiwagi S. Near-infrared II photobiomodulation augments nitric oxide bioavailability via phosphorylation of endothelial nitric oxide synthase. FASEB J. 2022;36:e22490. [pubmed] [Project 4]

Savitska D et al., Front Neurosci. 2022

Savitska D, Hess M, Calis D, Marchetta P, Harasztosi C, Fink S, Eckert P, Ruth P, Rüttiger L, Knipper M, Singer W. Stress affects central compensation of neural responses to cochlear synaptopathy in a cGMP-dependent way. Front Neurosci. 2022;16:864706. [pubmed] [Project 6] [Project 9]

Seifert J et al., Nanoscale. 2022

Seifert J, Rheinlaender J, von Eysmondt H, Schäffer TE. Mechanics of migrating platelets investigated with scanning ion conductance microscopy. Nanoscale. 2022;14:8192-8199. [pubmed] [Project 3]

Zhang Y et al., Open Biol. 2022

Zhang Y, Benz P, Stehle D, Yang S, Kurz H, Feil S, Nagel G, Feil R, Gao S, Bender M. Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes. Open Biol. 2022;12:220058. [pubmed] [Project 1] [Project 4]

Baumann J et al., Sci Adv. 2022

Baumann J, Sachs L, Otto O, Schoen I, Nestler P, Zaninetti C, Kenny M, Kranz R, von Eysmondt H, Rodriguez J, Schäffer TE, Nagy Z, Greinacher A, Palankar R, Bender M. Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease. Sci Adv. 2022;8:eabn2627. [pubmed] [Project 3]

Marchetta P et al., iScience. 2022

Marchetta P, Eckert P, Lukowski R, Ruth P, Singer W, Rüttiger L, Knipper M. Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea. iScience. 2022;25:103981. [pubmed] [Project 2] [Project 6] [Project 9]

Nestele J A et al., Int J Mol Sci. 2022

Nestele J A, Rohlfing AK, Dicenta V, Bild A, Eißler D, Emschermann F, Kremser M, Krutzke K, Schäffer TE, Borst O, Levi M, Korin N, Gawaz MP. Characterization of GPVI- or GPVI-CD39-coated nanoparticles and their impact on in vitro thrombus formation. Int J Mol Sci. 2022;23:11. [pubmed] [Project 3] [Project 5]

Rohlfing AK et al., Nat Commun. 2022

Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke M-C, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Caglar Beker M, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer H F, Rath D, Gawaz MP. ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nat Commun. 2022;13:1823. [pubmed] [Project 3] [Project 5]

Lukowski R et al., Br J Pharmacol. 2022

Lukowski R, Cruz Santos M, Kuret A, Ruth P. cGMP and mitochondrial K+ channels-compartmentalized but closely connected in cardioprotection. Br J Pharmacol. 2022;179:2344-2360. [pubmed] [Project 2] [Project 6]

Schmidt H et al., Br J Pharmacol. 2022

Schmidt H, Böttcher A, Gross A, Schmidtko A. cGMP signalling in dorsal root ganglia and the spinal cord: various functions in development and adulthood. Br J Pharmacol. 2022;179:2361-2377. [pubmed] [Project 7]

Marchetta P et al., Br J Pharmacol. 2022

Marchetta P, Rüttiger L, Hobbs AJ, Singer W, Knipper M. The role of cGMP signalling in auditory processing in health and disease. Br J Pharmacol. 2022;179:2378-2393. [Project 9]

Feil R et al., Br J Pharmacol. 2022

Feil R, Lehners M, Stehle D, Feil S. Visualising and understanding cGMP signals in the cardiovascular system. Br J Pharmacol. 2022;179:2394-2412. [pubmed] [Project 1] [Project 4]

2021

Bork NI et al., Redox Biol. 202, 2021

Bork NI, Kuret A, Cruz Santos M, Molina CE, Reiter B, Reichenspurner H, Friebe A, Skryabin BV, Rozhdestvensky TS, Kuhn M, Lukowski R, Nikolaev VO. Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia. Redox Biol. 202;48:102179. [pubmed] [Project 2]

Gonschorek D et al., NeurIPS 2021

Gonschorek D, Höfling L, Szatko KP, Franke K, Schubert T, DunnB A, Berens P, Klindt DA, Euler T. Removing inter-experimental variability from functional data in systems neuroscience. Thirty-Fifth Conference on Neural Information Processing Systems (NeurIPS 2021). doi:10.1101/2021.10.29.466492. [Project 8]

Matt L at al., Cell Mol Life Sci. 2021

Matt L, Pham T, Skrabak D, Hoffmann F, Eckert P, Yin J, Gisevius M, Ehinger R, Bausch A, Ueffing M, Boldt K, Ruth P, Lukowski R. The Na+-activated K+ channel Slack contributes to synaptic development and plasticity. Cell Mol Life Sci. 2021;78:7569-7587. [pubmed] [Project 2] [Project 6]

Petersen-Uribe A et al., Int J Mol Sci. 2021

Petersen-Uribe A, Kremser M, Rohlfing AK , Castor T, Kolb K, Dicenta V, Emschermann F, Li B, Borst O, Rath D, Müller K, Gawaz MP. Platelet-derived PCSK9 is associated with LDL metabolism and modulates atherothrombotic mechanisms in coronary artery disease. Int J Mol Sci. 2021;22:11179. [pubmed] [Project 5]

Längst N et al., Int J Mol Sci. 2021

Längst N, Adler J, Schweigert O, Kleusberg F, Cruz Santos M, Knauer A, Sausbier M, Zeller T, Ruth P, Lukowski R. Cyclic GMP-dependent regulation of vascular tone and blood pressure involves cysteine-rich LIM-Only protein 4 (CRP4). Int J Mol Sci. 2021; 22:9925. [pubmed] [Project 2] [Project 6]

Stehle D et al., Br J Pharmacol. 2021

Stehle D, Xu MZ, Schomber T, Hahn MG, Schweda F, Feil S, Kraehling JR, Eitner F, Patzak A, Sandner P, Feil R, Benardeau A. Novel sGC activators increase glomerular cGMP, induce vasodilation, and improve blood flow in the murine kidney. Br J Pharmacol. 2021;179;2476-2489. [pubmed]  [Project 1] [Project 4]

Eckert P et al., Front Mol Neurosci. 2021

Eckert P, Marchetta P, Manthey MK, Walter MH, Jovanovic S, Savitska D, Singer W, Jacob MH, Rüttiger L, Schimmang T, Milenkovic I, Pilz PKD, Knipper M. Deletion of BDNF in Pax2+ lineage-derived interneuron precursors in the hindbrain hampers maturation of excitation/inhibition balance, learning and behavior. Front Mol Neurosci. 2021;14:642679. [pubmed] [Project 9]

Tikoo S et al., J Invest Dermatol. 2021

Tikoo S, Jain R, Tomasetig F, On K, Martinez B, Heu C, Stehle D, Obeidy P, Guo D, Vincent JN, Cook AJL, Roediger B, Feil R, Whan RM, Weninger W. Amelanotic B16-F10 melanoma compatible with advanced 3-D imaging modalities. J Invest Dermatol. 2021; 141:2090-2094.e6. [pubmed] [Project 1]

Krämer MS et al., Methods Mol Biol. 2021

Krämer MS, Feil R, Schmidt H. Analysis of gene expression using lacZ reporter mouse lines. Methods Mol Biol. 2021;2224:29-45.  [pubmed] [Project 1] [Project 7]

2020

Marchetta P et al., Brain Sci. 2020

Marchetta P, Savitska D, Kübler A, Asola G, Manthey M, Möhrle D, Schimmang T, Rüttiger L, Knipper M, Singer W. Age-dependent auditory processing deficits after cochlear synaptopathy depend on auditory nerve latency and the ability of the brain to recruit LTP/BDNF. Brain Sci. 2020;10:710. [pubmed] [Project 9]

Marchetta P et al., Front Aging Neurosci. 2020

Marchetta P, Möhrle D, Eckert P, Reimann K, Wolter S, Tolone A, Lang I, Wolters M, Feil R, Engel J, Paquet-Durand F, Kuhn M, Knipper M, Rüttiger L. Guanylyl cyclase A/cGMP signaling slows hidden, age- and acoustic trauma-induced hearing loss. Front Aging Neurosci. 2020;12:83 [pubmed] [Project 1] [Project 9]