Interfakultäres Institut für Biochemie
Universität Tübingen
Hoppe-Seyler-Str. 4
72706 Tübingen
Phone: 07071-29 74184
E-mail: doron.rapaportspam prevention@uni-tuebingen.de
Postdoc:
Dr. Janani Nataranjan Tel: -74168; jaannatz@gmail.com
Summary
BamA in bacteria and Tob55 in mitochondria are the central components in complexes that mediate assembly of β-barrel proteins. Both proteins contain POTRA domains with an unclear function. To better understand the role of these domains we will construct hybrid Tob55/BamA proteins with differently configured POTRA domains and will examine the activity of such hybrid proteins in both mitochondria and bacteria. In the second part of the project we will compare the assembly of β-barrel proteins to that of secretins. Using yeast as a model system we will dissect the stages in the assembly process of secretins and investigate the requirement for periplasmic assembly factors.
Zusammenfassung
Die zentralen Komponenten in den Komplexen, die die Assemblierung von β-barrel Proteinen bewerk-stelligen sind BamA in Bakterien und Tob55 in Mitochondrien. Beide Proteine enthalten POTRA Domänen unbekannter Funktion. Um die Rolle dieser Domänen besser zu verstehen, werden wir Hybridproteine aus Tob55 und BamA mit unterschiedlich zusammengesetzten POTRA Domänen herstellen und die Aktivität dieser Hybridproteine sowohl in Mitochondrien als auch in Bakterien untersuchen. Im zweiten Teil des Projektes werden wir die Assemblierung von β-barrel Proteinen mit der von Sekreti-nen vergleichen. Mit Hilfe von Hefe als Modellsystem werden wir die Schritte des Assemblierungsmechanismus der Sekretine analysieren und die Rolle von periplasmatischen Assemblierungsfaktoren in diesem Prozess untersuchen.
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