Identification of transformation products

Transformation products (TP) are an emerging issue for risk assessment of chemicals in the environment. We are developing approaches and analytical methods to identify TPs by LC-HRMS and generate TPs with electrochemical oxidation, direct and indirect photodegradation with simulated sunlight and biodegradation with activated sludge and aquatic biofilms. 

• Lege, S., Eisenhofer, A., Heras, J.E.Y. and Zwiener, C. (2019) Identification of transformation products of denatonium – Occurrence in wastewater treatment plants and surface waters. Science of the Total Environment 686, 140-150.   https://doi.org/10.1016/j.scitotenv.2019.05.423

• Timm, A., Borowska, E., Majewsky, M., Merel, S., Zwiener, C., Bräse, S. and Horn, H. (2019) Photolysis of four β‑lactam antibiotics under simulated environmental conditions: Degradation, transformation products and antibacterial activity. Science of the Total Environment 651, 1605-1612.   doi.org/10.1016/j.scitotenv.2018.09.248
• Tisler, S., Zindler, F., Freeling, F., Nödler, K., Toelgyesi, L., Braunbeck, T. and Zwiener, C. (2019) Transformation Products of Fluoxetine Formed by Photodegradation in Water and Biodegradation in Zebrafish Embryos (Danio rerio). Environmental Science & Technology 53, 7400-7409.   10.1021/acs.est.9b00789

• Tisler, S. and Zwiener, C. (2018) Formation and occurrence of transformation products of metformin in wastewater and surface water. Science of the Total Environment 628–629, 1121-1129.   doi.org/10.1016/j.scitotenv.2018.02.105
• Merel, S., Lege, S., Yanez Heras, J.E. and Zwiener, C. (2017) Assessment of N-oxide Formation during Wastewater Ozonation. Environmental Science & Technology 51(1), 410-417.   10.1021/acs.est.6b02373