As any living structure, neurons require energy to process and transmit electrochemical signals. We investigate how interactions between energy availability and neuronal dynamics influences excitability and the associated neuronal response. As energetics is especially critical in neuronal disorders, we analyze the role of metabolic failure in epileptiform activity and Parkinson disease.
- Tanguy Fardet
- Manos Giannakakis
- Tanguy Fardet, and Anna Levina. "Energy-based models to describe complex neuronal activities and metabolic constraints." BioRxiv (2020). Link: https://www.biorxiv.org/content/10.1101/2020.02.19.955898v1.abstract
- Felix Effenberger, Juergen Jost, Anna Levina (2015). Self-organization in Balanced State Networks by STDP and Homeostatic Plasticity. PLoS Computational Biology, 11(9), 1–30. https://doi.org/10.1371/journal.pcbi.1004420