Weigel, Detlef, Prof. Dr. Dr. h. c.
Max-Planck-Institut für Entwicklungsbiologie
Abt. Molekularbiologie
Spemannstraße 35
72076 Tübingen
+49 7071 601 1411
weigelspam prevention@tue.mpg.de
Einige RPW8/HR-Proteine sind an der Immunantwort beteiligt, aber sie variieren erheblich in ihrer Struktur und Sequenz und es ist unklar, ob sie trotzdem auf gleiche Weise wirken. Zu diesem Zweck wird die allelische Diversität der RPW8/HR-Familie in Arabidopsis thaliana erforscht, und die wichtigsten Varianten werden auf ihre Fähigkeiten getestet, zelluläre, molekulare und organismische Phänotypen zu verändern. Diese Beobachtungen werden mit Diversität in der Proteinstruktur und -anordnung in Membranen sowie unterschiedlichen Netzwerken von Signalkomponenten und Interaktoren verknüpft, über die RPW8/HR-Proteine ihre Wirkungen ausüben.
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