Prof. Dr. Thorsten Nürnberger
Universität Tübingen
ZMBP, Pflanzenbiochemie
Auf der Morgenstelle 32
72076 Tübingen
+49 7071 - 29 76658
Fax +49 7071 - 29 5226
nuernbergerspam prevention@zmbp.uni-tuebingen.de
Pflanzen nutzen Leuzinreiche Wiederholungen tragende Rezeptorkinasen (LRR-RK) und Rezeptor-proteine (LRR-RP) zur Immunaktivierung. Rezeptor-assoziierte zytoplasmatische Rezeptor-ähnliche Kinasen, EDS1-PAD4 Heterodimere und Helfer-NLR-Proteine des ADR1-Typs bilden eine Signal-transduktionsplattform, die essentiell für LRR-RP-vermittelte Immunaktivierung, aber nur partiell wichtig für LRR-RK-vermittelte Abwehr ist. In diesem Projekt bearbeiten wir die molekularen Grund-lagen der PBL31-induzierten Immunabwehr durch LRR-RP-Rezeptoren und eine Superkomplex-bildung von LRR-RP-Rezeptoren und EDS1-PAD4-ADR1-Proteinen an der inneren Plasmamembran.
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