antiSMASH

The antibiotics and secondary metabolites analysis shell antiSMASH is a comprehensive Genome Mining and Cluster annotation framework.

antiSMASH can be used interactively on antismash.secondarymetabolites.org or installed locally on a variety of platforms. Downloads are available at antismash.secondarymetabolites.org/download.html

If you use antiSMASH, please cite:

• Blin, K., Medema, M.H., Kazempour, D., Fischbach, M., Breitling, R., Takano, E., and Weber, T. 2013. antiSMASH 2.0 – a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. Webserver Issue, doi: 10.1093/nar/gkt1449 [Pubmed] [Full Text @NAR]
• Medema, M.H., Blin K., Cimermancic P., de Jager V., Zakrzewski P., Fischbach M.A., Weber T., Takano E., Breitling R. 2011. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucl Acids Res. 39, W339-W346, doi: 10.1093/nar/gkr466. [Pubmed]

CLUSEAN

CLUSEAN is a framework of perl programs to annotate and analyze secondary metabolite biosynthesis gene clusters. CLUSEAN includes automated blast and HMMer analyses against standard databases and specialized tools to predict domain organizations and substrate specificities of megaenzymes involved in secondary metabolite biosynthesis. Included in CLUSEAN also is a command-line version of our NRPSPredictor.

If you use CLUSEAN, please cite:

• Weber, T., Rausch, C., Lopez, P., Hoof, I., Gaykova, V., Huson, D.H., and Wohlleben, W. 2009. CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters. J. Biotechnol. 140:13-17.[Medline] [Full text article]

CLUSEAN is an Open Source annotation framwork.

• The current development version is available on Bitbucket