Interfakultäres Institut für Mikrobiologie und Infektionsmedizin

2019

Bitschar K, Sauer B, Focken J, Dehmer H, Moos S, Konnerth M, Schilling NA, Grond S, Kalbacher H, Kurschus FC, Götz F, Krismer B, Peschel A, Schittek B (2019) Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun 10(1):2730

van Dalen R, De La Cruz Diaz JS, Rumpret M, Fuchsberger FF, van Teijlingen NH, Hanske J, Rademacher C, Geijtenbeek TBH, van Strijp JAG, Weidenmaier C, Peschel A, Kaplan DH, van Sorge NM (2019) Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses. MBio 10(3). pii: e00330-19

Ernst CM, Peschel A (2019) MprF-mediated daptomycin resistance. Int J Med Microbiol 309(5):359-363

Gerlach D, Guo Y, Stehle T, Peschel A (2019) Reply to: Do not discard Staphylococcus aureus WTA as a vaccine antigen. Nature 572(7767):E3-E4

Jochim A, Shi T, Belikova D, Schwarz S, Peschel A, Heilbronner S (2019) Methionine Limitation Impairs Pathogen Expansion and Biofilm Formation Capacity. Appl Environ Microbiol 85(9). pii: e00177-19

Kim B, Jiang T, Bae JH, Yun HS, Jang SH, Kim JH, Kim JD, Hur JH, Shibata K, Kurokawa K, Jung Y, Peschel A, Bae T, Lee BL (2019) In Staphylococcus aureus, the particulate state of cell envelope is required for the efficient induction of host defense responses. Infect Immun pii IAI.00674-19 [Epub ahead of print]

Laux C, Peschel A, Krismer B (2019) Staphylococcus aureus Colonization of the Human Nose and Interaction with Other Microbiome Members. Microbiol Spectr 7(2)

Mnich ME, van Dalen R, Gerlach D, Hendriks A, Xia G, Peschel A, van Strijp JAG, van Sorge NM (2019) The C-type lectin receptor MGL senses N-acetylgalactosamine on the unique Staphylococcus aureus ST395 wall teichoic acid. Cell Microbiol 21(10):e13072

Schilling NA, Berscheid A, Schumacher J, Saur JS, Konnerth MC, Wirtz SN, Beltrán-Beleña JM, Zipperer A, Krismer B, Peschel A, Kalbacher H, Brötz-Oesterhelt H, Steinem C, Grond S (2019) Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability. Angew Chem Int Ed Engl 58(27):9234-9238

Weiß E, Schlatterer K, Beck C, Peschel A, Kretschmer D (2019) Formyl-peptide receptor activation enhances phagocytosis of community-acquired methicillin-resistant Staphylococcus aureus. J Infect Dis pii: jiz498 [Epub ahead of print]

2018

Jorge AM, Schneider J, Unsleber S, Xia G, Mayer, Peschel A (2018) Staphylococcus aureus counters phosphate limitation by scavenging wall teichoic acids from other staphylococci via the teichoicase. GlpQ J. Biol. Chem. jbc. RA118.004584

Gerlach D, Guo Y, De Castro C, Kim SH, Schlatterer K, Xu FF, Pereira C, Seeberger PH, Ali S, Codée J, Sirisarn W, Schulte B, Wolz C, Larsen J, Molinaro A, Lee BL, Xia G, Stehle T, Peschel A (2018)  Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature. 2018 Nov 21

Lee AS, de Lencastre H, Garau J, Kluytmans J, Malhotra-Kumar S, Peschel A, Harbarth S (2018) Methicillin-resistant Staphylococcus aureus. Nat Rev Dis Primers. 4:18033

Schlatterer K, Beck C, Hanzelmann D, Lebtig M, Fehrenbacher B, Schaller M, Ebner P, Nega M, Otto M, Kretschmer D, Peschel A (2018) The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus. MBio. 9(6)

Stoll H, Ost M, Singh A, Mehling R, Neri D, Schäfer I, Velic A, Macek B, Kretschmer D, Weidenmaier C, Hector A, Handgretinger R, Götz F, Peschel A, Hartl D, Rieber N (2018) Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells. Front Cell Infect Microbiol. 13;8:321

Weiss E, Kretschmer D (2018) Formyl-Peptide Receptors in Infection, Inflammation, and Cancer. Trends Immunol. 39(10):815-829

 

2017

Bleiziffer I, Eikmeier J, Pohlentz G, McAulay K, Xia G, Hussain M, Peschel A, Foster S, Peters G, Heilmann C (2017) The plasmin-sensitive protein Pls in methicillin-resistant Staphylococcus aureus (MRSA) is a glycoprotein. PLoS Pathog 13(1):e1006110

Bloes DA, Haasbach E, Hartmayer C, Kretschmer D, Planz O, Peschel A (2017) Phenol-soluble modulin peptides contribute to influenza-associated Staphylococcus aureus pneumonia. Infect Immun. In press

Burian M, Bitschar K, Dylus B, Peschel A, Schittek B (2017) The protective effect of microbiota on S. aureus skin colonization depends on the integrity of the epithelial barrier. J Invest Dermatol. 137(4):976-979

Deibert J, Kühner D, Stahl M, Koeksoy E, Bertsche U (2016) The Peptidoglycan Pattern of Staphylococcus carnosus TM300-Detailed Analysis and Variations Due to Genetic and Metabolic Influences. Antibiotics 5:33

Dhom J*, Bloes DA*, Peschel A, Hofmann UK (2017) Bacterial adhesion to suture material in a contaminated wound model: Comparison of monofilament, braided, and barbed sutures. J. Orthop. Res. 35: 925–933 *, shared first authorship

Jorge AM, Schneider J, Unsleber S, Göhring N, Mayer C, Peschel A. (2017). Utilization of glycerophosphodiesters by Staphylococcus aureus. Mol Microbiol. 103(2):229-241

Krismer B, Weidenmaier C, Zipperer A, Peschel A (2017) The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota. Nat Rev Microbiol. 15(11):675-687

Larsen J, Andersen PS, Winstel V, Peschel A (2017) Staphylococcus aureus CC395 harbours a novel composite staphylococcal cassette chromosome mec element. J Antimicrob Chemother. 72(4):1002–1005

Slavetinsky C, Kuhn S, Peschel A (2017). Bacterial aminoacyl phospholipids - biosynthesis and role in basic cellular processes and pathogenicity. Biochim Biophys Acta. In press

Taconnelli E, Autenrieth IB, Peschel A (2017) Fighting the enemy within. Science 355(6326):689-690

Vestergaard M, Nøhr-Meldgaard K, Bojer MS, Krogsgård Nielsen C, Meyer RL, Slavetinsky C, Peschel A, Ingmer H (2017) Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins. mBio 8:e01114-17

Weiss E, Hanzelmann D, Fehlhaber B, Klos A, von Loewenich FD, Liese J, Peschel A, Kretschmer D (2017) Formyl-peptide receptor 2 governs leukocyte influx in local Staphylococcus aureus infections. Faseb J In Press

2016

Armbruster NS, Richardson JR, Schreiner J, Klenk J, Günter M, Kretschmer D, Pöschel S, Schenke-Layland K, Kalbacher H, Clark K, Autenrieth SE (2016). PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming. J Immunol. 196:1284-9

Blättner S, Das S, Paprotka K, Eilers U, Krischke M, Kretschmer D, Remmele CW, Dittrich M, Müller T, Schuelein-Voelk C, Hertlein T, Mueller MJ, Huettel B, Reinhardt R, Ohlsen K, Rudel T, Fraunholz MJ (2016). Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes. PLoS Pathog 12:e1005857

Hanzelmann D, Joo HS, Franz-Wachtel M, Hertlein T, Stevanovic S, Macek B, Wolz C, Götz F, Otto M, Kretschmer D, Peschel A (2016). Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants. Nat Commun 7:12304

Heilbronner S, Monk IR, Brozyna JR, Heinrichs DE, Skaar EP, Peschel A, Foster TJ (2016). Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation. PLoS Genet. 12:e1006246

Idelevich EA, Schaumburg F, Knaack D, Scherzinger AS, Mutter W, Peters G, Peschel A, Becker K (2016). The Recombinant Bacteriophage Endolysin HY-133 Exhibits In Vitro Activity against Different African Clonal Lineages of the Staphylococcus aureus Complex, Including Staphylococcus schweitzeri. Antimicrob Agents Chemother 60:2551-3

Janek D, Zipperer A, Kulik A, Krismer B, Peschel A (2016). High Frequency and Diversity of Antimicrobial Activities Produced by Nasal Staphylococcus Strains against Bacterial Competitors. PLoS Pathog. 12:e1005812

Koç C, Xia G, Kühner P, Spinelli S, Roussel A, Cambillau C, Stehle T (2016) Structure of the host-recognition device of Staphylococcus aureus phage ϕ11. Sci Rep. 6:27581

Kretschmer D, Hanzelmann D, Peschel A (2016). Lipoprotein immunoproteomics question the potential of Staphylococcus aureus TLR2 agonists as vaccine antigens. Proteomics. 16:2603-2604

Li X, Koç C, Kühner P, Stierhof YD, Krismer B, Enright MC, Penadés JR, Wolz C, Stehle T, Cambillau C, Peschel A, Xia G (2016). An essential role for the baseplate protein Gp45 in phage adsorption to Staphylococcus aureus. Sci Rep 6:26455

Liesenborghs L, Peetermans M, Claes J, Veloso TR, Vandenbriele C, Criel M, Lox M, Peetermans WE, Heilbronner S, de Groot PG, Vanassche T, Hoylaerts MF, Verhamme P (2016). Shear-Resistant Binding to von Willebrand Factor Allows Staphylococcus lugdunensis to Adhere to the Cardiac Valves and Initiate Endocarditis. J Infect Dis. 213:1148-56

Nguyen MT, Hanzelmann D, Härtner T, Peschel A, Götz F (2016). Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response. Infect Immun. 84:205-15.

Ost M, Singh A, Peschel A, Mehling R, Rieber N, Hartl D (2016). Myeloid-Derived Suppressor Cells in Bacterial Infections. Front Cell Infect Microbiol. 6:37

Peschel A (2016) Intelligente Kriegsführung bei Staphylococcus aureus. Biospektrum 22:611

Winstel V, Kühner P, Rohde H, Peschel A (2016). Genetic engineering of untransformable coagulase-negative staphylococcal pathogens. Nat Protoc 11:949-59

Zipperer A, Konnerth MC, Laux C, Berscheid A, Janek D, Weidenmaier C, Burian M, Schilling NA, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Schittek B, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B (2016). Human commensals producing a novel antibiotic impair pathogen colonization. Nature 535:511-6

2015

Bloes DA, Kretschmer D, Peschel A (2015) Enemy attraction: bacterial agonists for leukocyte chemotaxis receptors. Nat Rev Microbiol. 13:95-104

Kuhn S, Slavetinsky CJ, Peschel A (2015) Synthesis and function of phospholipids in Staphylococcus aureus. Int J Med Microbiol. 305:196-202

Weidenmaier C, Janek D, Kokai-Kun J, Peschel A (2015) Crucial role of MprF-mediated defensin resistance in Staphylococcus aureus nasal colonization. Old Herborn University Seminar Monograph. 28:43-49

Winstel V, Kühner P, Krismer B, Peschel A, Rohde H (2015) Transfer of plasmid DNA to clinical coagulase-negative staphylococcal pathogens by using a unique bacteriophage. Appl Environ Microbiol. 81:2481-8

Ernst CM, Kuhn S, Slavetinsky CJ, Krismer B, Heilbronner S, Gekeler C, Kraus D, Wagner S, Peschel A (2015) The lipid-modifying multiple peptide resistance factor is an oligomer consisting of distinct interacting synthase and flippase subunits. MBio. 6 pii: e02340-14.

Koç C, Gerlach D, Beck S, Peschel A, Xia G, Stehle T (2015) Structural and enzymatic analysis of TarM glycosyltransferase from Staphylococcus aureus reveals an oligomeric protein specific for the glycosylation of wall teichoic acid. J Biol Chem. 290:9874-85

Kretschmer D, Rautenberg M, Linke D, Peschel A (2015) Peptide length and folding state govern the capacity of staphylococcal β-type phenol-soluble modulins to activate human formyl-peptide receptors 1 or 2. J Leukoc Biol. 97:689-97.

Liu H, Zhao Y, Zhao D, Gong T, Wu Y, Han H, Xu T, Peschel A, Han S, Qu D (2015) Antibacterial and anti-biofilm activities of thiazolidione derivatives against clinical staphylococcus strains. Emerg Microbes Infect. 4:e1.

Winstel V, Kühner P, Salomon F, Larsen J, Skov R, Hoffmann W, Peschel A, Weidenmaier C (2015) Wall Teichoic Acid Glycosylation Governs Staphylococcus aureus Nasal Colonization. MBio. 6:e00632.

Lee JH, Kim NH, Winstel V, Kurokawa K, Larsen J, An JH, Khan A, Seong MY, Lee MJ, Andersen PS, Peschel A, Lee BL (2015) Surface Glycopolymers Are Crucial for In Vitro Anti-Wall Teichoic Acid IgG-Mediated Complement Activation and Opsonophagocytosis of Staphylococcus aureus. Infect Immun. 83:4247-55.

Chaves-Moreno D, Plumeier I, Kahl S, Krismer B, Peschel A, Oxley AP, Jauregui R, Pieper DH (2015) The microbial community structure of the cotton rat nose. Environ Microbiol Rep. 7, 929-935

Li X, Gerlach D, Du X, Larsen J, Stegger M, Kühner P, Peschel A, Xia G, Winstel V (2015) An accessory wall teichoic acid glycosyltransferase protects Staphylococcus aureus from the lytic activity of Podoviridae. Sci Rep. 5:17219.

Cheung GY, Yeh AJ, Kretschmer D, Duong AC, Tuffuor K, Fu CL, Joo HS, Diep BA, Li M, Nakamura Y, Nunez G, Peschel A, Otto M (2015) Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S. Sci Rep. 5:18023.

Schuster CF, Mechler L, Nolle N, Krismer B, Zelder ME, Götz F, Bertram R (2015) The MazEF Toxin-Antitoxin System Alters the β-Lactam Susceptibility of Staphylococcus aureus. PLoS One. 10:e0126118.

Nega M, Dube L, Kull M, Ziebandt AK, Ebner P, Albrecht D, Krismer B, Rosenstein R, Hecker M, Götz F (2015) Secretome analysis revealed adaptive and non-adaptive responses of the Staphylococcus carnosus femB mutant. Proteomics.15(7):1268-79.

Farrand AJ, Haley KP, Lareau NM, Heilbronner S, McLean JA, Foster T, Skaar EP (2015) An Iron-Regulated Autolysin Remodels the Cell Wall To Facilitate Heme Acquisition in Staphylococcus lugdunensis. Infect Immun. 83:3578-89.

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