Research Group Jürgens
Selected Publications
2025
Singh MK, Lauster T, Huhn K, Richter S, Kientz M, Neher RA, Jürgens G (2025). Evolutionary origin and functional diversification of plant GBF1-type ARF guanine-nucleotide exchange factors. bioRxiv. doi: doi.org/10.1101/2025.06.03.657657.
2023
Park M, Mayer U, Richter S, Jürgens G (2023). NSF/αSNAP2-mediated cis-SNARE complex disassembly precedes vesicle fusion in Arabidopsis cytokinesis. Nat Plants 9, 889-897. doi: 10.1038/s41477-023-01427-8.
2022
Brumm S, Singh MK, Kriechbaum C, Richter S, Huhn K, Kucera T, Baumann S, Wolters H, Takada S, Jürgens G (2022). N-terminal domain of ARF-GEF GNOM prevents heterodimerization with functionally divergent GNL1 in Arabidopsis. Plant J 112, 772-785. doi: 10.1111/tpj.15979.
Cheung AY, Cosgrove DJ, Hara-Nishimura I, Jürgens G, Lloyd C, Robinson DG, Staehelin LA, Weijers D (2022). A rich and bountiful harvest: Key discoveries in plant cell biology.
Plant Cell 34, 53-71. doi: 10.1093/plcell/koab234.
2020
Brumm S, Singh MK, Nielsen ME, Richter S, Beckmann H, Stierhof YD, Fischer AM, Kumaran M, Sundaresan V, Jürgens G (2020). Coordinated activation of ARF1 GTPases by ARF-GEF GNOM dimers is essential for vesicle trafficking in Arabidopsis. Plant Cell 32, 2491-2507. doi: 10.1105/tpc.20.00240.
2018
Singh MK, Richter S, Beckmann H, Kientz M, Stierhof YD, Anders N, Fäßler F, Nielsen M, Knöll C, Thomann A, Franz-Wachtel M, Macek B, Skriver K, Pimpl P, Jürgens G (2018). A single class of ARF GTPase activated by several pathway-specific ARF-GEFs regulates essential membrane traffic in Arabidopsis. PLoS Genet 14, e1007795. doi: 10.1371/journal.pgen.1007795.
Karnahl M, Park M, Krause C, Hiller U, Mayer U, Stierhof Y-D, Jürgens G (2018). Functional diversification of Arabidopsis SEC1-related SM proteins in cytokinetic and secretory membrane fusion. PNAS 115, 6309-6314. doi: 10.1073/pnas.1722611115.
Park M, Krause C, Karnahl M, Reichardt I, El Kasmi F, Mayer U, Stierhof Y-D, Hiller U, Strompen G, Bayer M, Kientz M, Sato MH, Nishimura MT, Dangl JL, Sanderfoot AA, Jürgens G (2018). Concerted action of evolutionarily ancient and novel SNARE complexes in flowering-plant cytokinesis. Dev Cell 44, 500-511. doi: 10.1016/j.devcel.2017.12.027.
Singh MK, Jürgens G (2018). Specificity of plant membrane trafficking - ARFs, regulators and coat proteins. Semin Cell Dev Biol 80, 85-93. doi: 10.1016/j.semcdb.2017.10.005.
2017
Karnahl M, Park M, Mayer U, Hiller U, Jürgens G (2017). ER assembly of SNARE complexes mediating formation of partitioning membrane in Arabidopsis cytokinesis. eLife 6, e25327. doi: 10.7554/eLife.25327.
2016
Müller S, Jürgens G (2016). Plant cytokinesis – no ring, no constriction but centrifugal construction of the partitioning membrane. Sem Cell Dev Biol 53, 10-18. doi: 10.1016/j.semcdb.2015.10.037.
2015
Jürgens G, Park M, Richter S, Touihri S, Krause C, El Kasmi F, Mayer U (2015). Plant cytokinesis – a tale of membrane traffic and fusion. Biochem Soc Trans 43, 73-78. doi: 10.1042/BST20140246.
2014
Singh MK, Krüger F, Beckmann H, Brumm S, Vermeer JEM, Munnik T, Mayer U, Stierhof YD, Grefen C, Schumacher K, Jürgens G (2014). Protein delivery to vacuole requires SAND protein-dependent Rab GTPase conversion for MVB-vacuole fusion. Curr Biol 24, 1383-1389. doi: 10.1016/j.cub.2014.05.005.
Richter S, Kientz M, Brumm S, Nielsen ME, Park M, Gavidia R, Krause C, Voss U, Beckmann H, Mayer U, Stierhof YD, Jürgens G (2014). Delivery of endocytosed proteins to the cell-division plane requires change of pathway from recycling to secretion. eLife 3, e02131. doi: 10.7554/eLife.02131.
2013
Park M, Song KY, Reichardt I, Kim H, Mayer U, Stierhof YD, Hwang I, Jürgens G (2013). Arabidopsis AP1M adaptin subunit of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth. PNAS 110, 10318–10323. doi: 10.1073/pnas.1300460110.
El Kasmi F, Krause C, Hiller U, Stierhof YD, Mayer U, Conner L, Kong L, Reichardt I, Sanderfoot AA, Jürgens G (2013). SNARE complexes of different composition jointly mediate membrane fusion during cytokinesis in Arabidopsis. Mol Biol Cell 24, 1593-1601. doi: 10.1091/mbc.E13-02-0074.
2012
Park M, Touihri S, Müller I, Mayer U, Jürgens G (2012). Sec1/Munc18 protein stabilizes fusion-competent syntaxin for membrane fusion in Arabidopsis cytokinesis. Dev Cell 22, 989-1000. doi: 10.1016/j.devcel.2012.03.002.
2011 and earlier
Richter S, Müller L, Takada N, Kost B, Vieten A, Geldner N, Koncz C, Stierhof Y-D, Mayer U, Jürgens G. (2011). Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors. Nature Cell Biol 14, 80-86. doi: 10.1038/ncb2389.
Touihri S, Knöll C, Stierhof Y-D, Müller I, Mayer U, Jürgens G. (2011). Functional anatomy of Arabidopsis cytokinesis-specific syntaxin KNOLLE. Plant J 68, 755-764.
Reichardt I, Slane D, El Kasmi F, Knöll C, Fuchs R, Mayer U, Lipka V, Jürgens G. (2011). Mechanisms of functional specificity among plasma-membrane syntaxins in Arabidopsis. Traffic 12, 1269-1280.
Anders N, Nielsen M, Keicher J, Stierhof Y-D, Furutani M, Tasaka M, Skriver K, Jürgens G. (2008). Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains. Plant Cell 20, 142-151.
Reichardt I, Stierhof Y-D, Mayer U, Richter S, Schwarz H, Schumacher K, JürgensG. (2007) Plant cytokinesis requires de novo secretory trafficking but not endocytosis. Curr Biol 17, 2047-2053.
Richter S, Geldner N, Schrader J, Wolters H, Stierhof Y-D, Rios G, Koncz C, Robinson DG, Jürgens G. (2007). Functional diversification of closely related ARF-GEFs in protein secretion and recycling. Nature 448, 488-492.
Geldner N, Richter S, Vieten A, Marquardt S, Torres-Ruiz RA, Mayer U, Jürgens G. (2004). Partial loss-of-function alleles reveal a role for GNOM in auxin transport-related, post-embryonic development of Arabidopsis. Development 131, 389-400.
Geldner N, Anders N, Wolters H, Keicher J, Kornberger W, Muller P, Delbarre A, Ueda T, Nakano A, Jürgens G. (2003). The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth. Cell 112, 219-230.
Müller I, Wagner W, Völker A, Schellmann S, Nacry P, Küttner F, Schwarz-Sommer Z, Mayer U, Jürgens G. (2003). Syntaxin specificity of cytokinesis in Arabidopsis. Nature Cell Biol 5, 531-534.
Assaad FF, Huet Y, Mayer U, Jürgens G. (2001). The cytokinesis gene KEULE encodes a Sec1 protein which binds the syntaxin KNOLLE. J Cell Biol 152, 531-544.
Geldner N, Friml J, Stierhof Y-D, Jürgens G, Palme K. (2001). Auxin-transport inhibitors block PIN1 cycling and vesicle trafficking. Nature 413, 425-428.
Heese M, Gansel,X, Sticher L, Wick P, Grebe M, Granier F, Jürgens G. (2001). Functional characterization of the KNOLLE-interacting t-SNARE AtSNAP33 and its role in plant cytokinesis. J Cell Biol 155, 239-250.
Grebe M, Gadea J, Steinmann T, Kientz M, Rahfeld JU, Salchert K, Koncz C, Jürgens G. (2000). A conserved domain of the Arabidopsis GNOM protein mediates subunit interaction and cyclophilin 5 binding. Plant Cell 12, 343-356.
Waizenegger I, Lukowitz W, Assaad F, Schwarz H, Jürgens G, Mayer U. (2000). The Arabidopsis KNOLLE and KEULE genes interact to promote vesicle fusion during cytokinesis. Curr Biol 10, 1371-1374.
Steinmann T, Geldner N, Grebe M, Mangold S, Jackson CL, Paris S, Gälweiler L, Palme K, Jürgens G. (1999). Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF. Science 286, 316-318.
Lauber MH, Waizenegger I, Steinmann T, Schwarz H, Mayer U, Hwang I, Lukowitz W, Jürgens G. (1997). The Arabidopsis KNOLLE protein is a cytokinesis-specific syntaxin. J Cell Biol139, 1485-1493.
Busch M, Mayer U, Jürgens G. (1996). Molecular analysis of the Arabidopsis pattern-formation gene GNOM: gene structure and intragenic complementation. Molec Gen Genet 250, 681-691.
Lukowitz W, Mayer U, Jürgens G. (1996). Cytokinesis in the Arabidopsis embryo involves the syntaxin-related KNOLLE gene product. Cell 84, 61-71.
Mayer U, Büttner G, Jürgens G. (1993). Apical-basal pattern formation in the Arabidopsis embryo: studies on the role of the gnom gene. Development 117, 149-162.
Mayer U, Torres Ruiz RA, Berleth T, Miséra S, Jürgens G. (1991). Mutations affecting body organization in the Arabidopsis embryo. Nature 353, 402-407.