On the one hand, our research group is concerned with the separation of stereoisomers by chromatography and by electromigration techniques. Different methods, involving gas chromatography, supercritical fluid chromatography, micro liquid chromatography and capillary electrochromatography are employed. A unified approach toward an enantioselective separation system was developed.
Mechanistic aspects of enantiorecognition are investigated thoroughly. Target molecules are chiral drugs, pheromones, flavours, fragrances, inhalation anesthetics and research chemicals. Efforts are directed also to small chiral molecules such as alkyloxiranes, aziridines and fluorochloro(bromo,iodo)methane. In the field of chiral environmental organochlorines, enantiomeric ratios in biogenic matrices are determined. Kinetic data of interconverting enantiomers (enantiomerization) are determined by dynamic chromatography and by stopped-flow multidimensional chromatography.
