Interfaculty Institute of Microbiology and Infection Medicine

Selected Publications

Dickey AK, Chantratita N, Tandhavanant S, Ducken D, Lovelace-Macon L, Seal S, Robertson J, Myers ND, Schwarz S, Wurfel MM, Kosamo S and West TE (2019) Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei. PLoS Negl Trop Dis 13(5):e0007354

Jochim A, Shi T, Belikova D, Schwarz S, Peschel A and Heilbronner S (2019) Methionine limitation impairs pathogen expansion and biofilm formation capacity. Appl. Environ. Microbiology in press

Lennings J, Mayer C, Makhlouf M, Brötz-Oesterhelt H and Schwarz S (2019) Polar localization of the ATPase ClpV-5 occurs independent of type VI secretion system apparatus proteins in Burkholderia thailandensis. BMC Research Notes 12(1):109

Lennings J, West TE and Schwarz S (2019) The Burkholderia Type VI Secretion System 5: Composition, Regulation and Role in Virulence. Front Microbiol 9:3339

Willmann M, Goettig S, Bezdan D, Macek B, Velic A, Marschal M, Vogel W, Flesch I, Markert U, Schmidt A, Kuebler P, Haug M, Javed M, Jentzsch B, Oberhettinger P, Schuetz M, Bohn E, Sonnabend M, Klein K, Autenrieth I, Ossowski S, Schwarz S and Peter S (2018) Multi-omics approach identifies novel pathogen-derived prognostic biomarkers in patients with Pseudomonas aeruginosa bloodstream infection. bioRxiv

Duong LT*, Schwarz S*, Gross H, Breitbach K, Hochgräfe F, Mostertz J, Eske-Pogodda K, Wagner GE, Steinmetz I and Kohler C (2018) GvmR - A novel LysR-type transcriptional regulator involved in virulence and primary and secondary metabolism of Burkholderia pseudomallei. Front Microbiol 9:935; *equal contribution

Whiteley L, Haug M, Klein K, Willmann M, Bohn E, Chiantia S and Schwarz S (2017) Cholesterol and host cell surface proteins contribute to cell-cell fusion induced by the Burkholderia type VI secretion system 5. PLoS One 3;12(10):e0185715

Whiteley L, Meffert T, Haug M, Weidenmaier C, Hopf V, Bitschar K, Schittek B, Kohler C, Steinmetz I, West TE and Schwarz S (2017) Entry, Intracellular Survival, and Multinucleated-Giant-Cell-Forming Activity of Burkholderia pseudomallei in Human Primary Phagocytic and Nonphagocytic Cells. Infect Immun 20;85(10)

Schwarz S & van Dijck P (2017). Trehalose metabolism: a sweet spot for Burkholderia pseudomallei virulence. Virulence 8(1):5-7

Carevic M, Öz H, Fuchs K, Laval J, Schroth C, Frey N, Hector A, Bilich T, Haug M, Schmidt A, Autenrieth SE, Bucher K, Beer-Hammer S, Gaggar A, Kneilling M, Benarafa C, Gao JL, Murphy PM, Schwarz S, Moepps B, Hartl D. (2016) CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense. J Innate Immun 8:362-373

Schmidt A, Hammerbacher AS, Bastian M, Nieken KJ, Klockgether J, Merighi M, Lapouge K, Poschgan C, Kölle J, Acharya KR, Ulrich M, Tümmler B, Unden G, Kaever V,  Lory S, Haas D, Schwarz S*, Döring G* (2016). Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa. Environ Microbiol 18(10):3390-3402 *equal contribution

Nell S*, Kennemann L*, Schwarz S*, Josenhans C, Suerbaum S (2014) Dynamics of Lewis b binding and sequence variation of the babA adhesin gene during chronic Helicobacter pylori infection in humans. mBio 5(6):e02281-14; *equal contribution

Schmidt A, Belaaouaj A, Bissinger R, Koller G, Malleret L, D'Orazio C, Facchinelli M, Schulte-Hubbert B, Molinaro A, Holst O, Hammermann J, Schniederjans M, Meyer KC, Damkiaer S, Piacentini G, Assael B, Bruce K, Häußler S, Lipuma JJ, Seelig J, Worlitzsch D, Döring G (2014). Neutrophil elastase-mediated increase in airway temperature during inflammation. J Cyst Fibros. S1569-1993(14)00073-3

Schwarz S, Singh P, Robertson JD, LeRoux M, Skerrett SJ, Goodlett DR, West TE, Mougous JD (2014). VgrG-5 is a Burkholderia type VI secretion system-exported protein required for multinucleated giant cell formation and virulence. Infect Immun. 82(4):1445-52

Russell AB, Singh P, Brittnacher M, Khai Bui N, Hood RD, Carl MA, Agnello DM, Schwarz S, Goodlett DR, Vollmer W, and Joseph D. Mougous JD (2012) A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host Microbe 11(5): 538-549

Schwarz S, Hood RD, Mougous JD (2010) What is type VI secretion doing in all those bugs? Trends Microbiol. 2010 18(12):531-7

Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD (2010) Burkholderia Type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog 6(8): e1001068