Head: Prof. Dr. Heike Brötz-Oesterhelt
Welcome to the Department of Microbial Bioactive Compounds
Bacterial resistance to antibiotics spreads at an alarming rate worldwide and has developed against every clinically applied antibiotic. New antibiotics devoid of cross-resistance to established antibiotic classes are urgently needed in order to avert the looming threat of a post-antibiotic era.
At the Department of Microbial Bioactive Compounds we study novel antibacterial agents, predominately bacterial and fungal products from various origins and geographic locations. Microbial natural products are privileged structures for antibiotic discovery as they emerged in a long period of co-evolution between antibiotic producing strains and bacterial target species.
We perform fundamental research on new antibacterial targets and mechanistic details of their inhibition or deregulation. Using antibiotics to inhibit these targets we also gain insight into their physiological functions and interactions in bacterial cells. With an applied interest, we search for and characterize new antibacterial agents to serve as lead structures for antibiotic development.