Interfaculty Institute of Microbiology and Infection Medicine

Curriculum vitae of Friedrich Götz

Education and professional experience

1968 - 1973 Study of Biology and Chemistry at the Ludwig Maximilians University (LMU) München
1974 - 1978 Doctoral Thesis at LMU München, under Prof. Dr. K.H. Schleifer at the Department of Microbiology
1978 Received PhD
1985 Habilitation at the TU München on: "Development of a Host-Vector system in staphylococci"
1987 - 2015 Appointed professor for the chair "Microbial Genetics" at the University Tübingen
2015 - Endowed Senior-Professorship

Awards / Honors

1979/81 EMBO long term fellowship, Biomedical Center Uppsala
1989 DECHEMA award 1988 for developing a new cloning system in Staphylococcus carnosus
1991 DGHM Award 1990 for scientific works on microbial genetics
2003 - 2009 President and Vice president of the VAAM (association of general and applied microbiology)
2011 - Member of: European Academy of Microbiology (EAM)

Project Management, editorial work and consultant

2001 - 2010 Speaker of Graduate college 685 (DFG): Infection biology: human- and plant pathogenic bacteria and fungi
2006 - 2013 Coordinator of the Tübingen Group of Transregio SFB Greifswald Tübingen-Würzburg-Münster (TR34)

2000, 2004,

2008 - 2012

Member of DFG Panel 204 "Microbiology, Virology, and Immunology"
1992 - 2000 Editorials FEMS Microbiology Letters
1993 - 1999 Editorials Applied and Environmental Microbiology
2003 - 2006 Editorials "Molecular Microbiology"
2004 - Editorials "Medical Microbiology and Immunology"
2009 Co-founder of IMIT (Interfaculty Institute for Microbiology and Infectionmedicine Tübingen). This is the association of the former separated microbiological institutes at the Sience Faculty and the Medical Microbiology and Clinical Infectiology and Immunology. IMIT is Germanwide the first institute of this kind. It comprises 7 Full Professorships and several Assistant Professorships.
2011 Jodi Lindsay & Fritz Götz: Organizers of the Gordon Research Conference "Staphylococcal Diseases" Il Ciocco, Italy
2011 Ralph Bertram & Fritz Götz: Organizers of "How dead is dead II" Tübingen

Current research topics

Staphylococcal physiology and impact in infection:

Biofilm, small colony, antibiotic resistance, excretion of cytoplasmic proteins, new antibiotic development, Interaction of staphylococci with our immune system

Publications: > 380 peer reviewed Publications - h-factor 93

Citation indices All Since 2015
Citations 31400 10600
h-index 93 55
i10-index 292 211  (no. of citations with at least 10 citation)

Former PhD students and/or postdocs in academia:

Prof. Raja Biswas, Center for Nanoscience and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Kerala, India

Prof. Chih-Jung Chen, Department of Pediatric, Chang Gung Children’s Hospital, Taoyuan, Taiwan

Prof. Jiří Doškař, Genetics and Molecular Biology, Brno University of Technology, Czech Republic

Prof. Qiang Gao, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China

PD Christine Heilmann, Medical Microbiology, University Münster, Germany

Prof. Wolfgang Liebl, Technical University München, Germany

Prof. Per-Eric Lindgren, Div. Microbiology and Infection, Linköping University, Sweden

Dr. Minh Thu Nguyen, Inst Med Mikrobiol, Univ Klinik Münster, Germany

Dr. Michael Otto, Director, Pathogen Molecular Genetics Section, NIH, Washington D.C. USA

Prof. Andreas Peschel, Infection Biology Department, University Tübingen, Germany

Prof. Waldemar Vollmer, Bacterial Biochemistry, Newcastle University, UK

Ass. Prof. Wenqi Yu, Department of Cell Biology, Microbiology and Molecular Biology (CMMB), University of South Florida

Selected publications from 2015 – 2019

Wang H, Kraus F, Popella P, Baykal A, Guttroff C, Francois P, Sass P, Plietker B, Götz F. 2019. The Polycyclic Polyprenylated Acylphloroglucinol Antibiotic PPAP 23 Targets the Membrane and Iron Metabolism in Staphylococcus aureus. Front Microbiol 10:14.

Tribelli PM, Luqman A, Nguyen MT, Madlung J, Fan SH, Macek B, Sass P, Bitschar K, Schittek B, Kretschmer D, Götz F. 2019. Staphylococcus aureus Lpl protein triggers human host cell invasion via activation of Hsp90 receptor. Cell Microbiol doi:10.1111/cmi.13111:e13111.

Nguyen MT, Saising J, Tribelli PM, Nega M, Diene SM, Francois P, Schrenzel J, Sproer C, Bunk B, Ebner P, Hertlein T, Kumari N, Hartner T, Wistuba D, Voravuthikunchai SP, Mader U, Ohlsen K, Götz F. 2019. Inactivation of farR Causes High Rhodomyrtone Resistance and Increased Pathogenicity in Staphylococcus aureus. Front Microbiol 10:1157.
Mohammad M, Nguyen MT, Engdahl C, Na M, Jarneborn A, Hu Z, Karlsson A, Pullerits R, Ali A, Götz F, Jin T. 2019. The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus. PLoS Pathog 15:e1007877
Luqman A, Ebner P, Reichert S, Sass P, Kabagema-Bilan C, Heilmann C, Ruth P, Götz F. 2019. A new host cell internalisation pathway for SadA-expressing staphylococci triggered by excreted neurochemicals. Cell Microbiol doi:10.1111/cmi.13044:e13044.
Fan SH, Ebner P, Reichert S, Hertlein T, Zabel S, Lankapalli AK, Nieselt K, Ohlsen K, Götz F. 2019. MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels. Nat Commun 10:3627
Saising J, Nguyen MT, Hartner T, Ebner P, Al Mamun Bhuyan A, Berscheid A, Muehlenkamp M, Schakermann S, Kumari N, Maier ME, Voravuthikunchai SP, Bandow J, Lang F, Brötz-Oesterhelt H, Götz F. 2018. Rhodomyrtone (Rom) is a membrane-active compound. Biochim Biophys Acta 1860:1114- 1124.
Reichert S, Ebner P, Bonetti EJ, Luqman A, Nega M, Schrenzel J, Sproer C, Bunk B, Overmann J, Sass P, Francois P, Götz F. 2018. Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus. Front Microbiol 9:1539.
Nguyen MT, Peisl L, Solari FB, Luqman A, Götz F. 2018. Toll-Like Receptor 2 and Lipoprotein-Like Lipoproteins Enhance Staphylococcus aureus Invasion in Epithelial Cells. Infect Immun 86.
Luqman A, Nega M, Nguyen MT, Ebner P, Götz F. 2018. SadA-Expressing Staphylococci in the Human Gut Show Increased Cell Adherence and Internalization. Cell Rep 22:535-545.
Ebner P, Reichert S, Luqman A, Krismer B, Popella P, Götz F. 2018. Lantibiotic production is a burden for the producing staphylococci. Sci Rep 8:7471.
Ebner P, Götz F. 2018. Bacterial Excretion of Cytoplasmic Proteins (ECP): Occurrence, Mechanism, and Function. Trends Microbiol doi:10.1016/j.tim.2018.10.006
Nguyen MT, Uebele J, Kumari N, Nakayama H, Peter L, Ticha O, Woischnig AK, Schmaler M, Khanna N, Dohmae N, Lee BL, Bekeredjian-Ding I, Götz F. 2017. Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses. Nat Commun 8:2246.
Guttroff C, Baykal A, Wang H, Popella P, Kraus F, Biber N, Krauss S, Götz F, Plietker B. 2017. Polycyclic Polyprenylated Acylphloroglucinols: An Emerging Class of Non-Peptide-Based MRSA- and VRE-Active Antibiotics. Angew Chem Int Ed Engl 56:DOI: 10.1002/anie.201707069.
Ebner P, Luqman A, Reichert S, Hauf K, Popella P, Forchhammer K, Otto M, Götz F. 2017. Nonclassical Protein Excretion Is Boosted by PSMalpha-Induced Cell Leakage. Cell Rep 20:1278-1286
Shahmirzadi SV, Nguyen MT, Götz F. 2016. Evaluation of Staphylococcus aureus Lipoproteins: Role in Nutritional Acquisition and Pathogenicity. Front Microbiol 7:1404.
Popella P, Krauss S, Ebner P, Nega M, Deibert J, Götz F. 2016. VraH Is the Third Component of the Staphylococcus aureus VraDEH System Involved in Gallidermin and Daptomycin Resistance and Pathogenicity. Antimicrob Agents Chemother 60:2391-401.
Nguyen MT, Hanzelmann D, Hartner T, Peschel A, Götz F. 2016. Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response. Infect Immun 84:205-15.
Nguyen MT, Götz F. 2016. Lipoproteins of Gram-Positive Bacteria: Key Players in the Immune Response and Virulence. Microbiol Mol Biol Rev 80:891-903.
Nguyen MT, Deplanche M, Nega M, Le Loir Y, Peisl L, Götz F, Berkova N. 2016. Staphylococcus aureus Lpl Lipoproteins Delay G2/M Phase Transition in HeLa Cells. Front Cell Infect Microbiol 6:201.
Mechler L, Bonetti EJ, Reichert S, Flötenmeyer M, Schrenzel J, Bertram R, Francois P, Götz F. 2016. Daptomycin Tolerance in the Staphylococcus aureus pitA6 Mutant Is Due to Upregulation of the dlt Operon. Antimicrob Agents Chemother 60:2684-91.
Ebner P, Rinker J, Nguyen MT, Popella P, Nega M, Luqman A, Schittek B, Di Marco M, Stevanovic S, Götz F. 2016. Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus. Infect Immun 84:1672-81.
Nguyen MT, Kraft B, Yu W, Demicrioglu DD, Hertlein T, Burian M, Schmaler M, Boller K, BekeredjianDing I, Ohlsen K, Schittek B, Götz F. 2015. The νSaα Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells. PLoS Pathog 11:e1004984.
. Mayer S, Steffen W, Steuber J, Götz F. 2015. The Staphylococcus aureus NuoL-Like Protein MpsA Contributes to the Generation of Membrane Potential. J Bacteriol 197:794-806.
Ebner P, Prax M, Nega M, Koch I, Dube L, Yu W, Rinker J, Popella P, Flötenmeyer M, Götz F. 2015. Excretion of cytoplasmic proteins (ECP) in Staphylococcus aureus. Mol Microbiol 97:775-89.
Deplanche M, Filho RA, Alekseeva L, Ladier E, Jardin J, Henry G, Azevedo V, Miyoshi A, Beraud L, Laurent F, Lina G, Vandenesch F, Steghens JP, Le Loir Y, Otto M, Götz F, Berkova N. 2015. Phenolsoluble modulin alpha induce G2/M phase transition delay in eukaryotic HeLa cells. FASEB J pii: fj.14- 260513.