Interfaculty Institute of Microbiology and Infection Medicine

Curriculum vitae of Friedrich Götz

Prof. Dr. Friedrich Götz

Senior professorship

Head of Microbial Genetics

Interfaculty Institute for Microbiology and Infection-medicine Tübingen (IMIT)

University Tübingen-Germany

E-mail: friedrich.goetz@uni-tuebingen.de

www.imit.uni-tuebingen.de/beteiligte-einheiten/mikrobielle-genetik.html

Education and professional experience

1968 - 1973

Biology and Chemistry, Ludwig Maximilians University (LMU) München,

1974 - 1978

Department of Microbiology, Ph.D., LMU München

1985

Habilitation at the TU München

1987 - 2015

Appointed professor and chair of "Microbial Genetics" at the University Tübingen

2015 - 

Senior professor of "Microbial Genetics" at the University Tübingen

Awards / Honors

1979-1981

EMBO long term fellowship, Biomedical Center Uppsala

1989

DECHEMA award for developing a new cloning system in Staphylococcus carnosus

1991

DGHM award for scientific work in microbial genetics

1994 Offered Chair in Microbiology at University Göttingen (Succession of Professor Dr. Dr. h.c. Hans Günter Schlegel)

2003-2009

President and Vice president of the VAAM (association of general and applied microbiology)

2009

DGHM Lecturer Award; Co-founder of the IMIT (Interfaculty Institute for Microbiology and Infection-medicine Tübingen)

2011-

Member of European Academy of Microbiology (EAM)

2018- Member of the Cluster of Excellence - CMFI
2020- Visiting Professor at Shiraz University of Medical Sciences (SUMS)

Project Management, editorial work and consultant

 

 

 

Project

management

Speaker of Graduate college 685 (DFG): Infection biology: human and plant pathogenic bacteria and fungi, 2010-2011

Coordinator of the Tübingen Group of Transregio SFB Greifswald Tübingen-Würzburg-Münster (TR34), 2006-2013

Member of DFG Panel 204 "Microbiology, Virology, and Immunology", 2008-2012

Organizers of the Gordon Research Conference "Staphylococcal Diseases" Il Ciocco, Italy, 2011

 

 

 

Editor

"Molecular Microbiology", 1993-1999

"Applied and Environmental Microbiology", 2003-2006

"Medical Microbiology and Immunology", 2004-now

Associate Editor, "Emerging Microbes and Infections" (EMI)

Associate Editor, "Microbial Physiology and Metabolism section in Frontiers in Microbiology"

Advisory Board

2020 - Currently member of advisory boards of three larger international research institutionsCurrently of three larger research institutions

Current research topics

He is a leading scientist in microbiology and infection biology. The current objectives of his research are: The physiology of staphylococci, lipoproteins as key players in immune response and virulence, analysis of new antimicrobial compounds and bacterial-derived effector molecules and their interaction with the host. Currently he is studying how commensal bacteria on the skin overcome the immunological barriers of, how they can survive in the host, and how they control human cell's proliferation, motility and immune response. The bacterial influence on skin even goes so far that they are able to accelerate wound healing through their secreted effectors. This was also one of the recent scientific breakthroughs, namely, to demonstrate that many members of the skin microbiota and even gut microbiota secrete neurotransmitters that interact with adrenergic receptors of host cells to interfere with their metabolism. The commensal microbiota is important for human health. But we know too little about it.

Academic roles

He is working for many microbiology/immunology related journals as reviewer and as associate editor and is consultant for various national and international research institutions. He supervised > 120 PhD students and postdocs, >15 obtained a professorship.

Publications: > 380 peer reviewed Publications - h-factor 96

He has published > 380 peer-reviewed publications, which have been > 34000 times cited. h-index = 96 (More details can be found at: https://scholar.google.com/citations?hl=en&user=uq_ofGsAAAAJ&view_op=list_works)

Selected publications of last 4 years

Ebner, P., and Götz, F. (2018) Bacterial Excretion of Cytoplasmic Proteins (ECP): Occurrence, Mechanism, and Function. Trends Microbiol.

Fan, S.H., Ebner, P., Reichert,  nS., Hertlein, T., Zabel, S., Lankapalli, A.K., Nieselt, K., Ohlsen, K., and Götz, F. (2019) MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels. Nat Commun 10: 3627

Gardiner, J.H.t., Komazin, G., Matsuo, M., Cole, K., Götz, F., and Meredith, T.C. (2020) Lipoprotein N-Acylation in Staphylococcus aureus Is Catalyzed by a Two-Component Acyl Transferase System. mBio 11.

Luqman, A., Ebner, P., Reichert, S., Sass, P., Kabagema-Bilan, C., Heilmann, C., Ruth, P., and Götz, F. (2019) A new host cell internalisation pathway for SadA-expressing staphylococci triggered by excreted neurochemicals. Cell Microbiol: e13044.

Luqman, A., Kharisma, V.D., Ruiz, R.A., and Götz, F. (2020a) In Silico and in Vitro Study of Trace Amines (TA) and Dopamine (DOP) Interaction with Human Alpha 1-Adrenergic Receptor and the Bacterial Adrenergic Receptor QseC. Cell Physiol Biochem 54: 888-898.

Luqman, A., Muttaqin, M.Z., Yulaipi, S., Ebner, P., Matsuo, M., Zabel, S., Tribelli, P.M., Nieselt, K., Hidayati, D., and Götz, F. (2020b) Trace amines produced by skin bacteria accelerate wound healing in mice. Commun Biol 3: 277.

Nega, M., Tribelli, P.M., Hipp, K., Stahl, M., and Götz, F. (2020) New insights in the coordinated amidase and glucosaminidase activity of the major autolysin (Atl) in Staphylococcus aureus. Commun Biol 3: 695.

Nguyen, M.T., Uebele, J., Kumari, N., Nakayama, H., Peter, L., Ticha, O., Woischnig, A.K., Schmaler, M., Khanna, N., Dohmae, N., Lee, B.L., Bekeredjian-Ding, I., and Götz, F. (2017) Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses. Nat Commun 8: 2246.

Tribelli, P.M., Luqman, A., Nguyen, M.T., Madlung, J., Fan, S.H., Macek, B., Sass, P., Bitschar, K., Schittek, B., Kretschmer, D., and Götz, F. (2019) Staphylococcus aureus Lpl protein triggers human host cell invasion via activation of Hsp90 receptor. Cell Microbiol: e13111.

Wang, H., Kraus, F., Popella, P., Baykal, A., Guttroff, C., Francois, P., Sass, P., Plietker, B., and Götz, F. (2019) The Polycyclic Polyprenylated Acylphloroglucinol Antibiotic PPAP 23 Targets the Membrane and Iron Metabolism in Staphylococcus aureus. Front Microbiol 10