The antimicrobial fibupeptide lugdunin forms water-filled channel structures in lipid membranes

Dominik Ruppelt, Marius F. W. Trollmann, Taulant Dema, Sebastian N. Wirtz, Hendrik Flegel, Sophia Mönnikes, Stephanie Grond, Rainer A. Böckmann, Claudia Steinem

Nat. Comm. (2024), doi:10.1038/s41467-024-47803-6

Conformations and Rearrangements of Collinolactone – Experiments and Theory on a Dynamic Cyclodecatriene

Rhena L. Decker, David Schray, Heiko I. Pfeffer, Prof. Dr. Stephanie Grond, Dr. J. Philipp Wagner

Chem. Eur. J. (2024), doi:10.1002/chem.202303435

Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus

Benjamin O. Torres Salazar, Taulant Dema, Nadine A. Schilling, Daniela Janek, Jan Bornikoel, Anne Berscheid, Ahmed M. A. Elsherbini, Sophia Krauss, Simon J. Jaag, Michael Lämmerhofer, Min Li, Norah Alqahtani, Malcolm J. Horsburgh, Tilmann Weber, José Manuel Beltrán-Beleña, Heike Brötz-Oesterhelt, Stephanie Grond, Bernhard Krismer, Andreas Peschel

Nat. Microbiol. (2024), doi:10.1038/s41564-023-01544-2

Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A

Astrid Illigmann, Marie-Theres Vielberg, Markus Lakemeyer, Felix Wolf, Taulant Dema, Patrik Stange, Wolfgang Kuttenlochner, Elisa Liebhart, Andreas Kulik, Nicole Staudt, Imran Malik, Stephanie Grond, Stephan A. Sieber, Leonard Kaysser, Michael Groll, Heike Brötz-Oesterhelt

Angew. Chem. Int. Ed. (2024), doi: 10.1002/anie.202314028

Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides

Mathias H. Hansen, Martina Adamek, Dumitrita Iftime, Daniel Petras, Frauke Schuseil, Stephanie Grond, Evi Stegmann, Max J. Cryle, Nadine Ziemert

Nat. Comm. (2023), doi:10.1038/s41467-023-43451-4

Horizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Sophia Krauss, Theresa A. Harbig, Johanna Rapp, Timm Schaefle, Mirita Franz-Wachtel, Leonie Reetz, Ahmed M. A. Elsherbini, Boris Macek, Stephanie Grond, Hannes Link, Kay Nieselt, Bernhard Krismer, Andreas Peschel & Simon Heilbronner

Microbiol. Spectr. (2023), doi: 10.1128/spectrum.03176-22

Complete Genome Sequence of the Collinolactone Producer Streptomyces sp. Strain Gö40/10

Eva B. Sterndorff, Tue S. Jørgensen, Jaime Felipe Guerrero Garzón, Julian Schmid, Stephanie Grond & Tilmann Weber

Microbiol. Resour. Announc. (2022), doi: 10.1128/mra.00220-22

Hybrid Chemoenzymatic Synthesis of C₇-Sugars for Molecular Evidence of in vivo Shikimate Pathway Inhibition

Pascal Rath, Johanna Rapp, Klaus Brilisauer, Marvin Braun, Üner Kolukisaoglu, Karl Forchhammer & Stephanie Grond

Chem. Bio. Chem. (2022), doi: 10.1002/cbic.202200241

The Structure of Cyclodecatriene Collinolactone, its Biosynthesis, and Semisynthetic Analogues: Effects of Monoastral Phenotype and Protection from Intracellular Oxidative Stress

Julian C. Schmid, Kerstin Frey, Matthias Scheiner, Jaime Felipe Guerrero Garzón, Luise Stafforst, Jan-Niklas Fricke, Michaela Schuppe, Hajo Schiewe, Axel Zeeck, Tilmann Weber, Isabel Usón, Ralf Kemkemer, Michael Decker & Stephanie Grond 

Angew. Chem. Int. Ed. (2021), doi: 10.1002/anie.202106802

A bioactive molecule made by unusual salvage of radical SAM enzyme by-product 5-deoxyadenosine blurs the boundary of primary and secondary metabolism

Johanna Rapp, Pascal Rath, Joachim Kilian, Klaus Brilisauer, Stephanie Grond & Karl Forchhammer

J. Biol. Chem. (2021), doi: 10.1016/j.jbc.2021.100621

Distinct Lugdunins from a New Efficient Synthesis and Broad Exploitation of Its MRSA-Antimicrobial Structure

Julian S. Saur, Sebastian N. Wirtz, Nadine A. Schilling, Bernhard Krismer, Andreas Peschel & Stephanie Grond

J. Med. Chem. (2021) doi: 10.1021/acs.jmedchem.0c02170

Bioreporters for direct mode of action-informed screening of antibiotic producer strains

Katharina W. Wex, Julian S. Saur, Franziska Handel, Nico Ortlieb, Vladislav Mokeev, Andreas Kulik, Timo H. J. Niedermeyer, Yvonne Mast, Stephanie Grond, Anne Berscheid & Heike Brötz-Oesterhelt

Cell Chem. Biol. (2021), doi: 10.1016/j.chembiol.2021.02.022

Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis

Sophia Krauss, Alexander Zipperer, Sebastian Wirtz , Julian Saur, Martin C Konnerth, Simon Heilbronner, Benjamin O Torres Salazar, Stephanie Grond, Bernhard Krismer &  Andreas Peschel

Antimicrob. Agents Chemother. (2020), doi: 10.1128/AAC.01734-20.

Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors

Katharina Bitschar, Birgit Sauer, Jule Focken, Hanna Dehmer, Sonja Moos, Martin Konnerth, Nadine A. Schilling, Stephanie Grond, Hubert Kalbacher, Florian C. Kurschus, Friedrich Götz, Bernhard Krismer, Andreas Peschel & Birgit Schittek

Nat. Commun. (2019), doi:10.1038/s41467-019-10646-7

Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability

Dr. Nadine A. Schilling Dr. Anne Berscheid Johannes Schumacher Julian S. Saur Dr. Martin C. Konnerth Sebastian N. Wirtz José M. Beltrán‐Beleña Dr. Alexander Zipperer Dr. Bernhard Krismer Prof. Andreas Peschel Dr. Hubert Kalbacher Prof. Heike Brötz‐Oesterhelt Prof. Claudia Steinem Prof. Stephanie Grond

Angew. Chem. Int. Ed. (2019) doi.org/10.1002/anie.201901589

Caprazamycins: Biosynthesis and structure activity relationship studies

Franziska Wiker, Nils Hauck, Stephanie Grond & Bertolt Gust

Int. J. Med. Microbiol. (2019), doi: 10.1016/j.ijmm.2019.05.004

Viridicatol and viridicatin isolated from a shark-gill-derived fungus Penicilliumpolonicum AP2T1 as MMP-2 and MMP-9 inhibitors in HT1080 cells by MAPKs signaling pathway and docking studies

Yuan Zhang, Ping Yang, Stephanie Grond, Yi Zhang, Zhong-Ji Qian

Med Chem Res (2019) 28: 1039. doi.org/10.1007/s00044-019-02358-w

Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms

Klaus Brilisauer, Johanna Rapp, Pascal Rath, Anna Schöllhorn, Lisa Bleul, Elisabeth Weiß, Mark Stahl, Stephanie Grond & Karl Forchhammer

Nat. Commun. (2019) 10: 545. doi.org/10.1038/s41467-019-08476-8

Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus

Torben Hofeditz, Claudia Eva-Maria Unsin, Jutta Wiese, Johannes F. Imhoff, Wolfgang Wohlleben, Stephanie Grond, Tilmann Weber

Antibiotics 2018, 7(3), 53; doi.org/10.3390/antibiotics7030053

Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Robertsen HL, Musiol-Kroll EM, Ding L, Laiple KJ, Hofeditz T, Wohlleben W, Lee SY, Grond S, Weber T.

Sci Rep. 2018 Feb 19;8(1):3230. doi: 10.1038/s41598-018-21507-6.

Production of functionalized oligo‐isoprenoids by enzymatic cleavage of rubber

Röther W, Birke J, Grond S, Beltran JM, Jendrossek D.

Microb Biotechnol. 2017 Nov;10(6):1426-1433. doi: 10.1111/1751-7915.12748. Epub 2017 Jul 11.

A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium polonicum AP2T1.

Zhang Y, Mu J, Essmann F, Feng Y, Kramer M, Bao HY, Grond S.

Nat Prod Res. 2017 May;31(9):985-989. doi: 10.1080/14786419.2015.1045906. Epub 2015 Jul 17. Erratum in: Nat Prod Res. 2017 May;31(9):1106.

Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII.

Musiol-Kroll EM, Zubeil F, Schafhauser T, Härtner T, Kulik A, McArthur J, Koryakina I, Wohlleben W, Grond S, Williams GJ, Lee SY, Weber T.

ACS Synth Biol. 2017 Mar 17;6(3):421-427. doi: 10.1021/acssynbio.6b00341. Epub 2017 Feb 22.

Human commensals producing a novel antibiotic impair pathogen colonization.

Zipperer A, Konnerth MC, Laux C, Berscheid A, Janek D, Weidenmaier C, Burian M, Schilling NA, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Schittek B, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B.

Nature. 2016 Jul 27;535(7613):511-6. doi: 10.1038/nature18634.

Epoxomicin and Eponemycin Biosynthesis Involves gem-Dimethylation and an Acyl-CoA Dehydrogenase-Like Enzyme.

Zettler J, Zubeil F, Kulik A, Grond S, Kaysser L.

Chembiochem. 2016 May 3;17(9):792-8. doi: 10.1002/cbic.201500567. Epub 2016 Feb 25.

Rare actinomycetes Nocardia caishijiensis and Pseudonocardia carboxydivorans as endophytes, their bioactivity and metabolites evaluation.

Tanvir R, Sajid I, Hasnain S, Kulik A, Grond S.

Microbiol Res. 2016 Apr;185:22-35. doi: 10.1016/j.micres.2016.01.003. Epub 2016 Jan 23.

A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium crustosum AP2T1.

Zhang Y, Mu J, Essmann F, Feng Y, Kramer M, Bao HY, Grond S.

Nat Prod Res. 2015 Jul 17:1-5. [Epub ahead of print]

New aminocoumarins from the rare actinomycete Catenulispora acidiphila DSM 44928: identification, structure elucidation, and heterologous production.

Zettler J, Xia H, Burkard N, Kulik A, Grond S, Heide L, Apel AK.

Chembiochem. 2014 Mar 3;15(4):612-21. doi: 10.1002/cbic.201300712. Epub 2014 Feb 19.

A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase.

Tang X, Eitel K, Kaysser L, Kulik A, Grond S, Gust B.

Nat Chem Biol. 2013 Oct;9(10):610-5. doi: 10.1038/nchembio.1310. Epub 2013 Aug 4.

Unusual N-prenylation in diazepinomicin biosynthesis: the farnesylation of a benzodiazepine substrate is catalyzed by a new member of the ABBA prenyltransferase superfamily.

Bonitz T, Zubeil F, Grond S, Heide L.

PLoS One. 2013 Dec 23;8(12):e85707. doi: 10.1371/journal.pone.0085707. eCollection 2013.

A new class of quorum quenching molecules from Staphylococcus species affects communication and growth of gram-negative bacteria.

Chu YY, Nega M, Wölfle M, Plener L, Grond S, Jung K, Götz F.

PLoS Pathog. 2013;9(9):e1003654. doi: 10.1371/journal.ppat.1003654. Epub 2013 Sep 26.

Full List of Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=Stephanie+Grond

Patents

"Melanogenesis - modulating macrolides assessed by mammalian cell based activity assays": S. Grond, M. Krohn, U. Dechert, J. Eck, Eur. Patent EP1568781B1, 2005.

Book contributions

A. Zeeck, S. Grond, I. Papastavrou, S. C. Zeeck, (8., überarbeitete Auflage 2014). Chemie für Mediziner. Urban & Fischer, München, Jena.

S. Grond, (1. Auflage 2014). Chemie für Mediziner-Last Minute. Urban & Fischer, München, Jena-in Vorbereitung-.

S. Grond, I. Papastavrou, A. Zeeck, (überarbeitete Auflage 2012). Prüfungstraining „Chemie für Mediziner“. Elsevier. Urban & Fischer, München, Jena.

A. Zeeck, S. Grond, I. Papastavrou, S. C. Zeeck, (7., überarbeitete Auflage 2009). Chemie für Mediziner. Urban & Fischer, München, Jena.

S. Grond, I. Papastavrou, A. Zeeck, (2008). Prüfungstraining „Chemie für Mediziner“. Elsevier. Urban & Fischer, München, Jena.

A. Zeeck, S. Grond, I. Papastavrou, S. C. Zeeck, (überarbeiteter Nachdruck 2006). Chemie für Mediziner. Urban & Fischer, München, Jena.

A. Zeeck, S. Fischer, S. Grond, I. Papastavrou, (völlig neu überarbeitete Auflage 2005). Chemie für Mediziner. Urban & Fischer, München, Jena.

A. Zeeck, S. Fischer, S. Grond, I. Papastavrou, (völlig neu überarbeitete Auflage 2003). Chemie für Mediziner. Urban & Fischer, München, Jena.

S. Grond (1997). Die Bildung von 1-O-Acylrhamnosiden und anderen Metaboliten durch dirigierte Biosynthese mit Streptomyces griseoviridis (Tü 3634) und Untersuchung ihrer Biogenese. Cuvillier Verlag, Göttingen (ISBN 3-89588-940-7).

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