Forschungsschwerpunkte

• LCMS-Analytik
• Festphasenpeptidsynthese
• Peptid-Derivatisierung (SAR-Studien)
• Strukturaufklärung von Naturstoffen

Publikation

• Zipperer, A., Konnerth, M. C., Laux, C., Berscheid, A., Janek, D., Weidenmaier, C., Burian, M., Schilling, N. A., Slavetinsky, C., Marschal, M., Willmann, M., Kalbacher, H., Schittek, B., Brötz-Oesterhelt, H., Grond, S., Peschel, A. & Krismer, B. Human commensals producing a novel antibiotic impair pathogen colonization. Nature 535, 511-516, doi:10.1038/nature18634 (2016).

• Fuchs, K., Cardona Gloria, Y., Wolz, O. O., Herster, F., Sharma, L., Dillen, C. A., Täumer, C., Dickhöfer, S., Bittner, Z., Dang, T. M., Singh, A., Haischer, D., Schlöffel, M. A., Koymans, K. J., Sanmuganantham, T., Krach, M., Roger, T., Le Roy, D., Schilling, N. A., Frauhammer, F., Miller, L. S., Nürnberger, T., LeibundGut‐Landmann, S., Gust, A. A., Macek, B., Frank, M., Gouttefangeas, C., Dela Cruz, C. S., Hartl, D. & Weber, A. N. The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size. EMBO reports, doi:10.15252/embr.201846065 %J EMBO reports (2018).

• Krismer, B., Peschel, A., Grond, S., Zipperer, A., Konnerth, M. C., Janek, D., Kalbacher, H. & Schilling, N. A. Novel anti-infective compound. (2018).

• Schilling, N. A., Berscheid, A., Schumacher, J., Saur, J. S., Konnerth, M. C., Wirtz, S. N., Beltrán-Beleña, J. M., Zipperer, A., Krismer, B., Peschel, A., Kalbacher, H., Brötz-Oesterhelt, H., Steinem, C. & Grond, S. Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability. Angew. Chem. Int. Ed., doi:10.1002/anie.201901589.

• Schilling, N. A., Berscheid, A., Schumacher, J., Saur, J. S., Konnerth, M. C., Wirtz, S. N., Beltrán-Beleña, J. M., Zipperer, A., Krismer, B., Peschel, A., Kalbacher, H., Brötz-Oesterhelt, H., Steinem, C. & Grond, S. Synthetische Analoga zeigen die essentiellen Strukturmotive von Lugdunin und seinen Protonentransport. Angew. Chem., doi:10.1002/ange.201901589.

• Bitschar, K., Sauer, B., Focken, J., Dehmer, H., Moos, S., Konnerth, M., Schilling, N. A., Grond, S., Kalbacher, H., Kurschus, F. C., Götz, F., Krismer, B., Peschel, A. & Schittek, B. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat. Commun. 10, 2730, doi:10.1038/s41467-019-10646-7 (2019)

• Alexander, S., Sumbla, S., Hubert, K., Thomas, N., Christopher, W., Bettina, M. W.-B., Nadine, S., Ulrike, E. & Stefan, H. Synthesis of a novel curcumin derivative as potential imaging probe in Alzheimer’s disease imaging. Current Alzheimer Research 16, 1-1, doi:http://dx.doi.org/10.2174/1567205016666190816130516 (2019)

• Z. A. Bittner, X. Liu, S. Dickhoefer, H. Kalbacher, K. Bosch, L. Andreeva, A. Marcu, S. Stevanovic, M. Mangan, P. Duewell, M. Lovotti, F. Herster, M. W. Loeffler, S. Shankar, A. Tapia-Abellan, O. O. Wolz, N. A. Shilling, J. Kuemmerle-Deschner, S. Wagner, A. Delor, B. Grimbacher, H. Wu, E. Latz, A. N. Weber. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. bioRxiv 2019, 864702. doi: https://doi.org/10.1101/864702

• Angelika Jochim, Lea Adolf, Darya Belikova, Nadine Anna Schilling, Inda Setyawati, Denny Chin, Severien Meyers, Peter Verhamme, David E Heinrichs, Dirk J Slotboom, Simon Heilbronner. An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis. eLife 2020;9 :e57322 doi: 10.7554/eLife.57322

• Julian S. Saur, Sebastian N. Wirtz, Nadine A. Schilling, Bernhard Krismer, Andreas Peschel, and Stephanie Grond. Distinct Lugdunins from a New Efficient Synthesis and Broad Exploitation of Its MRSA-Antimicrobial Structure. J. Med. Chem. 2021, 64, 7, 4034–4058 https://doi.org/10.1021/acs.jmedchem.0c02170

• Zsófia Agnes Bittner,Xiao Liu,Maria Mateo Tortola,Ana Tapia-Abellán,Sangeetha Shankar,Liudmila Andreeva,Matthew Mangan,Marianne Spalinger,Hubert Kalbacher,Peter Düwell,Marta Lovotti,Karlotta Bosch,Sabine Dickhöfer,Ana Marcu,Stefan Stevanović,Franziska Herster,Yamel Cardona Gloria,Tzu-Hsuan Chang,Francesca Bork,Carsten L. Greve,Markus W. Löffler,Olaf-Oliver Wolz,Nadine A. Schilling,Jasmin B. Kümmerle-Deschner,Samuel Wagner,Anita Delor,Bodo Grimbacher,Oliver Hantschel,Michael Scharl,Hao Wu,Eicke Latz,Alexander N.R. Weber. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. J Exp Med (2021) 218 (11): e20201656. https://doi.org/10.1084/jem.20201656