Uni-Tübingen

Subproject C09: Kontrolle der vaskulären Musterbildung durch zelltypspezifische Depletion von miRNAs

Teilprojektleiter:

Dr. Sebastian Wolf
Universität Tübingen
ZMBP, Pflanzen Biochemie
Auf der Morgenstelle 32
72076 Tübingen
+49 7071 29 76669
Fax +49 7071 29 5226
sebastian.wolfspam prevention@zmbp.uni-tuebingen.de
 

Zusammenfassung:

Im Vaskulärgewebe kontrolliert ein miRNA-Gradient die Expression von HD-ZIP III Transkriptions-faktoren, welche das Zellschicksal bestimmen und die Zellproliferation räumlich beschränken. Wir zeigten, dass AGO10 für die Zelltypspezifikation und die Kontrolle der Zellteilungs-aktivität im Zentral-zylinder essentiell ist. Wir wollen aufklären, wie die AGO10-vermittelte Depletion von miRNA für die Entwicklung und eine angemessene Reaktion auf Umweltreize sorgt. Zudem wollen wir die zelltyp-spezifische Dekodierung des miR165/6-Gradienten entschlüsseln, um die Rolle der Abstammung und positionaler Signale für die Spezifikation des Zelltyps im Wurzelgefäßsystem zu verstehen.

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