Subproject C09: Control of vascular patterning through cell type-specific depletion of miRNAs
Principal Investigator:
Dr. Sebastian Wolf
University of Tuebingen
ZMBP, Plant Biochemistry
Auf der Morgenstelle 32
72076 Tübingen
+49 7071 29 76669
Fax +49 7071 29 5226
sebastian.wolf@zmbp.uni-tuebingen.de
Summary:
In the root vasculature, a gradient of miRNAs controls the abundance of HD-ZIP III transcription factors, which control cell fate and spatially restrict vascular cell proliferation to specific cells. We revealed that balancing of the miR165/6 gradient with an opposing gradient of AGO10 is required for normal cell type specification and the control of cell division activity in the stele. We will unravel how AGO10-mediated depletion of miRNA provides developmental robustness and shapes the responses to the environment. In addition, we will decipher the cell type-specific decoding of miR165/6 gradient to elucidate the role of cell lineage and positional signalling for cell type specification in the vasculature.