Subproject A07: Specificity of proteasome regulation by tail-anchored transcription factors
Principal Investigator:
Dr. Suayb Üstün
Universität Tübingen
ZMBP General Genetics
Auf der Morgenstelle 32
72076 Tübingen
+49 7071 29 73230
suayib.uestuen@zmbp.uni-tuebingen.de
Summary:
The proteasome is involved in plant defence and is therefore exploited by pathogens. We have shown that the transcription factors NAC53/78 (i) regulate proteotoxic stress during bacterial infection, are essential for plant defence, and are degraded by the proteasome. We aim to elucidate (i) which other target genes are regulated by NACs, (ii) by which factors NACs are posttranslationally regulated, (iii) how subcellular sorting of NACs functions, and (iv) how NACs specifically modulate target genes. This should decipher how NACs integrate different signals to balance the trade-off between proteasome regulation and defence.