Publications
2017
• Fitzgerald JC, Zimprich A, Carvajal Berrio DA, Schindler KM, Maurer B, Schulte C, Bus C, Hauser AK, Kübler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wüst R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Krüger R. 2017. Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease. Brain 140(9):2444-2459.
• Castaneda Vega S, Weinl C, Calaminus C, Wang L, Harant M, Ehrlichmann W, Thiele D, Kohlhofer U, Reischl G, Hempel JM, Ernemann U, Quintanilla Martinez L, Nordheim A, Pichler BJ. 2017. Characterization of a novel murine model for spontaneous hemorrhagic stroke using in vivo PET and MR multiparametric imaging. Neuroimage 155:245-256.
• Hermanns C, Hampl V, Holzer K, Aigner A, Penkava J, Frank N, Martin DE, Maier KC, Waldburger N, Roessler S, Goppelt-Struebe M, Akrap I, Thavamani A, Singer S, Nordheim A, Gudermann T, Muehlich S. 2017. The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma. Oncogene 36(24):3464-3476.
2016
• Akrap I, Thavamani A, Nordheim A. 2016. Vps4A-mediated tumor suppression upon exosome modulation? Ann Transl Med. 2016 May;4(9):180.
• Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, Kerama-Likoko C, Violette SM, Weinreb PH, Knox AJ, Laurent G, Parfrey H, Wolters PJ, Wallace W, Alberti S, Nordheim A, Jenkins G. 2015. Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression. J Biol Chem. 291(18):9540-53.
2015
• Denisova E, Heidenreich B, Nagore E, Rachakonda PS, Hosen I, Akrap I, Traves V, García-Casado Z, López-Guerrero JA, Requena C, Sanmartin O, Serra-Guillén C, Llombart B, Guillén C, Ferrando J, Gimeno E, Nordheim A, Hemminki K, Kumar R. 2015. Frequent DPH3 promoter mutations in skin cancers. Oncotarget 6(34):35922-30.
• Weinl C, Castaneda Vega S, Riehle H, Stritt C, Calaminus C, Wolburg H, Mauel S, Breithaupt A, Gruber AD, Wasylyk B, Olson EN, Adams RH, Pichler BJ, Nordheim A. 2015. Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke. Proc Natl Acad Sci U S A. 112(32):9914-9.
• Cavignac Y, Lieber D, Laib Sampaio K, Madlung J, Lamkemeyer T, Jahn G, Nordheim A, Sinzger C. 2015. The Cellular Proteins Grb2 and DDX3 Are Increased upon Human Cytomegalovirus Infection and Act in a Proviral Fashion. PLoS One 10(6):e013161.
• Anastasiadou S, Liebenehm S, Sinske D, Meyer zu Reckendorf C, Moepps B, Nordheim A, Knöll B. 2015. Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model. Glia 63(6):958-76.
• Ohrnberger S, Thavamani A, Braeuning A, Lipka DB, Kirilov M, Geffers R, Autenrieth SE, Römer M, Zell A, Bonin M, Schwarz M, Schütz G, Schirmacher P, Plass C, Longerich T, Nordheim A. 2015. Dysregulated serum response factor triggers formation of hepatocellular carcinoma. Hepatology 61(3):979-89.
2014
• Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A. 2014. Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae. PLoS One 9(9):e107048.
2013
• Stern, S., Haverkamp, S. Sinske, D., Tedeschi, A., Naumann, U., Di Giovanni, S., Kochanek, S., Nordheim, A.,</span><span style="text-indent: -36pt; "> and B. Knöll (2013) The transcription factor serum response factor (SRF) stimulates axon regeneration through cytoplasmic localization and cofilin interaction,
• Wuestefeld, T., Pesic, M., Rudalska, R., Dauch, D., Longerich, T., Kang, T. W., Yevsa, T., Heinzmann, F., Hoenicke, L., Hohmeyer, A., Potapova, A., Rittelmeier, I., Jarek, M., Geffers, R., Scharfe, M., Klawonn, F., Schirmacher, P., Malek, N. P., Ott, M., Nordheim, A., Vogel, A., Manns, M. P., and Zender, L. (2013) A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration, Cell 153, 389-401.
• Weinl, C., Riehle, H., Park, D., Stritt, C., Beck, S., Huber, G., Wolburg, H., Olson, E. N., Seeliger, M. W., Adams, R. H., and Nordheim, A. (2013) Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae, The Journal of Clinical Investigation 123, 2193-2206.
2012
• Franz-Wachtel, M., Eisler, S.A., Krug, K., Wahl, S., Carpy, A., Nordheim, A., Pfizenmaier, K., Hausser, A., and Macek, B. 2012. Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11:160-170.
• Sessler, N., Krug, K., Nordheim, A., Mordmuller, B., and Macek, B. 2012. Analysis of the Plasmodium falciparum proteasome using Blue Native PAGE and label-free quantitative mass spectrometry. Amino Acids.
2011
• Nahnsen, S., Bertsch, A., Rahnenfuhrer, J., Nordheim, A., and Kohlbacher, O. 2011. Probabilistic consensus scoring improves tandem mass spectrometry peptide identification. J Proteome Res 10:3332-3343.
•Tiffert, Y., Franz-Wachtel, M., Fladerer, C., Nordheim, A., Reuther, J., Wohlleben, W., and Mast, Y. 2011. Proteomic analysis of the GlnR-mediated response to nitrogen limitation in Streptomyces coelicolor M145. Appl Microbiol Biotechnol 89:1149-1159.
• Sandstrom, J., Heiduschka, P., Beck, S.C., Philippar, U., Seeliger, M.W., Schraermeyer, U., and Nordheim, A. 2011. Degeneration of the mouse retina upon dysregulated activity of serum response factor. Mol Vis 17:1110-1127.
2010
• Saleem, M., Lamkemeyer, T., Schutzenmeister, A., Madlung, J., Sakai, H., Piepho, H.P., Nordheim, A., and Hochholdinger, F. 2010. Specification of cortical parenchyma and stele of maize primary roots by asymmetric levels of auxin, cytokinin, and cytokinin-regulated proteins. Plant Physiol 152:4-18.
• Muthreich, N., Schutzenmeister, A., Schutz, W., Madlung, J., Krug, K., Nordheim, A., Piepho, H.P., and Hochholdinger, F. 2010. Regulation of the maize (Zea mays L.) embryo proteome by RTCS which controls seminal root initiation. Eur J Cell Biol 89:242-249.
• Olson, E.N., and Nordheim, A. 2010. Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol 11:353-365.
• Werth, D., Grassi, G., Konjer, N., Dapas, B., Farra, R., Giansante, C., Kandolf, R., Guarnieri, G., Nordheim, A., and Heidenreich, O. 2010. Proliferation of human primary vascular smooth muscle cells depends on serum response factor. Eur J Cell Biol 89:216-224.
• Costello, P., Nicolas, R., Willoughby, J., Wasylyk, B., Nordheim, A., and Treisman, R. 2010. Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development. J Immunol 185:1082-1092.
• Burbulla, L.F., Schelling, C., Kato, H., Rapaport, D., Woitalla, D., Schiesling, C., Schulte, C., Sharma, M., Illig, T., Bauer, P., et al. 2010. Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis. Hum Mol Genet 19:4437-4452.
• Liu, Y., von Behrens, I., Muthreich, N., Schutz, W., Nordheim, A., and Hochholdinger, F. 2010. Regulation of the pericycle proteome in maize (Zea mays L.) primary roots by RUM1 which is required for lateral root initiation. Eur J Cell Biol 89:236-241.
• Parkitna, J.R., Bilbao, A., Rieker, C., Engblom, D., Piechota, M., Nordheim, A., Spanagel, R., and Schutz, G. 2010. Loss of the serum response factor in the dopamine system leads to hyperactivity. FASEB J 24:2427-2435.
• Pasztor, L., Ziebandt, A.K., Nega, M., Schlag, M., Haase, S., Franz-Wachtel, M., Madlung, J., Nordheim, A., Heinrichs, D.E., and Gotz, F. 2010. Staphylococcal major autolysin (Atl) is involved in excretion of cytoplasmic proteins. J Biol Chem 285:36794-36803.
• Jung, S., Fladerer, C., Braendle, F., Madlung, J., Spring, O., and Nordheim, A. 2010. Identification of a novel Plasmopara halstedii elicitor protein combining de novo peptide sequencing algorithms and RACE-PCR. Proteome Sci 8:24.
• Borchert, N., Dieterich, C., Krug, K., Schutz, W., Jung, S., Nordheim, A., Sommer, R.J., and Macek, B. 2010. Proteogenomics of Pristionchus pacificus reveals distinct proteome structure of nematode models. Genome Res 20:837-846.
• Bertsch, A., Jung, S., Zerck, A., Pfeifer, N., Nahnsen, S., Henneges, C., Nordheim, A., and Kohlbacher, O. 2010. Optimal de novo design of MRM experiments for rapid assay development in targeted proteomics. J Proteome Res 9:2696-2704.
2009
• Saleem, M., Lamkemeyer, T., Schutzenmeister, A., Fladerer, C., Piepho, H.P., Nordheim, A., and Hochholdinger, F. 2009. Tissue specific control of the maize (Zea mays L.) embryo, cortical parenchyma, and stele proteomes by RUM1 which regulates seminal and lateral root initiation. J Proteome Res 8:2285-2297.
• Koegel, H., von Tobel, L., Schafer, M., Alberti, S., Kremmer, E., Mauch, C., Hohl, D., Wang, X.J., Beer, H.D., Bloch, W., et al. 2009. Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice. J Clin Invest 119:899-910.
• Walker, T., Wendel, H.P., Raabe, C., Wiechnik, P., Spranger, L., Heidenreich, O., Scheule, A.M., Nordheim, A., and Ziemer, G. 2009. Graft protection in bypass surgery: siRNA-mediated silencing of adhesion molecules. Oligonucleotides 19:15-21.
• Sprossmann, F., Pankert, P., Sausbier, U., Wirth, A., Zhou, X.B., Madlung, J., Zhao, H., Bucurenciu, I., Jakob, A., Lamkemeyer, T., et al. 2009. Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J 276:1680-1697.
• Stritt, C., Stern, S., Harting, K., Manke, T., Sinske, D., Schwarz, H., Vingron, M., Nordheim, A., and Knoll, B. 2009. Paracrine control of oligodendrocyte differentiation by SRF-directed neuronal gene expression. Nat Neurosci 12:418-427.
• Nentwich, O., Dingwell, K.S., Nordheim, A., and Smith, J.C. 2009. Downstream of FGF during mesoderm formation in Xenopus: the roles of Elk-1 and Egr-1. Dev Biol 336:313-326.
Knoll, B., and Nordheim, A. 2009. Functional versatility of transcription factors in the nervous system: the SRF paradigm. Trends Neurosci 32:432-442.
• Barjaktarovic, Z., Schutz, W., Madlung, J., Fladerer, C., Nordheim, A., and Hampp, R. 2009. Changes in the effective gravitational field strength affect the state of phosphorylation of stress-related proteins in callus cultures of Arabidopsis thaliana. J Exp Bot 60:779-789.
2008
• Niu, Z., Iyer, D., Conway, S.J., Martin, J.F., Ivey, K., Srivastava, D., Nordheim, A., and Schwartz, R.J. 2008. Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A 105:17824-17829.
• Hoecker, N., Lamkemeyer, T., Sarholz, B., Paschold, A., Fladerer, C., Madlung, J., Wurster, K., Stahl, M., Piepho, H.P., Nordheim, A., et al. 2008. Analysis of nonadditive protein accumulation in young primary roots of a maize (Zea mays L.) F(1)-hybrid compared to its parental inbred lines. Proteomics 8:3882-3894.
• Petit, M.M., Lindskog, H., Larsson, E., Wasteson, P., Athley, E., Breuer, S., Angstenberger, M., Hertfelder, D., Mattsson, E., Nordheim, A., et al. 2008. Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin. Circ Res 103:61-69.
• Hala, M., Cole, R., Synek, L., Drdova, E., Pecenkova, T., Nordheim, A., Lamkemeyer, T., Madlung, J., Hochholdinger, F., Fowler, J.E., et al. 2008. An exocyst complex functions in plant cell growth in Arabidopsis and tobacco. Plant Cell 20:1330-1345.
2007
• Angstenberger, M., Wegener, J.W., Pichler, B.J., Judenhofer, M.S., Feil, S., Alberti, S., Feil, R., and Nordheim, A. 2007. Severe intestinal obstruction on induced smooth muscle-specific ablation of the transcription factor SRF in adult mice. Gastroenterology 133:1948-1959.
• Knoll, B., Weinl, C., Nordheim, A., and Bonhoeffer, F. 2007. Stripe assay to examine axonal guidance and cell migration. Nat Protoc 2:1216-1224.
• Balabanov, S., Gontarewicz, A., Ziegler, P., Hartmann, U., Kammer, W., Copland, M., Brassat, U., Priemer, M., Hauber, I., Wilhelm, T., et al. 2007. Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach. Blood 109:1701-1711.
• Dembinsky, D., Woll, K., Saleem, M., Liu, Y., Fu, Y., Borsuk, L.A., Lamkemeyer, T., Fladerer, C., Madlung, J., Barbazuk, B., et al. 2007. Transcriptomic and proteomic analyses of pericycle cells of the maize primary root. Plant Physiol 145:575-588.
• Fleige, A., Alberti, S., Grobe, L., Frischmann, U., Geffers, R., Muller, W., Nordheim, A., and Schippers, A. 2007. Serum response factor contributes selectively to lymphocyte development. J Biol Chem 282:24320-24328.
• Lianguzova, M.S., Chuykin, I.A., Nordheim, A., and Pospelov, V.A. 2007. Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells. Cell Biol Int 31:330-337.
• Barjaktarovic, Z., Nordheim, A., Lamkemeyer, T., Fladerer, C., Madlung, J., and Hampp, R. 2007. Time-course of changes in amounts of specific proteins upon exposure to hyper-g, 2-D clinorotation, and 3-D random positioning of Arabidopsis cell cultures. J Exp Bot 58:4357-4363.
• Proikas-Cezanne, T., Ruckerbauer, S., Stierhof, Y.D., Berg, C., and Nordheim, A. 2007. Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy. FEBS Lett 581:3396-3404.
2006
• Proikas-Cezanne, T., Gaugel, A., Frickey, T., and Nordheim, A. 2006. Rab14 is part of the early endosomal clathrin-coated TGN microdomain. FEBS Lett 580:5241-5246.
• Zimmermann, U., Junker, H., Kramer, F., Balabanov, S., Kleist, B., Kammer, W., Nordheim, A., and Walther, R. 2006. Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue. Biol Chem 387:437-440.
• Resch, A., Leicht, S., Saric, M., Pasztor, L., Jakob, A., Gotz, F., and Nordheim, A. 2006. Comparative proteome analysis of Staphylococcus aureus biofilm and planktonic cells and correlation with transcriptome profiling. Proteomics 6:1867-1877.
• Mordmuller, B., Fendel, R., Kreidenweiss, A., Gille, C., Hurwitz, R., Metzger, W.G., Kun, J.F., Lamkemeyer, T., Nordheim, A., and Kremsner, P.G. 2006. Plasmodia express two threonine-peptidase complexes during asexual development. Mol Biochem Parasitol 148:79-85.
• Etkin, A., Alarcon, J.M., Weisberg, S.P., Touzani, K., Huang, Y.Y., Nordheim, A., and Kandel, E.R. 2006. A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 50:127-143.
• Sauer, M., Jakob, A., Nordheim, A., and Hochholdinger, F. 2006. Proteomic analysis of shoot-borne root initiation in maize (Zea mays L.). Proteomics 6:2530-2541.
• Knoll, B., Kretz, O., Fiedler, C., Alberti, S., Schutz, G., Frotscher, M., and Nordheim, A. 2006. Serum response factor controls neuronal circuit assembly in the hippocampus. Nat Neurosci 9:195-204.
• Lianguzova, M.S., Chuikin, I.A., Nordheim, A., and Pospelov, V.A. 2006. [PI3-kinase inhibitors LY294002 and wortmannin have different effects on proliferation of murine embryonic stem cells]. Tsitologiia 48:560-568.
• Liu, Y., Lamkemeyer, T., Jakob, A., Mi, G., Zhang, F., Nordheim, A., and Hochholdinger, F. 2006. Comparative proteome analyses of maize (Zea mays L.) primary roots prior to lateral root initiation reveal differential protein expression in the lateral root initiation mutant rum1. Proteomics 6:4300-4308.
• Ronnefarth, V.M., Erbacher, A.I., Lamkemeyer, T., Madlung, J., Nordheim, A., Rammensee, H.G., and Decker, P. 2006. TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus. J Immunol 177:7740-7749.
• Berg, C.P., Stein, G.M., Klein, R., Pascu, M., Berg, T., Kammer, W., Priemer, M., Nordheim, A., Schulze-Osthoff, K., Gregor, M., et al. 2006. Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients. Liver Int 26:846-855.
• Neubauer, H., Clare, S.E., Kurek, R., Fehm, T., Wallwiener, D., Sotlar, K., Nordheim, A., Wozny, W., Schwall, G.P., Poznanovic, S., et al. 2006. Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection. Electrophoresis 27:1840-1852.
2005
• Neugebauer, H., Herrmann, C., Kammer, W., Schwarz, G., Nordheim, A., and Braun, V. 2005. ExbBD-dependent transport of maltodextrins through the novel MalA protein across the outer membrane of Caulobacter crescentus. J Bacteriol 187:8300-8311.
• Alberti, S., Krause, S.M., Kretz, O., Philippar, U., Lemberger, T., Casanova, E., Wiebel, F.F., Schwarz, H., Frotscher, M., Schutz, G., et al. 2005. Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc Natl Acad Sci U S A 102:6148-6153.
• Junker, H., Spate, K., Suofu, Y., Walther, R., Schwarz, G., Kammer, W., Nordheim, A., Walker, L.C., Runge, U., Kessler, C., et al. 2005. Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy. Epilepsia 46:339-343.
• Li, S., Czubryt, M.P., McAnally, J., Bassel-Duby, R., Richardson, J.A., Wiebel, F.F., Nordheim, A., and Olson, E.N. 2005. Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A 102:1082-1087.
• Niu, Z., Yu, W., Zhang, S.X., Barron, M., Belaguli, N.S., Schneider, M.D., Parmacek, M., Nordheim, A., and Schwartz, R.J. 2005. Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem 280:32531-32538.
• Hennersdorf, F., Florian, S., Jakob, A., Baumgartner, K., Sonneck, K., Nordheim, A., Biedermann, T., Valent, P., and Buhring, H.J. 2005. Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. Cell Res 15:325-335.
2004
• Cesari, F., Brecht, S., Vintersten, K., Vuong, L.G., Hofmann, M., Klingel, K., Schnorr, J.J., Arsenian, S., Schild, H., Herdegen, T., et al. 2004. Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activation. Mol Cell Biol 24:294-305.
• Lautwein, A., Kraus, M., Reich, M., Burster, T., Brandenburg, J., Overkleeft, H.S., Schwarz, G., Kammer, W., Weber, E., Kalbacher, H., et al. 2004. Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner. J Leukoc Biol 75:844-855.
• Martinez, N., Drescher, B., Riehle, H., Cullmann, C., Vornlocher, H.P., Ganser, A., Heil, G., Nordheim, A., Krauter, J., and Heidenreich, O. 2004. The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells. BMC Cancer 4:44.
• Philippar, U., Schratt, G., Dieterich, C., Muller, J.M., Galgoczy, P., Engel, F.B., Keating, M.T., Gertler, F., Schule, R., Vingron, M., et al. 2004. The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Mol Cell 16:867-880.
• Proikas-Cezanne, T., Waddell, S., Gaugel, A., Frickey, T., Lupas, A., and Nordheim, A. 2004. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. Oncogene 23:9314-9325.
• Schratt, G., Philippar, U., Hockemeyer, D., Schwarz, H., Alberti, S., and Nordheim, A.2004. SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. EMBO J 23:1834-1844.
• Wang, Z., Wang, D.Z., Hockemeyer, D., McAnally, J., Nordheim, A., and Olson, E.N. 2004. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428:185-189.
• Riess, T., Andersson, S.G., Lupas, A., Schaller, M., Schafer, A., Kyme, P., Martin, J., Walzlein, J.H., Ehehalt, U., Lindroos, H., et al. 2004. Bartonella adhesin a mediates a proangiogenic host cell response. J Exp Med 200:1267-1278.
• Cesari, F., Rennekampff, V., Vintersten, K., Vuong, L.G., Seibler, J., Bode, J., Wiebel, F.F., and Nordheim, A. 2004. Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange. Genesis 38:87-92.