IFIB – Interfakultäres Institut für Biochemie


PubMed search for all articles by Robert Feil



Stehle D, Xu MZ, Schomber T, Hahn MG, Schweda F, Feil S, Kraehling JR, Eitner F, Patzak A, Sandner P, Feil R, Benardeau A. (2021). Novel sGC activators increase glomerular cGMP, induce vasodilation, and improve blood flow in the murine kidney. Br J Pharmacol, epub 7 Jun 2021. doi: 10.1111/bph.15586. [Abstract]

Schmidt H, Böttcher A, Gross T, Schmidtko A. (2021). cGMP signalling in dorsal root ganglia and the spinal cord: Various functions in development and adulthood. Br J Pharmacol, epub 3 May 2021. doi: 10.1111/bph.15514. (Review Article) [Abstract]

Feil R, Lehners M, Stehle D, Feil S. (2021). Visualising and understanding cGMP signals in the cardiovascular system. Br J Pharmacol, epub 20 Apr 2021. doi: 10.1111/bph.15500. (Review Article) [Abstract]

Tchernychev B, Li H, Lee SK, Gao X, Ramanarasimhaiah R, Liu G, Hall KC, Bernier SG, Jones JE, Feil S, Feil R, Buys ES, Graul RM, Frenette PS, Masferrer JL. (2021). Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease. Br J Pharmacol, epub 17 Apr 2021. doi: 10.1111/bph.15492. [Abstract]

Tikoo S, Jain R, Tomasetig F, On K, Martinez B, Heu C, Stehle D, Obeidy P, Guo D, Vincent JN, Cook AJL, Roediger B, Feil R, Whan RM, Weninger W. (2021). Amelanotic B16-F10 melanoma compatible with advanced 3-D imaging modalities. J Invest Dermatol, epub 4 Mar 2021. doi: 10.1016/j.jid.2021.01.025. [Abstract]

Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Köhl J, Gawaz M, Langer HF. (2021). The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun 12, 3352. doi: 10.1038/s41467-021-23499-w. [Abstract]

Krämer MS, Feil R, Schmidt H. (2021). Analysis of gene expression using lacZ reporter mouse lines. Methods Mol Biol 2224, 29-45. doi: 10.1007/978-1-0716-1008-4_2. (Methods Article) [Abstract]

Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, Weigert A, Laban H, Salinas G, Stingl H, Günther L, Popp R, Hu J, Vanhollebeke B, Schmidt H, Acker-Palmer A, Renné T, Fleming I, Benz PM. (2021). EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep 22, e48961. doi: 10.15252/embr.201948961. [Abstract]

Dumoulin A, Schmidt H, Rathjen FG. (2021). Sensory Neurons: The formation of T-shaped branches is dependent on a cGMP-dependent signaling cascade. Neuroscientist 27, 47. (Review Article) [Abstract]


Lauffer P., Miranda-Laferte E., van Duyvenvoorde H.A., van Haeringen A., Werner F., Boudin E., Schmidt H., Mueller T.D., Kuhn M., van der Kaay D.C.M. (2020). An activating deletion variant in the sub-membrane region of natriuretic peptide receptor-B causes tall stature. J Clin Endocrinol Metab 105, 2354. [Abstract]

Marchetta P., Möhrle D., Eckert P., Reimann K., Wolter S., Tolone A., Lang I., Wolters M., Feil R., Engel J., Paquet-Durand F., Kuhn M., Knipper M., Rüttiger L. (2020). Guanylyl cyclase A/cGMP signaling slows hidden, age- and acoustic trauma-induced hearing loss. Front Aging Neurosci 12, 83. [Abstract]


Shvedova M., Litvak M.M., Roberts J.D. Jr, Fukumura D., Suzuki T., Şencan I., Li G., Reventun P., Buys E.S., Kim H.H., Sakadžić S., Ayata C., Huang P.L., Feil R., Atochin D.N (2019). cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. J Cereb Blood Flow Metab 39, 2379. [Abstract]

Schmidt H., Fritzsch B. (2019). Npr2 null mutants show initial overshooting followed by reduction of spiral ganglion axon projections combined with near-normal cochleotopic projection. Cell Tissue Res 378, 15.  [Abstract]


Wen L., Feil S., Wolters M., Thunemann M., Regler F., Schmidt K., Friebe A., Olbrich M., Langer H., Gawaz M., de Wit C., Feil R. (2018). A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis. Nat Commun 9, 4301. [Article] [News Article & Press Release]

Grundy L., Harrington A.M., Castro J., Garcia-Caraballo S., Deiteren A., Maddern J., Rychkov G.Y., Ge P., Peters S., Feil R., Miller P., Ghetti A., Hannig G., Kurtz C.B., Silos-Santiago I., Brierley S.M. (2018). Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction. JCI Insight 3, e121841. [Abstract]

Zalucki O., Harris L., Harvey T.J., Harkins D., Widagdo J., Oishi S., Matuzelski E., Yong X.L.H., Schmidt H., Anggono V., Burne T.H.J., Gronostajski R.M., Piper M. (2018). NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular-subventricular zone. Cereb Cortex 9, 3590. [Abstract]

Schmidt H., Dickey D.M., Dumoulin A., Octave M., Robinson J.W., Kühn R., Feil R., Potter L.R., Rathjen F.G. (2018). Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons. J Neurosci 38, 9768. [Abstract]

Franko A., Kovarova M., Feil S., Feil R., Wagner R., Heni M., Königsrainer A., Ruoß M., Nüssler A.K., Weigert C., Häring H.U., Lutz S.Z., Peter A. (2018). cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation. Metabolism 88, 32. [Abstract]

Wolter S., Möhrle D., Schmidt H., Pfeiffer S., Zelle D., Eckert P., Krämer M., Feil R., Pilz P.K.D., Knipper M., Rüttiger L. (2018). GC-B deficient mice with axon bifurcation loss exhibit compromised auditory processing. Front Neural Circuits 12, 65. [Abstract]

Peters S., Paolillo M., Mergia E., Koesling D., Kennel L., Schmidtko A., Russwurm M., Feil R. (2018). cGMP imaging in brain slices reveals brain region-specific activity of NO-sensitive guanylyl cyclases (NO-GCs) and NO-GC stimulators. Int J Mol Sci 19, E2313. [Abstract]

Paolillo M., Peters S., Schramm A., Schlossmann J., Feil R. (2018). Real-time imaging reveals augmentation of glutamate-induced Ca2+ transients by the NO-cGMP pathway in cerebellar granule neurons. Int J Mol Sci 19, E2185. [Abstract]

Lehners M., Dobrowinski H., Feil S., Feil R. (2018). cGMP signaling and vascular smooth muscle cell plasticity. J Cardiovasc Dev Dis 5, E20. (Review Article) [Abstract]

Tröster P., Haseleu J., Petersen J., Drees O., Schmidtko A., Schwaller F., Lewin G.R., Ter-Avetisyan G., Winter Y., Peters S., Feil S., Feil R., Rathjen F., Schmidt H. (2018). The absence of sensory axon bifurcation affects nociception and termination fields of afferents in the spinal cord. Front Mol Neurosci 11, 19. [Abstract]

Stroppel A.S., Paolillo M., Ziegler T., Feil R., Stafforst T. (2018). Npom-protected NONOate enables light-triggered NO/cGMP signalling in primary vascular smooth muscle cells. Chembiochem 19, 1312. [Abstract]

Subramanian H., Froese A., Jönsson P., Schmidt H., Gorelik J., Nikolaev V.O. (2018). Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP. Nat Commun 9, 2446. [Abstract]

Ter-Avetisyan G., Dumoulin A., Herrel A., Schmidt H., Strump J., Afzal S., Rathjen F.G. (2018). Loss of axon bifurcation in mesencephalic trigeminal neurons impairs the maximal biting force in Npr2-deficient mice. Front Cell Neurosci 12, 153. [Abstract]

Špiranec K., Chen W., Werner F., Nikolaev V.O., Naruke T., Koch F., Werner A., Eder-Negrin P., Diéguez-Hurtado R., Adams R.H., Baba H.A., Schmidt H., Schuh K., Skryabin B.V., Movahedi K., Schweda F., Kuhn M. (2018). Endothelial C-type natriuretic peptide acts on pericytes to regulate microcirculatory flow and blood pressure. Circulation 138, 494. [Abstract]

Dumoulin A., Ter-Avetisyan G., Schmidt H., Rathjen F.G. (2018). Molecular analysis of sensory axon branching unraveled a cGMP-dependent signaling cascade. Int J Mol Sci 19, E1266. (Review Article) [Abstract]


Shuhaibar L.C., Robinson J.W., Vigone G., Shuhaibar N.P., Egbert J.R., Baena V., Uliasz T.F., Kaback D., Yee S.P., Feil R., Fisher M.C., Dealy C.N., Potter L.R., Jaffe L.A. (2017). Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor. Elife 6, e31343. [Abstract]

Wen L., Feil S., Feil R. (2017). cGMP signaling in platelets. In: Zirlik, A., Bode C., Gawaz M. (eds) Platelets, Haemostasis and Inflammation. Cardiac and Vascular Biology. Springer, Cham. [Abstract]

Thunemann M., Schörg B.F., Feil S., Lin Y., Voelkl J., Golla M., Vachaviolos A., Kohlhofer U., Quintanilla-Martinez L., Olbrich M., Ehrlichmann W., Reischl G., Griessinger C.M., Langer H.F., Gawaz M., Lang F., Schäfers M., Kneilling M., Pichler B.J., Feil R. (2017). Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography. Nat Commun 8, 444. [Abstract] [Article] [News Article & Press Release]

Möhrle D., Reimann K., Wolter S., Wolters M., Varakina K., Mergia E., Eichert N., Geisler H.S., Sandner P., Ruth P., Friebe A., Feil R., Zimmermann U., Koesling D., Knipper M., Rüttiger L. (2017). NO-sensitive guanylate cyclase isoforms NO-GC1 and NO-GC2 contribute to noise-induced inner hair cell synaptopathy. Mol Pharmacol 92, 375. [Abstract]

Donzelli S., Goetz M., Schmidt K., Wolters M., Stathopoulou K., Diering S., Prysyazhna O., Polat V., Scotcher J., Dees C., Subramanian H., Butt E., Kamynina A., Schobesberger S., King S.B., Nikolaev V.O., de Wit C., Leichert L.I., Feil R., Eaton P., Cuello F. (2017). Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity. Sci Rep 7, 9938. [Abstract]

Füger P., Hefendehl J.K., Veeraraghavalu K., Wendeln A.C., Schlosser C., Obermüller U., Wegenast-Braun B.M., Neher J.J., Martus P., Kohsaka S., Thunemann M., Feil R., Sisodia S.S., Skodras A., Jucker M. (2017). Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nat Neurosci 20, 1371. [Abstract]

Qin X., Liu S., Lu Q., Zhang M., Jiang X., Hu S., Li J., Zhang C., Gao J., Zhu M.S., Feil R., Li H., Chen M., Weinstein L.S., Zhang Y., Zhang W. (2017). Heterotrimeric G stimulatory protein α subunit is required for intestinal smooth muscle contraction in mice. Gastroenterology 152, 1114. [Abstract]

Straubinger J., Boldt K., Kuret A., Deng L., Krattenmacher D., Bork N., Desch M., Feil R., Feil S., Nemer M., Ueffing M., Ruth P., Just S., Lukowski R. (2017). Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts. FASEB J 31, 1620. [Abstract]

Robinson J.W., Egbert J.R., Davydova J., Schmidt H., Jaffe L.A., Potter L.R. (2017). Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B. Cell Signal 40, 222. [Abstract]


Schmidt H., Peters S., Frank K., Wen L., Feil R., Rathjen F.G. (2016). DRG axon bifurcation tolerates increased cGMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3. Eur J Neurosci 44, 2991. [Abstract]

Feil R. (2016). Viagra releases the brakes on melanoma growth. Mol Cell Oncol 4, e1188874. (Editorial) [Abstract] [Article]

Dhayade S., Kaesler S., Sinnberg T., Dobrowinski H., Peters S., Naumann U., Liu H., Hunger R.E., Thunemann M., Biedermann T., Schittek B., Simon H.-U., Feil S., Feil R. (2016). Sildenafil potentiates a cGMP-dependent pathway to promote melanoma growth. Cell Reports 14, 2599. [Abstract] [Article] [Editorial on this Article] [News Article & Press Release]


Vogel S., Bodenstein R., Chen Q., Feil S., Feil R., Rheinlaender J., Schäffer T., Bohn E., Frick J.S., Borst O., Münzer P., Walker B., Markel J., Csanyi G., Pagano P.J, Loughran P., Jessup M.E., Watkins SC., Bullock G.C., Sperry J.L., Zuckerbraun B.S., Billiar T.R., Lotze M.T., Gawaz M., Neal M.D. (2015). Platelet-derived HMGB1 is a critical mediator for thrombosis. J Clin Invest 125, 4638. [Abstract]

Shuhaibar L.C., Egbert J.R., Norris R.P., Lampe P.D., Nikolaev V.O., Thunemann M., Wen L., Feil R., Jaffe L.A. (2015). Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc Natl Acad Sci U S A 112, 5527. [Abstract]


Thunemann M., Schmidt K., de Wit C., Han X., Jain R.K., Fukumura D., Feil R. (2014). Correlative intravital imaging of cGMP signals and vasodilation in mice. Front Physiol 5, 394. (Methods Article) [Abstract] [Article]

Feil S., Fehrenbacher B., Lukowski R., Essmann F., Schulze-Osthoff K., Schaller M., Feil R. (2014). Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ Res 115, 662. [Abstract] [Article] [Editorial on this Article] [News Article] [Press Release]

Feil S., Krauss J., Thunemann M., Feil R. (2014). Genetic inducible fate mapping in adult mice using tamoxifen-dependent cre recombinases. Methods Mol Biol 1194, 113. (Methods Article) [Abstract]

Kröner C., Thunemann M., Vollmer S., Kinzer M., Feil R., Richert C. (2014). Endless: A purine-binding RNA motif that can be expressed in cells. Angew Chem Int Ed Engl 53, 9198. [Abstract] [News Article] [Press Release]

Samanta A., Thunemann M., Feil R., Stafforst T. (2014). Upon the photostability of 8-nitro-cGMP and its caging as a 7-dimethylaminocoumarinyl ester. Chem Commun (Camb) 50, 7120. [Abstract]

Cooley B.C., Nevado J., Mellad J., Yang D., St Hilaire C., Negro A., Fang F., Chen G., San H., Walts A.D., Schwartzbeck R.L., Taylor B., Lanzer J.D., Wragg A., Elagha A., Beltran L.E., Berry C., Feil R., Virmani R., Ladich E., Kovacic J.C., Boehm M. (2014). TGF-beta signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med 6, 227ra234. [Abstract]

Vallur R., Kalbacher H., Feil R. (2014). Catalytic activity of cGMP-dependent protein kinase type I in intact cells is independent of N-terminal autophosphorylation. PLoS One 9, e98946. [Abstract]

Corradini E., Vallur R., Raaijmakers L.M., Feil S., Feil R., Heck A.J., Scholten A. (2014). Alterations in the cerebellar (phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse. Mol Cell Proteomics 13, 2004. [Abstract]

Dettling J., Franz C., Zimmermann U., Lee S.C., Bress A., Brandt N., Feil R., Pfister M., Engel J., Flamant F., Ruttiger L., Knipper M. (2014). Autonomous functions of murine thyroid hormone receptor TRalpha and TRbeta in cochlear hair cells. Mol Cell Endocrinol 382, 26. [Abstract]

Rahman A., Davis B., Lovdahl C., Hanumaiah V.T., Feil R., Brakebusch C., Arner A. (2014). The small GTPase Rac1 is required for smooth muscle contraction. J Physiol 592, 915. [Abstract]

Takenouchi K., Shrestha B., Yamakuchi M., Yoshinaga N., Arimura N., Kawaguchi H., Nagasato T., Feil R., Kawahara K., Sakamoto T., Maruyama I., Hashiguchi T. (2014). Upregulation of non-beta cell-derived vascular endothelial growth factor A increases small clusters of insulin-producing cells in the pancreas. Exp Clin Endocrinol Diabetes 122, 308. [Abstract]


Thunemann M.*, Wen L.*, Hillenbrand M., Vachaviolos A., Feil S., Ott T., Han X., Fukumura D., Jain R.K., Russwurm M., de Wit C., Feil R. (2013). Transgenic mice for cGMP imaging. Circ Res 113, 365. [*, contributed equally] [Abstract] [Article] [also featured "In This Issue"] [News Article]
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Thunemann, M., N. Formin, C. Krawutschke, M. Russwurm, Feil R. (2013). Visualization of cGMP with cGi biosensors. Methods Mol Biol 1020, 89. (Methods Article) [Abstract]

Turlo K., Scapa J., Bagher P., Jones A., Feil R., Korthuis R., Segal S., Iruela-Arispe L. (2013). Beta1 integrin is essential for vasoregulation and smooth muscle cell survival in vivo. Arterioscler Thromb Vasc Biol 33, 2325. [Abstract]

Chen W., Oberwinkler H., Werner F., Gaßner B., Nakagawa H., Feil R., Hofmann F., Schlossmann J., Dietrich A., Gudermann T., Nishida M., Del Galdo S., Wieland T., Kuhn M. (2013). ANP-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6. Arterioscler Thromb Vasc Biol 33, 2121. [Abstract]

Klein S., Seidler B., Kettenberger A., Sibaev A., Rohn M., Feil R., Allescher H.-D., Vanderwinden J.-M., Hofmann F., Schemann M., Rad R., Storr M.A., Schmid R.M., Schneider G., Saur D. (2013). Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun 4, 1630. [Abstract]

Galmiche G., Labat C., Mericskay M., Ait Aissa K., Blanc J., Retailleau K., Bourhim M., Coletti D., Loufrani L., Gao-Li J., Feil R., Challande P., Henrion D., Decaux J.-F., Regnault V., Lacolley P., Li Z. (2013). Inactivation of serum response factor contributes to decrease vascular muscular tone and arterial stiffness in mice. Circ Res 112, 1035. [Abstract]

Retailleau K., Toutain B., Galmiche G., Fassot C., Sharif-Naeini R., Kauffenstein G., Mericskay M., Duprat F., Grimaud L., Merot J., Lardeux A., Pizard A., Baudrie V., Jeunemaitre X., Feil R., Göthert J.R., Lacolley P., Henrion D., Li Z., Loufrani L. (2013). Selective involvement of serum response factor in pressure-induced myogenic tone in resistance arteries. Arterioscler Thromb Vasc Biol 33, 339. [Abstract]

Welter H., Kampfer C., Lauf S., Feil R., Schwarzer J.U., Kohn F.M., Mayerhofer A. (2013). Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. Andrology 1, 318.[Abstract]

Frantz S., Klaiber M., Baba H.A., Oberwinkler H., Völker K., Gaßner B., Bayer B., Abeßer M., Schuh K., Feil R., Hofmann F., Kuhn M. (2013). Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I. Eur Heart J 34, 1233. [Abstract] [Editorial on this article]


Jaumann M., Dettling J., Gubelt M., Zimmermann U., Gerling A., Paquet-Durand F., Feil S., Wolpert S., Franz C., Varakina K., Xiong H., Brandt N., Kuhn S., Geisler H., Rohbock K., Ruth P., Schlossmann J., Hütter J., Sandner P., Feil R., Engel J., Knipper M., Rüttiger L. (2012). cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med 18, 2529. [Abstract]

Bucci M., Papapetropoulos A., Vellecco V., Zhou Z., Zaid A., Giannogonas P., Cantalupo A., Dhayade S., Karalis K.P., Wang R., Feil R., Cirino G. (2012). cGMP-dependent protein kinase contributes to hydrogen sulphide-stimulated vasorelaxation. PLoS ONE 7, e53319. [Abstract]

Nistri S., Di Cesare Mannelli L., Mazzetti L., Feil R., Bani D., Failli P. (2012). Restoring nitric oxide cytosolic calcium regulation by cyclic guanosine monophosphate protein kinase I alpha transfection in coronary endothelial cells of spontaneously hypertensive rats. J Vasc Res 49, 221. [Abstract]

Müller P.M., Gnügge R., Dhayade S., Thunemann M., Krippeit-Drews P., Drews G., Feil R. (2012). H(2)O(2) lowers the cytosolic Ca(2+) concentration via activation of cGMP-dependent protein kinase Iα. Free Radic Biol Med 53, 1574. [Abstract]

Luo C., Gangadharan V., Bali K., Xie R., Agarwal N., Kurejova M., Tappe-Theodor A., Tegeder I., Feil S., Lewin G., Polgar E., Todd A.J., Schlossmann J., Hofmann F., Liu D., Hu S., Feil R., Kuner T., Kuner R. (2012). Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. PLoS Biol 10, e1001283. [Abstract]


Lutz S.Z., Hennige A.M., Feil S., Peter A., Gerling A., Machann J., Kröber S.M., Rath M., Schürmann A., Weigert C., Häring H.U., Feil R. (2011). Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia. Diabetes 60, 1566. [Abstract]

Fenske S., Mader R., Scharr A., Paparizos C., Cao-Ehlker X., Michalakis S., Shaltiel L., Weidinger M., Stieber J., Feil S., Feil R., Hofmann F., Wahl-Schott C., Biel M. (2011). HCN3 contributes to the ventricular action potential waveform in the murine heart. Circ Res 109, 1015. [Abstract]

Ghoreschi K., Brück J., Kellerer C., Deng C., Peng H., Rothfuss O., Hussain R.Z., Gocke A.R., Respa A., Glocova I., Valtcheva N., Alexander E., Feil S., Feil R., Schulze-Osthoff K., Rupec R.A., Lovett-Racke A.E., Dringen R., Racke M.K., Röcken M. (2011). Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 208, 2291. [Abstract]

Marshall C., Krofft R., Blonski M., Kowalewska, J. Logar C., Pippin J., Kim F., Feil R., Alpers C., Shankland S. (2011). The role of smooth muscle protein SM22α in glomerular epithelial cell injury. Am J Physiol Renal Physiol 300, F1026. [Abstract]

Klaiber M., Dankworth B., Kruse M., Hartmann M., Nikolaev V.O., Yang R., Völker K., Gaßner B., Oberwinkler H., Feil R., Freichel M., Groschner K., Skryabin B.V., Frantz S., Birnbaumer L., Pongs O., Kuhn M. (2011). A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proc Natl Acad Sci U S A 108, 18500. [Abstract]

1992-2010 (selected articles)

Klaiber M., Kruse M., Völker K., Schröter J., Feil R., Freichel M., Gerling A., Feil S., Dietrich A., Camacho Londono J.E., Baba H.A., Abramowitz J., Birnbaumer L., Penninger J.M., Pongs O., Kuhn M. (2010). Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol 105, 583. [Abstract]

Desch, M., Sigl K., Hieke B., Salb K., Kees F., Bernhard D., Jochim A., Spiessberger B., Höcherl K., Feil R., Feil S., Lukowski R., Wegener J.W., Hofmann F., Schlossmann J. (2010). IRAG determines NO- and ANP-mediated smooth muscle relaxation. Cardiovasc Res 86, 496. [Abstract]

Tedeschi A., Nguyen T., Steele S., Feil S., Naumann U., Feil R., Di Giovanni S. (2009). The tumour suppressor p53 transcriptionally regulates cGKI expression during neuronal maturation and is required for cGMP-dependent growth cone collapse. J Neurosci 29, 15155. [Abstract]

Feil R., Hölter S.M., Weindl K., Wurst W., Langmesser S., Gerling A., Feil S., Albrecht U. (2009). cGMP-dependent protein kinase I, the circadian clock, sleep, and learning. Commun Integr Biol 2, 298. [Abstract]

Di Cesare Mannelli, L., Nistri S., Mazzetti L., Bani D., Feil R., Failli P. (2009). Altered nitric oxide calcium responsiveness of aortic smooth muscle cells in spontaneously hypertensive rats depends on low expression of cyclic guanosine monophosphate-dependent protein kinase type I. J Hypertens 27, 1258. [Abstract]

Aicher A., Heeschen C., Feil S., Hofmann F., Mendelsohn M.E., Feil R., Dimmeler S. (2009). cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis. PLoS ONE 4, e4879. [Abstract]

Langmesser S., Franken P., Feil S., Emmenegger Y., Albrecht U., Feil R. (2009). cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness. PLoS ONE 4, e4238. [Abstract]

Zhao Z., Wang Z., Gu Y., Feil R., Hofmann F., Ma L. (2009). Regulate axon branching by the cyclic GMP pathway via inhibition of glycogen synthase kinase 3 in dorsal root ganglion sensory neurons. J Neurosci 29, 1350. [Abstract]

Valtcheva N., Nestorov P., Beck A., Russwurm M., Hillenbrand M., Weinmeister P., Feil R. (2009). The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J Biol Chem 284, 556. [Abstract]

Feil S., Valtcheva N., Feil R. (2009). Inducible Cre mice. In Gene Knockout Protocols, Second Edition, eds. R. Kühn, W. Wurst, Springer-Verlag, Methods Mol Biol 530, 343. (Methods Article) [Abstract]

Kleppisch T., Feil R. (2009). cGMP signalling in the mammalian brain: role in synaptic plasticity and behaviour. In cGMP: Generators, Effectors and Therapeutic Implications, eds. H. Schmidt, F. Hofmann, J.P. Stasch, Springer-Verlag, Handb Exp Pharmacol 191, 549. (Review Article) [Abstract]

Weinmeister P., Lukowski R., Linder S., Traidl-Hoffmann C., Hengst L., Hofmann F., Feil R. (2008). cGMP-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells. Mol Biol Cell 19, 4434. [Abstract]

He W.Q., Peng Y.J., Zhang W.C., Lv N. , Tang J., Chen C., Zhang C.H., Gao S., Chen H.Q., Zhi G., Feil R., Kamm K.E., Stull J.T., Gao X., Zhu M.S. (2008). Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology 135, 610. [Abstract]

Jawien J., Bian Z., Sheikine Y., Oloffson P.S., Pang Y., Edholm T., Dou Y., Metzger D., Hellström P.M., Feil R., Hansson G.K. (2008). Abrogation of mitochondrial transcription in smooth muscle cells impairs smooth muscle contractility and vascular tone. J Physiol Pharamacol 59, 239. [Abstract]

Hoesl E., Stieber J., Herrmann S., Feil S., Tybl E., Hofmann F., Feil R., Ludwig A. (2008). Tamoxifen-inducible gene deletion in the cardiac conduction system. J Mol Cell Cardiol 45, 62. [Abstract]

Lukowski R., Weinmeister P., Bernhard D., Feil S., Gotthardt M., Herz J., Massberg S., Zernecke A., Weber C., Hofmann F., Feil R. (2008). Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis. Arterioscler Thromb Vasc Biol 28, 1244. [Abstract] [Editorial on this article]

Föller M., Feil S., Ghoreschi K., Koka S., Gerling A., Thunemann M., Hofmann F., Schuler B., Vogel J., Pichler B., Kasinathan R.S., Nicolay J.P., Huber S.M., Lang F., Feil R. (2008). Anemia and splenomegaly in cGKI-deficient mice. Proc Natl Acad Sci U S A 105, 6771. [Abstract] ["In This Issue"]

Katajisto P., Vaahtomeri K., Ekman N., Ventelä E., Ristimäki A., Bardeesy N., Feil R., DePinho R.A., Mäkelä T.P. (2008). LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet 40, 455. [Abstract]

Kemp-Harper B., Feil R. (2008). Meeting report: cGMP matters. Sci Signal 1, pe12. (Review Article) [Abstract]

Feil R., Kleppisch T. (2008). NO/cGMP-dependent modulation of synaptic transmission. In Pharmacology of Neurotransmitter Release, eds. T. Südhof and K. Starke, Springer-Verlag, Handb Exp Pharmacol 184, 529. (Review Article) [Abstract]

Weber S., Bernhard D., Lukowski R., Weinmeister P., Wörner R., Wegener J.W., Valtcheva N., Feil S., Schlossmann J., Hofmann F., Feil R. (2007). Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. Circ Res 101, 1096. [Abstract] [Editorial on this article]

Schmidt H., Stonkute A., Jüttner R., Schäffer S., Buttgereit J., Feil R., Hofmann F., Rathjen F.G. (2007). The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol 179, 331. [Abstract]

Angstenberger M., Wegener J.W., Pichler B.J., Judenhofer M.S., Feil S., Alberti S., Feil R., Nordheim A. (2007). Severe intestinal obstruction on induced smooth muscle-specific ablation of the transcription factor SRF in adult mice. Gastroenterology 133, 1948. [Abstract] [Editorial on this article]

Mericskay M., Blanc J., Tritsch E., Moriez R., Aubert P., Neunlist M., Feil R., Li Z.(2007). Inducible mouse model of chronic intestinal pseudo-obstruction by smooth muscle-specific inactivation of the SRF gene. Gastroenterology 133, 1960. [Abstract] [Editorial on this article]

Feil R. (2007). Conditional somatic mutagenesis in the mouse using site-specific recombinases. In Conditional Mutagenesis: An Approach to Disease Models, eds. R. Feil and D. Metzger, Springer-Verlag, Handb Exp Pharmacol 178, 3. (Review Article) [Abstract]

Fiedler B., Feil R., Hofmann F., Willenbockel C., Drexler H., Smolenski A., Lohmann S.M., Wollert K.C. (2006). cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase-apoptosis signaling in cardiac myocytes. J Biol Chem 281, 32831. [Abstract]

Wegener J.W., Schulla V., Koller A., Klugbauer N., Feil R., Hofmann F. (2006 ). Control of intestinal motility by the Cav1.2 L-type calcium channel in mice. FASEB J 20, 1260. [Abstract]

Feil R., Kemp-Harper B. (2006). cGMP signalling: from bench to bedside. EMBO Rep 7, 149. (Review Article) [Abstract]

Hofmann F., Feil R., Kleppisch T., Schlossmann J. (2006). Function of cGMP-dependent protein kinases as revealed by gene deletion. Physiol Rev 86, 1. (Review Article) [Abstract]

Feil, S., Zimmermann P., Knorn A., Brummer S., Schlossmann J., Hofmann F., Feil R. (2005). Distribution of cyclic GMP-dependent protein kinase type I and its isoforms in the mouse brain and retina. Neuroscience 135, 863. [Abstract]

Lukowski R., Weber S., Weinmeister P., Feil S., Feil R. (2005). Cre/loxP-vermittelte konditionale Mutagenese des cGMP-Signalwegs in der Maus. Biospektrum 3/05, 287. (Review Article) [Article]

Feil R., Feil S., Hofmann F. (2005). A heretical view on the role of NO and cGMP in vascular proliferative diseases. Trends Mol Med 11, 71. (Review Article) [Abstract]

Koeppen M., Feil R., Siegl D., Feil S., Hofmann F., Pohl U., de Wit C. (2004). cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo. Hypertension 44: 952. [Abstract]

Feil S., Hofmann F., Feil R. (2004). SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis. Circ Res 94, 863. [Abstract]

Feil R., Hartmann J., Luo C., Wolfsgruber W., Schilling K., Feil S., Barski J.J., Meyer M., Konnerth A., De Zeeuw C.I., Hofmann F. (2003). Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. J Cell Biol 163, 295. [Abstract]

Wolfsgruber W., Feil S., Brummer S., Kuppinger O., Hofmann F., Feil R. (2003). A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells. Proc Natl Acad Sci USA 100, 13519. [Abstract]

Kleppisch T., Wolfsgruber W., Feil S., Allmann R., Wotjak C.T., Goebbels S., Nave K.A., Hofmann F., Feil R. (2003). Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory. J Neurosci 23, 6005. [Abstract]

Li Z., Xi X., Gu M., Feil R., Ye R.D., Eigenthaler M., Hofmann F., Du X. (2003). A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 112, 77. [Abstract]

Feil R., Lohmann S.M., de Jonge H., Walter U., Hofmann F. (2003). Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice. Circ Res, 93, 907. (Review Article) [Abstract]

Schmidt H., Werner M., Heppenstall P.A., Henning M., More M.I., Kuhbandner S., Lewin G.R., Hofmann F., Feil R., Rathjen F.G. (2002). cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. J Cell Biol 159, 489. [Abstract]

Feil R., Gappa N., Rutz M., Schlossmann J., Rose C.R., Konnerth A., Brummer S., Kuhbandner S., Hofmann F. (2002). Functional reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms. Circ Res 90, 1080. [Abstract]

Wegener J.W., Nawrath H., Wolfsgruber W., Kuhbandner S., Werner C., Hofmann F., Feil R. (2002). cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res 90, 18. [Abstract]

Kühbandner S., Brummer S., Metzger D., Chambon P., Hofmann F., Feil R. (2000). Temporally controlled somatic mutagenesis in smooth muscle. Genesis 28, 15. [Abstract]

Metzger D., Feil R. (1999). Engineering the mouse genome by site-specific recombination. Curr Opin Biotechnol 10, 470. (Review Article) [Abstract]

Feil R., Wagner J., Metzger D., Chambon P. (1997). Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun 237, 752. [Abstract]

Feil R., Brocard J., Mascrez B., LeMeur M., Metzger D., Chambon P. (1996). Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci USA 93, 10887. [Abstract]

Feil R., Kellermann J., Hofmann F. (1995). Functional cGMP-dependent protein kinase is phosphorylated in its catalytic domain at threonine-516. Biochemistry 34, 13152. [Abstract]

Feil R., Müller S., Hofmann F. (1993). High-level expression of functional cGMP-dependent protein kinase using the baculovirus system. FEBS Lett 336, 163. [Abstract]

Liebl W., Feil R., Gabelsberger J., Kellermann J., Schleifer K.H. (1992). Purification and characterization of a novel thermostable 4-alpha-glucanotransferase of Thermotoga maritima cloned in Escherichia coli. Eur J Biochem 207, 81. [Abstract]