The research of the IFIZ endeavours to advance our understanding of the molecular mechanisms that regulate human development and health and how diseases like cancers affect these mechanisms.
The knowledge of the underlying molecular mechanisms can then, in collaboration with clinicians, support the development of cures, e.g. against cancers.
The IFIZ has four research units: Molecular Biology, Immunology, Quantitative Proteomics, and Animal Genetics.
The research unit Molecular Biology investigates the molecular genetics of vertebrate (murine, human) organ development, organ function and pathologic organ dysfunction. Furthermore, the molecular mechanism of cellular autophagy in health and disease are investigated.
The major focus of the research unit Immunology is on Translational Immunology. Its spectrum of basic research covers T cell biology, antibodies, antigen presentation and innate immunity. The new findings and insights resulting from the research projects are invested into clinical applications that are carried out in close collaboration with the University Hospital.
The research unit Quantitative Proteomics led by Prof. Boris Macek performs active research in the areas of proteogenomics, phosphoproteomics, biological signal transduction and quantitative analysis of protein modifications.
The research unit Animal Genetics investigates the molecular mechanisms underlying organogenesis during Drosophila development. Research areas are the cell biology of gastrulation, the molecular biology of hematopoiesis, the molecular basis of cell migration, the developmental genetics of gut formation and the molecular mechanisms of cuticle differentiation.
The research unit Molecular Cell Biology uses the model organism yeast to investigate how cells ensure that their resources are allocated well, and that their physiology is regulated according to nutrient supply. Their favourite tools are live-cell imaging and mass spectrometry.