Neuronal constraints and self-organization

Subproject: Neuronal energetics

As any living structure, neurons require energy to process and transmit electrochemical signals. We investigate how interactions between energy availability and neuronal dynamics influences excitability and the associated neuronal response. As energetics is especially critical in neuronal disorders, we analyze the role of metabolic failure in epileptiform activity and Parkinson disease.

People involved:

Tanguy Fardet
Manos Giannakakis

Selected presentations and publications:

Tanguy Fardet, and Anna Levina. "Energy-based models to describe complex neuronal activities and metabolic constraints." BioRxiv (2020). Link: https://www.biorxiv.org/content/10.1101/2020.02.19.955898v1.abstract
Felix Effenberger, Juergen Jost, Anna Levina (2015). Self-organization in Balanced State Networks by STDP and Homeostatic Plasticity. PLoS Computational Biology, 11(9), 1–30. https://doi.org/10.1371/journal.pcbi.1004420

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