Publications

2013

Weber, T. 2013. In silico tools for the analysis of antibiotic biosynthetic pathways. Int. J. Med. Microbiol., in press.
Rückert, C., Szczepanowski, R., Albersmeier, A., Goesmann, A., Iftime, D., Musiol, E.M., Wohlleben, W., Pühler, A., Kalinowski, J., and Weber, T. (2013). Complete genome sequence of the kirromycin producer Streptomyces collinus Tü 365 consisting of a linear chromosome and two linear plasmids. J. Biotechnol., in press.
Kurth, F., Zeitler, K., Feldhahn, L., Neu, T.R., Weber, T., Kri, T.F.V., Wubet, T., Herrmann, S., Buscot, F., and Tarkka, M.T. (2013). Detection and quantification of a mycorrhization helper bacterium and a mycorrhizal fungus in plant-soil microcosms at different levels of complexity. BMC Microbiol. 13, 205. [Pubmed]
Musiol, E.M., Greule, A., Härtner, T., Kulik, A., Wohlleben, W., and Weber, T. 2013. The AT2 domain of KirCI loads malonyl extender units to the ACPs of the kirromycin PKS. ChemBioChem 14, 1343-1352. [Pubmed]
Blin, K., Medema, M.H., Kazempour, D., Fischbach, M., Breitling, R., Takano, E., and Weber, T. 2013. antiSMASH 2.0 – a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. 41:W204-W212 (Webserver Issue), doi: 10.1093/nar/gkt1449 [Pubmed] [Full Text @NAR]
Koryakina, I., McArthur, J., Randall, S., Draelos, M., Musiol, E.M., Muddiman, D.C., Weber, T., and Williams, G.J. 2012. Poly-specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases. ACS Chem. Biol. 8:200-208. doi:10.1021/cb3003489 [Pubmed]

2012

Weber, T., and Blin, K. 2012. CLUSEAN, Overview, in K.E. Nelson (ed.) Springer Encyclopedia of Metagenomics. DOI: 10.1007/SpringerReference_310542 2012-07-28 20:48:00 UTC [www.springerreference.com]
Wohlleben, W., Mast, Y., Muth, G., Röttgen, M., Stegmann, E., and Weber, T. 2012. Synthetic biology of secondary metabolite biosynthesis in actinomycetes: engineering precursor supply as a way to optimize antibiotic production. FEBS Lett. 586: 2171-2176. [Pubmed]
Musiol, E., Weber, T. 2012. Discrete acyltransferases involved in polyketide biosynthesis. MedChemComm. 8: 871-886
Vongsangnak W., Figueiredo L.F., Förster J., Weber T., Thykaer J., Stegmann E., Wohlleben W., Nielsen J. 2012. Genome-scale metabolic representation of Amycolatopsis balhimycina. Biotechnol. Bioeng. 109:1798-807. [Pubmed]

2011

Medema, M.H., Blin K., Cimermancic P., de Jager V., Zakrzewski P., Fischbach M.A., Weber T., Takano E., Breitling R. 2011. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucl Acids Res. 39, W339-W346, doi: 10.1093/nar/gkr466. [Pubmed]
Röttig, M., Medema, M.H. Blin, K., Weber, T., Rausch, C. and Kohlbacher, O. 2011. NRPSpredictor2 - a webserver for prediction NRPS adenylation domain specificity. Nucl. Acids. Res. 39, W362-367, doi:10.1093/nar/gkr323. [Pubmed]
Musiol, E.M., Härtner, T., Kulik, A. Moldenhauer J. Piel, J. Wohlleben, W. and Weber, T. Supramolecular templating in kirromycin Biosynthesis - the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans AT-PKS. Chem. Biol. 18:438-444 [Pubmed]
Pavlidou, M., Pross, E.K., Musiol, E.M., Kulik, A., Wohlleben, W., and Weber, T. 2011. The phosphopantetheinyl transferase KirP activates the ACPand PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tü 365. FEMS Microbiol. Lett. 319:26-33 [Pubmed]
Mast, Y., Weber, T., Gölz, M., Ort-Winkelbauer, R., Gondran, A., Wohlleben, W., and Schinko, E. 2011. Characterization of the "pristinamycin supercluster" of Streptomyces pristinaespiralis. Microbioal Biotechnology 4:192-206, doi: 10.1111/j.1751-7915.2010.00213.x [Pubmed] [Abstract]

2010

Weber, T. 2010. Making E. coli an Erythromycin Production Plant. Chem. Biol 17:1168-1169. [Pubmed]
Thykaer, J., Nielsen, J., Wohlleben, W., Weber, T., Gutknecht, M., Eliasson-Lantz, A., and Stegmann, E. 2010. Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster. Metb. Eng. 12:455-461. [Pubmed]
Lopez, P.^*, Hornung, A.^*, Welzel, K., Unsin, C., Wohlleben, W., Weber, T.⁺, and Pelzer, S.⁺ 2010. Isolation of the lysolipin gene cluster of Streptomyces tendae Tü 4042. Gene 461: 5-14. [Pubmed]
^* equal contribution // ⁺ shared senior authorship
Geib, N., T. Weber, T. Wörtz, K. Zerbe, W. Wohlleben, and J. A. Robinson. 2010. Genome mining in Amycolatopsis balhimycina for ferredoxins capable of supporting cytochrome P450 enzymes involved in glycopeptide antibiotic biosynthesis. FEMS Microbiol Lett 306:45-53. [Pubmed]
Weber, T. 2010. Antibiotics, Biosynthesis in: Flickinger, M.C. Encyclopedia of Industrial Biotechnology. John Wiley and Sons, Hoboken, NJ, USA. DOI: 10.1002/9780470054581.eib040
Gallo, G., Renzone, G., Alduina, R., Stegmann, E., Weber, T., Eliasson-Lantz, A., Thykaer, J., Sangiorgi, F., Scaloni, A., and Puglia, A. M. 2010. Differential Proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina. Proteomics 10:1336-1358. [Pubmed] [Full text article]
Weber, T., and W. Wohlleben. 2010. Wirkstoff-Forschung aktuell: Funktionelle Genomforschung zur Suche und Optimierung neuer Antibiotika. GenomXPress Scholae 1:35-38.

2009

Weber, T., and Wohlleben, W. 2009. Functional Genomics zur Suche und Optimierung neuer Wirkstoffe. GenomXpress 3.09: 11-13. [Online Article, german]
Laiple, K.J., Härtner, T., Fiedler, H.-P., Wohlleben, W., and Weber, T., 2009, The kirromycin gene cluster of Streptomyces collinus Tü 365 codes for an aspartate-alpha-decarboxylase, KirD, which is involved in the biosynthesis of the precursor beta-alanine. J. Antibiotics, 62:465-468. [Pubmed]
Weber, T., Rausch, C., Lopez, P., Hoof, I., Gaykova, V., Huson, D.H., and Wohlleben, W. 2009. CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters. J. Biotechnol. 140:13-17. [Medline] [Full text article]

2008

Butz, D., T. Schmiederer, B. Hadatsch, W. Wohlleben, T. Weber, and R. D. Süßmuth. 2008. Module Extension of a Non-Ribosomal Peptide Synthetase of the Glycopeptide Antibiotic Balhimycin Produced by Amycolatopsis balhimycina. ChemBioChem. 215:175-188. [PubMed][Full text article]
Weber, T., K. J. Laiple, E. K. Pross, A. Textor, S. Grond, K. Welzel, S. Pelzer, A. Vente, and W. Wohlleben. 2008. Molecular analysis of the kirromycin biosynthetic gene cluster revealed β-alanine as precursor of the pyridone moiety. ChemBiol. 15:175-188. [Medline][Full text article]

until 2007

Rausch, C., I. Hoof, T. Weber, W. Wohlleben and D.H. Huson. 2007. Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution. BMC Evolutionary Biology, 7:78. [Medline] [Full text article]
Rausch, C., T. Weber, O. Kohlbacher, W. Wohlleben, D. H. Huson. 2005. Specifity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using Transductive Support Vector Machines (TSVM). Nucl. Acid. Res., 33(18),5799-808. [Medline] [Full text article]
Donadio, S., M. Sosio, T. Weber, E. Stegmann, W. Wohlleben. 2005. Insights into the evolution of gene clusters for glycopeptide biosynthesis. Mol. Gen. Genet., 274(1):40-50. [Medline]
Weber, T., K. Welzel, K., S. Pelzer, A. Vente, W. Wohlleben. 2003. Exploiting the genetic potential of polyketide producing streptomycetes. J. Biotechnol. 106, 221-232. [Medline]
Vierling, S., T. Weber, W. Wohlleben, G. Muth. 2001. Evidence that an additional mutation is required to tolerate insertional inactivation of the Streptomyces lividans recA gene. J. Bacteriol. 183, 4374-4381. [Medline] [Full text article]
Vierling, S., T. Weber, W. Wohlleben, G. Muth. 2000. Transcriptional and Mutational Analysis of the Streptomyces lividans recX Gene and Its Interference with RecA Activity. J. Bacteriol. 182, 4005-4011. [Medline] [Full text article]