Interfakultäres Institut für Mikrobiologie und Infektionsmedizin

Curriculum vitae von Friedrich Götz

Bildung und Berufserfahrung

1968 - 1973 Studium der Biologie und Chemie an der Ludwig-Maximilians-Universität (LMU) München
1974 - 1978 Doktorand an der LMU München unter Prof. Dr. K. H. Schleifer in der Abteilung für Mikrobiologie
1978 Promotion
1985 Habilitation an der TU München über "Devolpment of a Host-Vector system in staphylococci"
1987 - 2015 Professor für Mikrobielle Genetik an der Universität Tübingen
2015 - Senior-Professor

Auszeichnungen / Ehrungen

1979/81 EMBO long term fellowship, Biomedical Center Uppsala
1989 DECHEMA award 1988 für die Entwicklung eines neuen Klonierungssystem in Staphylococcus carnosus
1991 DGHM Award 1990 für die wissenschaftliche Arbeit über die mikrobielle Genetik
2003 - 2009 Präsident und Vizepräsident der VAAM (Vereinigung für Allgemeine und Angewandte Mikrobiologie)
2011 - Mitglied der European Academy of Microbiology (EAM)

Projektmanagement, editoriale Arbeit und Beratung

2001 - 2010 Sprecher des Graduiertenkollegs 685 (DFG): Infection biology: human- and plant pathogenic bacteria and fungi
2006 - 2013 Koordinator der Tübinger Gruppe des Transregio SFB Greifswald Tübingen-Würzburg-Münster (TR34)

2000, 2004,

2008 - 2012

 Mitglied des DFG Panel 204 "Microbiology, Virology, and Immunology"
1992 - 2000 Editor FEMS Microbiology Letters
1993 - 1999 Editor Applied and Environmental Microbiology
2003 - 2006 Editor "Molecular Microbiology"
2004 - Editor "Medical Microbiology and Immunology"
2009 Mitbegründer des IMIT (Interfakultäres Institut für Mikrobiologie und Infektionsmedizin Tübingen (IMIT). Dies ist die Zusammenschließung der früher getrennten Mikrobiologischen Institute in der MathematischNaturwissenschaftliche Fakultät und dem Institut für Medizinische Mikrobiologie und Hygiene und der Medizinischen Fakultät. IMIT ist das erste Deutschland-weite Institut dieser Art. Es umfasst 7 Vollprofessuren und mehrere Assistenzprofessuren.
2011 Jodi Lindsay & Fritz Götz: Organisatoren der Gordon Research Conference "Staphylococcal Diseases" Il Ciocco, Italy
2011 Ralph Bertram & Fritz Götz: Organisatoren von "How dead is dead II" Tübingen
  • Reviewer für viele Journals
  • Berater für viele nationale und internationale Forschungsinstitute

Aktuelle Forschungsthemen

Physiologie der Staphylokokken und Rolle in der Infektion:

Biofilmbildung, 'small colony' Varianten, Ausschleusung zytoplasmatischer Proteine, Antibiotikaresistenz und Entwicklung neuer Antibiotika, Interaktion von Bakterien mit dem Immunsystem

Publikationen: > 360 peer reviewed Publikationen - h-Faktor 93

Citation indices All Since 2015
Citations 31400 10600
h-index 93 55
i10-index 292 211  (no. of citations with at least 10 citation)

https://scholar.google.com/citations?hl=en&user=uq_ofGsAAAAJ&view_op=list_works

Ehemalige Doktoranden und/oder Postdocs in der Wissenschaft:

Prof. Raja Biswas, Center for Nanoscience and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Kerala, India

Prof. Chih-Jung Chen, Department of Pediatric, Chang Gung Children’s Hospital, Taoyuan, Taiwan

Prof. Jiří Doškař, Genetics and Molecular Biology, Brno University of Technology, Czech Republic

Prof. Qiang Gao, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, China

PD Christine Heilmann, Medical Microbiology, University Münster, Germany

Prof. Wolfgang Liebl, Technical University München, Germany

Prof. Per-Eric Lindgren, Div. Microbiology and Infection, Linköping University, Sweden
Dr. Minh Thu Nguyen, Inst Med Mikrobiol, Univ Klinik Münster, Germany

Dr. Michael Otto, Director, Pathogen Molecular Genetics Section, NIH, Washington D.C. USA

Prof. Andreas Peschel, Infection Biology Department, University Tübingen, Germany

Prof. Waldemar Vollmer, Bacterial Biochemistry, Newcastle University, UK
Ass. Prof. Wenqi Yu, Department of Cell Biology, Microbiology and Molecular Biology (CMMB), University of South Florida

Ausgewählte Publikationen von 2015 – 2019

Wang H, Kraus F, Popella P, Baykal A, Guttroff C, Francois P, Sass P, Plietker B, Götz F. 2019. The Polycyclic Polyprenylated Acylphloroglucinol Antibiotic PPAP 23 Targets the Membrane and Iron Metabolism in Staphylococcus aureus. Front Microbiol 10:14.

Tribelli PM, Luqman A, Nguyen MT, Madlung J, Fan SH, Macek B, Sass P, Bitschar K, Schittek B, Kretschmer D, Götz F. 2019. Staphylococcus aureus Lpl protein triggers human host cell invasion via activation of Hsp90 receptor. Cell Microbiol doi:10.1111/cmi.13111:e13111.
Nguyen MT, Saising J, Tribelli PM, Nega M, Diene SM, Francois P, Schrenzel J, Sproer C, Bunk B, Ebner P, Hertlein T, Kumari N, Hartner T, Wistuba D, Voravuthikunchai SP, Mader U, Ohlsen K, Götz F. 2019. Inactivation of farR Causes High Rhodomyrtone Resistance and Increased Pathogenicity in Staphylococcus aureus. Front Microbiol 10:1157.
Mohammad M, Nguyen MT, Engdahl C, Na M, Jarneborn A, Hu Z, Karlsson A, Pullerits R, Ali A, Götz F, Jin T. 2019. The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus. PLoS Pathog 15:e1007877
Luqman A, Ebner P, Reichert S, Sass P, Kabagema-Bilan C, Heilmann C, Ruth P, Götz F. 2019. A new host cell internalisation pathway for SadA-expressing staphylococci triggered by excreted neurochemicals. Cell Microbiol doi:10.1111/cmi.13044:e13044.
Fan SH, Ebner P, Reichert S, Hertlein T, Zabel S, Lankapalli AK, Nieselt K, Ohlsen K, Götz F. 2019. MpsAB is important for Staphylococcus aureus virulence and growth at atmospheric CO2 levels. Nat Commun 10:3627
Saising J, Nguyen MT, Hartner T, Ebner P, Al Mamun Bhuyan A, Berscheid A, Muehlenkamp M, Schakermann S, Kumari N, Maier ME, Voravuthikunchai SP, Bandow J, Lang F, Brötz-Oesterhelt H, Götz F. 2018. Rhodomyrtone (Rom) is a membrane-active compound. Biochim Biophys Acta 1860:1114- 1124.
Reichert S, Ebner P, Bonetti EJ, Luqman A, Nega M, Schrenzel J, Sproer C, Bunk B, Overmann J, Sass P, Francois P, Götz F. 2018. Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus. Front Microbiol 9:1539.
Nguyen MT, Peisl L, Solari FB, Luqman A, Götz F. 2018. Toll-Like Receptor 2 and Lipoprotein-Like Lipoproteins Enhance Staphylococcus aureus Invasion in Epithelial Cells. Infect Immun 86.
Luqman A, Nega M, Nguyen MT, Ebner P, Götz F. 2018. SadA-Expressing Staphylococci in the Human Gut Show Increased Cell Adherence and Internalization. Cell Rep 22:535-545.
Ebner P, Reichert S, Luqman A, Krismer B, Popella P, Götz F. 2018. Lantibiotic production is a burden for the producing staphylococci. Sci Rep 8:7471.
Ebner P, Götz F. 2018. Bacterial Excretion of Cytoplasmic Proteins (ECP): Occurrence, Mechanism, and Function. Trends Microbiol doi:10.1016/j.tim.2018.10.006
Nguyen MT, Uebele J, Kumari N, Nakayama H, Peter L, Ticha O, Woischnig AK, Schmaler M, Khanna N, Dohmae N, Lee BL, Bekeredjian-Ding I, Götz F. 2017. Lipid moieties on lipoproteins of commensal and non-commensal staphylococci induce differential immune responses. Nat Commun 8:2246.
Guttroff C, Baykal A, Wang H, Popella P, Kraus F, Biber N, Krauss S, Götz F, Plietker B. 2017. Polycyclic Polyprenylated Acylphloroglucinols: An Emerging Class of Non-Peptide-Based MRSA- and VRE-Active Antibiotics. Angew Chem Int Ed Engl 56:DOI: 10.1002/anie.201707069.
Ebner P, Luqman A, Reichert S, Hauf K, Popella P, Forchhammer K, Otto M, Götz F. 2017. Nonclassical Protein Excretion Is Boosted by PSMalpha-Induced Cell Leakage. Cell Rep 20:1278-1286
Shahmirzadi SV, Nguyen MT, Götz F. 2016. Evaluation of Staphylococcus aureus Lipoproteins: Role in Nutritional Acquisition and Pathogenicity. Front Microbiol 7:1404.
Popella P, Krauss S, Ebner P, Nega M, Deibert J, Götz F. 2016. VraH Is the Third Component of the Staphylococcus aureus VraDEH System Involved in Gallidermin and Daptomycin Resistance and Pathogenicity. Antimicrob Agents Chemother 60:2391-401.
Nguyen MT, Hanzelmann D, Hartner T, Peschel A, Götz F. 2016. Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response. Infect Immun 84:205-15.
Nguyen MT, Götz F. 2016. Lipoproteins of Gram-Positive Bacteria: Key Players in the Immune Response and Virulence. Microbiol Mol Biol Rev 80:891-903.
Nguyen MT, Deplanche M, Nega M, Le Loir Y, Peisl L, Götz F, Berkova N. 2016. Staphylococcus aureus Lpl Lipoproteins Delay G2/M Phase Transition in HeLa Cells. Front Cell Infect Microbiol 6:201.
Mechler L, Bonetti EJ, Reichert S, Flötenmeyer M, Schrenzel J, Bertram R, Francois P, Götz F. 2016. Daptomycin Tolerance in the Staphylococcus aureus pitA6 Mutant Is Due to Upregulation of the dlt Operon. Antimicrob Agents Chemother 60:2684-91.
Ebner P, Rinker J, Nguyen MT, Popella P, Nega M, Luqman A, Schittek B, Di Marco M, Stevanovic S, Götz F. 2016. Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus. Infect Immun 84:1672-81.
Nguyen MT, Kraft B, Yu W, Demicrioglu DD, Hertlein T, Burian M, Schmaler M, Boller K, BekeredjianDing I, Ohlsen K, Schittek B, Götz F. 2015. The νSaα Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells. PLoS Pathog 11:e1004984.
Mayer S, Steffen W, Steuber J, Götz F. 2015. The Staphylococcus aureus NuoL-Like Protein MpsA Contributes to the Generation of Membrane Potential. J Bacteriol 197:794-806.
Ebner P, Prax M, Nega M, Koch I, Dube L, Yu W, Rinker J, Popella P, Flötenmeyer M, Götz F. 2015. Excretion of cytoplasmic proteins (ECP) in Staphylococcus aureus. Mol Microbiol 97:775-89.
Deplanche M, Filho RA, Alekseeva L, Ladier E, Jardin J, Henry G, Azevedo V, Miyoshi A, Beraud L, Laurent F, Lina G, Vandenesch F, Steghens JP, Le Loir Y, Otto M, Götz F, Berkova N. 2015. Phenolsoluble modulin alpha induce G2/M phase transition delay in eukaryotic HeLa cells. FASEB J pii: fj.14- 260513.