Interfakultäres Institut für Mikrobiologie und Infektionsmedizin

Publications

2018

  • Handayani I, Ratnakomala S, Lisdiyanti P, Fahrurrozi, Alanjary M, Wohlleben W, Mast Y (2018). Complete Genome Sequence of Streptomyces sp. Strain BSE7F, a Bali Mangrove Sediment Actinobacterium with Antimicrobial Activities. Genome Announc. Accepted (genomeA00618-18).

  • Osipenkov N, Kulik A, Mast Y (2018) Characterization of the phenylglycine aminotransferase PglE from Streptomyces pristinaespiralis. J Biotechnol. 278:34-38.

2017

  • Mast Y (2017) Kontrollierte Biosynthese eines synergistischen Wirkstoffpaares. In Biospektrum 23:594-596. Springer Nature, London, UK.

  • Wohlleben W, Bera, A, Mast Y, Stegmann E (2017) Regulation of secondary metabolites of actinobacteria. p.181-232. In J. Wink, F. Mohammadipanah, J. Hamedi (ed.), Biology and Biotechnology of Actinobacteria. Springer Nature, London, UK.

  • Meng J, Feng R, Zheng G, Ge M, Wohlleben W, Mast Y, Jiang W, Lu Y (2017) Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches. Synth Syst Biotechnol. 2: 130-136.

2016

  • Schmidt K, Schmidtke J, Mast Y, Waldvogel E, Wohlleben W, Klemke F, Lockau W, Hausmann T, Hühns M, Broer I (2017) Comparative statistical component analysis of transgenic, cyanophycin-producing potatoes in greenhouse and field trials. Transgenic Res. 26:529-539.

  • Wohlleben W, Mast Y, Stegmann E, Ziemert N (2016) Antibiotic Drug Discovery. Microb Biotechnol. 9:541-548.

2015

  • Medema MH, ...Mast Y, ...et al., (2015) Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 11:625-631.

  • Mast Y, Guezguez J, Handel F, Schinko E. (2015) Regulatory Aspects of Pristinamycin Biosynthesis in Streptomyces pristinaespiralis. Appl Environ Microbiol. 81:6621-6636.

2014

  • Michta E, Ding W, Shaochun Z, Blin K, Wang R, Wohlleben W, Mast Y. (2014) Proteomic approach to reveal the function of aconitase AcnA in oxidative stress response of Streptomyces viridochromogenes Tü494. PlosOne. 9:e87905.

  • Mast Y, Wohlleben W (2014) Streptogramins – Two are better than one! Int. J. Med. Microbiol. 304:44-50.

2013

  • Wang R, Zhu H, Zheng G, Mast Y, Yang S, Wohlleben W, Lu Y, Jiang W. (2013) Identification of two-component system AfsQ1/Q2 regulon and cross-regulation with GlnR in nitrogen metabolism in Streptomyces coelicolor. Mol. Microbiol. 87:30-48.

2012

  • Michta E, Schad K, Blin K, Ort-Winklbauer R, Röttig M, Kohlbacher O, Wohlleben W, Schinko E, Mast Y. (2012) The bifunctional role of aconitase in Streptomyces viridochromogenes Tü494. Environ. Microbiol. 14:3203-2319.

  • Wohlleben W, Mast Y, Muth G, Röttgen M, Stegmann E, Weber T. (2012) Synthetic Biology of Secondary Metabolite Biosynthesis in Actinomycetes: Engineering precursor supply as a way to optimize antibiotic production. FEBS Lett. 586:2171-2176.

  • Iqbal M, Mast Y, Amin R, Hodgson DA, The STREAM Consortium, Wohlleben W, Burroughs NJ. (2012) Extracting regulator activity profiles by integration of de novo motifs and expression data: characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor. Nucleic Acids Res. 40:5227-5239.

  • Amin R, Reuther J, Bera A, Wohlleben W, Mast Y. (2012) Novel GlnR-target gene nnaR is involved in nitrate/nitrite assimilation in Streptomyces coelicolor. Microbiology. 158:1172-1182.

2011

  • Waldvogel E, Herbig A, Battke F, Amin R, Nentwich M, Nieselt K, Ellingsen TE, Wentzel A, Hodgson DA, Wohlleben W, Mast Y. (2011) The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor. Appl Microbiol Biotechnol. 92:1219-1236.

  • Mast Y, Weber T, Gölz M, Ort-Winklbauer R, Gondran A, Wohlleben W, Schinko E. (2011) Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis. Microb Biotechnol. 4:192-206.

  • Tiffert Y, Franz-Wachtel M, Fladerer C, Nordheim A, Reuther J, Wohlleben W, Mast Y. (2011) Proteomic analysis of the GlnR-mediated response to nitrogen limitation in Streptomyces coelicolor M145. Appl Microbiol Biotechnol. 89:1149-1159.

  • Mast Y, Wohlleben W, Schinko E. (2011) Identification and functional characterization of phenylglycine biosynthetic genes involved in pristinamycin biosynthesis in Streptomyces pristinaespiralis. J Biotechnol. 155:63-67.

  • Wohlleben W, Mast Y, Reuther, J. (2011) Regulation of Nitrogen Assimilation in Streptomyces and other Actinobacteria. P.125-136. In P. Dyson (ed.), Streptomyces Molecular Biology and Biotechnology. Caister Academic Press, Norfolk, UK.

Others

  • Schinko E, Schad K, Eys S, Keller U, Wohlleben W. (2009) Phosphinothricin-tripeptide biosynthesis: an original version of bacterial secondary metabolism? Phytochemistry. 70:1787-1800.
  • Eys S, Schwartz D, Wohlleben W, Schinko E. (2008) Three thioesterases are involved in the biosynthesis of phosphinothricin tripeptide in Streptomyces viridochromogenes Tü494. Antimicrob. Agents Chemother. 52:1686-1696.
  • Schwartz D, Grammel N, Heinzelmann E, Keller U, Wohlleben W. (2005) Phosphinothricin tripeptide synthetase in Streptomyces viridochromogenes Tü494. Antimicrob. Agents Chemother. 49:4598-4607.
  • Schwartz D, Berger S, Heinzelmann E, Muschko K, Welzel K, Wohlleben W. (2004) Biosynthetic gene cluster of the herbicide phosphinothricin tripeptide from Streptomyces viridochromogenes Tü494. Appl. Environ. Microbiol. 70:7093-7102.
  • Muschko K, Kienzlen G, Fiedler HP, Wohlleben W, Schwartz D. (2002) Tricarboxylic acid cycle aconitase activity during life cycle of Streptomyces viridochromogenes Tü494. Arch. Microbiol. 178:499-505.
  • Heinzelmann E, Kienzlen G, Kaspar S, Recktenwald J, Wohlleben W, Schwartz D. (2001) The phosphinomethylmalate isomerase gene pmi, encoding an aconitase-like enzyme, is involved in the synthesis of phosphinothricin tripeptide from Streptomyces viridochromogenes. Appl. Environ. Microbiol. 67:3603-3609.
  • Schwartz D, Kaspar S, Kienzlen G, Muschko K, Wohlleben W. (1999) Inactivation of the tricarboxylic acid cycle aconitase gene from Streptomyces viridochromogenes Tü494 impairs morphological and physiological differentiation. J. Bacteriol. 181:7131-7135.
  • Schwartz D, Recktenwald J, Pelzer S, Wohlleben W. (1998) Isolation and characterization of the PEP-phosphomutase and the phosphonopyruvate decarboxylase genes from the phosphinothricin tripeptide producer Streptomyces viridochromogenes Tü494.FEMS Microbiol. Lett. 163:149-157.
  • Grammel N, Schwartz D, Wohlleben W, Keller U. (1998) Phosphinothricin-tripeptide synthetases from Streptomyces viridochromogenes. Biochemistry. 37:1596-1603.
  • Schwartz D, Alijah R, Nussbaumer B, Pelzer S, Wohlleben W. The peptide synthetase gene phsA from Streptomyces viridochromogenes is not juxtaposed with other genes involved in nonribosomal biosynthesis of peptides. Appl. Environ. Microbiol. 62:570-577.
  • Wohlleben W, Alijah R, Dorendorf J, Hillemann D, Nussbaumer B, Pelzer S. (1992) Identification and characterization of phosphinothricin-tripeptide biosynthetic genes in Streptomyces viridochromogenes. Gene. 115:127-132.
  • Alijah R, Dorendorf J, Talay S, Pühler A, Wohlleben W. (1991) Genetic analysis of the phosphinothricin-tripeptide biosynthetic pathway of Streptomyces viridochromogenes Tü494. Appl. Microbiol. Biotechnol. 34:749-755.
  • Hillemann D, Pühler A, Wohlleben W. (1991) Gene disruption and gene replacement in Streptomyces via single stranded DNA transformation of integration vectors. Nucleic Acids. Res. 25:727-731.
  • Behrmann I, Hillemann D, Pühler A, Strauch E, Wohlleben W. (1990) Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine. J. Bacteriol. 172:5326-5334.
  • Wohlleben W, Arnold W, Broer I, Hillemann D, Strauch E, Pühler A. (1998) Nucleotide sequence of the phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Nicotiana tabacum. Gene. 70:25-37.
  • Strauch E, Wohlleben W, Pühler A. (1988) Cloning of a phosphinothricin N-acetyltransferase gene from Streptomyces viridochromogenes Tü494 and its expression in Streptomyces lividans and Escherichia coli. Gene. 63:65-74.