Publications
Google Scholar ORCID ResearchGate
Precise in-vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA
P. Reautschnig*, C. Fruhner, N. Wahn, C. P. Weigand, S. Kragness, J. F. Yung, D. T. Hofacker, J. Fisk, M. Edelman, N. Waffenschmidt, M. Feige, L. S. Pfeiffer, A. E. Schulz, Y, Füll, E. Y. Levanon, G. Mandel, T. Stafforst*, Nature Biotechnology 2024, accepted
Profiling the Interactome of Oligonucleotide Drugs by Proximity Biotinylation
A. Hanswillemenke, D. T. Hofacker, M. Sorgenfrei, C. Fruhner, M. Franz-Wachtel, D. Schwarzer, B. Macek and T. Stafforst*, Nature Chemical Biology 2024, in press
Review: Precision RNA base editing with engineered and endogenous effectors
L. S. Pfeiffer and T. Stafforst*, Nature Biotechnology 2023, 41, 1526-42.
Precise and efficient C-to-U RNA Base Editing with SNAP-CDAR-S
N. Latifi, A. M. Mack, I. Tellioglu, S. Di Giorgio, T. Stafforst*, Nucl. Acids Res. 2023, gkad598.
ADAR1-mediated RNA editing promotes B cell lymophomagenesis
R. Pecori et al., iScience 2023, 26, 106864.
M. Helm et al., ACS Chem. Biol. 2023, 18, 2441-9.
CLUSTER guide RNAs enable precise and efficient RNA editing in cell culture and in vivo
P. Reautschnig, N. Wahn, J. Wettengel, A. E. Schulz, N. Latifi, P. Vogel, T.-W. Kang, L. S. Pfeiffer, C. Zarges, U. Naumann, L. Zender, J. B. Li and T. Stafforst*, Nature Biotechnology 2022, 40, 759–768.
Harnessing self-labeling enzymes for selective and concurrent A-to-I and C-to-U RNA base editing
A. Stroppel, N. Latifi, A. Hanswillemenke, R.N. Tasakis, F.N. Papavasiliou and T. Stafforst*, Nucl. Acids Res. 2021, 49, gkab541.
Controlling Site-directed RNA Editing by Chemically Induced Dimerization
A. Stroppel, R. Lappalainen and T. Stafforst*, ChemEurJ 2021, 27, 12300-12304.
New Frontiers for Site-Directed RNA Editing: Harnessing Endogenous ADARs
T. Merkle and T. Stafforst*, Methods in Molecular Biology 2021, 2181. Humana press, New York (eds, E. Picardi, G. Pesole)
Protocols for the generation of caged guideRNAs for light-triggered RNA-targeting with SNAP-ADARs
A. Hanswillemenke and T. Stafforst*, Methods Enzym. 2019, 624, 47-68.
Chemistry helps to bump off-target edits away
T. Stafforst*, Cell Chem. Biol. 2019, 26, 151-152.
Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
T. Merkle, S. Merz, P. Reautschnig, A. Blaha, Q. Li, P. Vogel, J. Wettengel, J. B. Li, T. Stafforst*, Nature Biotechnology 2019, 37, 133-138.
Critical review on engineering deaminases for site-directed RNA editing
P. Vogel, T. Stafforst*, Current Opin. Biotech. 2019, 55, 74-80.
Efficient and Precise Editing of Endogenous Transcripts with SNAP-tagged ADARs
P. Vogel, M. Moschref, Q. Li, T. Merkle, K. D. Selvasaravanan, J. B. Li, T. Stafforst*. Nature Methods 2018, 15, 535-38.
A. S. Stroppel, M. Paolillo, T. Ziegler, R. Feil, T. Stafforst*. ChemBioChem 2018, 19, 1312-18.
*highlighted in ChemistryViews*
highlighted as "very important paper"
Switching protein localization by site-directed RNA editing under control of light
P. Vogel, A. Hanswillemenke, T. Stafforst*, ACS Synth. Biol. 2017, 6, 1642-9.
*open access*
M. Heep, P. Mach, P. Reautschnig, J. Wettengel, T. Stafforst*, Genes 2017, 8, 34 (special issue on RNA editing).
*open access*
Harnessing human ADAR2 for RNA repair – Recoding a PINK1 mutation rescues mitophagy
J. Wettengel, P. Reautschnig, S. Geisler, P. J. Kahle, T. Stafforst*, Nucl. Acids Res. 2017, 45, 2797-2808.
*open access*
The notorious R.N.A. in the Spotlight - Drug or Target for the Treatment of Disease
P. Reautschnig, P. Vogel, T. Stafforst*, RNA Biology 2017, 14, 651-668 (invited review).
*open access*
A. Hanswillemenke, T. Kuzdere, P. Vogel, G. Jekely, T. Stafforst*, J. Am. Chem. Soc. 2015, 137, 15 875-81.
*open access*
Trendbericht Biochemie 2014: Biochemie natürlicher RNA-Modifikationen
T. Stafforst*, Nachrichten aus der Chemie 2015, 63, 306-9.
Upon the photostability of 8-nitro-cGMP and its caging as a 7-dimethylaminocoumarinyl ester
A. Samanta, M. Thunemann, R. Feil, T. Stafforst*, Chem. Commun. 2014, 50, 7120-23.
Site-directed RNA editing with Antagomir-deaminases - a tool to study protein and RNA function
P. Vogel, T. Stafforst*, ChemMedChem 2014, 9, 2021-25.
Improving Directed RNA Editing In Vitro and in Cell Culture by Chemical Modification of the guideRNA
P. Vogel, M. F. Schneider, J. Wettengel, T. Stafforst*, Angew. Chem. Int. Ed. 2014, 53, 6267-71.
German version:
Angew. Chem. 2014, 126, 6382-86.
Optimal guideRNAs for Re-directing Deaminase Activity of hADAR1 and hADAR2 in trans
M. F. Schneider, J. Wettengel, P. C. Hoffmann, T. Stafforst*, Nucl. Acids Res. 2014, 42, e87.
*open access*
Pyrene Chromophores for the Photoreversal of Psoralen Interstrand Crosslinks
J. M. Stadler, T. Stafforst*, Org. Biomol. Chem. 2014, 12, 5260-66.
Gerichtete Editierung – ein Werkzeug zur Reprogrammierung von RNA
T. Stafforst*, Biospektrum 2014, 20, 231-233.
T. Stafforst*, ChemBioChem 2014, 15, 356-58.
Diskussionspapier: Biotechnologie - der Schlüssel zur Bioökonomie
Zukunftsforum der Dechema, Dechema 2014.
S. J. Bachmann, Z. Lin, T. Stafforst, W. F. van Gunsteren, J. Dolenc*, J. Chem. Theor. Comp. 2014, 10, 391-400.
Photoactivation of a Psoralen-blocked Luciferase Gene by Blue Light
T. Stafforst*, J. M. Stadler, Angew. Chem. Int. Ed. 2013, 52, 12448-51.
German version:
Photoaktivierung eines Psoralen-vernetzten Luciferasegens mit blauem Licht
Angew. Chem. 2013, 125, 12676-80.
An RNA-Deaminase Conjugate Selectively Repairs Point Mutations
T. Stafforst*, M. F. Schneider, Angew. Chem. Int. Ed. 2012, 51, 11166-9.
German version:
Ein RNA-Deaminase-Konjugat ermöglicht die selektive Reparatur von Punktmutationen
Angew. Chem. 2012, 124, 11329-32.
A FlAsH Reporter for Protein-Dimerization Triggers
T. Stafforst*, ChemBioChem 2012, DOI: 10.1002/cbic.201100787
Photolyase-like Repair of Psoralen-crosslinked Nucleic Acids
T. Stafforst*, D. Hilvert*, Angew. Chem. Int. Ed. 2011, 50, 9483-9486; Angew. Chem. 2011, 123, 9655-9658.
German version:
Photolyase-artige Reparatur Psoralen-quervernetzter Nucleinsäuren
Angew. Chem. 2011, 123, 9655-58.
K. E. Otto, S. Hesse, T. N. Wassermann, C. A. Rice, M. A. Suhm*, T. Stafforst, U. Diederichsen, Phys. Chem. Chem. Phys. 2011, 13, 14119 - 14130.
Modulating PNA-DNA Hybridization by Light
T. Stafforst*, D. Hilvert*,
Angew. Chemie Int. Ed. 2010, 49, 9998-10001; Angew. Chem. 2010, 122, 10195-10198
German version:
Photokontrolle der PNA-DNA-Hybridisierung
Angew. Chem. 2010, 122, 10195-98.
Kinetic Characterization of Spiropyrans in Aqueous Media
T. Stafforst*, D. Hilvert, Chem. Commun. 2009, 287 - 288.
T. Stafforst, U. Diederichsen*, Eur. J. Org. Chem. 2007, 899 - 911.
Synthesis of acid-sensitive N-(2-aminoethyl)glycine-PNA oligomers via Fmoc/Bhoc strategy
T. Stafforst, U. Diederichsen*, Eur. J. Org. Chem. 2007, 681 - 688.
T. Stafforst, U. Diederichsen*, Angew. Chem. Int. Ed. 2006, 45, 5376 - 5380.
German version:
Angew. Chem. 2006, 118, 5502 – 06.
(6-4)-Photolyase activity requires a charge shift reaction
T. Stafforst, U. Diederichsen*, Chem. Commun. 2005, 3430 - 3432.
Aggregation behaviour of p-n-alkylbenzamidinium chloride surfactants
R. Talhout, T. Stafforst, J. B. F. N. Engberts*, J. Colloid Interface Sci. 2004, 276, 212 - 220