Werner Reichardt Centrum für Integrative Neurowissenschaften (CIN)

Physiology of Neural Circuits

Research interests

The main scientific interest of our laboratory is to understand the mechanisms underlying in vivo function of neural networks. The major research lines include 

  • Characterization of the endogenous brain rhythms during early postnatal development, in the adulthood and during ageing/neurodegenerative diseases 
  • Elucidation of the mechanisms underlying processing of sensory signals 
  • Understanding the rules governing the integration of neurons in the preexisting neural networks
  • Interactions between nervous and immune systems of the brain Interactions between nervous and immune systems of the brain

Methods

Cellular activity is often associated with an increase in the intracellular calcium concentration. We use this property of neural, neuroglial and immune cells for monitoring their function in vivo by means of two-photon calcium imaging. In combination with state-of-the art electrophysiological, optical and molecular biological techniques (multi-color two-photon microscopy, expression of function-modifying proteins, cell attached and whole-cell patch clamp recordings) this approach allows to study function of multi-cellular networks at single cell or even subcellular resolution.

Projects

  • Mechanisms underlying processing of sensory signals in the visual cortex and the olfactory bulb
  • Mechanisms governing migration and integration of adult stem cells in the preexisting neural networks
  • Neuroglial function in the aging and diseased brain
  • Understanding the cause of neuroglial hyperactivity in mouse models of Alzheimer's disease