Interfakultäres Institut für Mikrobiologie und Infektionsmedizin

Publications

1. Robertsen, H.L.; Musiol-Kroll, E.M. Actinomycete-derived polyketides as a source of antibiotics and lead structures for the development of new antimicrobial drugs. Antibiotics 2019, 8, 157.

2. Musiol-Kroll, E.M.; Tocchetti, A.; Sosio, M.; Stegmann, E. Challenges and advances in genetic manipulation of filamentous actinomycetes - the remarkable producers of specialized metabolites. Natural product reports 2019, 36, 1351-1369.

3. Robertsen, H.L.*; Musiol-Kroll, E.M.*; Ding, L.; Laiple, K.J.; Hofeditz, T.; Wohlleben, W.; Lee, S.Y.; Grond, S.; Weber, T. Filling the gaps in the kirromycin biosynthesis: Deciphering the role of genes involved in ethylmalonyl-CoA supply and tailoring reactions. Sci Rep 2018, 8, 3230.

*equal contribution

4. Musiol-Kroll, E.M.; Wohlleben, W. Acyltransferases as tools for polyketide synthase engineering. Antibiotics 2018, 7.

5. Musiol-Kroll, E.M.; Zubeil, F.; Schafhauser, T.; Hartner, T.; Kulik, A.; McArthur, J.; Koryakina, I.; Wohlleben, W.; Grond, S.; Williams, G.J., et al. Polyketide bioderivatization using the promiscuous acyltransferase KirCII. ACS Synth Biol 2017, 6, 421-427.

6. Weber, T.; Charusanti, P.; Musiol-Kroll, E.M.; Jiang, X.; Tong, Y.; Kim, H.U.; Lee, S.Y. Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes. Trends Biotechnol 2015, 33, 15-26.

7. Ye, Z.; Musiol, E.M.; Weber, T.; Williams, G.J. Reprogramming acyl carrier protein interactions of an acyl-CoA promiscuous trans-acyltransferase. Chem Biol 2014, 21, 636-646.

8. Ruckert, C.; Szczepanowski, R.; Albersmeier, A.; Goesmann, A.; Iftime, D.; Musiol, E.M.; Blin, K.; Wohlleben, W.; Puhler, A.; Kalinowski, J., et al. Complete genome sequence of the kirromycin producer Streptomyces collinus Tu 365 consisting of a linear chromosome and two linear plasmids. J Biotechnol 2013, 168, 739-740.

9. Musiol, E.M.; Greule, A.; Hartner, T.; Kulik, A.; Wohlleben, W.; Weber, T. The AT(2) domain of KirCI loads malonyl extender units to the ACPs of the kirromycin PKS. Chembiochem 2013, 14, 1343-1352.

10. Koryakina, I.; McArthur, J.; Randall, S.; Draelos, M.M.; Musiol, E.M.; Muddiman, D.C.; Weber, T.; Williams, G.J. Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases. ACS Chem Biol 2013, 8, 200-208.

11. Musiol, E.M.; Weber, T. Discrete acyltransferases involved in polyketide biosynthesis MedChemComm 2012, 3, 871-886.

12. Musiol, E.M.; Hartner, T.; Kulik, A.; Moldenhauer, J.; Piel, J.; Wohlleben, W.; Weber, T. Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS. Chem Biol 2011, 18, 438-444.

13. Pavlidou, M.; Pross, E.K.; Musiol, E.M.*; Kulik, A.; Wohlleben, W.; Weber, T. The phosphopantetheinyl transferase KirP activates the ACP and PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tü 365. FEMS Microbiol Lett 2011, 319, 26-33.

*equal contribution