Subproject V: Epigenetics

Research Question

The term “epigenetics” describes molecular mechanisms, such as alterations at specific proteins that lead to a stronger or weaker expression of specific genes. Epigenetic mechanisms help to adapt the genetic information saved in our DNA to environmental circumstances without altering the genetic information itself. In this project, we are analyzing the question how individual physiological adaptation reactions correlate with epigenetic characteristics. Furthermore, across projects, we aim to analyze if there are correlations between physiological training adaptation, biographical and emotional characteristics and epigenetic changes.

Methods

Specifically, our project aims to investigate the question whether in the model system “skeletal muscle tissue”, specific epigenetic markers can be determined that allow to predict an individual’s response to a specific exercise stimulus. After sampling tissue specimens, a broad variety of these markers will be analyzed before and directly after a single bout of exercise, as well as after a longer period of training. Subsequently, the data will be correlated with those of the other subprojects. By this means, we plan to determine a panel of markers, one of them being epigenetic characteristics in skeletal muscle, that helps to predict an individual’s reaction to a specific training stimulus and eventually leads to the development of individualized training regimens.