IFIB – Interfakultäres Institut für Biochemie



Moe, A., R. Dimogkioka, D. Rapaport, L. Näsvik Öjemyr, and P.  Brzezinski (2023) Structure and function of the S. pombe III-IV-cyt c supercomplex. Proc. Natl. Acad. Sci., 120, e2307697120. doi: 10.1073/pnas.2307697120

Moitra, A., V. Tiku, and D. Rapaport (2023) Yeast mitochondria can process de novo designed β-barrel proteins. FEBS J. doi: 10.1111/febs.16950

Rapaport, D. and J.M. Herrmann (2023) Chasing the right tail: How the ER membrane complex recognizes its substrates. J. Cell Biol. 222, e202306035. doi: 10.1083/jcb.202306035.


Drwesh, L., B. Heim, M. Graf, L. Kehr, L. Hansen-Palmus, M.  Franz-Wachtel, B. Macek, H. Kalbacher, J. Buchner, and D. Rapaport (2022) A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins. eLife, 11:  e77706. doi: 10.7554/eLife.77706.

Maruszczak, K.K., M Jung, S. Rasool, J.-F. Trempe, and D. Rapaport (2022) The role of the individual TOM subunits in the association of PINK1 with depolarized mitochondria. J. Mol. Med. 100, 747–762. doi:  10.1007/s00109-022-02191-6.

Zhou, J., M. Jung, K.S. Dimmer, and D. Rapaport (2021) The multi-factor modulated biogenesis of the mitochondrial multi-span protein Om14. J. Cell Biol., 221, e202112030. doi:  10.1083/jcb.202112030.


Eisenberg-Bord, M., N. Zung, J. Collado, L. Drwesh, E. Fenech, A. Fadel, N. Dezorella, Y. Bykov, D. Rapaport, R. Fernandez Busnadiego, and M. Schuldiner (2021) Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels. J. Cell Biol., 220, e202104100. doi.org/10.1083/jcb.202104100.

Moitra, A. and D. Rapaport (2021) The biogenesis process of VDAC-from early cytosolic events to its final membrane integration. Frontiers in Physiology, 12, 732742. doi: 10.3389/fphys.2021.732742.

Backes, S., Y.S. Bykov, T. Flohr, M. Räschle, J. Zhou, S. Lenhard, L. Krämer, T. Mühlhaus, C. Bibi, C. Jann, J.D. Smith, L.M. Steinmetz, D. Rapaport, Z. Storchová, M. Schuldiner, F. Boos, and J.M. Herrmann (2021) The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress. Cell Rep., 35, 108936. doi: 10.1016/j.celrep.2021.108936.


Bus, C, L. Zizmare, M. Feldkaemper, S. Geisler, M. Zarani, A. Schaedler, F. Klose, J. Admard, C. Mageean, G. Arena, P. Fallier-Becker, A. Ugun-Klusek, K.K. Maruszczak, K. Kapolou, B. Schmid, D. Rapaport, M. Ueffing, N. Casadei, R. Krüger, T. Gasser, D. Vogt-Weisenhorn, P.J. Kahle1, C. Trautwein, C.J. Gloeckner, and J.C. Fitzgerald (2020) Human dopaminergic neurons lacking PINK1 exhibit disrupted dopamine metabolism related to vitamin B6 co-factors. iScience. 23, 101797. doi: 10.1016/j.isci.2020.101797.

Sucec, I., Y. Wang, O. Dakhlaoui, K. Weinhäupl, T. Jores, D. Costa, A. Hessel, M. Brennich, D. Rapaport, K. Lindorff-Larsen, B. Bersch, and P. Schanda (2020) Structural basis of client specificity in mitochondrial membrane-protein chaperones. Science Advances, 6, eabd0263. doi: 10.1126/sciadv.abd0263.

Ferdigg, A., K.S. Dimmer, D. Rapaport, and D.G. Vitali (2020) Hydrogenosomal tail-anchored proteins are targeted to both mitochondria and ER upon their expression in yeast cells. PLOS One, 15(8): e0237982. doi: 10.1371/journal.pone.0237982.

Rosenthal, M., E. Metzl-Raz, J. Bürgi, E. Yifrach, L. Drwesh, A. Fadel, Y. Peleg, D. Rapaport, M. Wilmanns, N. Barkai, M. Schuldiner, and E. Zalckvar (2020) Uncovering targeting priority to yeast peroxisomes using an in-cell competition assay. Proc. Natl. Acad. Sci. USA, 117, 21432-21440. doi: 10.1073/pnas.1920078117.

Bykov, Y.S., D. Rapaport, J.M. Herrmann, and M. Schuldiner (2020) Cytosolic events in the biogenesis of mitochondrial proteins. Trends Biochem. Sci., 45, 650-667. doi: 10.1016/j.tibs.2020.04.001.

Drwesh, L., and D. Rapaport (2020) Biogenesis pathways of α-helical mitochondrial outer membrane proteins. Biol. Chem., 401, 677-686. doi: 10.1515/hsz-2019-0440

Vitali, D.G., L. Drwesh, B.A. Cichocki, A. Kolb, and D. Rapaport (2020) The biogenesis of mitochondrial outer membrane proteins show variable dependence on import factors. iScience, 23, 100779. doi: 10.1016/j.isci.2019.100779. 

Natarajan, J., A. Moitra, S. Zabel, N. Singh, S. Wagner, and D. Rapaport (2020) Yeast can express and assemble bacterial secretins in the mitochondrial outer membrane. Microbial Cell, 7, 15-27. doi: 10.15698/mic2020.01.703.


Rapaport, D. (2019) Protein translocation- The mitochondrial gate reveals its secrets. Nat. Struc. Mol. Biol. (News & Views). 26, 1083-1085. doi: 10.1038/s41594-019-0346-3.

Natarajan, J., N. Singh, and D. Rapaport (2019) Assembly and targeting of Secretins in the bacterial outer membrane. Int. J. Med. Microbiol., 309, 151322. doi: 10.1016/j.ijmm.2019.06.002.

Odendall1, F., S. Backes, T. Tatsuta, U. Weill, M. Schuldiner, T. Langer, J. Herrmann, D. Rapaport, and K.S. Dimmer (2019) The mitochondrial intermembrane space facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism. Mol. Biol. Cell, 30, 2681–2694. doi: 10.1091/mbc.E19-03-0166.

Grossmann, D., C. Berenguer-Escuder, M.E. Bellet, D. Scheibner, J. Bohler, F. Massart, D. Rapaport, A. Skupin, A. Fouquier d'Hérouël, M. Sharma, J. Ghelfi, A. Rakovic, P. Lichtner, P. Antony, E. Glaab, P. May, K.S. Dimmer, J.C. Fitzgerald, A. Gruenewald, and R. Krüger (2019) Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson’s disease. Antioxid. Redox Signal., 31, 1213-1234. doi: 10.1089/ars.2018.7718.

Eisenberg-Bord, M., H.S. Tsui, D. Antunes, L. Fernández-del-Río, C.D. Dunn, D. Rapaport, C.F. Clarke, and M. Schuldiner (2019) The ER-Mitochondria contact site coordinates coenzyme Q biosynthesis. Contact, 2, 1-14. doi:  10.1177/ 2515256418825409.

Antunes, D., A. Chowdhury, A. Aich, S. Saladi, N. Harpaz, M. Stahl, M. Schuldiner, J.M. Herrmann, P. Rehling, and D. Rapaport (2019) Overexpression of Branched-Chain Amino Acid Aminotransferases rescues the growth defects of cells lacking the Barth Syndrome related gene TAZ1. J. Mol. Med., 97, 269-279. doi: 10.1007_s00109-018-1728-4.

Makki, A., P. Rada, V. Žárský, S. Kereïche, L. Kováčik, M. Novotný, T. Jores, D. Rapaport, and J. Tachezy (2019) Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes of Trichomonas vaginalis. PLOS Biol., doi: 10.1371/journal.pbio.3000098. 


Weinhäupl, K., C. Lindau, A. Hessel, Y. Wang, C. Schütze, T. Jores, L. Melchionda, B. Schönfisch, H. Kalbacher, B. Bersch, D. Rapaport, M. Brennich, K. Lindorff-Larsen, N. Wiedemann, and P. Schanda (2018) Structural basis of membrane protein chaperoning through the mitochondrial intermembrane space. Cell, 175, 1365-1379. doi: 10.1016/j.cell.2018.10.039

Cichocki, B.A., K. Krumpe, D.G. Vitali, and D. Rapaport (2018) Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomes. Traffic, 19, 770-785. doi: 10.1111/tra.12604.

Jores, T., J. Lawatscheck, V. Beke, M. Franz-Wachtel, K. Yunoki, J.C. Fitzgerald, B. Macek, T. Endo, H. Kalbacher, J. Buchner, and D. Rapaport (2018) Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins. J. Cell Biol., 217. doi: 10.1083/jcb.201712029.

Vitali1, D.G., S. Käser, A. Kolb, K.S. Dimmer, A. Schneider, and D. Rapaport (2018) Independent evolution of functionally exchangeable mitochondrial outer membrane import complexes. eLife, 7:e34488. doi: 10.7554/eLife.34488.

Weill, U., I. Yofe, E. Sass, B. Stynen, D. Davidi, J. Natarajan, R. Ben-Menachem, Z. Avihou, O. Goldman, N. Harpaz, S. Chuartzman, K. Kniazev, B. Knoblach, J. Laborenz, J. Kowarzyk, S. Ben-Dor, E. Zalckvar, J.M. Herrmann, R.A. Rachubinski, O. Pines, D. Rapaport, S.W. Michnick, E.D. Levy, and M. Schuldiner (2018) Exploring the yeast proteome using a whole genome SWAp-Tag (SWAT) library. Nature Methods, doi: 10.1038/s41592-018-0044-9.

Vitali, D.G., M. Sinzel, E. Bulthuis, A. Kolb, S. Zabel, D.G. Mehlhorn, A. Clancy, A. Farkas, B. Costa, M. Schuldiner, C. Grefen, B. Schwappach, N. Borgese, and D. Rapaport (2018) The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ER. J. Cell Sci. 131(10). doi: 10.1242/jcs.211110.


Singhal, R.K., C. Kruse, J. Heidler, V. Strecker, K. Zwicker, L. Düsterwald, B. Westermann, J.M. Herrmann, I. Wittig, and D. Rapaport (2017) Coi1 is a novel assembly factor of the yeast complex III-complex IV supercomplex. Mol. Biol. Cell 28, 2609-2622.

Peter, A.T.J, B. Herrmann, D. Antunes, D. Rapaport, K.S. Dimmer, and B. Kornmann (2017) Vps13-Mcp1 interact at the vacuole-mitochondria interface and bypass ERMES-mediated ER-mitochondria contact sites. J. Cell Biol. 216, 3219-3229.

Jores, T. and D. Rapaport (2017) Early stages in the biogenesis of eukaryotic β-barrel proteins. FEBS Lett. 591, 2671-2681.

Dimmer, K.S., and D. Rapaport (2017) Mitochondrial contact sites as platforms for phospholipid exchange. Biochim. Biophys. Acta 1862, 69-80.


Pfitzner, A.K., N. Steblau, T. Ulrich, P. Oberhettinger, I.B. Autenrieth, M. Schütz, and D. Rapaport (2017) Mitochondrial-bacterial hybrids of BamA/Tob55 suggest variable requirements for the membrane integration of β-barrel proteins. Sci. Reports 6, 39053.

Hoseini, H., S. Pandey, T. Jores, A. Schmitt, M. Franz-Wachtel, B. Macek, J. Buchner, K. S. Dimmer, and D. Rapaport (2016) The cytosolic co-chaperone Sti1 is relevant for mitochondrial biogenesis and morphology. FEBS J., 283, 3338-3352.

Jores, T., A. Klinger, L. Groß, S. Kawano, N. Flinner, E. Duchardt-Ferner, J. Wöhnert, H. Kalbacher, T. Endo, E. Schleiff, and D. Rapaport (2016) Characterization of the targeting signal in mitochondrial β-barrel proteins. Nature Comm7, 12036.

Sinzel, M., T. Tan, P. Wendling, H. Kalbacher, C. Özbalci, X. Chelius, B. Westermann, B. Brügger, D. Rapaport and K.S. Dimmer (2016) Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathway. EMBO Rep17, 965-981.

Zabezhinsky. D., B. Slobodin, D. Rapaport and J.E. Gerst (2016) An essential role for COPI in mRNA localization to mitochondria and mitochondrial function. Cell Rep15, 540-549.

Casadei, N., P. Sood, T. Ulrich, N. Kieper, S. Helling, C. May, E. Glaab, J. Chen, S. Nuber, K. Marcus, D. Rapaport, T. Ott, O. Riess, R. Krüger, and J.C. Fitzgerald (2016) Mitochondrial Defects and Neurodegeneration in Mice Overexpressing Wild Type or G399S Mutant HtrA2. Hum. Mol. Gen. 25, 459–471.


Ulrich, T., and D. Rapaport (2015) Biogenesis of β-barrel proteins in evolutionary context. Int. J. Med. Microbiol. 305, 259-264.

Sauerwald, J., T. Jores, M. Eisenberg-Bord, S.G. Chuartzman, M. Schuldiner, and D. Rapaport (2015) Genome-wide screens in yeast highlight a role for cardiolipin in biogenesis of mitochondrial outer membrane multispan proteins. Mol. Cell. Biol., 35, 3200-3211.

Ulrich, T., P. Oberhettinger, I.B. Autenrieth, and D. Rapaport (2015) Yeast mitochondria as a model system to study the biogenesis of bacterial β-barrel proteins. In S. Buchanan and N. Noinaj (Eds.) Methods in Molecular Biology, Vol. “The BAM Complex: Methods and protocols”, Humana Press, New-York, pp. 17-31.


Burbulla, L., J. Fitzgerald, K. Stegen, J. Westermeier, A.-K. Thost, H. Kato, D. Mokranjac, J. Sauerwald, L. Martins, D. Woitalla, D. Rapaport, O. Riess, T. Proikas-Cezanne, T. Rasse, and R. Krueger (2014) Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1. Cell Death Dis., 5, e1180.

Hermesh, O., C. Genz, I. Yofe, M. Sinzel, D. Rapaport, M. Schuldiner, and R.-P. Jansen (2014) Yeast phospholipid biosynthesis is linked 1 to mRNA localization. J. Cell Sci., 127, 3373-3381.

Ulrich, T., P. Oberhettinger, M. Schütz, K. Holzer, A. S. Ramms, D. Linke, I.B. Autenrieth, and D. Rapaport (2014) Evolutionary Conservation in Biogenesis of β-Barrel Proteins Allows Mitochondria to Assemble a Functional Bacterial Trimeric Autotransporter Protein. J. Biol. Chem., 289, 29457-29470.

Synofzik, M., T.B. Haack, R. Kopajtich, M. Gorza, D. Rapaport, M. Greiner, C. Schönfeld, C. Freiberg, R. Holl, M.A. Gonzalez, A. Fritsche, H. Wolburg, R. Zimmermann, T.M. Strom, T. Meitinger, S. Züchner , R. Schüle, L. Schöls, and H. Prokisch (2014) Absence of BiP co-chaperone DNAJC3 causes diabetes mellitus and multisystemic neurodegeneration. Am. J. Hum. Genet. 95, 689-697.


Kato, H., Q. Lu, D. Rapaport, and V. Kozjak-Pavlovic (2013) Tom70 is essential for PINK1 import into mitochondria. PLOS One, 8(3): e58435.

Tan, T. C. Özbalci, B. Brügger, D. Rapaport, and K. S. Dimmer (2013) Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. J. Cell Sci., 126, 3563-3574.

Krumpe, K. and D. Rapaport (2013) An assay to monitor the membrane integration of single-span proteins. In D. Rapaport and J. Herrmann (Eds.) Methods in Molecular Biology, Vol. “Membrane Biogenesis: Methods and protocols”, pp. 301-306, Humana Press, New-York.

Papić, D., Y. Elbaz-Alon, S.N. Koerdt, K. Leopold, D. Worm, M. Jung, M. Schuldiner, and D. Rapaport (2013) The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a co-chaperone and its substrate protein. Mol. Cell. Biol., 33, 4083-4094.

Grau, T., L.F. Burbulla, G. Engl, C. Delettre, B. Delprat, K. Oexle, B. Leo-Kottler, T. Roscioli, R. Krüger, D. Rapaport, B. Wissinger, and S. Schimpf-Linzenbold (2013) A novel heterozygous OPA3 mutation located in the mitochondrial target sequence results in altered steady-state levels and fragmented mitochondrial network. J. Med. Genet., 50, 848-858.


Krumpe, K., I. Frumkin, Y. Herzig, N. Rimon, C. Özbalci, B. Brügger, D. Rapaport, and M. Schuldiner (2012) Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol. Biol. Cell, 23, 3927-3935.

Dimmer, K.S., D. Papić, B. Schumann, D. Sperl, K. Krumpe, D.M. Walther, and D. Rapaport (2012) A crucial role of Mim2 in the biogenesis of mitochondrial outer membrane proteins. J. Cell Sci. 125, 3464-3473.

Ulrich, T., L.E. Gross, M.S. Sommer, E. Schleiff, and D. Rapaport (2012) Chloroplast ß-barrel proteins are assembled into the mitochondrial outer membrane in a process that depends on the TOM and TOB complexes. J. Biol. Chem. 287, 27467-27479.

Körner, C., M. Barrera, J. Dukanovic, K. Eydt, M. Harner, R. Rabl, F. Vogel, D. Rapaport, W. Neupert, and A.S. Reichert (2012) Formation of crista junctions depends on the C-terminal domain of Fcj1 and the TOB/SAM complex. Mol. Biol. Cell, 23, 2143-2155.

Dimmer, K.S. and D. Rapaport (2012) Unresolved mysteries in the biogenesis of mitochondrial membrane proteins. Biochim. Biophys. Acta 1818, 1085-1090.

Merklinger, E., Y. Gofman, A. Kedrov, A.J.M. Driessen, N. Ben-Tal, Y. Shai and D. Rapaport (2012) Membrane-integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors. Biochem. J. 442, 381-389.

Engl, G., S. Florian, L. Tranebjærg, and D. Rapaport (2012) Alterations in expression levels of Deafness Dystonia Protein 1 affect mitochondrial morphology. Hum. Mol. Gen. 21, 287-299.


Papić, D., K. Krumpe, J. Dukanovic, K.S. Dimmer, and D. Rapaport (2011) Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J. Cell Biol. 194, 397-405.

Müller, J.E.N., D. Papic, T. Ulrich, I. Grin, M. Schütz, P. Oberhettinger, J. Tommassen, D. Linke, K.S. Dimmer, I.B. Autenrieth, and D. Rapaport (2011) Mitochondria can recognize and assemble fragments of a ß-barrel structure. Mol. Biol. Cell 22, 1638-1647.

Dukanovic, J. and D. Rapaport (2011) Multiple pathways in the integration of proteins into the mitochondrial outer membrane. Biochim. Biophys. Acta 1808, 971-980.

D. Rapaport (2011) Protein translocation across or insertion into membranes (Editorial Preface for Special Review Issue). Biochim. Biophys. Acta 1808, 840.


Burbulla L.F., C. Schelling, H. Kato, D. Rapaport, D. Woitalla, C. Schiesling, C. Schulte, M. Sharma, T. Illig, P. Bauer, S. Jung, A. Nordheim, L. Schöls, O. Riess, and R. Krüger (2010) Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis. Hum Mol Genet. 19, 4437-4452.

Wideman, J.G., N.E. Go, A. Klein, E. Redmond, S.W.K. Lackey, T. Tao, H. Kalbacher, D. Rapaport, W. Neupert, and F.E. Nargang (2010) Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa. Mol. Biol. Cell 21, 1725-1736.

Eliyahu, E., L. Pnueli, D. Melamed, T. Scherrer, A.P. Gerber, O. Pines, D. Rapaport, and Y. Arava (2010) Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner. Mol. Cell. Biol. 30, 284-294.

Kamenisch, Y., M. Fousteri, J. Knoch, A.-K. von Thaler, B. Fehrenbacher, H. Kato, T. Becker, M. Dolle, R. Kuiper, M. Majora, M. Schaller, G. van der Horst, H. van Steeg, M. Röcken, D. Rapaport, J. Krutmann, L.H. Mullenders, and M. Berneburg (2010) Proteins of nucleotide excision repair and base excision repair interact in mitochondria to protect from a hallmark of aging: loss of subcutaneous fat. J. Exp. Med. 207, 379-390.

Walther, D.M., M.P. Bos, D. Rapaport, and J. Tommassen (2010) The mitochondrial porin, VDAC, has retained the ability to be assembled in the bacterial outer membrane. Mol. Biol. Evol. 27, 887-895.

Dimmer, K.S. and D. Rapaport (2010) The enigmatic role of Mim1 in mitochondrial biogenesis. Eur. J. Cell Biol. 89, 212-215.


Walther, D.M. and D. Rapaport (2009) Biogenesis of mitochondrial outer membrane proteins. Biochim. Biophys. Acta 1793, 42-51.

Walther, D.M., D. Papic, M.P. Bos, J. Tommassen, and D. Rapaport (2009) Signals in bacterial ß-barrel proteins are functional in eukaryotic cells for targeting to and assembly in mitochondria. Proc. Natl. Acad. Sci. USA 106, 2531-2536.

Borgese, N., A.J.M. Driessen, D. Rapaport, and C. Robinson (2009) The quest for a better resolution of protein translocation processes. EMBO Rep. 10, 337-342.

Stapleford, K.A., D. Rapaport, and D.J. Miller (2009) Mitochondrial enriched anionic phospholipids facilitate flock house virus polymerase membrane association. J. Virol. 83, 4498-4507.

Walther, D.M., D. Rapaport, and J. Tommassen (2009) Biogenesis of β-Barrel Membrane Proteins in Bacteria and Eukaryotes: Evolutionary Conservation and Divergence. Cell. Mol. Life Sci. 66, 2789-2804.

Dukanovic, J., K.S. Dimmer, N. Bonnefoy, K. Krumpe and D. Rapaport (2009) Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37. Mol. Cell. Biol. 29, 5975–5988.


Dimmer, K.S. and D. Rapaport (2008) Proteomic view of mitochondrial function. Genome Biol. 9:209.

Meineke, B., G. Engl, C. Kemper, A. Vasiljev-Neumeyer, H. Paulitschke and D. Rapaport (2008) The outer membrane form of the mitochondrial protein Mcr1 follows a TOM-independent membrane insertion pathway. FEBS Lett. 582, 855-860.

Kemper, C., S.J. Habib, G. Engl, P. Heckmeyer, K.S. Dimmer and D. Rapaport (2008) The integration of tail-anchored proteins into the mitochondrial outer membrane does not require the known import components. J. Cell Sci. 121, 1990-1998.

Hildenbeutel, M., S.J. Habib, J.M. Herrmann, and D. Rapaport (2008) New insights into the mechanism of precursor protein insertion into the mitochondrial membranes. In K. W. Jeon (Ed.) International Review of Cell & Molecular Biology, Vol. 268, pp. 147-190, Elsevier/Academic Press, San-Diego.

Popov-Čeleketić, J., T. Waizenegger, and D. Rapaport (2008) Mim1 functions in an oligomeric form to facilitate the integration of Tom20 into the mitochondrial outer membrane. J. Mol. Biol. 376, 671-680.


Habib, S.J., T. Waizenegger, A. Niewienda, S.A. Paschen, W. Neupert and D. Rapaport (2007) The N-terminal Domain of Tob55 has a Receptor-like Function in the Biogenesis of Mitochondrial beta-Barrel Proteins. J. Cell Biol. 176, 77-88.

Nargang, F.E. and D. Rapaport (2007) Neurospora crassa as a model organism for mitochondrial biogenesis. In J. Herrmann and D. Leister (Eds.) Methods in Molecular Biology, Vol. 372 “Mitochondria”, pp. 107-123, Humana Press, New-York.

Waizenegger, T. and D. Rapaport (2007) Analyzing import intermediates of mitochondrial proteins by blue native gel electrophoresis. In J. Herrmann and D. Leister (Eds.) Methods in Molecular Biology, Vol. 372, “Mitochondria”, pp. 287-295, Humana Press, New-York.

Habib, S.J., W. Neupert and D. Rapaport (2007) Analysis and Prediction of Mitochondrial Targeting Signals. In L. A. Pon and E. A. Schon (Eds.) Methods in Cell Biology, Vol. 80, pp. 761-781, Elsevier/Academic Press, San-Diego.

Hoppins, S.C., N.E. Go, A. Klein, S. Schmitt, W. Neupert, D. Rapaport, and F.E. Nargang (2007) Alternative splicing gives rise to different isoforms of the Neurospora crassa Tob55 protein that vary in their ability to insert β-barrel proteins into the outer mitochondrial membrane. Genetics 177, 137-149.

Ott, M., E. Norberg, K.M. Walter, P. Schreiner, C. Kemper, D. Rapaport, B. Zhivotovsky, and S. Orrenius (2007) The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release. J. Biol. Chem. 282, 27633-27639.


Schmitt, S., H. Prokisch, T. Schlunck, D.G. Camp II, U. Ahting, T. Waizenegger, C. Scharfe, T. Meitinger, A. Imhof, W. Neupert, P.J. Oefner, and D. Rapaport (2006) Proteome analysis of mitochondrial outer membrane from Neurospora crassa. Proteomics 6, 72-80.

Rambold, A.S., M. Miesbauer, D. Rapaport, T. Bartke, M. Baier, K.F. Winklhofer and J. Tatzelt (2006) Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol. Biol. Cell 17, 3356-3368.


Rapaport, D. (2005) The mitochondrial protein import machinery. In J. Eichler (Ed.) Protein Movement across Membranes, pp. 113-124, Landes Bioscience, Georgetown.

Waizenegger, T., S. Schmitt, J. Zivkovic, W. Neupert and D. Rapaport (2005) Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO Rep. 6, 57-62.

Ahting, U., T. Waizenegger, W. Neupert, and D. Rapaport (2005) Signal-anchor proteins follow a unique insertion pathway into the outer membrane of mitochondria. J. Biol. Chem. 280, 48-53.

Habib, S.J., T. Waizenegger, M. Lech, W. Neupert, and D. Rapaport (2005) Assembly of the TOB complex of mitochondria. J. Biol. Chem. 280, 6434-6440.
Paschen, S.A., W. Neupert, and D. Rapaport (2005) Biogenesis of ß-barrel proteins in mitochondria. Trends Biochem. Sci. 30, 575-582.

Rapaport, D. (2005) How does the TOM complex mediate insertion of precursor proteins into the mitochondrial outer membrane? J. Cell Biol. 171, 419-423.

2001 - 2004

Waizenegger, T., S.J. Habib, M. Lech, D. Mokranjac, S.A. Paschen, K. Hell, W. Neupert and D. Rapaport (2004) Tob38, a novel essential component in the biogenesis of ß-barrel proteins of mitochondria. EMBO Rep. 5, 704-709.

Vasiljev, A., U. Ahting, F.E. Nargang, N.E. Go, S.J. Habib, C. Kozany, V. Panneels, I. Sinning, H. Prokisch, W. Neupert, S. Nussberger and D. Rapaport (2004) Reconstituted TOM core complex and Tim9/Tim10 complex of mitochondria are sufficient for translocation of the ADP/ATP carrier across membranes. Mol. Biol. Cell 15, 1445-1458.

Stan, T., J. Brix, J. Schneider-Mergener, N. Pfanner, W. Neupert and D. Rapaport (2003) Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex. Mol. Cell. Biol. 23, 2239-2250.

Waizenegger, T., T. Stan, W. Neupert and D. Rapaport (2003) Signal-anchor domains of proteins of the outer membrane of mitochondria: structural and functional characteristics. J. Biol. Chem. 278, 42064-42071.

Rapaport, D. (2003) Finding the right organelle - Targeting signals in mitochondrial outer membrane proteins. EMBO Rep. 4, 948-952.

Habib, S.J., A. Vasiljev, W. Neupert and D. Rapaport (2003) Multiple functions of tail-anchor domains of mitochondrial outer membrane proteins. FEBS Lett. 555, 511-515.

Paschen, S.A., T. Waizenegger, T. Stan, M. Preuss, M. Cyrklsff, K. Hell, D. Rapaport and W. Neupert (2003) Evolutionary conservation of biogenesis of ß-barrel membrane proteins. Nature 426, 862-866.

Rapaport, D. and F.E. Nargang (2003) Mitochondrial Biogenesis: Protein Import Into and Across the Outer Membrane. In C. M. Koehler and M. F. Bauer (Eds.) Topics in Current Genetics, Vol. 8 “Mitochondrial Function and Biogenesis”, pp. 37-58, Springer-Verlag, Berlin.

Rapaport, D. (2002) Biogenesis of the mitochondrial TOM complex. Trends Biochem. Sci. 26, 191-197.

Krimmer, T., D. Rapaport, M.T. Ryan, C. Meisinger, C.K. Kassenbrock, M. Forte, M.G. Douglas, W. Neupert, F.E. Nargang and N. Pfanner (2001) Biogenesis of the major mitochondrial outer membrane protein porin involves a complex import pathway via receptors and the general import pore. J. Cell Biol. 152, 289-300.

Fritz, S., D. Rapaport, E. Klanner, W. Neupert and B. Westermann (2001) Connection of the Mitochondrial Outer and Inner Membranes by Fzo1 is Critical for Organellar Fusion. J. Cell Biol. 152, 683-692.

Rapaport, D., R.D. Taylor, M. Käser, T. Langer, W. Neupert and F.E. Nargang (2001) Structural requirements of Tom40 for assembly into preexisting TOM complexes of mitochondria. Mol. Biol. Cell 12, 1189-1198.

Dembowski, M., K.-P. Künkele, F.E. Nargang, W. Neupert and D. Rapaport (2001) Assembly of Tom6 and Tom7 into the TOM Core Complex of Neurospora crassa. J. Biol. Chem. 276, 17679-17685.

1997 - 2000

Stan, T., U. Ahting, M. Dembowski, K.-P. Künkele, S. Nussberger, W. Neupert and D. Rapaport (2000) Recognition of Preproteins by the Isolated TOM Complex of Mitochondria. EMBO J. 19, 4895-4902.

Rapaport, D. and W. Neupert (1999) Biogenesis of Tom40, core component of the TOM complex of mitochondria. J. Cell Biol. 146, 321-331.

Rapaport, D., A. Mayer, W. Neupert and R. Lill (1998) Cis and trans sites of the TOM complex in unfolding and initial translocation of preproteins across the outer membrane of mitochondria. J. Biol. Chem. 273, 8806-8813.

Nargang, F.E., D. Rapaport, R. G. Ritzel, W. Neupert and R. Lill (1998) Role of the negative charges in the cytosolic domain of Tom22 in the import of precursor proteins into mitochondria. Mol. Cell. Biol. 18, 3173-3181.

Rapaport, D., K.-P. Künkele, M. Dembowski, U. Ahting, F.E. Nargang, W. Neupert and R. Lill (1998) Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins. Mol. Cell. Biol. 18, 5256-5262.

Rapaport, D., M. Brunner, W. Neupert and B. Westermann (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J. Biol. Chem. 273, 20150-20155.

Rapaport, D., W. Neupert and R. Lill (1997) Mitochondrial protein Import: Tom40 plays a major role in targeting and translocation of preproteins by forming a specific binding site for the presequence. J. Biol. Chem. 272, 18725-18731.

Kliger, Y., A. Aharoni, D. Rapaport, P. Jones, R. Blumenthal and Y. Shai (1997) Fusion peptides derived from the HIV Type 1 glycoprotein 41 associate within phospholipid membranes and inhibit cell-cell fusion: structure-function study. J. Biol. Chem. 272, 13496-13505.

1991 - 1996

Rapaport, D., R. Peled, S. Nir and Y. Shai (1996) Reversible surface aggregation in pore formation by pardaxin. Biophys. J. 70, 2502-2512.

Rapaport, D., M. Ovadia and Y. Shai (1995) A synthetic peptide corresponding to a conserved heptad repeat domain is a potent inhibitor of Sendai virus-cell fusion: an emerging similarity with functional domains of other viruses. EMBO J. 14, 5524-5531.

Rapaport, D., S. Nir and Y. Shai (1994) Capacities of pardaxin analogues to induce fusion and leakage of negatively charged phospholipid vesicles are not necessarily correlated. Biochemistry 33, 12615-12624.

Rapaport, D. and Y. Shai (1994) Interaction of fluorescently-labeled analogues of the N-terminal fusion peptide of Sendai virus with phospholipid membranes. J. Biol. Chem. 269, 15124-15131.

Rapaport, D., G.R. Hague, Y. Pouny and Y. Shai (1993) pH and ionic strength dependent fusion of phospholipid vesicles induced by pardaxin analogues or by mixture of charge reversed peptides. Biochemistry 32, 3291-3297.

Rapaport, D., M. Danin, E. Gazit and Y. Shai (1992) Membrane interaction of the sodium channel S4 segment and its fluorescently-labeled analogues. Biochemistry 31, 8868-8875.

Pouny, Y., D. Rapaport, A. Mor, P. Nicolas and Y. Shai (1992) Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes. Biochemistry 31, 12416-12423.

Rapaport, D. and Y. Shai (1992) Aggregation and organization of pardaxin in phospholipid membranes. J. Biol. Chem.267, 6502-6509.

Rapaport, D. and Y. Shai (1991) Interaction of fluorescently labeled pardaxin and its analogues with lipid bilayers. J. Biol. Chem. 266, 23769-23775.