IFIB – Interfakultäres Institut für Biochemie

News

07.05.2018

Polysialic acid is a cellular receptor for human adenovirus

Receptor for adenovirus could be useful in cancer therapy

In collaboration with investigators from Umea University in Sweden and the Imperial College in London, IFIB researchers have shown that polysialic acid functions as a specific cellular receptor for a human adenovirus. Since polysialic acid can be found in high expression levels in brain and lung cancers where its presence is associated with poor prognosis, the findings provide a useful platform for the design of adenovirus-based vectors for gene therapy of these cancers.

Publication:

Annasara Lenman, A. Manuel Liaci, Yan Liu, Lars Frängsmyr, Martin Frank, Bärbel S. Blaum, Wengang Chai, Iva I. Podgorski, Balázs Harrach, Mária Benkő, Ten Feizi, Thilo Stehle and Niklas Arnberg.Polysialic acid is a cellular receptor for human adenovirus 52.Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4264-E4273. doi: 10.1073/pnas.1716900115. Epub 2018 Apr 19.

Link to publication

Contact information:

Prof. Dr. Thilo Stehle

Interfaculty Institute of Biochemistry

University of Tuebingen

Email: thilo.stehlespam prevention@uni-tuebingen.de

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