Polysialic acid is a cellular receptor for human adenovirus
Receptor for adenovirus could be useful in cancer therapy
In collaboration with investigators from Umea University in Sweden and the Imperial College in London, IFIB researchers have shown that polysialic acid functions as a specific cellular receptor for a human adenovirus. Since polysialic acid can be found in high expression levels in brain and lung cancers where its presence is associated with poor prognosis, the findings provide a useful platform for the design of adenovirus-based vectors for gene therapy of these cancers.
Annasara Lenman, A. Manuel Liaci, Yan Liu, Lars Frängsmyr, Martin Frank, Bärbel S. Blaum, Wengang Chai, Iva I. Podgorski, Balázs Harrach, Mária Benkő, Ten Feizi, Thilo Stehle and Niklas Arnberg.Polysialic acid is a cellular receptor for human adenovirus 52.Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4264-E4273. doi: 10.1073/pnas.1716900115. Epub 2018 Apr 19.
Prof. Dr. Thilo Stehle
Interfaculty Institute of Biochemistry
University of Tuebingen