Algorithmen der Bioinformatik

Bachelor Theses

Here is a listing of possible topics for projects. Please come and see us if you want to learn more about the topics. Further suggestions are welcome.


We will post new topics in early 2023


  • Unrooted densitrees - Fabian Rosner
  • LP and neighbor-net - Julian Wolff 
  • Using the BioSurfantDB classification in microbiome analysis using MEGAN - Niclas Fischer
  • A machine learning approach for survival prediction using transcriptome profiling data from lung cancer patients - Jonathan Fricke
  • Analysis of long read metagenomic samples - Comparison of methods published in Arumugam et al ‎2019 and EL Moss et al ‎2020 - AVAILABLE
    • The aim is to apply the methods described in the one paper to the data of the other paper, and vice versa, to compare the two approaches


    Implementation and improvement of MEGAN's taxonomic binning algorithms, in Python - done
  • Implementation of a MDA simulator with applications to COVID, in Python - done


  • Contamination filtering in microbiome analysis - done
  • Inter-study comparison in metagenomics - done


  • Analysis of metagenomic long-read sequences from a biorector - done
  • Using Mash, Dashing and other k-mer approaches to compute phylogenetic networks on bacteria - done


  • Analyse unterschiedlicher Zellpopulationen von und nach Therapie - done
  • Improved taxonomic profiles based on simulated binning - done
  • Completeness, contamination and annotation of long read metagenome datasets - done


  • Analysis of antimicrobial resistance in microbiome sequencing data - done
  • Application of MetaCyc in microbiome analysis - done
  • Classification of phages and visualization -  done
  • Comparison of different KEGG-based microbiome analysis approaches - done


  • Development of a MobileApp/Website for advising proper antibiotics usage - done
  • Phage identification in metagenomics - done
  • Fast computation of consensus splits - done
  • Structural variants of Bacteroides vulgatus - done
  • Ecoli assembly - done
  • NanoChain: An Empirical Nanopore Read Simulator - done


  • Design and implementation of a web portal for microbiome data - done
  • Analysis of microbiome data in the context of Adipositas - done
  • Analysis of publicly available 16S human gut microbiome data - done
  • Deploying bioinformatics tools in the cloud using Docker -done
  • Steered Molecular Dynamics of 2fdt structure - done
  • Influence of Processing on 16S Analysis Data - done


  • Visualisierung taxonomischer Daten mit Voronoi Trees - done
  • Fast comparison of metagenomic samples - done
  • Functional analysis using BioCyce - done
  • Genes associated with diabetes in the microbiome -done


  • Comparision of metagenomic DNA, done
  • Clouding computing in bioinformatics, done
  • Android app for phylogenetic trees - done
  • Hybrid approach to analysis of 16S rRNA data - done


  • Transskriptomanalyse von Krebszellen, done


  • Vergleich von existierenden Metagenomics Pipelines -done
  • Analysis of ancient DNA - done


  • Plattform für Next-Gen Transkriptomanalyse- done