To characterize the association between cGMP levels in platelets and the platelet lipidome driving thromboinflammation during stroke in murine stroke models and cerebral stroke patients. Further, we would like to validate the potential therapeutic impact of NO donors and cGMP analogs in regulating the platelet lipidome and, thereby, thrombotic disposition and thromboischaemic events.
In the Atochin lab in Boston, the doctoral researchers will be taught the
- middle cerebral artery occlusion (MCAO) stroke model,
- state of the art technologies to measure cerebral blood flow (CBF), and
- functional analysis of platelets in the murine stroke models.
Supported by the long standing expertise of the Atochin lab, CBF will be evaluated under basal conditions and following stroke in mice with perturbed cGMP signaling in platelets as well as in eNOS-/- bone marrow chimeras fed different diets.
Marcel Kremser earned his B.Sc. in Molecular Biology at the University in Bielefeld with a focus on cell biology. After earning his M.Sc. in Medical Biology in Essen, Marcel began his doctoral studies in the laboratory of Meinrad Gawaz. Here, his research focusses on the role of cGMP signaling in platelets and further deepens our understanding of cardiovascular diseases.
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