UNC-Chapel Hill is Tübingen's closest partner in the United States, with a high number of research collaborations across many research fields as well as some student exchange programs.

Faculty and students in biology, Germanic languages and literature, and American studies have long been engaged in collaborations, and the partnership is expanding to include Classics, communication and media, data science, digital humanities, education, exercise & sport science, information & library science, law, linguistics, and philosophy, as well as areas in the health affairs and sciences, with joint research and student engagement emerging in biochemistry & biophysics, epidemiology, environmental sciences and engineering, geosciences, genetics, infectious diseases, microbiology and immunology, nutrition, oncology, pharmacy and pharmacology, and psychology.

UNC-Chapel Hill and the University of Tübingen are committed to supporting joint research projects. Since 2022, there have been several succesfull seed fund rounds, financing various projects in the thematic field of “Application and/or Impact of Data on Democratic Societies”.