Agents that modulate cGMP signaling pathways have emerged as one of the most successful areas in recent drug discovery and clinical pharmacology. Historically, the focus has been on cardiovascular disease phenotypes. However, compelling evidence, obtained as a result of previous work performed in Tübingen and Boston, suggests that cGMP’s relevance goes far beyond current cardiovascular indications. Hence, increasing our understanding of cGMP signaling in healthy and disease states in multiple cell- and tissue-types is a core goal of the proposed projects. In particular, the Research Training Group ("Graduiertenkolleg", GRK) at the University of Tübingen will collaborate with partners in Boston and other renowned international institutions to translate clinical experience with cGMP drugs “back” from “bedside to bench”, which is also reflected by its title GRK 2381 “cGMP: From Bedside to Bench”. Doctoral researchers will interact with basic and clinical scientists who are experienced mentors, and they will also develop contacts with leading pharmaceutical companies, providing an exceptional educational environment.
An important element of the GRK is its strong international dimension. Each student will be co-mentored by a principal investigator at a renowned institution abroad (in Boston, Chicago, London, or St. Louis, depending on the project) who works on a related topic, and she/he will visit the partner laboratory for a period of three months. Using state-of-the-art techniques, transgenic mice and human cell models (developed by members of the GRK) fellows will gain critical new insights into cGMP’s role in cancer, cardiovascular diseases, and neurological disorders. They will not only elucidate the cellular and molecular mechanisms behind cGMP-based therapies currently used in the clinics. GRK projects will also define novel functions for cGMP pathways in different cell types and, thereby, identify novel indications as well as potential side effects of cGMP-modulating drugs. We anticipate that an enhanced understanding of the mechanisms underlying the therapeutic effects of targeting cGMP signaling will facilitate translating the use of existing drugs to treat various important diseases. Based on an environment of scientific excellence, intensive co-mentoring, and a highly interactive, structured training program in multi-disciplinary skills and critical thinking, doctoral researchers of the GRK 2381 will be well-prepared for the challenges of the job market in academia and industry.
Our website uses cookies. Some of them are mandatory, while others allow us to improve your user experience on our website. The settings you have made can be edited at any time.
or
Essential
in2cookiemodal-selection
Required to save the user selection of the cookie settings.
3 months
be_lastLoginProvider
Required for the TYPO3 backend login to determine the time of the last login.
3 months
be_typo_user
This cookie tells the website whether a visitor is logged into the TYPO3 backend and has the rights to manage it.
Browser session
ROUTEID
These cookies are set to always direct the user to the same server.
Browser session
fe_typo_user
Enables frontend login.
Browser session
Videos
iframeswitch
Used to show all third-party contents.
3 months
yt-player-bandaid-host
Is used to display YouTube videos.
Persistent
yt-player-bandwidth
Is used to determine the optimal video quality based on the visitor's device and network settings.
Persistent
yt-remote-connected-devices
Saves the settings of the user's video player using embedded YouTube video.
Persistent
yt-remote-device-id
Saves the settings of the user's video player using embedded YouTube video.
Persistent
yt-player-headers-readable
Collects data about visitors' interaction with the site's video content - This data is used to make the site's video content more relevant to the visitor.
Persistent
yt-player-volume
Is used to save volume preferences for YouTube videos.
Persistent
yt-player-quality
Is used to save the quality settings for YouTube videos.
Persistent
yt-remote-session-name
Saves the settings of the user's video player using embedded YouTube video.
Browser session
yt-remote-session-app
Saves the settings of the user's video player using embedded YouTube video.
Browser session
yt-remote-fast-check-period
Saves the settings of the user's video player using embedded YouTube video.
Browser session
yt-remote-cast-installed
Saves the user settings when retrieving a YouTube video integrated on other web pages
Browser session
yt-remote-cast-available
Saves user settings when retrieving integrated YouTube videos.
Browser session
ANID
Used for targeting purposes to profile the interests of website visitors in order to display relevant and personalized Google advertising.
2 years
SNID
Google Maps - Google uses these cookies to store user preferences and information when you view pages with Google Maps.
1 month
SSID
Used to store information about how you use the site and what advertisements you saw before visiting this site, and to customize advertising on Google resources by remembering your recent searches, your previous interactions with an advertiser's ads or search results, and your visits to an advertiser's site.
6 months
1P_JAR
This cookie is used to support Google's advertising services.
1 month
SAPISID
Used for targeting purposes to profile the interests of website visitors in order to display relevant and personalized Google advertising.
2 years
APISID
Used for targeting purposes to profile the interests of website visitors in order to display relevant and personalized Google advertising.
6 months
HSID
Includes encrypted entries of your Google account and last login time to protect against attacks and data theft from form entries.
2 years
SID
Used for security purposes to store digitally signed and encrypted records of a user's Google Account ID and last login time, enabling Google to authenticate users, prevent fraudulent use of login credentials, and protect user data from unauthorized parties. This may also be used for targeting purposes to display relevant and personalized advertising content.
6 months
SIDCC
This cookie stores information about user settings and information for Google Maps.
3 months
NID
The NID cookie contains a unique ID that Google uses to store your preferences and other information.
6 months
CONSENT
This cookie tracks how you use a website to show you advertisements that may be of interest to you.
18 years
__Secure-3PAPISID
This cookie is used to support Google's advertising services.
2 years
__Secure-3PSID
This cookie is used to support Google's advertising services.
6 months
__Secure-3PSIDCC
This cookie is used to support Google's advertising services.
6 months